Search Results (253)

Background: The Pharm2Home Initiative’s Community Health Arm adopts a health-equitable approach to chronic disease education and medication therapy management (MTM). We serve senior residents of Solano County, California, who live in affordable housing and have limited financial resources. Aim: This evaluation assesses the uptake of chronic disease management recommendations provided by clinical pharmacists during MTM sessions at community events. Methods: The program engaged clinical pharmacists to provide tailored education and healthcare interventions in senior housing facilities. The goal was to empower seniors to manage their health effectively. The sessions covered various topics, including expired or duplicated medications, incorrect medication use, consultations on medication management, immunizations, and lifestyle adjustments. Results: Over an 18-month period, from January 2022 to August 2023, the program involved 65 participants across ten community health events. These events provided approximately 65 h of direct intervention. Many participants reported significant improvements in understanding their treatment plans and navigating their health needs more confidently. Feedback from 60 seniors after the sessions indicated that 88% felt much better informed about their medications, and 75% expressed that their concerns were addressed extremely well. Conclusions: These outcomes demonstrate the importance of clinical pharmacist-led interventions in improving seniors’ medication use and chronic disease management. The initiative’s approach advocates for integrating clinical pharmacists into community health settings, suggesting a scalable model for enhancing person-centered care. However, further studies are necessary to assess the long-term impacts of these interventions and explore their effectiveness across diverse age groups and more complex conditions. Full article

This paper presents an intelligent design framework for a high-performance 26 GHz MIMO antenna array tailored to 5G applications, built upon a compact single-element patch. The 11.5 mm × 11.5 mm × 1.6 mm microstrip patch on FR4 exhibits near-unity electrical length, an ultra-deep return loss (S11 < −40 dB at 26 GHz), and a wide operational bandwidth from 24.4 to 31.2 GHz (6.8 GHz, ~26.2%). A two-element array, spaced at λ/2, is first augmented with a inspired metamaterial (MTM) unit cell whose dimensions are optimized via a Multi-Layer Perceptron (MLP) model to maximize gain (+2 dB) while preserving S11. In the second phase, a closed-square parasitic ring is introduced between the elements; its side length, thickness, and position are predicted by a Random Forest (RF) model with Bayesian optimization to minimize mutual coupling (S12) from −25 dB to −58 dB at 26 GHz without significantly degrading S11 (remains below −25 dB). Full-wave simulations and anechoic chamber measurements confirm the ML predictions. The close agreement among predicted, simulated, and measured S-parameters validates the efficacy of the proposed AI-assisted optimization methodology, offering a rapid and reliable route to next-generation millimeter-wave MIMO antenna systems. Full article

Carbonic anhydrase (CA), an enzyme that accelerates CO₂ hydration, is one of the most widely used enzymes in the aid of CO₂ sequestration. We entrapped CA from Sulfurihydrogenibium azorense (SazCA) within biomimetic silica; to enhance the activity of the entrapped enzyme, the microenvironment of the silica particles was modified by using methyltrimethoxysilane (MTMS) or dimethyldimethoxysilane (DMDMS) as part of the precursors. When 10% (mol/mol) MTMS or 20% DMDMS was added to tetramethoxysilane (TMOS), the activity of entrapped SazCA increased by almost threefold when compared with the control group without these methyl-substituted silanes. In addition, all three types of entrapped SazCA, namely, the silica formed with only TMOS, 10% MTMS in TMOS, and 20% DMDMS in TMOS, exhibited improved thermal stability and pH stability. All three types of entrapped SazCA also showed good storage stability, with at least 79% of their initial activities retained after being stored at room temperature for six weeks, while the activity of the free enzyme dropped to 14% after only two days. When all three types of entrapped SazCA were applied to carbon sequestration, the efficiency remained above 90% even after ten cycles of reuse. Full article

Pharmacists are increasingly expected to deliver medication therapy management (MTM) services, yet many pharmacy students report insufficient confidence and preparedness in executing these complex tasks. This study evaluated a scaffolded MTM instructional series integrated into a second-year pharmacy skills laboratory, aiming to enhance student competence through progressive, structured learning. A mixed-methods design assessed changes in self-reported confidence, performance-based outcomes, and reflective insights among 154 students across three educational tracks. The 14-week intervention included sequential activities such as medication history interviews, drug-related problem (DRP) identification, care plan development, and comprehensive MTM simulations. Pre- and post-intervention surveys revealed statistically significant improvements in all 18 confidence domains, with the greatest gains in therapeutic recommendations and prescriber communication. Effect sizes ranged from small to very large (Cohen’s d 0.33–1.05), indicating gains that were both statistically reliable and educationally meaningful. Performance assessments showed consistent proficiency across MTM components, with average scores ranging from 90% to 96%. Qualitative reflections reinforced these findings, highlighting growth in communication, individualized patient care, and professional identity formation. The scaffolded approach aligns with accreditation standards and instructional design theory, offering a model for pharmacy curricula. Despite limitations such as lack of a comparator group and potential response bias, the study demonstrates that scaffolded MTM instruction effectively supports skill acquisition and confidence, preparing students for real-world clinical practice. Full article

The MTM-1 analysis has a very high level of detail and takes a very long time for to perform. A possible way to reduce the performance time while maintaining accuracy is by using Industry 4.0 technologies. The goal of the article is to investigate the potential for the implementation of Industry 4.0 technologies in the preparation of MTM-1 analysis for improving its speed and accuracy in the automotive industry, based on a unique survey. The results indicate that speed reduction and accuracy increase mainly depend on which Industry 4.0 technology is chosen and its capabilities. Full article

Road safety in cities is becoming a bigger concern worldwide. As more people own cars and traffic congestion increases on old roads, the risk of accidents also grows, which severely affects victims and their families. In 2023, data from the Société de l’Assurance Automobile du Québec (SAAQ) reported that 380 people died in traffic accidents in Quebec. A study of road accidents in Montreal between 2012 and 2021 looked at the most dangerous locations, times, and traffic patterns. In this paper, we investigate the role of autonomous vehicles (AVs) vs human-driven vehicles (HDVs) in reducing road accidents in mixed traffic situations. The reaction time of human drivers to road accidents at signalized intersections affects safety and is used to compare the difference between the two situations. Microscopic traffic simulation models (MTMs) namely the Krauss car-following model is developed using SUMO to assess the vehicles performance. Case study 1 assesses the effect of reaction time on human-driven vehicles. The findings show that longer reaction times lead to more collisions. Case study 2 looks at autonomous vehicles and how human-driven vehicles interact in mixed traffic. The simulations tested various levels of AV penetration (0%, 25%, 50%, 75%, and 100%) in mixed traffic and found that more AVs on the road improve safety and reduce the number of accidents. Full article

Variable-flow displacement has been effectively used to enhance oil recovery; however, it has rarely been investigated for coalbed methane production, and the CH₄ diffusion laws in this process are not clear. In this paper, we carried out a study on the CH₄ diffusion law in the bidirectional diffusion process displaced by variable-flow gas injection. The emission and desorption quantity of CH₄ under variable-flow gas injection, the displacement effect under the principle of equal time and quantity, and the applicability of the CH₄ diffusion model for the bidirectional diffusion process were analyzed. The results indicate that the variable-flow injection modes emit more CH₄ compared to constant flow injection. The CH₄ emission and desorption quantities for each injection mode are as follows: step-changed > sinusoidal-changed > constant flow. Secondly, the order of CH₄ emission and desorption quantity in each gas injection mode is as follows: step-changed > sinusoidal-changed > constant flow. When CO₂ is the injection gas source, the outlet CH₄ emission and desorption quantity are larger than N₂ injection. Thirdly, through the analysis of the principle of equal time and equal quantity, the variable-flow injection modes consume less gas for each volume of emitted CH₄, resulting in a more effective displacement. Finally, the diffusion fitting effect of the bidisperse model for CH₄ in the bidirectional diffusion process is better than that of the unipore model, and the bidisperse diffusion model can better fit the m_t/m_∞ curve of CH₄ diffusion during the variable-flow gas injection replacement process. Full article

In rotating machines, any faults in anti-friction bearings occurring during operation can lead to failures that are unacceptable due to considerable downtime losses and maintenance costs. Hence, early fault detection is essential, and different vibration-based methods (VBMs) are explored to recognise incipient fault signatures. Based on rotordynamics, if a bearing defect causes metal-to-metal (MtM) impacts during shaft rotation, the impacts excite high-frequency resonance responses of the bearing assembly. The defect-related frequencies are modulated with the resonance responses and rely on signal demodulation for fault detection. However, the current study highlights that the bearing fault/faults may not be detected if the defect in a bearing is not causing MtM impacts nor exciting the high-frequency resonance of the bearing assembly. In a roller bearing, a localised defect may maintain persistent contact between rolling elements and raceways, thereby preventing the occurrence of impulse vibration responses. Due to contact persistence, such defects may not generate impact and may not be detected by existing VBMs, and the bearing could behave as healthy. This paper investigates such specific cases by exploring the relationship between roller-bearing defect characteristics and their potential to generate impact loads during operation. Using an experimental bearing rig, different roller and inner-race defects are presented while their fault characteristic frequencies remain undetected by the envelope analysis, fast Kurtogram, cyclic spectral coherence, and tensor decomposition methods. This study highlights the significance of both the dimension and location of defects within bearings on their detectability based on the rotordynamics concept. Further, simple roller-beam experiments are carried out to visualise and validate the reliability of the experimental observations made on the roller bearing dynamics. Full article

Background: Cardiovascular diseases, particularly hypertension, and gastrointestinal disorders represent major public health concerns in Mexico. Although a range of pharmacological treatments exists, their use is associated with adverse effects, highlighting the need for safer therapeutic alternatives. Species of the Ipomoea genus are widely employed in Mexican traditional medicine (MTM) for their purgative, anti-inflammatory, analgesic, and sedative properties. Particularly, Ipomoea purpurea is traditionally used as a diuretic and purgative; its leaves and stems are applied topically for their anti-inflammatory and soothing effects. This study aimed to determine their phytochemical composition and to evaluate the associated vasodilatory activity, modulatory effects on intestinal smooth-muscle motility, and toxicological effects of the methanolic (ME-Ip) and dichloromethane (DE-Ip) extracts obtained from the aerial parts of I. purpurea. Methods: The phytochemical composition of the ME-Ip and DE-Ip extracts of I. purpurea was assessed using UPLC-QTOF-MS and GC-MS, respectively. For both extracts, the vasodilatory activity and effects on intestinal smooth muscle were investigated using ex vivo models incorporating isolated rat aorta and ileum, respectively, whereas acute toxicity was evaluated in vivo. Results: Phytochemical analysis revealed, for the first time, the presence of two glycosylated flavonoids within the Ipomoea genus; likewise, constituents with potential anti-inflammatory activity were detected. The identified compounds in I. purpurea extracts may contribute to the vasodilatory, biphasic, and purgative effects observed in this species. The EC₅₀ values for the vasodilatory effects of the methanolic (ME-Ip) and dichloromethane (DE-Ip) extracts were 0.80 and 0.72 mg/mL, respectively. In the initial phase of the experiments on isolated ileal tissues, both extracts induced a spasmodic (contractile) effect on basal motility, with ME-Ip exhibiting higher potency (EC₅₀ = 27.11 μg/mL) compared to DE-Ip (EC₅₀ = 1765 μg/mL). In contrast, during the final phase of the experiments, both extracts demonstrated a spasmolytic effect, with EC₅₀ values of 0.43 mg/mL for ME-Ip and 0.34 mg/mL for DE-Ip. In addition, both extracts exhibited low levels of acute toxicity. Conclusions: The phytochemical profile and the vasodilatory and biphasic effects of the I. purpurea extracts explain, in part, the use of I. purpurea in MTM. The absence of acute toxic effects constitutes a preliminary step in the toxicological safety assessment of I. purpurea extracts and demonstrates their potential for the development of phytopharmaceutic agents as adjuvants for the treatment of cardiovascular and gastrointestinal disorders. Full article

This study investigates the effectiveness of the Xsens motion capture system in performing ergonomic analysis compared to traditional manual assessments by experts in the specific environment of assembly lines. A comprehensive literature review emphasizes the need to investigate the reliability of new, promising high-tech systems. The main objective was therefore to compare the Ergonomic Assessment Worksheet (EAWS) assessment approach performed with Xsens motion capture technology and Process Simulate V16 software with the manual method using EAWS digital prepared by experts in the controlled workflow. The greatest value of the research conducted lies in the novel integration of the state-of-the-art Xsens motion capture technology with the Process Simulate V16 software environment and the use of the licensed EAWS ergonomic method and Methods-Time Measurement Universal Analyzing System (MTM-UAS). The results are presented in the form of a case study. The results show a large similarity between the whole-body results and a large difference in the upper limb results, confirming the initial benefits of the Xsens equipment but also pointing to the need to verify its reliability on larger samples. The study highlights the potential of integrating Xsens motion capture data into ergonomic assessments and tuning of the assembly line to increase productivity and worker safety. Full article

The development of effective oil adsorbents has attracted a great deal of attention due to the increasingly serious problem of oil pollution. A light and porous collagen (COL)/polyvinyl alcohol (PVA)/vanadium carbide (V₂CT_x) composite aerogel was synthesized using a simple method of blending, directional freezing, and drying. After modification with methyltriethoxysilane (MTMS) via chemical vapor deposition, the aerogel possessed an excellent hydrophobicity and its water contact angle reached 135°. The hydrophobic COL/PVA/V₂CT_x composite aerogel exhibits a porous structure with a specific surface area of 49 m²/g. It also possesses prominent mechanical properties with an 80.5 kPa compressive stress at 70% strain, a low density (about 28 mg/cm³), and outstanding thermal stability, demonstrating a 61.02% weight loss from 208 °C to 550 °C. Importantly, the hydrophobic COL/PVA/V₂CT_x aerogel exhibits a higher oil absorption capacity and stability, as well as a faster absorption rate, than the COL/PVA aerogel when tested with various oils. The hydrophobic COL/PVA/V₂CT_x aerogel has the capacity to adsorb 80 times its own weight of methylene chloride, with help from hydrophobic interactions, Van der Waals forces, intermolecular interactions, and capillary action. Compared with the pseudo first-order model, the pseudo second-order model is more suitable for oil adsorption kinetics. Therefore, the hydrophobic COL/PVA/V₂CT_x aerogel can be used as an environmentally friendly and efficient oil adsorbent. Full article

Preventable adverse drug events (ADEs) remain a significant threat in community settings, a challenge that is critical in community pharmacy settings where continuity of care and healthcare access can be limited. This qualitative study explored the perspectives of 13 community pharmacists through focus groups and interviews to identify barriers and propose solutions to enhance their role in patient care. Pharmacists emphasized their critical position in ensuring safe medication use, particularly for older adults managing multiple chronic conditions. Key findings revealed five themes: (1) defining medication safety as minimizing risk and empowering patients; (2) characteristics of the “perfect patient,” including medication awareness and proactive engagement; (3) the pharmacist’s role in detecting and resolving medication-related problems; (4) systemic barriers such as time constraints, lack of access to patient records, insufficient privacy, and undervaluation of pharmacists’ roles; and (5) proposed solutions including private counseling areas, increased staffing, integrated electronic health records, and legislative recognition of pharmacists as healthcare providers. Strengthening collaboration with physicians and empowering patients through education were also highlighted as key strategies. These findings underscore the need for systemic changes—especially in light of lessons learned during the pandemic—to support pharmacists in delivering comprehensive medication management and improving patient safety. Full article

This paper presents a novel, four-port, rectangular microstrip, inset-feed multiple-input and multiple-output (MIMO) antenna array, enhanced with metamaterials for improved gain and isolation, specifically designed for multi-operator 5G open radio access network (ORAN)-based indoor software-defined radio (SDR) applications. ORAN is an open-source interoperable framework for radio access networks (RANs), while SDR refers to a radio communication system where functions are implemented via software on a programmable platform. A 3 × 3 metamaterial (MTM) superstrate is placed above the MIMO antenna array to improve gain and reduce the mutual coupling of MIMO. The proposed MIMO antenna operates over a 300 MHz bandwidth (3.5–3.8 GHz), enabling shared infrastructure for multiple operators. The antenna’s dimensions are 75 × 75 × 18.2 mm³. The antenna possesses a reduced mutual coupling less than −30 dB and a 3.5 dB enhancement in gain with the help of a novel 3 × 3 MTM superstrate 15 mm above the radiating MIMO elements. A performance evaluation based on simulated results and lab measurements demonstrates the promising value of key MIMO metrics such as a low envelope correlation coefficient (ECC) < 0.002, diversity gain (DG) ~10 dB, total active reflection coefficient (TARC) < −10 dB, and channel capacity loss (CCL) < 0.2 bits/sec/Hz. Real-world testing of the proposed antenna for ORAN-based sub-6 GHz indoor wireless systems demonstrates a downlink throughput of approximately 200 Mbps, uplink throughput of 80 Mbps, and transmission delays below 80 ms. Additionally, a walk test in an indoor environment with a corresponding floor plan and reference signal received power (RSRP) measurements indicates that most of the coverage area achieves RSRP values exceeding −75 dBm, confirming its suitability for indoor applications. Full article

With the rapid development of marine renewable energy, especially offshore photovoltaic systems, the problem of biofouling of photovoltaic equipment in the marine environment has become increasingly prominent. The attachment of marine organisms such as algae will significantly affect the photoelectric conversion efficiency of photovoltaic panels, thereby reducing the stability and economy of the system. In this study, a composite siloxane coating was designed and prepared. Methyltrimethoxysilane (MTMS) was used as the organosilicon component. The negative potential of the coating was significantly enhanced by incorporating hexagonal boron nitride nanosheets (h-BNNS). This negative potential and the negative charge on the surface of marine organisms, especially algae, would produce electrostatic repulsion, which can effectively reduce the attachment of organisms. The results show that the prepared coating exhibits excellent performance in anti-biofouling, adhesion, chemical stability, transparency, and self-cleaning properties. The transparency of the coating reached 92.7%. After immersion with Chlorella for 28 days, the coverage percentage on the coating surface was only 0.98%, while the coverage percentage on the blank sample was 23.25%. The corrosion resistance and salt resistance of the coating also ensure its stability in complex marine environments, and it has broad application prospects. Full article

The surface bonding of silica sol particles modified by methyltrimethoxysilane (MTMS) at different temperatures was investigated. Following modification, MTMS hydrolysis products react with silica hydroxyl groups on the surface of silica particles to create a -Si-O-Si-network structure. Additionally, the hydrolysis products formed hydrogen bonds with the silica hydroxyl groups in the silica sol, which strengthened the bonding strength between the silica particles in a synergistic manner. Increasing the modification temperature accelerated the hydrolysis rate of MTMS, promoted the formation of -Si-O-Si-, and enhanced its binding properties. A silica sol model of grafted MTMS was established using molecular dynamics methods at different modification temperatures to explore the effect of hydrogen bonding on the surface bonding of silica sol particles. Ultimately, it was confirmed experimentally that MTMS modification significantly enhanced the bonding strength on the surface of silica particles in silica sols. Full article