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Article

6 Citations

2,984 Views

16 Pages

Exploring the Assembly of Resorc[4]arenes for the Construction of Supramolecular Nano-Aggregates

Fabio Buonsenso,
Francesca Ghirga,
Isabella Romeo,
Gabriella Siani,
Serena Pilato,
Deborah Quaglio,
Marco Pierini,
Bruno Botta and
Andrea Calcaterra

Int. J. Mol. Sci.2021, 22(21), 11785;https://doi.org/10.3390/ijms222111785

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29 October 2021

Many biologically active compounds feature low solubility in aqueous media and, thus, poor bioavailability. The formation of the host-guest complex by using calixarene-based macrocycles (i.e., resorcinol-derived cyclic oligomers) with a good solubili...

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Article

4 Citations

2,073 Views

15 Pages

Hedgehog Pathway Inhibition by Novel Small Molecules Impairs Melanoma Cell Migration and Invasion under Hypoxia

Alessandro Falsini,
Gaia Giuntini,
Mattia Mori,
Francesca Ghirga,
Deborah Quaglio,
Antonino Cucinotta,
Federica Coppola,
Irene Filippi,
Antonella Naldini and
Bruno Botta
+ 1 author

Pharmaceuticals2024, 17(2), 227;https://doi.org/10.3390/ph17020227

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8 February 2024

Melanoma is the principal cause of death in skin cancer due to its ability to invade and cause metastasis. Hypoxia, which characterises the tumour microenvironment (TME), plays an important role in melanoma development, as cancer cells can adapt and...

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