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12,162 Results Found

  • Review
  • Open Access
76 Citations
11,055 Views
15 Pages

Biofilms are a communal way of living for microorganisms in which microorganism cells are surrounded by extracellular polymeric substances (EPS). Most microorganisms can live in biofilm form. Since microorganisms are everywhere, understanding biofilm...

  • Review
  • Open Access
37 Citations
8,728 Views
20 Pages

Raman Plus X: Biomedical Applications of Multimodal Raman Spectroscopy

  • Nandan K. Das,
  • Yichuan Dai,
  • Peng Liu,
  • Chuanzhen Hu,
  • Lieshu Tong,
  • Xiaoya Chen and
  • Zachary J. Smith

7 July 2017

Raman spectroscopy is a label-free method of obtaining detailed chemical information about samples. Its compatibility with living tissue makes it an attractive choice for biomedical analysis, yet its translation from a research tool to a clinical too...

  • Article
  • Open Access
5 Citations
3,056 Views
15 Pages

9 November 2023

Raman enhancement techniques are essential for gas analysis to increase the detection sensitivity of a Raman spectroscopy system. We have developed an efficient Raman enhancement technique called the collision-enhanced Raman scattering (CERS), where...

  • Article
  • Open Access
2 Citations
2,123 Views
11 Pages

Numerical Investigation of Raman-Assisted Four-Wave Mixing in Tapered Fiber Raman Fiber Amplifier

  • Shanmin Huang,
  • Yang Zhang,
  • Xiulu Hao,
  • Chenchen Fan,
  • Xiao Chen,
  • Jun Ye,
  • Tianfu Yao,
  • Hanwei Zhang,
  • Liangjin Huang and
  • Pu Zhou
  • + 3 authors

12 November 2024

The generation of unwanted higher-order Raman effects is the main factor restricting the power scaling of Raman fiber amplifiers (RFAs). This phenomenon arises from an interplay of physical processes, including stimulated Raman scattering (SRS), four...

  • Review
  • Open Access
56 Citations
10,030 Views
19 Pages

Raman Imaging of Nanocarriers for Drug Delivery

  • Sally Vanden-Hehir,
  • William J. Tipping,
  • Martin Lee,
  • Valerie G. Brunton,
  • Anna Williams and
  • Alison N. Hulme

The efficacy of pharmaceutical agents can be greatly improved through nanocarrier delivery. Encapsulation of pharmaceutical agents into a nanocarrier can enhance their bioavailability and biocompatibility, whilst also facilitating targeted drug deliv...

  • Article
  • Open Access
3 Citations
3,571 Views
13 Pages

Terahertz Raman Measurements Using a Spatial Heterodyne Raman Spectrometer

  • Yuqi Sun,
  • Xiaotian Li,
  • Jiri Galantu,
  • Qihang Chu,
  • Jun Chen,
  • Zhongkai Liu,
  • Xiaotao Mi,
  • Xuefeng Yao and
  • Pan Li

31 August 2021

We propose a method of measuring the terahertz (THz) Raman spectra of a material. As Raman spectroscopy is a measurement of the relative frequency spectrum relative to the frequency of the excitation source, sometimes it is not necessary to use an ex...

  • Review
  • Open Access
74 Citations
10,159 Views
35 Pages

Raman Scattering-Based Biosensing: New Prospects and Opportunities

  • Kseniya V. Serebrennikova,
  • Anna N. Berlina,
  • Dmitriy V. Sotnikov,
  • Anatoly V. Zherdev and
  • Boris B. Dzantiev

13 December 2021

The growing interest in the development of new platforms for the application of Raman spectroscopy techniques in biosensor technologies is driven by the potential of these techniques in identifying chemical compounds, as well as structural and functi...

  • Review
  • Open Access
198 Citations
28,541 Views
19 Pages

9 March 2010

In this review we describe label-free optical spectroscopy techniques which are able to non-invasively measure the (bio)chemistry in biological systems. Raman spectroscopy uses visible or near-infrared light to measure a spectrum of vibrational bonds...

  • Article
  • Open Access
38 Citations
8,146 Views
9 Pages

Charge Transfer Effect on Raman and Surface Enhanced Raman Spectroscopy of Furfural Molecules

  • Fu Wan,
  • Haiyang Shi,
  • Weigen Chen,
  • Zhaoliang Gu,
  • Lingling Du,
  • Pinyi Wang,
  • Jianxin Wang and
  • Yingzhou Huang

2 August 2017

The detection of furfural in transformer oil through surface enhanced Raman spectroscopy (SERS) is one of the most promising online monitoring techniques in the process of transformer aging. In this work, the Raman of individual furfural molecules an...

  • Article
  • Open Access
1 Citations
4,085 Views
15 Pages

Optical Fiber Probe with Integrated Micro-Optical Filter for Raman and Surface-Enhanced Raman Scattering Sensing

  • Md Abdullah Al Mamun,
  • Tomas Katkus,
  • Anita Mahadevan-Jansen,
  • Saulius Juodkazis and
  • Paul R. Stoddart

14 August 2024

Optical fiber Raman and surface-enhanced Raman scattering (SERS) probes hold great promise for in vivo biosensing and in situ monitoring of hostile environments. However, the silica Raman scattering background generated within the optical fiber incre...

  • Article
  • Open Access
2,340 Views
13 Pages

Raman-Activated Cell Ejection for Validating the Reliability of the Raman Fingerprint Database of Foodborne Pathogens

  • Shuaishuai Yan,
  • Xinru Guo,
  • Zheng Zong,
  • Yang Li,
  • Guoliang Li,
  • Jianguo Xu,
  • Chengni Jin and
  • Qing Liu

15 June 2024

Raman spectroscopy for rapid identification of foodborne pathogens based on phenotype has attracted increasing attention, and the reliability of the Raman fingerprint database through genotypic determination is crucial. In the research, the classific...

  • Review
  • Open Access
13 Citations
4,938 Views
17 Pages

Multifunctional Optical Crystals for All-Solid-State Raman Lasers

  • Hui Zhao,
  • Shibo Dai,
  • Siqi Zhu,
  • Hao Yin,
  • Zhen Li and
  • Zhenqiang Chen

26 January 2021

In the past few decades, the multifunctional optical crystals for all-solid-state Raman lasers have been widely studied by many scholars due to their compactness, convenience and excellent performance. In this review, we briefly show two kinds of mul...

  • Article
  • Open Access
5 Citations
2,849 Views
23 Pages

Comprehensive Raman Fingerprinting and Machine Learning-Based Classification of 14 Pesticides Using a 785 nm Custom Raman Instrument

  • Meral Yüce,
  • Nazlı Öncer,
  • Ceren Duru Çınar,
  • Beyza Nur Günaydın,
  • Zeynep İdil Akçora and
  • Hasan Kurt

5 March 2025

Raman spectroscopy enables fast, label-free, qualitative, and quantitative observation of the physical and chemical properties of various substances. Here, we present a 785 nm custom-built Raman spectroscopy instrument designed for sensing applicatio...

  • Article
  • Open Access
4 Citations
3,263 Views
14 Pages

We previously developed a hollow-core photonic crystal fiber (HCPCF) based Raman scattering enhancement technique for gas/human breath analysis. It enhances photon–gas molecule interactions significantly but is still based on CW laser excitatio...

  • Article
  • Open Access
64 Citations
11,484 Views
13 Pages

Raman Imaging with a Fiber-Coupled Multichannel Spectrograph

  • Elmar Schmälzlin,
  • Benito Moralejo,
  • Monika Rutowska,
  • Ana Monreal-Ibero,
  • Christer Sandin,
  • Nicolae Tarcea,
  • Jürgen Popp and
  • Martin M. Roth

20 November 2014

Until now, spatially resolved Raman Spectroscopy has required to scan a sample under investigation in a time-consuming step-by-step procedure. Here, we present a technique that allows the capture of an entire Raman image with only one single exposure...

  • Article
  • Open Access
428 Views
12 Pages

Raman Spectroscopy for Testing Wood Pellets

  • Tereza Zemánková,
  • Martin Kizovský,
  • Zdeněk Pilát,
  • Pavlína Modlitbová,
  • Jan Ježek,
  • Martin Šiler and
  • Ota Samek

21 December 2025

The creation of bioenergy based on the biomass wood pellet industry, which accounts for the majority of the global biomass supply, is one of the most common and important ways to utilize waste wood, wood dust, and other byproducts of wood manufacturi...

  • Article
  • Open Access
10 Citations
3,182 Views
7 Pages

Raman Spectroscopy of V4O7 Films

  • Petr Shvets,
  • Ksenia Maksimova and
  • Alexander Goikhman

22 February 2022

A thin film of vanadium oxide Magnéli phase V4O7 was produced using cathodic arc sputtering. X-ray diffraction, Rutherford backscattering spectrometry and Raman investigations confirmed the formation of this phase. The Raman spectrum of V4O7 d...

  • Review
  • Open Access
33 Citations
7,001 Views
21 Pages

5 December 2021

Raman scattering is one of the most used spectroscopy and imaging techniques in cancer nanomedicine due to its high spatial resolution, high chemical specificity, and multiplexity modalities. The flexibility of Raman techniques has led, in the past f...

  • Review
  • Open Access
317 Citations
54,732 Views
28 Pages

A Comprehensive Review on Raman Spectroscopy Applications

  • Andrea Orlando,
  • Filippo Franceschini,
  • Cristian Muscas,
  • Solomiya Pidkova,
  • Mattia Bartoli,
  • Massimo Rovere and
  • Alberto Tagliaferro

Raman spectroscopy is a very powerful tool for material analysis, allowing for exploring the properties of a wide range of different materials. Since its discovery, Raman spectroscopy has been used to investigate several features of materials such ca...

  • Review
  • Open Access
12 Citations
4,427 Views
18 Pages

Antibiotic Susceptibility Testing with Raman Biosensing

  • Andrei Novikov,
  • Adeliya Sayfutdinova,
  • Ekaterina Botchkova,
  • Dmitry Kopitsyn and
  • Rawil Fakhrullin

14 December 2022

Antibiotics guard us against bacterial infections and are among the most commonly used medicines. The immediate consequence of their large-scale production and prescription is the development of antibiotic resistance. Therefore, rapid detection of an...

  • Article
  • Open Access
7 Citations
2,919 Views
6 Pages

Comparison between Self-Raman Nd:YVO4 Lasers and NdYVO4/KGW Raman Lasers at Lime and Orange Wavelengths

  • Chi-Chun Lee,
  • Chien-Yen Huang,
  • Hao-Yun Huang,
  • Chao-Ming Chen and
  • Chia-Han Tsou

22 November 2021

The comparison of output powers between self-Raman Nd:YVO4 lasers and Nd:YVO4/KGW Raman lasers operating at lime and orange wavelengths is presented. We exploit the LBO crystal with cutting angle θ = 90° and φ = 8° for the lime wave...

  • Article
  • Open Access
11 Citations
4,251 Views
13 Pages

Application of the Dynamical Network Biomarker Theory to Raman Spectra

  • Takayuki Haruki,
  • Shota Yonezawa,
  • Keiichi Koizumi,
  • Yasuhiko Yoshida,
  • Tomonobu M. Watanabe,
  • Hideaki Fujita,
  • Yusuke Oshima,
  • Makito Oku,
  • Akinori Taketani and
  • Shigeru Saito
  • + 4 authors

22 November 2022

The dynamical network biomarker (DNB) theory detects the early warning signals of state transitions utilizing fluctuations in and correlations between variables in complex systems. Although the DNB theory has been applied to gene expression in severa...

  • Review
  • Open Access
114 Citations
9,403 Views
16 Pages

11 March 2021

Raman spectroscopy is one of the main analytical techniques used in optical metrology. It is a vibration, marker-free technique that provides insight into the structure and composition of tissues and cells at the molecular level. Raman spectroscopy i...

  • Proceeding Paper
  • Open Access
3 Citations
2,385 Views
4 Pages

Raman Spectroscopy and Cancer Diagnosis

  • Barbara Bravo,
  • Luigi Ciani and
  • Mario D’Acunto

Raman spectroscopy is a technique based on inelastic scattering of molecular systems when illuminated by monochromatic radiation. Owing to its high chemical specificity and noninvasive detection capability, in the last decade, Raman scattering has fo...

  • Review
  • Open Access
188 Citations
19,724 Views
22 Pages

8 June 2021

Food detection technologies play a vital role in ensuring food safety in the supply chains. Conventional food detection methods for biological, chemical, and physical contaminants are labor-intensive, expensive, time-consuming, and often alter the fo...

  • Article
  • Open Access
29 Citations
10,728 Views
18 Pages

Revisiting the Raman Spectra of Carbonate Minerals

  • Julliana F. Alves,
  • Howell G. M. Edwards,
  • Andrey Korsakov and
  • Luiz Fernando C. de Oliveira

25 October 2023

This work presents a new discussion about the vibrational properties of the carbonate ion displayed in several different environments. The microparameters introduced by cation substitution and different crystal lattices in addition to the crystal agg...

  • Review
  • Open Access
4 Citations
2,105 Views
8 Pages

Utility of Raman Spectroscopy in Pulmonary Medicine

  • Pauls Dzelve,
  • Arta Legzdiņa,
  • Andra Krūmiņa and
  • Madara Tirzīte

18 October 2024

The Raman effect, or as per its original description, “modified scattering”, is an observation that the number of scattered light waves shifts after photons make nonelastic contact with a molecule. This effect allows Raman spectroscopy to...

  • Article
  • Open Access
2,733 Views
12 Pages

Comparison of Novel Raman Techniques for Fiber Forensics

  • Benjamin R. Anderson,
  • Natalie Gese and
  • Hergen Eilers

28 July 2023

We have proposed three novel Raman techniques to expand capabilities for non-destructive dyed-fiber forensics: THz Raman spectroscopy (TRS), integrating-cavity-enhanced Raman spectroscopy (ICERS), and deep-UV Raman spectroscopy (DUVRS). In this study...

  • Communication
  • Open Access
11 Citations
3,987 Views
9 Pages

Cavity Enhanced Multi-Channels Gases Raman Spectrometer

  • Dewang Yang,
  • Qingsheng Liu,
  • Jinjia Guo,
  • Lulu Wu and
  • Andong Kong

31 May 2021

Raman spectroscopy has the advantages of multi-component detection, with a simple device and wide concentration ranges, and it has been applied in environmental monitoring and gas logging. However, its low sensitivity has limited its further applicat...

  • Article
  • Open Access
888 Views
17 Pages

BioRamanNet: A Neural Network Framework for Biological Raman Spectroscopy Classification

  • Pengju Yin,
  • Xin Li,
  • Yuxuan Lv,
  • Yan Li,
  • Yiping Zhao and
  • Bo Hu

18 November 2025

Raman spectroscopy has become an important tool for biomedical analysis due to its ability to provide label-free, non-destructive molecular fingerprints of biological samples. However, existing deep learning approaches for classifying biological Rama...

  • Review
  • Open Access
175 Citations
28,312 Views
15 Pages

Deep Learning for Raman Spectroscopy: A Review

  • Ruihao Luo,
  • Juergen Popp and
  • Thomas Bocklitz

19 July 2022

Raman spectroscopy (RS) is a spectroscopic method which indirectly measures the vibrational states within samples. This information on vibrational states can be utilized as spectroscopic fingerprints of the sample, which, subsequently, can be used in...

  • Communication
  • Open Access
23 Citations
5,106 Views
14 Pages

A Remote Raman System and Its Applications for Planetary Material Studies

  • Hongkun Qu,
  • Zongcheng Ling,
  • Xiaobin Qi,
  • Yanqing Xin,
  • Changqing Liu and
  • Haijun Cao

21 October 2021

A remote Raman prototype with a function of excitation energy adjusting for the purpose of obtaining a Raman signal with good signal-to-noise ratio (SNR), saving power consumption, and possibly avoiding destroying a target by high energy pulses, whic...

  • Article
  • Open Access
31 Citations
5,036 Views
9 Pages

Raman Spectroscopic Study of Coal Samples during Heating

  • Yingfang Xie,
  • Jinglin You,
  • Liming Lu,
  • Min Wang and
  • Jian Wang

4 November 2019

Raman spectroscopy can be used to record the characteristic spectra of carbonaceous materials. The D and G bands are the most popular and most important spectral characteristics when discussing carbonaceous materials. In this paper, a Raman spectrosc...

  • Article
  • Open Access
38 Citations
9,433 Views
17 Pages

Fast Detection of Different Water Contaminants by Raman Spectroscopy and Surface-Enhanced Raman Spectroscopy

  • Salvatore Almaviva,
  • Florinda Artuso,
  • Isabella Giardina,
  • Antonia Lai and
  • Alessandra Pasquo

30 October 2022

Fast monitoring of water quality is a fundamental part of environmental management and protection, in particular, the possibility of qualitatively and quantitatively determining its contamination at levels that are dangerous for human health, fauna a...

  • Review
  • Open Access
1 Citations
737 Views
16 Pages

The Intraoperative Utility of Raman Spectroscopy for Neurosurgical Oncology

  • Jia-Shu Chen,
  • Jun Yeop Oh,
  • Todd C. Hollon,
  • Shawn L. Hervey-Jumper,
  • Jacob S. Young and
  • Mitchel S. Berger

8 December 2025

Maximal safe surgical resection is a foundational principle in brain tumor surgery. To date, many intraoperative modalities have been developed to help facilitate the identification of brain tumor versus normal brain tissue so that surgical resection...

  • Article
  • Open Access
48 Citations
7,224 Views
25 Pages

Aberrant Protein Phosphorylation in Cancer by Using Raman Biomarkers

  • Halina Abramczyk,
  • Anna Imiela,
  • Beata Brożek-Płuska,
  • Monika Kopeć,
  • Jakub Surmacki and
  • Agnieszka Śliwińska

13 December 2019

(1) Background: Novel methods are required for analysing post-translational modifications of protein phosphorylation by visualizing biochemical landscapes of proteins in human normal and cancerous tissues and cells. (2) Methods: A label-free Raman me...

  • Article
  • Open Access
24 Citations
3,861 Views
20 Pages

Stimulated Raman Scattering in Alkali-Earth Tungstate and Molybdate Crystals at Both Stretching and Bending Raman Modes under Synchronous Picosecond Pumping with Multiple Pulse Shortening Down to 1 ps

  • Milan Frank,
  • Sergei N. Smetanin,
  • Michal Jelínek,
  • David Vyhlídal,
  • Vladislav E. Shukshin,
  • Lyudmila I. Ivleva,
  • Elizaveta E. Dunaeva,
  • Irina S. Voronina,
  • Petr G. Zverev and
  • Václav Kubeček

21 March 2019

Comparative investigation of characteristics of spontaneous and stimulated Raman scattering (SRS) in different alkali-earth tungstate and molybdate crystals at both high and low frequency anionic group vibrations is presented. It has been found that,...

  • Article
  • Open Access
1,915 Views
19 Pages

The influence of the interference between coherent processes in third-order nonlinear Raman scattering on the spectral shapes of Raman-scattered light waves is numerically modeled and discussed in the cases of commonly used coherent Raman spectroscop...

  • Review
  • Open Access
9 Citations
4,954 Views
15 Pages

Au Tip-Enhanced Raman Spectroscopy for Catalysis

  • Jingang Wang,
  • Wenhua Qiao and
  • Xijiao Mu

23 October 2018

Plasmon-driven chemical reactions have been a prospective field for surface plasmon resonance and tip-enhanced Raman scattering. In this review, the principles of tip-enhanced Raman spectroscopy (TERS) are first introduced. Following this, the use of...

  • Article
  • Open Access
46 Citations
10,732 Views
17 Pages

27 July 2017

Raman spectroscopy provides label-free biochemical information from tissue samples without complicated sample preparation. The clinical capability of Raman spectroscopy has been demonstrated in a wide range of in vitro and in vivo applications. Howev...

  • Review
  • Open Access
59 Citations
5,476 Views
23 Pages

Raman-Based Techniques in Medical Applications for Diagnostic Tasks: A Review

  • Yulia Khristoforova,
  • Lyudmila Bratchenko and
  • Ivan Bratchenko

26 October 2023

Raman spectroscopy is a widely developing approach for noninvasive analysis that can provide information on chemical composition and molecular structure. High chemical specificity calls for developing different medical diagnostic applications based o...

  • Article
  • Open Access
2 Citations
2,642 Views
8 Pages

Mid-Infrared Multispectral Gaseous Stimulated Raman Scattering Laser

  • Chencheng Shen,
  • Xianglong Cai,
  • Tiancheng Zheng,
  • Yuxi Jia,
  • Dong Liu,
  • Jinbo Liu and
  • Jingwei Guo

14 December 2021

We demonstrated mid-infrared gaseous stimulated Raman scattering lasers in free space. Mixed gases of hydrogen and deuterium were used as Raman gain media in one Raman cell. Pumped by laser pulses at 1064 nm, the first Stokes Raman components at 1560...

  • Proceeding Paper
  • Open Access
3 Citations
1,320 Views
5 Pages

Grading of Melanoma Tissues by Raman MicroSpectroscopy

  • Gianmarco Lazzini and
  • Mario D’Acunto

26 October 2023

Melanoma is one of the most aggressive forms of cancer. Early-stage diagnosis is therefore a landmark for the success of the therapies and to improve the prognosis. Raman spectroscopy represents a powerful and label-free approach for the molecular ch...

  • Article
  • Open Access
37 Citations
8,699 Views
9 Pages

31 July 2017

The results of a high-resolution Raman scattering study of a diamond crystal with a high content of single substitutional nitrogen impurities (550 ppm) in the temperature range from 50 to 673 K are presented and compared with the data for defect-free...

  • Review
  • Open Access
45 Citations
9,676 Views
19 Pages

Raman Microscopy: Progress in Research on Cancer Cell Sensing

  • Satheeshkumar Elumalai,
  • Stefano Managó and
  • Anna Chiara De Luca

27 September 2020

In the last decade, Raman Spectroscopy (RS) was demonstrated to be a label-free, non-invasive and non-destructive optical spectroscopy allowing the improvement in diagnostic accuracy in cancer and analytical assessment for cell sensing. This review d...

  • Review
  • Open Access
61 Citations
10,990 Views
24 Pages

Unveiling Cancer Metabolism through Spontaneous and Coherent Raman Spectroscopy and Stable Isotope Probing

  • Jiabao Xu,
  • Tong Yu,
  • Christos E. Zois,
  • Ji-Xin Cheng,
  • Yuguo Tang,
  • Adrian L. Harris and
  • Wei E. Huang

5 April 2021

Metabolic reprogramming is a common hallmark in cancer. The high complexity and heterogeneity in cancer render it challenging for scientists to study cancer metabolism. Despite the recent advances in single-cell metabolomics based on mass spectrometr...

  • Article
  • Open Access
4 Citations
2,209 Views
9 Pages

17 December 2024

Industrial agriculture, while necessary to meet current food production needs, can have damaging effects on the environment and local water supply. For monitoring purposes, Raman spectra of common fertilizers in solution are measured and presented. R...

  • Communication
  • Open Access
7 Citations
3,721 Views
11 Pages

Aerogel-Lined Capillaries for Raman Signal Gain of Aqueous Mixtures

  • Felix Spiske,
  • Martin Peter Dirauf and
  • Andreas Siegfried Braeuer

10 June 2022

We report an experimental study on the gain of the Raman signal of aqueous mixtures and liquid water when confined in aerogel-lined capillaries of various lengths of up to 20 cm and various internal diameters between 530 and 1000 µm. The lining...

  • Article
  • Open Access
21 Citations
3,879 Views
31 Pages

Raman Metabolomics of Candida auris Clades: Profiling and Barcode Identification

  • Giuseppe Pezzotti,
  • Miyuki Kobara,
  • Tamaki Nakaya,
  • Hayata Imamura,
  • Tomoya Fujii,
  • Nao Miyamoto,
  • Tetsuya Adachi,
  • Toshiro Yamamoto,
  • Narisato Kanamura and
  • Koichi Makimura
  • + 6 authors

3 October 2022

This study targets on-site/real-time taxonomic identification and metabolic profiling of seven different Candida auris clades/subclades by means of Raman spectroscopy and imaging. Representative Raman spectra from different Candida auris samples were...

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