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Keywords = HIV/HPgV co-infection

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1 pages, 139 KB  
Correction
Correction: Köksal et al. Interplay Between HIV and Human Pegivirus (HPgV) Load in Co-Infected Patients: Insights from Prevalence and Genotype Analysis. Viruses 2024, 16, 5
by Muammer Osman Köksal, Martin Pirkl, Kutay Sarsar, Mehmet Ilktaç, Gibran Horemheb-Rubio, Murat Yaman, Sevim Meşe, Haluk Eraksoy, Baki Akgül and Ali Ağaçfidan
Viruses 2024, 16(12), 1883; https://doi.org/10.3390/v16121883 - 5 Dec 2024
Cited by 1 | Viewed by 964
Abstract
In the original publication [...] Full article
(This article belongs to the Special Issue HIV and Co-infections: Updates and Insights, 2nd Edition)
11 pages, 1931 KB  
Article
Interplay Between HIV and Human Pegivirus (HPgV) Load in Co-Infected Patients: Insights from Prevalence and Genotype Analysis
by Muammer Osman Köksal, Martin Pirkl, Kutay Sarsar, Mehmet Ilktaç, Gibran Horemheb-Rubio, Murat Yaman, Sevim Meşe, Haluk Eraksoy, Baki Akgül and Ali Ağaçfidan
Viruses 2024, 16(1), 5; https://doi.org/10.3390/v16010005 - 19 Dec 2023
Cited by 5 | Viewed by 4007 | Correction
Abstract
Human pegivirus (HPgV) is transmitted through sexual or parenteral exposure and is common among patients receiving blood products. HPgV is associated with lower levels of human immunodeficiency virus (HIV) RNA and better survival among HIV-infected patients. This study aimed to investigate the prevalence [...] Read more.
Human pegivirus (HPgV) is transmitted through sexual or parenteral exposure and is common among patients receiving blood products. HPgV is associated with lower levels of human immunodeficiency virus (HIV) RNA and better survival among HIV-infected patients. This study aimed to investigate the prevalence of HPgV and determine its subtypes in HIV-infected individuals living in Istanbul, which has the highest rate of HIV infection in Türkiye. Total RNA extraction from plasma, cDNA synthesis, and nested PCR were performed for HPgV on plasma samples taken from 351 HIV-1-infected patients. The HPgV viral load was quantified on HPgV-positive samples. HPgV genotyping was performed by sequencing the corresponding amplicons. In the present study, the overall prevalence of HPgV RNA in HIV-infected patients was 27.3%. HPgV subtypes 1, 2a, and 2b were found, with subtype 2a being the most frequent (91.6%). Statistical analysis of HIV-1 viral load on HPgV viral load showed an opposing correlation between HIV-1 and HPgV loads. In conclusion, these data show that HPgV infection is common among HIV-positive individuals in Istanbul, Türkiye. Further comprehensive studies are needed to clarify both the cellular and molecular pathways of these two infections and to provide more information on the effect of HPgV on the course of the disease in HIV-infected individuals. Full article
(This article belongs to the Special Issue HIV and Co-infections: Updates and Insights, 2nd Edition)
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13 pages, 1522 KB  
Article
Prevalence and Clinical Impact of Human Pegivirus-1 Infection in HIV-1-Infected Individuals in Yunnan, China
by Zhijiang Miao, Li Gao, Yindi Song, Ming Yang, Mi Zhang, Jincheng Lou, Yue Zhao, Xicheng Wang, Yue Feng, Xingqi Dong and Xueshan Xia
Viruses 2017, 9(2), 28; https://doi.org/10.3390/v9020028 - 15 Feb 2017
Cited by 33 | Viewed by 7510
Abstract
Human Pegivirus-1 (HPgV-1) may have a beneficial impact on disease progression in human immunodeficiency virus-1 (HIV-1) infection. However, analysis of the genotypic diversity of HPgV-1 and its relevance to the progression of HIV-1 disease remains limited. A total of 1062 HIV-1-infected individuals were [...] Read more.
Human Pegivirus-1 (HPgV-1) may have a beneficial impact on disease progression in human immunodeficiency virus-1 (HIV-1) infection. However, analysis of the genotypic diversity of HPgV-1 and its relevance to the progression of HIV-1 disease remains limited. A total of 1062 HIV-1-infected individuals were recruited in all sixteen prefectures of Yunnan province, China. The reverse transcription nested polymerase chain reaction (RT-nPCR), phylogenetic analyses, and clinical data analyses were used to detect HPgV-1 infection, determine genotype, and analyze HPgV-1 genotype impact on HIV-1 disease progression. The overall positive rate of HPgV-1 RNA was 23.4% (248/1062), and the frequency of HPgV-1 infection in injecting drug users (IDUs) (28.5%, 131/460) was significantly higher than in heterosexuals (19.4%, 117/602). Multiple genotypes were identified in 212 subjects with successful sequencing for the E2 gene, including genotype 7 (55.7%), genotype 3 (34.9%), genotype 4 (4.7%), genotype 2 (3.3%), and an unclassified group (1.4%). Moreover, genotype 7 predominated in IDUs, whereas genotype 3 was the most common in heterosexuals. Our results revealed that HPgV-1 genotype 7 groups exhibited significantly lower HIV-1 viral load and higher CD4+ cell counts. This finding suggests that HPgV-1 genotype 7 may be associated with a better progression of HIV-1 disease. Full article
(This article belongs to the Special Issue Advances in Flavivirus Research)
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