Search Results (219)

The structure of N-[(2H-1,3-benzodioxol-5-yl)methyl]-2-(2,2,2-trichloroacetamido)benzamide was verified by using a combination of 1D and 2D NMR techniques. Fully assigned data from 1D NMR (¹H, ¹³C and DEPT 135) and 2D NMR (COSY, HMQC, HMBC) spectra was presented for the compound. The ¹H NMR spectrum of the ABX spin system in the benzodioxol moiety was simulated to predict the corresponding ⁿJ_HH coupling constants. The spectral assignments for the structure were supported by interpretive library search and HOSE predictions. Full article

Introduction: Osteoarthritis (OA) is a chronic degenerative joint disease with limited treatment options focused primarily on symptom management. Emerging evidence suggests that dietary interventions may influence inflammation and pain through modulation of the gut microbiome and metabolome. Methods: We conducted a 4-week open-label pilot trial evaluating the effects of an anti-inflammatory dietary intervention (ITIS diet) in 20 patients with knee OA (ClinicalTrials.gov ID: NCT05559463, registered prior to enrollment; sponsor: University of California, San Diego; responsible party: Monica Guma; study start date: 1 October 2021). The following were assessed before and after the intervention: (1) clinical outcomes; (2) gut and salivary microbiomes; and (3) salivary, stool, and plasma metabolomes. Responders were defined as patients achieving ≥30% reduction in Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain scores. Results: The ITIS diet was well-tolerated, with good adherence (66.2%) and a significant improvement in clinical outcomes, including reduced pain and improved overall health measured with the visual analog scale (VAS). Responders (n = 8) showed distinct gut microbiome and metabolome profiles compared to non-responders (n = 12). Notably, taxa within the Lachnospiraceae family exhibited dynamic, bidirectional shifts post-intervention: Anaerostipes and Limivivens were enriched among responders and negatively correlated with pain scores, while Oliverpabstia and Fusicatenibacter were depleted following dietary intervention. These taxa also showed strong correlations with anti-inflammatory metabolites, including hydroxydecanoic acid derivatives and pyridoxine. Furthermore, subsequent network analysis revealed more structured and selective microbiome–metabolome interactions in responders, specifically post-intervention. Conclusions: This pilot study shows that a short-term anti-inflammatory dietary intervention was associated with meaningful changes in the gut microbiome and metabolome. Members of the Lachnospiraceae family emerged as key taxa associated with pain reduction and anti-inflammatory metabolite production. Our findings suggest that specific microbial responses—rather than global diversity changes—may underlie dietary responsiveness in OA. Although exploratory and limited by sample size, our results support further investigation into personalized, microbiome-informed nutritional strategies for OA management. Full article

From the 17th century, European leisure travellers sought novel experiences, places and landscapes; they explored them within the context of contemporary, but temporally changing, social norms. Amongst travellers’ earliest motivations were reportage, curiosity and recuperation in managed landscapes. From the late 18th century, images in art galleries and then guidebooks directed leisure travellers into ‘wild’ places. Supporting and part-driving these developments were travel and antiquarian publications. That normalisation of ‘wild places’ exploration coincided with natural history’s popularisation. From the early 19th century, geosites were recognised, scientifically described, and popularised through a range of publications; this marked the beginning of geotourism. This can be contextualised within the rise in resort-based coastal tourism. These various themes are explored in relation to ‘Coastal Southern England’, an important tourism region from the early-18th century. By the Great War’s (1914–1918) close, its tourism patterns and nature, recognisable in present-day offerings, were established. Its development as a geotourism region can be conceptualised through the ‘travellers’ gaze’ and ‘adapted comfort zone’ models. Early geotourism literature and artistic representations, along with their creators’ biographies, could underpin modern geo-interpretation, of which some exemplars are given. General conclusions are drawn and future research suggested. Full article

This study is devoted to investigating the Lunar New Year effect on market returns for the Ho Chi Minh Stock Exchange (HOSE). The data employed in this study include a daily series of the VN30-Index, which is a market capitalization weighted index of 30 large capitalization and high liquidity stocks traded on the HOSE, for the period from 6 February 2012 to 31 December 2024. The empirical findings derived from ordinary least squares (OLS), exponential-generalized autoregressive conditional heteroskedasticity [EGARCH(1,1)] regression models consistently confirm that the average return in the last two days and five days before the Lunar New Year are significantly higher than the average market returns on other days of the year. However, this study finds that the average return during the first two trading days and five trading days following the Lunar New Year are not significantly different from the average market returns on other days throughout the year. Full article

Ovarian cancer is a deadly gynecological malignancy that will affect about 21,000 women and result in almost 153,000 deaths in the United States in 2025. New clinical tools that facilitate early diagnosis and treatment of ovarian malignancies will significantly help reduce mortality and improve current long-term survival rates. We utilized a previously identified single-strand DNA aptamer RLA01 that binds and internalizes into target epithelial ovarian cancer cells to label PLGA-based nanoparticles and determine their ability to selectively target EOC cells and deliver payloads for cellular internalization. Nanoparticles labeled with RLA01 significantly enhanced cellular uptake 20–85% by receptor-mediated endocytosis into target EOC Caov-3 cells and inhibited cellular uptake in non-target HOSE 6-3 cells. Further, labeling of paclitaxel-loaded nanoparticles with RLA01 significantly decreased cell proliferation and induced apoptosis. A preliminary pilot study looking at the in vivo stability of aptamers demonstrated their ability to promote retention and honing of nanoparticles at tumors. These data demonstrate the effective combinatorial use of aptamer RLA01 and nanoparticle technologies for the direct targeting of tumor cell populations both in vitro and in vivo. Full article

The widespread adoption of liquefied natural gas (LNG) as a marine fuel has driven the development of LNG bunkering operations in global ports. Major international hubs, such as Shenzhen Port, have implemented ship-to-ship (STS) bunkering practices. However, this process entails unique safety risks, particularly hazards associated with vapor cloud dispersion caused by bunkering hose releases. This study employs the Phast software developed by DNV to systematically simulate LNG release scenarios during STS operations, integrating real-world meteorological data and storage conditions. The dynamic effects of transfer flow rates, release heights, and release directions on vapor cloud dispersion are quantitatively analyzed under daytime and nighttime conditions. The results demonstrate that transfer flow rate significantly regulates dispersion range, with recommendations to limit the rate below 1500 m³/h and prioritize daytime operations to mitigate risks. Release heights exceeding 10 m significantly amplify dispersion effects, particularly at night (nighttime dispersion area at a height of 20 m is 3.5 times larger than during the daytime). Optimizing release direction effectively suppresses dispersion, with vertically downward releases exhibiting minimal impact. Horizontal releases require avoidance of downwind alignment, and daytime operations are prioritized to reduce lateral dispersion risks. Full article

The conveying hose is an important piece of equipment in the field of Marine engineering. Its spatial configuration and force conditions affect the normal operation of the Marine engineering system. This paper proposes a flexible, fully hose-based conveyance method for the field of deep-sea mining and mainly uses Orcaflex software to simulate and analyze the characteristics of the conveying hose in this system. This paper studies the influences of the top spacing, incoming flow direction, and placement and recovery processes on the configuration characteristics and force conditions of the hose. The conclusion drawn is that the conveying hose studied in this paper can maintain a good spatial configuration underwater and has a stable force condition. When the top spacing is 20 m, the transition of the curved section at the bottom of the hose is relatively smooth. The top tension of the hose has a good adaptability to the top spacing and the direction of the incoming flow. The conveying hose can stably complete the deployment and recovery operations. Full article

During the process of flexible aerial refueling, the flexible structure of the hose drogue assembly is affected by internal and external interference, such as docking maneuvering, deformation of the hose, attitude changes, and body vibrations, causing the hose to swing and the whipping phenomenon, which greatly limits the success rate and safety of aerial refueling operations. Based on a 2.4 m transonic wind tunnel, high-speed wind tunnel test technology of a flexible aerial refueling hose–drogue system was established to carry out experimental research on the coupling characteristics of aerodynamics and multi-body dynamics. Based on the aid of Videogrammetry Model Deformation (VMD), high-speed photography, dynamic balance, and other wind tunnel test technologies, the dynamic characteristics of the hose–drogue system in a high-speed airflow and during the approach of the receiver are obtained. Adopting flexible multi-body dynamics, a dynamic system of the tanker, hose, drogue, and receiver is modeled. The cable/beam model is based on an arbitrary Lagrange–Euler method, and the absolute node coordinate method is used to describe the deformation, movement, and length variation in the hose during both winding and unwinding. The aerodynamic forces of the tanker, receiver, hose, and drogue are modeled, reflecting the coupling influence of movement of the tanker and receiver, the deformation of the hose and drogue, and the aerodynamic forces on each other. The tests show that during the approach of the receiver (distance from 1000 mm to 20 mm), the sinking amount of the drogue increases by 31 mm; due to the offset of the receiver probe, the drogue moves sideways from the symmetric plane of the receiver. Meanwhile, the oscillation magnitude of the drogue increases (from 33 to 48 and from 48 to 80 in spanwise and longitudinal directions, respectively). The simulation results show that the shear force induced by the oscillation of the hose and the propagation velocity of both the longitudinal and shear waves are affected by the hose stiffness and Mach number. The results presented in this work can be of great reference to further increase the safety of aerial refueling. Full article

This paper addresses the need for an integrated approach to develop an improved clam dredge system. Current designs often rely on empirical methods, resulting in a disconnect between theoretical models, computational simulations, and experimental validation. To bridge this gap, the study integrates computational fluid dynamics (CFD), experimental tests, and analytical methods to develop a clam dredge system. Firstly, the paper introduces an analytical tool that facilitates decision making by evaluating pump parameters, and to determine the operating point for various hose and nozzle parameters. This guides the parameter selection of pump, hose and jets for maximum performance. Secondly, CFD is utilized to analyze flow behavior, enabling the design of internal nozzle geometries that minimize head losses and maximize the scouring effect. A full-scale experimental measurement was conducted to validate computational results. Furthermore, a replica manifold is constructed using 3D printing and tested, demonstrating improvements in jet speed with both original and new nozzle designs. Analytical results indicate that increasing hose length reduces BHP, flow rate, and jet velocity, while increasing hose or jet diameter boosts BHP and flow but reduces jet speed due to pressure drops. Switching pumps reduced power consumption by 10.5% with minimal speed loss. The CFD analysis optimized nozzle design, reducing jet loss and enhancing efficiency. The proposed slit nozzle design reduces the loss coefficient by 85.24% in small-scale runs and by 83% in full-scale runs compared to the original circular jet design. The experiments confirmed the pressure differences between the CFD and experimental tests are within 10%, and demonstrated that rectangular jets increase speed by 9% and seafloor force by 19%. This paper improved the hydrodynamic design of the clam dredge system, and provides a framework for future dredge system designs. Full article

In this study, a self-propelled hard hose traveler is developed as a modification of the conventional design. The traveler demonstrated enhanced field applicability and intelligence level in Europe and central–eastern China. A parametric configuration scheme was attained through the irrigator’s computational modeling and experimental validation. This study proposed a uniform water distribution calculation model for single-sprinkler linear-move irrigation. The deviation rate between calculated and experimental values was 7.3%. The average application depth decreased with increased sprinkler motion speed and path spacing. The uniformity of water distribution (CU value) exhibited an oscillating trend as the path spacing changed. As the sprinkler rotation angle increased along a specific path, the CU value first rose from 69.2% to 80.0% and then declined to 68.7%. When irrigation and sprinkler motions were combined, the CU value at 1.5 R initially decreased from 92.1% to 72.9%, then increased to 84.2% as the sprinkler rotation angle increased. The combined sprinkler and irrigation motions showed a significantly better uniformity than the specific path irrigation. The highest CU value was 95.0%, with a nozzle diameter of 16.0 × 6.0 mm, a sprinkler rotation angle of 180°, and a path spacing of 1.6 R. This study introduces a novel approach for water-saving irrigation equipment and offers practical guidance for farmers on operating the self-propelled hard hose traveler. Full article

Domestic showers are critical points of human exposure to microbial biofilms, which may harbor opportunistic pathogens such as Legionella spp. and nontuberculous Mycobacterium. However, biofilm development in reverse osmosis (RO)-treated drinking water systems remains poorly understood. We tested whether shower plumbing material (flexible polymer hose versus showerhead with inline polyethersulfone filter) and seasonal water variations influence biofilm community assembly. In a controlled field study, commercial shower systems were deployed in households supplied with RO-treated tap water from the KAUST Seawater Desalination Plant; biofilm samples were collected from hoses and filters over 3–17 months. Flow cytometry and 16S rRNA gene amplicon sequencing characterized microbial abundance, diversity, and taxonomic composition. We found that alpha diversity, measured by observed OTUs, was uniformly low, reflecting ultra-low biomass in RO-treated tap water. Beta diversity analyses revealed clear clustering by material type, with hoses exhibiting greater richness and evenness than filters. Core taxa—Pelomonas, Blastomonas, and Porphyrobacter—dominated both biofilm types, suggesting adaptation to low-nutrient, chlorinated conditions. Overall, our results demonstrate that ultra-low-nutrient RO tap water still supports the formation of material-driven, low-diversity biofilms dominated by oligotrophic taxa, underscoring plumbing-material choice as a critical factor for safeguarding shower water quality. These findings advance our understanding of biofilm ecology in RO-treated systems, informing strategies to mitigate potential health risks in shower water. Full article

Polybutadiene (PB) and polyisoprene (PI) rubbers are indispensable synthetic elastomeric materials widely used in tires, footwear, hose, belts, sealants, electricity, construction, and other applications. Nowadays, PB and PI elastomers are produced from butadiene (BD) and isoprene (IP) monomers via transition-metal-mediated coordination polymerization. Transition metal catalytic systems consist of a precise characteristic structural unit at the molecular level: well known as “single-site catalysts” (SSCs). These have experienced a revolutionary advance in the recently developed conjugated dienes synthetic rubber method. Among the SSCs, a class of rare-earth, metal-centered half-sandwich molecule has been identified as a high-performance catalytic system for conjugated dienes polymerization. These novel half-sandwich rare-earth (HSRE) catalytic systems exhibit several irreplaceable advantages compared with the conventional Ziegler–Natta-type catalytic systems. These HSRE catalytic systems can create novel conjugated diene rubbers (CDRs) with high catalytic reactivity, high stereoselectivity, an adjustable polymer chain microstructure, and high molecular weights and are considered to be the next generation of ecofriendly and economic catalytic systems for industrial applications. This paper delivers a concise review of some important synthetic methods for representative HSRE complexes with characteristic structures and of the utilization of some HSRE catalytic systems for the preparation of high-performance CDRs, especially highly stereoregular PI and PB materials. Full article

Nitrosamines (NAs) are toxic compounds associated with disinfection processes. Human exposure can occur through the hydraulic hoses and seals that are in contact with drinking water. This study develops and validates a chromatographic method to quantify 11 NAs in water leachates from four organic materials. The method is based on liquid–liquid extraction (LLE) followed by gas chromatography coupled with mass spectrometry (GC-MS). The method was validated by the application of several statistical tests, namely, linearity/working range, precision, trueness, and recovery tests. The GC-MS method showed a good linear range for all NAs with coefficients of determination (r²) higher than 0.9989, coefficients of variation of the method (CVm) lower than 2.5%, and PG < F (0.05; 1; N-3). The working range varies between 10 µg/L and 386.7 µg/L. The GC-MS method showed good precision under repeatability and reproducibility conditions with a relative standard deviation (RSD) lower than 12% and 10%, respectively. The GC-MS showed good trueness with a relative error lower than 20%. Matrix effects were significant, with recovery (Rec) values between 47% and 125% and an RSD lower than 20%. The limit of detection (LOD) and quantification (LOQ) ranged between 0.71 µg/L and 8.9 µg/L and between 2.3 µg/L and 29.8 µg/L, respectively. The method quantification limits (MQL) ranged from 0.0045 µg/L to 0.0378 µg/L. The sum of the MQL (0.2 µg/L) is lower than the reference limit of 0.3 µg/L for NAs in the leachates from the migration tests. Four organic materials were subjected to migration tests with demineralized and chlorinated water to assess their suitability for the water supply system. These materials met the NA specifications for use in the water network. Full article

To study the pathological contribution of fatty acid (FA) metabolism regulators including fatty acid binding protein 4 (FABP4), FABP5, peroxisome proliferator-activated receptor alpha (PPARα), and PPARγ in ovarian carcinoma, non-cancerous human ovarian surface epithelium (HOSE) cells and two epithelial ovarian carcinoma (EOC) cell lines, AMOC-2 and ES2 established from ovarian serous adenocarcinoma and ovarian clear cell carcinoma, respectively, were subjected to (1) an analysis of the physical properties of spheroids, (2) qPCR analysis, (3) cellular metabolic analysis, and (4) multiomic pan-cancer analysis using the Cancer Genome Atlas (TCGA). In contrast to globe-shaped spheroids of HOSE cells, AMOC-2 and ES2 cells formed non-globe-shaped spheroids and ES2 spheroids were much more fragile than AMOC-2 spheroids. Gene expression levels of FABP4 and FABP5 in AMOC-2 cells and those of PPARγ in AMOC-2 cells were significantly higher than those in HOSE cells. Metabolic phenotypes and the effectiveness against antagonists for regulators were significantly different in the two types of cancerous cells. Those regulators were identified by a multiomic pan-cancer analysis as novel factors for the prediction of the prognosis of ovarian serous adenocarcinoma. The results show that dysregulated FA metabolism in AMOC-2 and ES2 suggests that the regulation of FA metabolism may be a critical factor in the pathogenesis of EOC. Full article

The cement industry contributes approximately 7% of global anthropogenic CO₂ emissions, primarily through energy-intensive clinker production. This study evaluates the thermal behavior and gas emissions of seven waste materials (sawdust, pecan nutshell, wind blade waste, industrial hose waste, tire-derived fuel, plastic waste, and automotive shredder residue) as alternative fuels for cement manufacturing, motivated by the limited information available regarding their performance and environmental impact, with bituminous coal used as a reference. Thermogravimetric analysis and differential scanning calorimetry (TGA-DSC) were used to quantify mass loss and energy changes, while TGA coupled with mass spectrometry (TGA-MS) was used to identify volatile compounds released during thermal degradation. Both TGA-DSC and TGA-MS were conducted under oxidative conditions. The analysis revealed that these waste materials can generate up to 70% of coal’s energy, with combustion primarily occurring between 200 °C and 600 °C. The thermal profiles demonstrated that these materials can effectively replace fossil fuels without releasing harmful toxic gases like HCl, dioxins, or furans. Combustion predominantly emitted CO₂ and H₂O, with only trace volatile organic compounds such as C₃H₃ and COOH. The findings highlight the potential of alternative fuels to provide substantial energy for cement production while addressing waste management challenges and reducing the industry’s environmental impact through innovative resource valorization. Full article