The Movement Disorders Society recommends the DYT/PARK prefix for genes where dystonia and parkinsonism are prominent in approximately half or more of patients. This systematic review explores the genotype–phenotype correlations of
GLB1,
SLC6A3,
SLC30A10,
PLA2G6, and
SLC39A14—recently classified as DYT
SLC39A14 and historically linked to dystonia-parkinsonism. We searched PubMed and the Human Gene Mutation Database using standardized terms, including English-language, peer-reviewed publications up to February 2024. Following the MDSGene protocol, we extracted individual-level data on patients with biallelic pathogenic variants and at least one movement disorder. Features were marked “missing” if not explicitly reported. Of 1828 articles, 128 were eligible. We identified 386 patients and 262 variants. The median age at onset was 3 years for
GLB1, 3 months for
SLC6A3, 2.5 years for
SLC30A10, 1.5 years for
SLC39A14, and 16 years for
PLA2G6. Missing data may reflect underreporting of negative findings. Case reports/serie, may bias toward atypical presentations. Our analysis showed dystonia-parkinsonism predominates in
SLC6A3 and
PLA2G6, while
GLB1,
SLC30A10, and
SLC39A1 show predominantly dystonic phenotypes with a low frequency of parkinsonism. Ataxia was common in
GLB1 and
PLA2G6. Awareness of these phenotypes is essential for early diagnosis and intervention, particularly in treatable conditions like
SLC30A10 or
SLC39A14. The predominantly dystonic phenotype in
GLB1,
SLC30A10, and
SLC39A14 suggest that the DYT prefix may be more appropriate, highlighting the need to reconsider their nomenclature, and the importance of systematic reviews.
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