Search Results (4,917)

Environmental management systems (EMSs), such as ISO 14001, are commonplace across the architecture, engineering, construction, operations, and management (AECOM) sectors of advanced economies. However, their uptake remains limited across emerging markets and developing economies. This study explores stakeholders’ perceptions of the benefits and barriers to implementing EMSs within the AECOM sectors of Malaysia. Guided by a positivist stance, the study takes a quantitative approach using an online questionnaire to gather the opinions of AECOM professionals. The findings reveal that participants believe the most significant benefits of implementing EMSs in Malaysia are to improve corporate image and contribute to the environmental standards of the sector, whereas the most significant barriers to implementing EMSs are lack of client support and the difficulty in coordinating environmental performance among multi-tier subcontractors. Based on the evidence collected, the study recommends encouragement by the government of Malaysia to drive forward environmental management and further research into the reasons for the lack of reported support for ISO 14001 within the supply chain. Full article

Climate change is one of the most pressing global environmental challenges, driven by the accumulation of greenhouse gases in the atmosphere. Industrial processes, particularly plastic injection molding, are major contributors due to their high energy demand, raw material use, and waste generation. This study quantifies the carbon footprint of plastic injection molding operations and identifies emission hotspots to support alignment with sustainability objectives. A greenhouse gas inventory was developed for the production processes of Petka Mold Industry in Adana, Türkiye, covering 1 January–31 December 2023. The assessment followed the ISO 14064-1:2019 standard and included emissions from direct fuel consumption, purchased electricity, refrigerant leaks, company vehicles, employee commuting, business travel, purchased goods, and waste transportation. Carbon dioxide, methane, and nitrous oxide were calculated in carbon dioxide equivalent units. This research represents the first comprehensive carbon footprint study in the plastic mold sector integrating all categories (Categories 1–6). In addition, uncertainty and materiality analyses were applied to ensure robustness and transparency, an approach rarely adopted in similar industrial contexts. While most previous studies are limited to Categories 1–3, this work expands the boundaries to all categories, offering a pioneering model for industrial applications. The total corporate GHG emissions for 2023 were calculated as 3922.75 metric tons of CO₂e. Among the categories, purchased raw materials and end-of-life product stages were the most significant contributors, whereas transport and auxiliary services had smaller shares. The results provide a reliable baseline for developing action plans and pursuing emission reduction targets. By combining full category coverage with rigorous assessment tools, this study contributes methodological novelty to corporate carbon accounting and establishes a foundation for future progress toward carbon neutrality. Full article

In alignment with the United Nations’ Sustainable Development Goals (SDGs) and the global pursuit of net-zero emissions, higher education institutions (HEIs) are increasingly expected to demonstrate robust climate accountability and effective decarbonization strategies. This three-year longitudinal study presents a comprehensive assessment of greenhouse gas (GHG) emissions at a higher education institution, employing the ISO 14064-1:2018 framework to strengthen inventory design, boundary delineation, and data governance protocols. Findings indicate that purchased electricity constitutes the largest share; however, fugitive refrigerant leakage and Scope 3 activities—particularly commuting and business travel—represent substantial and often underestimated components of the institution’s carbon footprint. Methodological refinements, including the incorporation of updated emission factors coefficients and enhanced data verification, have revealed the sensitivity of GHG inventories to both policy reforms and behavioral changes, as well as institutional policy reforms. The study also demonstrates that targeted refrigerant management and low-carbon mobility initiatives can generate measurable mitigation effects, even under conditions of expanding campus activity. Beyond the institution-specific results, this research proposes a replicable framework that integrates ISO 14064-1 compliance with data quality assurance and digital verification tools. This framework provides HEIs globally with a structured pathway to enhance reporting credibility, develop evidence-based mitigation strategies, and accelerate progress toward carbon neutrality. These insights underline the strategic role of universities in advancing sector-wide climate leadership and contributing to sustainable development transitions. Full article

Two bacterial strains, designated LXY-1^T and LXY-4^T, were isolated from soil samples collected at a heavy metal smelting plant located in Guangxi, China. Phylogenetic analysis indicated that these strains formed two distinct lineages within the genus Neobacillus. Both strains were characterized as facultative anaerobic, Gram-positive staining, endospore-forming, non-motile, short-rod bacteria. The major cellular fatty acids identified in these strains included C_16:0, iso-C_15:0, antéiso-C_15:0, and antéiso-C_17:0. The predominant polar lipids comprised diphosphatidylglycerol (DPG), phosphatidylethanolamine (PE), and phosphatidylglycerol (PG). The average nucleotide identity (ANI) values between the newly isolated strains and their closest phylogenetic relatives, the type strains of the genus Neobacillus, were found to be below 95%, with corresponding digital DNA–DNA hybridization (dDDH) values remaining below 70%. Based on a comprehensive polyphasic taxonomic analysis incorporating chemotaxonomic, phenotypic, phylogenetic, and genomic data, we proposed that strains LXY-1^T and LXY-4^T represent two novel species of the genus Neobacillus, for which the names Neobacillus terrisolis sp. nov. and Neobacillus solisequens sp. nov. are designated. The type strains are LXY-1^T (= CGMCC 30313^T = JCM 37671^T) and LXY-4^T (= CGMCC 1.62901^T = JCM 37672^T), respectively. Full article

Recent research has increasingly emphasized the synergies between Supply Chain Management Practices (SCMPs) and Quality Management Principles (QMPs), particularly through the emerging concept of Supply Chain Quality Management (SCQM). Despite this recognition, empirical evidence on how these practices interact to influence performance remains very limited, especially in the context of developing countries. This study addresses the gap by interviewing 70 Tunisian agri-food companies to investigate the relationships between five dimensions of SCMP, strategic supplier partnerships, customer relationship, information sharing, information quality and postponement, and the seven principles of ISO9001 QMP: leadership, engagement of people, improvement, customer focus, process approach, evidence-based decision making, and relationship management. Using factor analysis and structural equation modelling, the study explores the mediating role of competitive advantage (CA): price/cost, product quality, product innovation, delivery dependability and time-to-market—on operational performance. The findings indicate that analyzing SCMP, QMP, and CA as aggregated blocks does not produce significant explanatory correlations. Instead, judiciously reorganizing their sub-constructs into five integrated groups provides a more effective model: (1) information and decision capacity, (2) customer-centric innovation, (3) process management and agility, (4) supplier and network management, and (5) leadership and workforce engagement. This integrated classification offers managers a coherent framework for implementing SCMP and QMP to enhance competitiveness results. Full article

Background: Strobilurin fungicides (SFs) are widely detected in the environment, but data on their occurrence in humans and potential health effects are scarce. Objective: This study aimed to characterize the exposure to SFs in a human population from South China and to investigate their potential association with biomarkers of oxidative stress and liver damage. Methods: In a cross-sectional study, we analyzed serum samples from healthy participants and secondary nonalcoholic fatty liver disease (S-NAFLD) patients. Concentrations of SFs and oxidative stress biomarkers including 8-iso-prostaglandin-F2α (8-PGF_2α), 11β-prostaglandin F2α (11-PGF_2α), 15(R)-prostaglandin F2α (15-PGF_2α), and 8-oxo-7,8-dihydro-20-deoxyguanosine (8-OHdG) were measured. Associations between SF exposure, liver function biomarkers, and S-NAFLD prevalence were assessed using multivariate regression models. A mediation analysis was conducted to explore the role of oxidative stress. Results: Azoxystrobin (AZ), fluoxastrobin (FLUO), and fenamidone (FE) were the predominant compounds, with median concentrations ranging from 0.016 to 0.042 ng/mL. Significant positive correlations were observed between all frequently detected SFs and oxidative stress biomarkers (p < 0.05). FE was associated with a modest, albeit statistically significant, prevalence of S-NAFLD. AZ and FE were also found to be statistically significantly associated with altered levels of direct bilirubin (DBIL, FDR-q < 0.05). The exploratory mediation analysis indicated a statistically significant indirect effect (17.1% to 31.2%), suggesting that lipid peroxidation biomarkers could serve as potential mediators between AZ exposure and DBIL levels. Conclusions: This study provides the first evidence of widespread SF exposure in a South Chinese population and reveals significant associations with oxidative stress and AZ exposure with liver function biomarkers (i.e., DBIL), with exploratory analyses suggesting a potential mediating role of oxidative stress in this relationship. However, the cross-sectional design precludes causal inference, and the modest effect sizes warrant cautious interpretation. These findings highlight the need for further longitudinal research to confirm the hepatotoxicity of SFs in humans. Full article

Occupational health and safety (OHS) is essential for protecting the life, health, and physical integrity of workers. In a complex and dynamic professional context, the prevention of occupational risks has become a priority for employers and decision-makers, going beyond legal compliance to create a safe and efficient work environment. This article explores the history and the main theoretical aspects of OHS and explores the implementation of the ISO 45001 standard and introduces managing workplace health and safety (WHS) risks based on the 5M Method and a weighted composite algorithm for OHS risk assessment integrating factors such as severity, probability, frequency of exposure, number of exposed employees, organizational response capacity, and incident history. Applied in a mixed industrial case study, this approach demonstrated superior risk prioritization compared to the classic severity–probability model. The findings have practical applications: organizations can use the Weighted Composite Score to prioritize interventions, allocate resources efficiently, and prevent high-risk incidents. The approach is adaptable across industries, supporting data-driven safety decisions. The integration of this method supports ISO 45001’s principles of a systematic, proactive, and continuous improvement approach to OHS management. Full article

Universities face continuous challenges in ensuring rapid and efficient communication during emergencies due to outdated, fragmented, and manual notification systems. This research presents the design, development, and implementation of a multiplatform mobile application to optimize emergency notifications at the Escuela Superior Politécnica de Chimborazo (ESPOCH). The application, developed using the Flutter framework, offers real-time alert dispatch, geolocation services, and seamless integration with ESPOCH’s Security Unit through Application Programming Interfaces (APIs). A descriptive and applied research methodology was adopted, analyzing existing notification workflows and evaluating agile development methodologies. MOBILE-D was selected for its rapid iteration capabilities and alignment with small development teams. The application’s architecture incorporates a Node.js backend, Firebase Realtime Database, Google Maps API, and the ESPOCH Digital ID API for robust and scalable performance. Efficiency metrics were evaluated using ISO/IEC 25010 standards, focusing on temporal behavior. The results demonstrated a 53.92% reduction in response times compared to traditional notification processes, enhancing operational readiness and safety across the campus. This study underscores the importance of leveraging mobile technologies to streamline emergency communication and provides a scalable model for educational institutions seeking to modernize their security protocols. Full article

Background: Sow reproductive performance is a critical parameter for the productivity of commercial pig farms. Gut microbiota is associated with performance in sow reproduction. At least, under healthy conditions, microbial metabolites from the gut microbiota are considered major contributors to host physiological regulation and productivity. However, information on the differences in gut-derived metabolites related to the sow reproductive performance remain scarce. Our aim was to investigate the relationship between the reproductive performance and microbial metabolite levels in sow’s feces and plasma. Methods: We selected four commercial farms: two with high- (group H) and two with low-reproductive performance (group L). Sows had their feces and blood collected. Results: Except for the iso-butyrate concentration, fecal short-chain fatty acid concentrations remained unchanged between groups. Among intestinal putrefactive metabolites, the indole concentration was higher (p < 0.05) in group H. The concentrations of plasma metabolites p-cresyl sulfate, p-cresyl glucuronide and trimethylamine N-oxide (TMAO) were higher (p < 0.05) in group L than in group H, while the opposite was true for the acetate concentration (p < 0.05). Among plasma biochemicals, tumor necrosis factor (TNF)-alpha and potassium concentrations were higher (p < 0.05) in group L. Conclusions: Blood metabolites, especially gut microbiota-derived metabolites, seemed to be associated with the performance related to sow reproduction. Particularly, harmful metabolites such as p-cresyl glucuronide, p-cresyl sulfate and TMAO were of importance, because they are potentially inflammation factors. In fact, TNF-alpha was stimulated in group L. According to our results, we estimated that p-cresyl glucuronide, p-cresyl sulfate, TMAO and TNF-alpha could be useful physiological indicators to understand sow reproductive performance. Full article

Background/Objectives: To investigate the effects of dark chocolate milk on physiological variables such as heart rate (HR), rate of perceived exertion (RPE), fatigue index and power output during an anaerobic sprint test. Methods: Twenty healthy participants underwent a randomised single-blinded experimental design and completed two trials—DC and iso-caloric white chocolate (WC) (used as a flavonoid-free control). Participants completed a running anaerobic sprint test (RAST, 35 m × 6 sprints × 2 sets, 4 min rest) with RPE and HR recorded after 2nd, 4th and 6th sprints. Results: Descriptive statistics of participants were for males: age: 23.8 ± 1.21 yrs; height: 174.51 ± 5.78 cm; weight: 73.91 ± 9.18 kg; body mass index (BMI): 24.18 ± 2.21 kg·m⁻²; body fat percent (BF%): 19.18 ± 6.17%; lean muscle mass percentage: 77.95 ± 6.16%; females: age: 26.33 ± 4.95 yrs; height: 160.69 ± 5.52 cm; weight: 55.72 ± 7.03 kg; BMI: 21.51 ± 2.02 kg·m⁻²; BF%: 27.24 ± 3.74%; lean muscle mass percentage: 69.20 ± 3.70%. A paired t-test revealed significant differences between trials for 2nd RAST average timings (DC 2nd RAST: 6.43 ± 0.97 s vs. WC 2nd RAST: 6.62 ± 1.05 s, p = 0.012); 2nd RAST total effort time (DC 2nd RAST: 38.58 ± 5.82 s vs. WC 2nd RAST: 39.72 ± 6.28 s, p = 0.012). Conclusions: Results indicated that DC supplementation significantly improved anaerobic sprint timings. Athletes, sports practitioners and coaches may consider implementing DC prior to training workouts and competitions to enhance sporting performance. Full article

Objectives: Research on the antimicrobial effect of Hypericum plant constituents is very rarely accompanied by studies of the cytotoxic effect on cell lines. In the current study, besides microbiological tests, an investigation of the cytotoxicity of Hypericum active ingredients on five non-tumorigenic cell lines, as well as research into the effect on other factors of host homeostasis, was performed. Methods: The main methods applied included an MTT assay, the broth microdilution method (BMD), real-time PCR, live cell imaging with Hoechst dye, Western blot, an enzyme-linked immunosorbent assay (ELISA), and skin irritation test on rabbits. Results: The mean inhibitory concentrations (IC₅₀) of six selected agents—previously phytochemically characterized extracts and compounds—ranged from 0.63 to 48 µg/mL. Due to their strong antimicrobial effect and favorable cytotoxic profile, the extract RochC from Hypericum rochelii and the compound olympiforin B from Hypericum olympicum were selected for subsequent studies at their previously determined minimum inhibitory concentrations (MICs) against Staphylococcus aureus—0.625 and 1 µg/mL, respectively. These doses were lower than their IC₅₀ values and the maximum tolerated concentrations (MTCs), according to ISO 10993-5, Annex C, for fibroblast cells, including a human gingival line. The MIC values of RochC and Olympiforin B against the cariogenic Streptococcus mutans were 6 and 3 µg/mL, respectively, values lower than the IC₅₀ values of the gingival cells. Olympiforin B inhibited the gene expression of the staphylococcal biofilm-related genes icaA and icaD, while RochC induced icaA and had a versatile effect on icaD. The MIC values for lactobacilli strains were higher than for S. aureus. The phytoconstituents did not cause cytopathic effects or apoptosis in CCL-1 fibroblasts at 2 × MIC. However, the agents at 1 × MIC significantly induced Atg5 and Atg7, proteins related to autophagy. Cytochrome P450 was not induced in liver cells, with the exception of a dose of 2 × MIC of RochC. The agents did not irritate rabbit skin in vivo at a dose of even 10 × MIC. Conclusions: The extract and compound have potential for further pharmacological development. Full article

Cryogenic industries handling liquid hydrogen and helium require rigorous safety verification. However, current standards (ASTM, ASME, ISO) are optimized for LNG at −163 °C and remain inadequate for extreme cryogenic conditions such as −253 °C. As the temperature decreases, materials experience ductile-to-brittle transition, raising the risk of sudden fracture in testing equipment. This study presents a fuzzy-integrated reliability framework that combines fault tree analysis (FTA) and Failure Modes, Effects, and Criticality Analysis (FMECA). The method converts qualitative expert judgments into quantitative risk indices for use in data-scarce conditions. When applied to a cryogenic impact testing apparatus, the framework produced a total failure probability of 1.52 × 10⁻³, about 7.5% lower than the deterministic FTA result (1.64 × 10⁻³). These results confirm the framework’s robustness and its potential use in cryogenic testing and hydrogen systems. Full article

This study focuses on the numerical analysis of a centrifugal pump’s suction capability, aiming to reliably predict its suction performance characteristics. The main emphasis of the research was placed on the influence of different turbulence models, the quality of the computational mesh, and the comparison between steady-state and unsteady numerical approaches. The results indicate that steady-state simulations provide an unreliable description of cavitation development, especially at lower flow rates where strong local pressure fluctuations are present. The unsteady k–ω SST model provides the best overall agreement with experimental NPSH₃ characteristics, as confirmed by the lowest mean deviation (within the ISO 9906 tolerance band, corresponding to an overall uncertainty of ±5.5%) and by multiple operating points falling entirely within this range. This represents one of the first detailed unsteady CFD verifications of NPSH prediction in centrifugal pumps operating at high rotational speeds (above 2900 rpm), achieving a mean deviation below ±5.5% and demonstrating improved predictive capability compared to conventional steady-state approaches. The analysis also includes an evaluation of the cavitation volume fraction and a depiction of pressure conditions on the impeller as functions of flow rate and inlet pressure. In conclusion, this study highlights the potential of advanced hybrid turbulence models (such as SAS or DES) as a promising direction for future research, which could further improve the prediction of complex cavitation phenomena in centrifugal pumps. Full article

Underwater Optical Camera Communication (UOCC) has emerged as a promising paradigm for short-range, high-bandwidth, and secure data exchange in autonomous underwater vehicles (AUVs). UOCC performance strongly depends on exposure time and International Standards Organization (ISO) sensitivity—two parameters that govern photon capture, contrast, and bit detection fidelity. However, optical propagation in aquatic environments is highly susceptible to turbidity, scattering, and illumination variability, which severely degrade image clarity and signal-to-noise ratio (SNR). Conventional systems with fixed imaging settings cannot adapt to time-varying conditions, limiting communication reliability. While validating the feasibility of deep learning for exposure prediction, this baseline lacked environmental awareness and generalization to dynamic scenarios. To overcome these limitations, we introduce a Real-to-Sim-to-Deployment framework that couples a physically calibrated emulation platform with a Hybrid CNN-MLP Model (HCMM). By fusing optical images, environmental states, and camera configurations, the HCMM achieves substantially improved parameter prediction accuracy, reducing RMSE to 0.23–0.33. When deployed on embedded hardware, it enables real-time adaptive reconfiguration and delivers up to 8.5 dB SNR gain, surpassing both static-parameter systems and the prior CNN baseline. These results demonstrate that environment-aware multimodal learning, supported by reproducible optical channel emulation, provides a scalable and robust solution for practical UOCC deployment in positioning, inspection, and laser-based underwater communication. Full article

This paper presents a case study in which the airborne sound insulation performance of vertical partitions is experimentally assessed and model-predicted by incorporating the indoor environment’s geometric configuration and material characteristics into the analysis. An experimental campaign was carried out to verify whether the partition actually installed in situ complies with the minimum acoustic requirements and to validate the results obtained from the predictive model, subsequently used to evaluate the acoustic performance of alternative configurations. Specifically, a case study was conducted on an existing wall separating two indoor environments at the University of Calabria (Italy), where experimental measurements revealed that the current structure fails to meet the minimum acoustic insulation requirement set by Italian regulation. To evaluate the potential improvement in acoustic performance resulting from the use of alternative structures, predictive modeling based on UNI EN ISO 12354-1 was carried out. In the simulations, the rooms were modeled according to their actual geometry, and different types of vertical partitions between the two spaces were assessed, including heavyweight masonry walls, lightweight gypsum-based systems, and drywall linings, all built using commercially available acoustic insulation materials. In addition, four other cost-effective insulated walls were evaluated, which were insulated, at most, using standard thermal insulation. In addition to acoustic performance, implementation costs were also considered. Among the acoustically insulated partitions, the highest-performing construction achieved a $R_w^{\prime }$ of 58.0 dB for €168.9/m², while a cost-effective construction based on double gypsum boards reached a $R_w^{\prime }$ equal to 51.4 dB with a cost of €65.9/m². Full article