Search Results (3)

Nowadays, product development times are constantly decreasing, while the requirements for the products themselves increased significantly in the last decade. Hence, manufacturers use Computer-Aided Design (CAD) and Finite-Element (FE) Methods to develop better products in shorter times. Shape optimization offers great potential to improve many high-fidelity, numerical problems such as the crash performance of cars. Still, the proper selection of optimization algorithms provides a great potential to increase the speed of the optimization time. This article reviews the optimization performance of two different algorithms and frameworks for the structural behavior of a b-pillar. A b-pillar is the structural component between a car’s front and rear door, loaded under static and crash requirements. Furthermore, the validation of the algorithm includes a feasibility constraint. Recently, an optimization routine was implemented and validated for a Non-dominated Sorting Genetic Algorithm (NSGA-II) implementation. Different multi-objective optimization algorithms are reviewed and methodically ranked in a comparative study by given criteria. In this case, the Gap Optimized Multi-Objective Optimization using Response Surfaces (GOMORS) framework is chosen and implemented into the existing Institut für Konstruktionstechnik Optimizes Shapes (IKOS) framework. Specifically, the article compares the NSGA-II and GOMORS directly for a linear, non-linear, and feasibility optimization scenario. The results show that the GOMORS outperforms the NSGA-II vastly regarding the number of function calls and Pareto-efficient results without the feasibility constraint. The problem is reformulated to an unconstrained, three-objective optimization problem to analyze the influence of the constraint. The constrained and unconstrained approaches show equal performance for the given scenarios. Accordingly, the authors provide a clear recommendation towards the surrogate-based GOMORS for costly and multi-objective evaluations. Furthermore, the algorithm can handle the feasibility constraint properly when formulated as an objective function and as a constraint. Full article

Karst aquifers are indispensable, yet vulnerable, resources; therefore, they require a comprehensive protection strategy. Since springs are the terminal points of the karst flow systems, knowledge of their distribution is a key element for the better understanding of groundwater flow, availability and vulnerability. The present study aims to introduce a data-driven analysis by the application of a spatial statistical technique (Weights of Evidence (WofE)) for the evaluation of factors influencing spring distribution in karst areas. A workflow was developed for investigating two questions: where will the springs locate, and where will the permanent springs evolve? This workflow has the potential for application to unconfined karst areas. This enhanced approach was applied to an unconfined transboundary aquifer, the Gömör–Torna Karst (HU and SK). The roles of five factors was statistically investigated: terrain elevation, distance to faults, distance of the carbonate–non-carbonate rock contact, distance to sinkholes, and precipitation distribution. The validation procedures confirmed the effectiveness of the approach. The resulting predictive maps are useful for decision-makers to delineate areas holding potential karst springs and to address water availability problems and protection measures. In addition, the WofE technique improved the comprehension of the geological conditions favourable for the formation of the springs. Full article

Since the advent of infliximab for the treatment of rheumatoid arthritis (RA), new genetically-engineered molecules have appeared. This review aims to present the current data and body of evidence for golimumab (GLM). Safety, efficacy, tolerability and immunogenicity are all being investigated, not only through phase III trials (GO-BEFORE, GO-FORWARD, GO-AFTER, GO-MORE, GO-FURTHER, GO-NICE), but also through studies of real-world data. It seems that GLM in the subcutaneous form is an efficacious molecule with a good safety profile at the standard dosage scheme, but a 100 mg subcutaneous dose is associated with a higher risk of opportunistic infections, lymphoma and demyelination. Furthermore, when compared to other tumor necrosis factor-α molecules, it is non-inferior, and, at some points, such as when it comes to immunogenicity and persistence of the drug, it has a better profile. In summary, GLM is an effective, well-tolerated option for the treatment of RA, for both the clinician and patients who are seeking a convenient dosage scheme. Full article