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Keywords = Neuro-Symbolic AI

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18 pages, 3219 KB  
Article
Designing Trustworthy AI Systems for PTSD Follow-Up
by María Cazares, Jorge Miño-Ayala, Iván Ortiz and Roberto Andrade
Technologies 2025, 13(8), 361; https://doi.org/10.3390/technologies13080361 - 15 Aug 2025
Viewed by 306
Abstract
Post-Traumatic Stress Disorder (PTSD) poses complex clinical challenges due to its emotional volatility, contextual sensitivity, and need for personalized care. Conventional AI systems often fall short in therapeutic contexts due to lack of explainability, ethical safeguards, and narrative understanding. We propose a hybrid [...] Read more.
Post-Traumatic Stress Disorder (PTSD) poses complex clinical challenges due to its emotional volatility, contextual sensitivity, and need for personalized care. Conventional AI systems often fall short in therapeutic contexts due to lack of explainability, ethical safeguards, and narrative understanding. We propose a hybrid neuro-symbolic architecture that combines Large Language Models (LLMs), Retrieval-Augmented Generation (RAG), symbolic controllers, and ensemble classifiers to support clinicians in PTSD follow-up. The proposal integrates real-time anonymization, session memory through patient-specific RAG, and a Human-in-the-Loop (HITL) interface. It ensures clinical safety via symbolic logic rules derived from trauma-informed protocols. The proposed architecture enables safe, personalized AI-driven responses by combining statistical language modeling with explicit therapeutic constraints. Through modular integration, it supports affective signal adaptation, longitudinal memory, and ethical traceability. A comparative evaluation against state-of-the-art approaches highlights improvements in contextual alignment, privacy protection, and clinician supervision. Full article
(This article belongs to the Special Issue AI-Enabled Smart Healthcare Systems)
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32 pages, 6394 KB  
Article
Neuro-Bridge-X: A Neuro-Symbolic Vision Transformer with Meta-XAI for Interpretable Leukemia Diagnosis from Peripheral Blood Smears
by Fares Jammal, Mohamed Dahab and Areej Y. Bayahya
Diagnostics 2025, 15(16), 2040; https://doi.org/10.3390/diagnostics15162040 - 14 Aug 2025
Viewed by 386
Abstract
Background/Objectives: Acute Lymphoblastic Leukemia (ALL) poses significant diagnostic challenges due to its ambiguous symptoms and the limitations of conventional methods like bone marrow biopsies and flow cytometry, which are invasive, costly, and time-intensive. Methods: This study introduces Neuro-Bridge-X, a novel neuro-symbolic hybrid model [...] Read more.
Background/Objectives: Acute Lymphoblastic Leukemia (ALL) poses significant diagnostic challenges due to its ambiguous symptoms and the limitations of conventional methods like bone marrow biopsies and flow cytometry, which are invasive, costly, and time-intensive. Methods: This study introduces Neuro-Bridge-X, a novel neuro-symbolic hybrid model designed for automated, explainable ALL diagnosis using peripheral blood smear (PBS) images. Leveraging two comprehensive datasets, ALL Image (3256 images from 89 patients) and C-NMC (15,135 images from 118 patients), the model integrates deep morphological feature extraction, vision transformer-based contextual encoding, fuzzy logic-inspired reasoning, and adaptive explainability. To address class imbalance, advanced data augmentation techniques were applied, ensuring equitable representation across benign and leukemic classes. The proposed framework was evaluated through 5-fold cross-validation and fixed train-test splits, employing Nadam, SGD, and Fractional RAdam optimizers. Results: Results demonstrate exceptional performance, with SGD achieving near-perfect accuracy (1.0000 on ALL, 0.9715 on C-NMC) and robust generalization, while Fractional RAdam closely followed (0.9975 on ALL, 0.9656 on C-NMC). Nadam, however, exhibited inconsistent convergence, particularly on C-NMC (0.5002 accuracy). A Meta-XAI controller enhances interpretability by dynamically selecting optimal explanation strategies (Grad-CAM, SHAP, Integrated Gradients, LIME), ensuring clinically relevant insights into model decisions. Conclusions: Visualizations confirm that SGD and RAdam models focus on morphologically critical features, such as leukocyte nuclei, while Nadam struggles with spurious attributions. Neuro-Bridge-X offers a scalable, interpretable solution for ALL diagnosis, with potential to enhance clinical workflows and diagnostic precision in oncology. Full article
(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
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20 pages, 1238 KB  
Article
A Hybrid Neuro-Symbolic Pipeline for Coreference Resolution and AMR-Based Semantic Parsing
by Christos Papakostas, Christos Troussas, Akrivi Krouska and Cleo Sgouropoulou
Information 2025, 16(7), 529; https://doi.org/10.3390/info16070529 - 24 Jun 2025
Viewed by 936
Abstract
Large Language Models (LLMs) have transformed Natural Language Processing (NLP), yet they continue to struggle with deep semantic understanding, particularly in tasks like coreference resolution and structured semantic inference. This study presents a hybrid neuro-symbolic pipeline that combines transformer-based contextual encoding with symbolic [...] Read more.
Large Language Models (LLMs) have transformed Natural Language Processing (NLP), yet they continue to struggle with deep semantic understanding, particularly in tasks like coreference resolution and structured semantic inference. This study presents a hybrid neuro-symbolic pipeline that combines transformer-based contextual encoding with symbolic coreference resolution and Abstract Meaning Representation (AMR) parsing to improve natural language understanding. The pipeline resolves referential ambiguity using a rule-based coreference module and generates semantic graphs from disambiguated input using a symbolic AMR parser. Experiments on public benchmark datasets—PreCo for coreference and the AMR 3.0 Public Subset for semantic parsing—demonstrate that our hybrid model consistently outperforms symbolic-only and neural-only baselines. The model achieved notable gains in F1 scores for coreference (72.4%) and Smatch scores for semantic parsing (76.5%), with marked improvements in pronoun resolution and semantic role labeling. In addition to accuracy, the pipeline offers interpretability through modular components and auditable intermediate outputs, making it suitable for high-stakes applications requiring transparency. These findings show that integrating symbolic reasoning within neural architecture offers a robust and practical path toward overcoming key limitations of current LLMs in semantic-level NLP tasks. Full article
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40 pages, 3397 KB  
Systematic Review
Intelligent Supply Chain Management: A Systematic Literature Review on Artificial Intelligence Contributions
by António R. Teixeira, José Vasconcelos Ferreira and Ana Luísa Ramos
Information 2025, 16(5), 399; https://doi.org/10.3390/info16050399 - 13 May 2025
Cited by 5 | Viewed by 7765
Abstract
This systematic literature review investigates the recent applications of artificial intelligence (AI) in supply chain management (SCM), particularly in the domains of resilience, process optimization, sustainability, and implementation challenges. The study is motivated by gaps identified in previous reviews, which often exclude literature [...] Read more.
This systematic literature review investigates the recent applications of artificial intelligence (AI) in supply chain management (SCM), particularly in the domains of resilience, process optimization, sustainability, and implementation challenges. The study is motivated by gaps identified in previous reviews, which often exclude literature published after 2020 and lack an integrated analysis of AI’s contributions across multiple supply chain phases. The review aims to provide an updated synthesis of AI technologies—such as machine learning, deep learning, and generative AI—and their practical implementation between 2021 and 2024. Following the PRISMA framework, a rigorous methodology was applied using the Scopus database, complemented by bibliometric and content analyses. A total of 66 studies were selected based on predefined inclusion criteria and evaluated for methodological quality and thematic relevance. The findings reveal a diverse classification of AI applications across strategic and operational SCM phases and highlight emerging techniques like explainable AI, neurosymbolic systems, and federated learning. The review also identifies persistent barriers such as data governance, ethical concerns, and scalability. Future research should focus on hybrid AI–human collaboration, transparency through explainable models, and integration with technologies such as IoT and blockchain. This review contributes to the literature by offering a structured synthesis of AI’s transformative impact on SCM and by outlining key research directions to guide future investigations and managerial practice. Full article
(This article belongs to the Special Issue Feature Papers in Information in 2024–2025)
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19 pages, 2604 KB  
Article
Quantifying Relational Exploration in Cultural Heritage Knowledge Graphs with LLMs: A Neuro-Symbolic Approach for Enhanced Knowledge Discovery
by Mohammed Maree
Data 2025, 10(4), 52; https://doi.org/10.3390/data10040052 - 10 Apr 2025
Cited by 1 | Viewed by 1179
Abstract
This paper introduces a neuro-symbolic approach for relational exploration in cultural heritage knowledge graphs, exploiting Large Language Models (LLMs) for explanation generation and a mathematically grounded model to quantify the interestingness of relationships. We demonstrate the importance of the proposed interestingness measure through [...] Read more.
This paper introduces a neuro-symbolic approach for relational exploration in cultural heritage knowledge graphs, exploiting Large Language Models (LLMs) for explanation generation and a mathematically grounded model to quantify the interestingness of relationships. We demonstrate the importance of the proposed interestingness measure through a quantitative analysis, highlighting its significant impact on system performance, particularly in terms of precision, recall, and F1-score. Utilizing the Wikidata Cultural Heritage Linked Open Data (WCH-LOD) dataset, our approach achieves a precision of 0.70, recall of 0.68, and an F1-score of 0.69, outperforming both graph-based (precision: 0.28, recall: 0.25, F1-score: 0.26) and knowledge-based (precision: 0.45, recall: 0.42, F1-score: 0.43) baselines. Furthermore, the proposed LLM-powered explanations exhibit better quality, as evidenced by higher BLEU (0.52), ROUGE-L (0.58), and METEOR (0.63) scores compared to baseline approaches. We further demonstrate a strong correlation (0.65) between the interestingness measure and the quality of generated explanations, validating its ability to guide the system towards more relevant discoveries. This system offers more effective exploration by achieving more diverse and human-interpretable relationship explanations compared to purely knowledge-based and graph-based methods, contributing to the knowledge-based systems field by providing a personalized and adaptable relational exploration framework. Full article
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23 pages, 3133 KB  
Article
Integrating Textual Queries with AI-Based Object Detection: A Compositional Prompt-Guided Approach
by Silvan Ferreira, Allan Martins, Daniel G. Costa and Ivanovitch Silva
Sensors 2025, 25(7), 2258; https://doi.org/10.3390/s25072258 - 3 Apr 2025
Viewed by 716
Abstract
While object detection and recognition have been extensively adopted by many applications in decision-making, new algorithms and methodologies have emerged to enhance the automatic identification of target objects. In particular, the rise of deep learning and language models has opened many possibilities in [...] Read more.
While object detection and recognition have been extensively adopted by many applications in decision-making, new algorithms and methodologies have emerged to enhance the automatic identification of target objects. In particular, the rise of deep learning and language models has opened many possibilities in this area, although challenges in contextual query analysis and human interactions persist. This article presents a novel neuro-symbolic object detection framework that aligns object proposals with textual prompts using a deep learning module while enabling logical reasoning through a symbolic module. By integrating deep learning with symbolic reasoning, object detection and scene understanding are considerably enhanced, enabling complex, query-driven interactions. Using a synthetic 3D image dataset, the results demonstrate that this framework effectively generalizes to complex queries, combining simple attribute-based descriptions without explicit training on compound prompts. We present the numerical results and comprehensive discussions, highlighting the potential of our approach for emerging smart applications. Full article
(This article belongs to the Special Issue Digital Imaging Processing, Sensing, and Object Recognition)
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26 pages, 30893 KB  
Article
Knowledge Enhanced Neural Networks for Point Cloud Semantic Segmentation
by Eleonora Grilli, Alessandro Daniele, Maarten Bassier, Fabio Remondino and Luciano Serafini
Remote Sens. 2023, 15(10), 2590; https://doi.org/10.3390/rs15102590 - 16 May 2023
Cited by 16 | Viewed by 3719
Abstract
Deep learning approaches have sparked much interest in the AI community during the last decade, becoming state-of-the-art in domains such as pattern recognition, computer vision, and data analysis. However, these methods are highly demanding in terms of training data, which is often a [...] Read more.
Deep learning approaches have sparked much interest in the AI community during the last decade, becoming state-of-the-art in domains such as pattern recognition, computer vision, and data analysis. However, these methods are highly demanding in terms of training data, which is often a major issue in the geospatial and remote sensing fields. One possible solution to this problem comes from the Neuro-Symbolic Integration field (NeSy), where multiple methods have been defined to incorporate background knowledge into the neural network’s learning pipeline. One such method is KENN (Knowledge Enhanced Neural Networks), which injects logical knowledge into the neural network’s structure through additional final layers. Empirically, KENN showed comparable or better results than other NeSy frameworks in various tasks while being more scalable. Therefore, we propose the usage of KENN for point cloud semantic segmentation tasks, where it has immense potential to resolve issues with small sample sizes and unbalanced classes. While other works enforce the knowledge constraints in post-processing, to the best of our knowledge, no previous methods have injected inject such knowledge into the learning pipeline through the use of a NeSy framework. The experiment results over different datasets demonstrate that the introduction of knowledge rules enhances the performance of the original network and achieves state-of-the-art levels of accuracy, even with subideal training data. Full article
(This article belongs to the Special Issue Semantic Segmentation Algorithms for 3D Point Clouds)
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19 pages, 11988 KB  
Article
Interaction with Industrial Digital Twin Using Neuro-Symbolic Reasoning
by Aziz Siyaev, Dilmurod Valiev and Geun-Sik Jo
Sensors 2023, 23(3), 1729; https://doi.org/10.3390/s23031729 - 3 Feb 2023
Cited by 15 | Viewed by 6679
Abstract
Digital twins have revolutionized manufacturing and maintenance, allowing us to interact with virtual yet realistic representations of the physical world in simulations to identify potential problems or opportunities for improvement. However, traditional digital twins do not have the ability to communicate with humans [...] Read more.
Digital twins have revolutionized manufacturing and maintenance, allowing us to interact with virtual yet realistic representations of the physical world in simulations to identify potential problems or opportunities for improvement. However, traditional digital twins do not have the ability to communicate with humans using natural language, which limits their potential usefulness. Although conventional natural language processing methods have proven to be effective in solving certain tasks, neuro-symbolic AI offers a new approach that leads to more robust and versatile solutions. In this paper, we propose neuro-symbolic reasoning (NSR)—a fundamental method for interacting with 3D digital twins using natural language. The method understands user requests and contexts to manipulate 3D components of digital twins and is able to read maintenance manuals and implement installations and removal procedures autonomously. A practical neuro-symbolic dataset of machine-understandable manuals, 3D models, and user queries is collected to train the neuro-symbolic reasoning interaction mechanism. The evaluation demonstrates that NSR can execute user commands accurately, achieving 96.2% accuracy on test data. The proposed method has industrial importance since it provides the technology to perform maintenance procedures, request information from manuals, and serve as a tool to interact with complex virtual machinery using natural language. Full article
(This article belongs to the Special Issue IoT, AI, and Digital Twin for Smart Manufacturing)
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