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Keywords = MMP3 and TESC

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18 pages, 5920 KB  
Article
Analysis of Differentially Expressed Genes, MMP3 and TESC, and Their Potential Value in Molecular Pathways in Colon Adenocarcinoma: A Bioinformatics Approach
by Constantin Busuioc, Andreea Nutu, Cornelia Braicu, Oana Zanoaga, Monica Trif and Ioana Berindan-Neagoe
BioMedInformatics 2022, 2(3), 474-491; https://doi.org/10.3390/biomedinformatics2030030 - 3 Sep 2022
Cited by 2 | Viewed by 3073
Abstract
Despite the great progress in its early diagnosis and treatment, colon adenocarcinoma (COAD) is still poses important issues to clinical management. Therefore, the identification of novel biomarkers or therapeutic targets for this disease is important. Using UALCAN, the top 25 upregulated and downregulated [...] Read more.
Despite the great progress in its early diagnosis and treatment, colon adenocarcinoma (COAD) is still poses important issues to clinical management. Therefore, the identification of novel biomarkers or therapeutic targets for this disease is important. Using UALCAN, the top 25 upregulated and downregulated genes in COAD were identified. Then, a Kaplan–Meier plotter was employed for these genes for survival analysis, revealing the correlation with overall survival rate only for MMP3 (Matrix Metallopeptidase 3) and TESC (Tescalcin). Despite this, the mRNA expression levels were not correlated with the tumor stages or nodal metastatic status. MMP3 and TESC are relevant targets in COAD that should be additionally validated as biomarkers for early diagnosis and prevention. Ingenuity Pathway Analysis revealed the top relevant network linked to Post-Translational Modification, Protein Degradation, and Protein Synthesis, where MMP3 was at the core of the network. Another important network was related to cell cycle regulation, TESC being a component of this. We should also not underestimate the complex regulatory mechanisms mediated by the interplay of the multiple other regulatory molecules, emphasizing the interconnection with molecules related to invasion and migration involved in COAD, that might serve as the basis for the development of new biomarkers and therapeutic targets. Full article
(This article belongs to the Special Issue Feature Papers in Medical Statistics and Data Science Section)
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