Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline

Journals

Article Types

Countries / Regions

Search Results (1)

Search Parameters:
Keywords = SR-μXRF (X-ray fluorescence analysis with microprobe)

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
11 pages, 6371 KB  
Article
Phosphorus Localization and Its Involvement in the Formation of Concentrated Uranium in the Renal Proximal Tubules of Rats Exposed to Uranyl Acetate
by Shino Homma-Takeda, Chiya Numako, Keisuke Kitahara, Takanori Yoshida, Masakazu Oikawa, Yasuko Terada, Toshiaki Kokubo and Yoshiya Shimada
Int. J. Mol. Sci. 2019, 20(19), 4677; https://doi.org/10.3390/ijms20194677 - 20 Sep 2019
Cited by 22 | Viewed by 3420
Abstract
Although the kidneys comprise a critical target of uranium exposure, the dynamics of renal uranium distribution have remained obscure. Uranium is considered to function physiologically in the form of uranyl ions that have high affinity for phosphate groups. The present study applied microbeam-based [...] Read more.
Although the kidneys comprise a critical target of uranium exposure, the dynamics of renal uranium distribution have remained obscure. Uranium is considered to function physiologically in the form of uranyl ions that have high affinity for phosphate groups. The present study applied microbeam-based elemental analysis to precisely determine the distribution of phosphorus and uranium in the kidneys of male Wistar rats exposed to uranium. One day after a single subcutaneous injection of uranyl acetate (2 mg/kg), areas of concentrated phosphorus were scattered in the S3 segments of the proximal tubule of the kidneys, whereas the S3 segments in control rats and in rats given a lower dose of uranium (0.5 mg/kg) contained phosphorus without concentrated phosphorus. Areas with concentrated phosphorus contained uranium 4- to 14-fold more than the mean uranium concentration (126–472 vs. 33.1 ± 4.6 μg/g). The chemical form of uranium in the concentrated phosphorus examined by XAFS was uranium (VI), suggesting that the interaction of uranyl ions with the phosphate groups of biomolecules could be involved in the formation of uranium concentration in the proximal tubules of kidneys in rats exposed to uranium. Full article
(This article belongs to the Special Issue Metallomics: Integrated Biosciences for Elements)
Show Figures

Graphical abstract

Back to TopTop