Previous studies on Escherichia coli demonstrated that sub-minimum inhibitory concentration (MIC) of fluoroquinolones induced the SOS response, increasing drug tolerance. We characterized the transcriptional response to moxifloxacin in Mycobacterium ...
A bioinformatic search for LexA boxes, combined with transcriptomic detection of loci responsive to DNA damage, identified 48 members of the SOS regulon in the genome of Salmonella enterica serovar Typhimurium. Single cell analysis using fluorescent...
The increase in antibiotic resistance represents a major global challenge for our health systems and calls for alternative treatment options, such as antimicrobial light-based therapies. Blue light has shown promising results regarding the inactivati...
The widespread and inappropriate use of antibiotics, for therapeutic and prophylactic purposes, has contributed to a global crisis of rapidly increasing antimicrobial resistance of microorganisms. This resistance is often associated with elevated mut...
DNA polymerase III (Pol III) is the replicative enzyme in bacteria. It consists of three subcomplexes, the catalytic core, the β clamp, and the clamp loader. While this complex has been thoroughly characterized in the model organism Escherichia ...
The SOS response is a conserved stress response pathway that is triggered by DNA damage in the bacterial cell. Activation of this pathway can, in turn, cause the rapid appearance of new mutations, sometimes called hypermutation. We compared the abili...
The Escherichia coli SOS response to DNA damage, discovered and conceptualized by Evelyn Witkin and Miroslav Radman, is the prototypic DNA-damage stress response that upregulates proteins of DNA protection and repair, a radical idea when formulated i...
Several classes of non-antibiotic drugs, including psychoactive drugs, proton-pump inhibitors (PPIs), non-steroidal anti-inflammatory drugs (NSAIDs), and others, appear to have strong antimicrobial properties. We considered whether psychoactive drugs...
A model system based on the Escherichia coli MG1655 (pRecA-lux) Lux-biosensor was used to evaluate the ability of the fermentates of eight probiotic strains to reduce the SOS response stimulated by ciprofloxacin in bacteria and mutagenesis mediated b...
The significant and rapidly growing impact that digital technologies has on all aspects of our lives has raised awareness of benefits but also concerns and worries linked to the development and use of these technologies. The concept of responsibility...
Extended producer responsibility (EPR) is a legislative mandate that requires a producer to be accountable for the whole life cycle of its product—from product design to final disposal. The EPR system is imposed to solve the problem of the grow...
The sequence-to-sequence model is a widely used model for dialogue response generators, but it tends to generate safe responses for most input queries. Since safe responses are unattractive and boring, a number of efforts have been made to make the g...
We provide an alternative psychometric perspective on the empirical statistical dependencies observed between response accuracy residuals (RARs) and response time residuals (RTRs) in the context of the van der Linden model. This perspective emphasize...
Responsible innovations in the industry gains important attention, however, a better understanding of the interaction of different components with regard to responsible innovation (RI) in the industry is still needed. Moreover, a firm acting in an op...
Composite membranes with stimuli-responsive properties can be made by coating a thermo-responsive hydrogel onto a micro- or macroporous support. These hydrogels undergo a temperature induced volume-phase transition, which contributes towards the comp...
Due to the massive global impact of the current COVID-19 pandemic, the call for social and environment responsibility has grown stronger, and discussion regarding responsible leadership has been aroused. Agreement on the antecedents of responsible le...
There recently have been many studies examining conditional dependence between response accuracy and response times in cognitive tests. While most previous research has focused on revealing a general pattern of conditional dependence for all responde...
The rise of Asian and the stagnation of Western middle classes over the last thirty years have resulted in gradual convergence of income of large parts of the world’s population. Recent global crises—the Great Recession and the COVID-19 pandemic—have...
Background: Response–response (RR) binding, involving the integration of independently planned and executed responses, presents a novel perspective on action control. While behavioral evidence on RR binding has been extensively examined, corres...
Demand response is nowadays considered as another type of generator, beyond just a simple peak reduction mechanism. A demand response service provider (DRSP) can, through its subcontracts with many energy customers, virtually generate electricity wit...
This study examines the relationship between Corporate Social Responsibility (CSR) and Socially Responsible Behaviors (SRBs), with a focus on the mediating effect of Meaningfulness of Work (MOW). Based on cue consistency theory and sensemaking theory...
The COVID-19 pandemic has caused significant impacts to the automotive manufacturing industry. Despite substantial financial uncertainty, disruptions to supply chains, and shutdowns of manufacturing operations, automotive firms supported crisis respo...
Over the past 10 years, stimuli-responsive polymeric biomaterials have emerged as effective systems for the delivery of therapeutics. Persistent with ongoing efforts to minimize adverse effects, stimuli-responsive biomaterials are designed to release...
This article explores innovations in and pedagogical approaches to Responsible Entrepreneurship Education (REE), with a specific focus on how to advance responsible entrepreneurial competencies (“know-how”) and entrepreneurial practices (...
The Quality of Life after Brain Injury (QoLIBRI) questionnaire was developed and validated to assess disease-specific health-related quality of life (HRQoL) in individuals after TBI. The present study aims to determine its longitudinal validity by as...
Alcohol hangover commonly occurs after an episode of heavy drinking. It has previously been demonstrated that acute high-dose alcohol intoxication reduces cognitive control, while automatic processes remain comparatively unaffected. However, it has r...
The spread of the respiratory viral infections is currently being widely investigated, and the influence of the immune response on the spread of these infections is of particular interest. In this work, the set of hierarchical models for the spread o...
Language proficiency assessments are pivotal in educational and professional decision-making. With the integration of AI-driven technologies, these assessments can more frequently use item types, such as dictation tasks, producing response features w...
Corporate social responsibility in the banking industry has an impact on the environment and society. Research was conducted on the impacts of environmental social responsibility disclosure on future income response coefficients of The Association of...
In a post-pandemic context, destinations are questioning mass tourism, and are focusing on more sustainable segments, looking for more responsible tourists. This requires obtaining relevant information to assess what kind of tourists visit the destin...
In our previous paper, we reported that thermo-responsive emulsions can be prepared based on a long-chain amidoamine derivative (C18AA) and tetraoctylammonium bromide (TOAB), and that the C18AA + TOAB emulsions developed a characteristic interference...
The general stress and innate immune responses are closely linked and overlap at many levels. The outcomes of these responses serve to reprogram host expression patterns to prevent viral invasions. In turn, viruses counter attack these cell responses...
The human physiological response “to stress” includes all metabolic and hormonal changes produced by a traumatic event at the micro or macro cellular levels. The main goal of the body’s first response to trauma is to keep physiologi...
Intelligent stimuli-responsive molecularly imprinted polymers (SR-MIPs) have attracted considerable research interest in recent years due to the potential applications in drug delivery, biotechnology and separation sciences. This review comprehensive...
Signal distortion can occur when the gain or attenuation of a component changes non-linearly with frequency, which is referred to as nonlinear frequency response. Common communications components such as filters, amplifiers, and mixers can lead to no...
This study examined the direct and indirect relationships between perceptions of destination social responsibility and environmentally responsible behavior. This paper uses the Stimulus–Organism–Response theory to evaluate the mediating r...
Although (micro)plastic contamination is a worldwide concern, most scientific literature only restates that issue rather than presenting strategies to cope with it. This critical review assembles the current knowledge on policies and responses to tac...
High-throughput screening of drug response in cultured cell lines is essential for studying therapeutic mechanisms and identifying molecular variants associated with sensitivity to drugs. Assessment of drug response is typically performed by construc...
Radiotherapy is one of the major cancer treatment strategies. Exposure to penetrating radiation causes cellular stress, directly or indirectly, due to the generation of reactive oxygen species, DNA damage, and subcellular organelle damage and autopha...
In recent decades, the power grid’s configuration is shifting towards a smart grid where responsive loads and energy storage systems (ESS) are finding an increased role in the power system operation. In the presented work, a mathematical formul...
Functional responses are non-linear functions commonly used to describe the variation in the rate of consumption of resources by a consumer. They have been widely used in both theoretical and empirical studies, but a comprehensive understanding of th...
To achieve low carbon emissions in the power system and contribute to economic growth, a low-carbon optimization scheduling strategy for a power system, considering carbon responsibility sharing and electric vehicle demand response, is proposed based...
Responsible sustainable consumer behavior might serve as a complex pattern of social and environmental issues, consistent with the perspective of sustainability as a construct with both social and environmental pillars. Anchored on signaling theory a...
Application of the concept of corporate social responsibility (CSR) is demanded of an ever-wider range of entities as time goes by, among which are municipalities. However, the topic of social responsibility of municipalities stands outside of the bo...
This study investigated the structural relationship between tourist destination identification and environmental responsibility practices based on the social responsibility activities for visitors of marine sports tourist destinations where domestic...
In recent literature, alternative models for handling missing item responses in large-scale assessments have been proposed. Based on simulations and arguments based on psychometric test theory, it is argued in this literature that missing item respon...
Governance for net-zero mobility is complex and risky. In this paper, we discuss conceptual analysis and design research with more than 250 stakeholders in the governance of mobility transformations in the North of England. Two key findings are that...
Fleshy fruits are generally hard and unpalatable when unripe; however, as they mature, their quality is transformed by the complex and dynamic genetic and biochemical process of ripening, which affects all cell compartments. Ripening fruits are enric...
Resonant response of turbomachinery blades can lead to high cycle fatigue (HCF) if the vibration amplitudes are significant. Therefore, the dangerousness assessment of the resonance crossing is important. It requires accurate predictions of the aerod...
This article discusses the Conservative Laestadian women’s desire to mother and the procreational ethos of the Conservative Laestadian religious movement in the framework of reproductive justice and ecological crisis. The data draws from my doc...
of 4,991