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2,196 Results Found

  • Article
  • Open Access
379 Views
20 Pages

8 January 2026

Despite being the most popular sutra tableau in Dunhuang, the utter lack of any comprehensive, or chronological academic analysis even in Chinese calls for a thorough research on the Medicine Buddha Sutra iconography at Dunhuang. This paper will expl...

  • Article
  • Open Access
9 Citations
6,389 Views
10 Pages

25 January 2022

Background and Objectives: This retrospective study investigates the action of a bipolar, temperature controlled, endovaginal RF handpiece for the treatment of mild, moderate, and severe stress urinary incontinence with a minimally invasive approach....

  • Article
  • Open Access
5,306 Views
36 Pages

25 March 2024

The corridor-enclosed cloister characterized Buddhist monasteries during the Sui and Tang periods. This architectural form was first introduced by Emperor Liang Wudi from the palace and continued to prevail until the eleventh century, when a gradual...

  • Article
  • Open Access
2 Citations
4,103 Views
14 Pages

28 November 2022

Besides the internal monastic supervision system of the “Three Principal Monks” already prevalent in the Sui and Tang dynasties, an additional lay-involved supervision system of jiansi was further added to the state religious policy to st...

  • Review
  • Open Access
146 Citations
10,264 Views
14 Pages

Current Taxonomical Situation of Streptococcus suis

  • Masatoshi Okura,
  • Makoto Osaki,
  • Ryohei Nomoto,
  • Sakura Arai,
  • Ro Osawa,
  • Tsutomu Sekizaki and
  • Daisuke Takamatsu

Streptococcus suis, a major porcine pathogen and an important zoonotic agent, is considered to be composed of phenotypically and genetically diverse strains. However, recent studies reported several “S. suis-like strains” that were identified as S. s...

  • Article
  • Open Access
11 Citations
4,839 Views
11 Pages

Contamination of Streptococcus suis and S. suis Serotype 2 in Raw Pork and Edible Pig Organs: A Public Health Concern in Chiang Mai, Thailand

  • Ratchadakorn Guntala,
  • Likhitphorn Khamai,
  • Nattawara Srisai,
  • Sakaewan Ounjaijean,
  • Woottichai Khamduang and
  • Sayamon Hongjaisee

3 July 2024

Streptococcus suis is one of the most important zoonotic pathogens causing serious diseases in both pigs and humans, especially serotype 2. In northern Thailand, there is a notable prevalence of S. suis infection in humans and transmission has occurr...

  • Review
  • Open Access
30 Citations
6,274 Views
10 Pages

Tools for Molecular Epidemiology of Streptococcus suis

  • Rujirat Hatrongjit,
  • Nahuel Fittipaldi,
  • Marcelo Gottschalk and
  • Anusak Kerdsin

27 January 2020

Diseases caused by Streptococcus suis are a significant economic and welfare concern in pigs as well as in humans. Several molecular methods have been applied to investigate S. suis strain diversity and identify phylogenetic groups. Multilocus sequen...

  • Article
  • Open Access
6 Citations
2,337 Views
12 Pages

Evaluating the Antibacterial and Antivirulence Activities of Floxuridine against Streptococcus suis

  • Jie Li,
  • Ning Han,
  • Yangyang Li,
  • Feifei Zhao,
  • Wenguang Xiong and
  • Zhenling Zeng

18 September 2023

Streptococcus suis is an emerging zoonotic pathogen that can cause fatal diseases such as meningitis and sepsis in pigs and human beings. The overuse of antibiotics is leading to an increased level of resistance in S. suis, and novel antimicrobial ag...

  • Conference Report
  • Open Access
118 Citations
14,043 Views
39 Pages

Update on Streptococcus suis Research and Prevention in the Era of Antimicrobial Restriction: 4th International Workshop on S. suis

  • Mariela Segura,
  • Virginia Aragon,
  • Susan L. Brockmeier,
  • Connie Gebhart,
  • Astrid de Greeff,
  • Anusak Kerdsin,
  • Mark A O’Dea,
  • Masatoshi Okura,
  • Mariette Saléry and
  • Marcelo Gottschalk
  • + 4 authors

Streptococcus suis is a swine pathogen and a zoonotic agent afflicting people in close contact with infected pigs or pork meat. Sporadic cases of human infections have been reported worldwide. In addition, S. suis outbreaks emerged in Asia, making th...

  • Review
  • Open Access
1,882 Views
14 Pages

Streptococcus suis: A Review of Its Effects on Immune Organs

  • Siyu Pan,
  • Haijuan He,
  • Tong-Qing An and
  • Shujie Wang

Streptococcus suis (S. suis) is a major pathogen in pigs and an emerging zoonotic agent which causes serious infections in humans. It is also an immunosuppressive pathogen that exerts detrimental effects on the thymus, spleen, lymph nodes, and macrop...

  • Article
  • Open Access
8 Citations
2,754 Views
14 Pages

Theaflavin Ameliorates Streptococcus suis-Induced Infection In Vitro and In Vivo

  • Ting Gao,
  • Yiqing Tan,
  • Yanjun Wang,
  • Fangyan Yuan,
  • Zewen Liu,
  • Keli Yang,
  • Wei Liu,
  • Rui Guo,
  • Chang Li and
  • Danna Zhou
  • + 1 author

Streptococcus suis (S. suis) is one of the most important zoonotic pathogens that threaten the lives of pigs and humans. Even worse, the increasingly severe antimicrobial resistance in S. suis is becoming a global issue. Therefore, there is an urgent...

  • Review
  • Open Access
32 Citations
2,267 Views
48 Pages

Recent Proceedings on Prevalence and Pathogenesis of Streptococcus suis

  • Chen Tan,
  • Anding Zhang,
  • Huanchun Chen and
  • Rui Zhou

Streptococcus suis (S. suis) is an important zoonotic pathogen that causes huge economic losses in the pig industry, as well as severe illness and even death in humans. The outbreak of human infection of S. suis in China in 2005 led to significant hu...

  • Article
  • Open Access
13 Citations
2,910 Views
10 Pages

The Ability of Nuclease-Resistant RNA Aptamer against Streptococcus suis Serotype 2, Strain P1/7 to Reduce Biofilm Formation In Vitro

  • Apinyapat Matchawong,
  • Chatchawan Srisawat,
  • Sirikwan Sangboonruang and
  • Chayada Sitthidet Tharinjaroen

17 June 2022

Streptococcus suis, a Gram-positive bacterium, is an important swine and human pathogen, with serotype 2 being the most prevalent strain found worldwide. Deafness, meningitis, and death (in severe cases) are observed in S. suis-infected cases. Develo...

  • Review
  • Open Access
6 Citations
3,664 Views
13 Pages

23 September 2020

Streptococcus suis causes severe infections in both swine and humans, making it a serious threat to the swine industry and public health. Insight into the physiology and pathogenesis of S. suis undoubtedly contributes to the control of its infection....

  • Editorial
  • Open Access
70 Citations
11,784 Views
8 Pages

27 August 2020

Streptococcus suis is considered among the top bacterial pathogens leading to important economic losses to the swine industry, with the incidence of disease increasing as the prophylactic use of antimicrobial is being vanished worldwide. S. suis is a...

  • Article
  • Open Access
29 Citations
6,940 Views
18 Pages

Streptococcus suis: An Underestimated Emerging Pathogen in Hungary?

  • Márió Gajdács,
  • Anita Németh,
  • Márta Knausz,
  • Ibrahim Barrak,
  • Anette Stájer,
  • Gyula Mestyán,
  • Szilvia Melegh,
  • Adrienn Nyul,
  • Ákos Tóth and
  • Edit Urbán
  • + 1 author

Streptococcus suis (S. suis) is an emerging zoonotic pathogen, demonstrated as an etiological agent in human infections in increasing frequency, including diseases like purulent meningitis, sepsis, uveitis-endophtalmitis and arthritis. Due to the inc...

  • Brief Report
  • Open Access
4 Citations
3,417 Views
10 Pages

Transferrins Reduce Replication of Chlamydia suis in McCoy Cells

  • Leentje De Puysseleyr,
  • Kristien De Puysseleyr,
  • Joanna Rybarczyk,
  • Paulien Vander Donck,
  • Winnok H. De Vos and
  • Daisy Vanrompay

Chlamydia suis (C. suis) resides in the intestines of pigs and tetracycline-resistant strains are emerging worldwide. Intestinal infections are often subclinical. However, the gut is regarded as a C. suis reservoir and clinical infections have been a...

  • Article
  • Open Access
5 Citations
3,068 Views
10 Pages

Peptidomics Analysis of Virulent Peptides Involved in Streptococcus suis Pathogenesis

  • Chadaporn Chaiden,
  • Janthima Jaresitthikunchai,
  • Narumon Phaonakrop,
  • Sittiruk Roytrakul,
  • Anusak Kerdsin and
  • Suphachai Nuanualsuwan

24 August 2021

Streptococcus suis (S. suis) is a zoonotic pathogen causing severe streptococcal disease worldwide. S. suis infections in pigs and humans are frequently associated with the virulent S. suis serotype 2 (SS2). Though various virulence factors of S. sui...

  • Article
  • Open Access
2 Citations
2,216 Views
12 Pages

Streptococcus suis Induces Macrophage M1 Polarization and Pyroptosis

  • Siqi Li,
  • Tianfeng Chen,
  • Kexin Gao,
  • Yong-Bo Yang,
  • Baojie Qi,
  • Chunsheng Wang,
  • Tongqing An,
  • Xuehui Cai and
  • Shujie Wang

Streptococcus suis is an important bacterial pathogen that affects the global pig industry. The immunosuppressive nature of S. suis infection is recognized, and our previous research has confirmed thymus atrophy with a large number of necrotic c...

  • Article
  • Open Access
9 Citations
3,673 Views
17 Pages

Screening of Virulence-Related Transcriptional Regulators in Streptococcus suis

  • Liang Liu,
  • Qiang Zhang,
  • Zhongmin Xu,
  • Bo Chen,
  • Anding Zhang,
  • Xiaomei Sun and
  • Meilin Jin

21 August 2020

Streptococcus suis (S.suis) is an important zoonotic pathogen that causes many severe diseases in pigs and humans. Virulence-related transcriptional regulators have been widely reported in pathogenic microorganisms, but only a few have been identifie...

  • Article
  • Open Access
3 Citations
2,425 Views
14 Pages

Isopropoxy Benzene Guanidine Ameliorates Streptococcus suis Infection In Vivo and In Vitro

  • Ning Han,
  • Jie Li,
  • Feifei Zhao,
  • Yangyang Li,
  • Jun Wang,
  • Xiaolan Dai,
  • Dongping Zeng,
  • Wenguang Xiong and
  • Zhenling Zeng

Streptococcus suis, an encapsulated zoonotic pathogen, has been reported to cause a variety of infectious diseases, such as meningitis and streptococcal-toxic-shock-like syndrome. Increasing antimicrobial resistance has triggered the need for new tre...

  • Article
  • Open Access
1,265 Views
30 Pages

26 October 2025

Current research on heritage corridors predominantly focuses on linear heritage in Europe and America, while studies in Asia urgently need to be expanded. This study investigates China’s linear heritage. Based on the minimum cumulative resistan...

  • Article
  • Open Access
3 Citations
3,479 Views
9 Pages

The Impact of SsPI-1 Deletion on Streptococcus suis Virulence

  • Yan Zhao,
  • Gang Li,
  • Xin-Yue Yao,
  • Shu-Guang Lu,
  • Jing Wang,
  • Xiao-Dong Shen and
  • Ming Li

6 December 2019

(1) Background: Streptococcus suis is an important zoonotic pathogen that infects pigs and can occasionally cause life-threatening systemic infections in humans. Two large-scale outbreaks of streptococcal toxic shock-like syndrome in China suggest th...

  • Article
  • Open Access
17 Citations
4,530 Views
13 Pages

CopA Protects Streptococcus suis against Copper Toxicity

  • Chengkun Zheng,
  • Mengdie Jia,
  • Tianyu Lu,
  • Miaomiao Gao and
  • Lingzhi Li

Streptococcus suis is a zoonotic pathogen that causes great economic losses to the swine industry and severe threats to public health. A better understanding of its physiology would contribute to the control of its infections. Although copper is an e...

  • Communication
  • Open Access
24 Citations
5,907 Views
9 Pages

18 November 2016

Streptococcus suis is a porcine commensal and pathogen with zoonotic potential. We recently identified a novel Type I restriction–modification (R–M) system in a zoonotic S. suis clone which has emerged in the Netherlands. Here, we describe the DNA in...

  • Article
  • Open Access
9 Citations
4,878 Views
14 Pages

Characteristics of Chlamydia suis Ocular Infection in Pigs

  • Christine Unterweger,
  • Aleksandra Inic-Kanada,
  • Sara Setudeh,
  • Christian Knecht,
  • Sophie Duerlinger,
  • Melissa Stas,
  • Daisy Vanrompay,
  • Celien Kiekens,
  • Romana Steinparzer and
  • Talin Barisani-Asenbauer
  • + 2 authors

29 August 2021

Chlamydia (C.) suis can often be isolated from conjunctival swab specimens from pigs with conjunctivitis or keratoconjunctivitis. In the field, it is assumed to be a multifactorial disease triggered by immunosuppressing factors. This is the first exp...

  • Article
  • Open Access
9 Citations
3,838 Views
14 Pages

Strain Characterization of Streptococcus suis Serotypes 28 and 31, Which Harbor the Resistance Genes optrA and ant(6)-Ia

  • Shujie Wang,
  • Defu Zhang,
  • Chenggang Jiang,
  • Haijuan He,
  • Chenchen Cui,
  • Weitong Duan,
  • Shouping Hu,
  • Jun Wang and
  • Xuehui Cai

16 February 2021

Streptococcus suis causes disease in pigs and is implicated increasingly in human disease worldwide. Although most clinical cases are associated with serotype 2, infections by other serotypes have sometimes been reported. Here, we sequenced the genom...

  • Article
  • Open Access
8 Citations
3,598 Views
13 Pages

Apigenin and Ampicillin as Combined Strategy to Treat Severe Streptococcus suis Infection

  • Hao Lu,
  • Chenchen Wang,
  • Wenjia Lu,
  • Xiaodan Li,
  • Zhaoyuan Wu,
  • Gaoyan Wang,
  • Wenqi Dong,
  • Chen Tan and
  • Manli Liu

As an important zoonotic pathogen, Streptococcus suis (S. suis) can cause a variety of diseases both in human and animals, especially Streptococcal toxic shock-like syndrome (STSLS), which commonly appears in severe S. suis infection. STSLS is often...

  • Article
  • Open Access
21 Citations
3,819 Views
13 Pages

Baicalein Ameliorates Streptococcus suis-Induced Infection In Vitro and In Vivo

  • Hao Lu,
  • Xiaodan Li,
  • Gaoyan Wang,
  • Chenchen Wang,
  • Jiajia Feng,
  • Wenjia Lu,
  • Xiangru Wang,
  • Huanchun Chen,
  • Manli Liu and
  • Chen Tan

As an important zoonotic pathogen, Streptococcus suis (S. suis) infection has been reported to be a causative agent for variety of diseases in humans and animals, especially Streptococcal toxic shock-like syndrome (STSLS), which is commonly seen in c...

  • Article
  • Open Access
10 Citations
7,412 Views
12 Pages

The Complete Genome of Brucella Suis 019 Provides Insights on Cross-Species Infection

  • Yuanzhi Wang,
  • Zhen Wang,
  • Xin Chen,
  • Hui Zhang,
  • Fei Guo,
  • Ke Zhang,
  • Hanping Feng,
  • Wenyi Gu,
  • Changxin Wu and
  • Shan Gao
  • + 3 authors

26 January 2016

Brucella species are the most important zoonotic pathogens worldwide and cause considerable harm to humans and animals. In this study, we presented the complete genome of B. suis 019 isolated from sheep (ovine) with epididymitis. B. suis 019 has a ro...

  • Article
  • Open Access
1 Citations
3,557 Views
16 Pages

Streptococcus suis: A Possible Emerging Zoonotic Pathogen in Romania

  • Serban Nicolae Benea,
  • Ruxandra Moroti,
  • Teodora Deaconu,
  • Corina Ciont,
  • Mihaela Anca Benea and
  • Ilinca Savulescu Fiedler

Streptococcus suis is a common germ in pig populations, with high carrier rates. Recent studies identify it as an emerging zoonotic pathogen, particularly in Southeast Asia, where raw pork is traditionally consumed. Data on Streptococcus suis infecti...

  • Article
  • Open Access
10 Citations
5,998 Views
11 Pages

Clearance of Streptococcus suis in Stomach Contents of Differently Fed Growing Pigs

  • Franziska Warneboldt,
  • Saara J. Sander,
  • Andreas Beineke,
  • Peter Valentin-Weigand,
  • Josef Kamphues and
  • Christoph Georg Baums

Streptococcus (S.) suis translocates across the intestinal barrier of piglets after intraintestinal application. Based on these findings, an oro-gastrointestinal infection route has been proposed. Thus, the objective of this study was to investigate...

  • Article
  • Open Access
47 Citations
5,692 Views
8 Pages

Genotypic Comparison between Streptococcus suis Isolated from Pigs and Humans in Thailand

  • Anusak Kerdsin,
  • Dan Takeuchi,
  • Aniroot Nuangmek,
  • Yukihiro Akeda,
  • Marcelo Gottschalk and
  • Kazunori Oishi

Streptococcus suis is a zoonotic pathogen of economic significance to the swine industry. The number of infected cases is increasing in humans worldwide. In this study, we determined the prevalence and diversity of S. suis carriage in slaughterhouse...

  • Article
  • Open Access
18 Citations
4,544 Views
12 Pages

Application of the Phage Lysin Ply5218 in the Treatment of Streptococcus suis Infection in Piglets

  • Zhaofei Wang,
  • Jingjiao Ma,
  • Jian Wang,
  • Denghui Yang,
  • Licheng Kong,
  • Qiang Fu,
  • Yuqiang Cheng,
  • Hengan Wang,
  • Yaxian Yan and
  • Jianhe Sun

5 August 2019

Streptococcus suis (S. suis) is a gram-positive bacterium and zoonotic pathogen. Currently it poses a serious problem in the swine industry due to the emergence of antibiotic-resistant bacteria. Thus, novel antimicrobials against S. suis infections a...

  • Feature Paper
  • Article
  • Open Access
26 Citations
5,657 Views
18 Pages

Recruitment of Factor H to the Streptococcus suis Cell Surface is Multifactorial

  • David Roy,
  • Daniel Grenier,
  • Mariela Segura,
  • Annabelle Mathieu-Denoncourt and
  • Marcelo Gottschalk

Streptococcus suis is an important bacterial swine pathogen and a zoonotic agent. Recently, two surface proteins of S. suis, Fhb and Fhbp, have been described for their capacity to bind factor H—a soluble complement regulatory protein that protects h...

  • Article
  • Open Access
4 Citations
2,787 Views
13 Pages

Cell-penetrating peptides (CPPs) are promising carriers to effectively transport antisense oligonucleotides (ASOs), including peptide nucleic acids (PNAs), into bacterial cells to combat multidrug-resistant bacterial infections, demonstrating signifi...

  • Article
  • Open Access
4 Citations
4,182 Views
13 Pages

Determination of Susceptibility Breakpoint for Cefquinome against Streptococcus suis in Pigs

  • Kun Mi,
  • Mei Li,
  • Lei Sun,
  • Yixuan Hou,
  • Kaixiang Zhou,
  • Haihong Hao,
  • Yuanhu Pan,
  • Zhenli Liu,
  • Changqing Xie and
  • Lingli Huang

Streptococcus suis (S. suis), a zoonotic pathogen, causes severe diseases in both pigs and human beings. Cefquinome can display excellent antibacterial activity against gram-negative and gram-positive bacteria. The aim of this study was to derive an...

  • Review
  • Open Access
20 Citations
10,330 Views
18 Pages

Bacterial Adhesion of Streptococcus suis to Host Cells and Its Inhibition by Carbohydrate Ligands

  • Annika Kouki,
  • Roland J. Pieters,
  • Ulf J. Nilsson,
  • Vuokko Loimaranta,
  • Jukka Finne and
  • Sauli Haataja

1 July 2013

Streptococcus suis is a Gram-positive bacterium, which causes sepsis and meningitis in pigs and humans. This review examines the role of known S. suis virulence factors in adhesion and S. suis carbohydrate-based adhesion mechanisms, as well as the in...

  • Article
  • Open Access
15 Citations
4,179 Views
21 Pages

Combined Immunoinformatics to Design and Evaluate a Multi-Epitope Vaccine Candidate against Streptococcus suis Infection

  • Song Liang,
  • Shidan Zhang,
  • Yinli Bao,
  • Yumin Zhang,
  • Xinyi Liu,
  • Huochun Yao and
  • Guangjin Liu

29 January 2024

Streptococcus suis (S. suis) is a zoonotic pathogen with multiple serotypes, and thus, multivalent vaccines generating cross-protection against S. suis infections are urgently needed to improve animal welfare and reduce antibiotic abuse. In this stud...

  • Review
  • Open Access
15 Citations
4,750 Views
25 Pages

Neutrophils in Streptococcus suis Infection: From Host Defense to Pathology

  • Marêva Bleuzé,
  • Marcelo Gottschalk and
  • Mariela Segura

Streptococcus suis is a swine pathogen and zoonotic agent responsible for economic losses to the porcine industry. Infected animals may develop meningitis, arthritis, endocarditis, sepsis and/or sudden death. The pathogenesis of the infection implies...

  • Article
  • Open Access
823 Views
28 Pages

2 November 2025

Background/Objectives: Streptococcus suis is a zoonotic pathogen that causes infections in pigs and humans, leading to significant economic losses. S. suis can evade the immune system of hosts and induce persistent infections. Early detection and vac...

  • Article
  • Open Access
1 Citations
2,063 Views
15 Pages

Isolation, Identification, and Molecular Genetic Characteristics of a Pathogenic Strain of Streptococcus suis Serotype 3

  • Longbai Wang,
  • Jingli Qiu,
  • Bing He,
  • Xuemin Wu,
  • Qiuyong Chen,
  • Quanxi Wang,
  • Renjie Wu,
  • Bohan Zheng,
  • Lunjiang Zhou and
  • Xiaohong Huang

14 February 2025

Streptococcus suis (S. suis) is considered as one of the most crucial bacterial pathogens that leads to serious economic losses to the swine industry. Different S. suis serotypes exhibit diverse characteristics in population structure and pathogenici...

  • Article
  • Open Access
799 Views
23 Pages

Extracellular Vesicles from Streptococcus suis Promote Bacterial Pathogenicity by Disrupting Macrophage Metabolism

  • Wenjie Jin,
  • Jinpeng Li,
  • Zhaoyu Yi,
  • Zhiheng Chang,
  • Yue Li,
  • Yamin Shen,
  • Yingying Quan,
  • Yuxin Wang,
  • Baobao Liu and
  • Yang Wang
  • + 1 author

Streptococcus suis (S. suis) is an important zoonotic pathogen that causes severe disease in both humans and pigs, leading to substantial economic losses in the swine industry. Extracellular vesicles (EVs), as critical mediators of host–pathoge...

  • Article
  • Open Access
10 Citations
4,985 Views
23 Pages

From Stable to Lab—Investigating Key Factors for Sudden Deaths Caused by Streptococcus suis

  • Isabel Hennig-Pauka,
  • Rabea Imker,
  • Leonie Mayer,
  • Michael Brügmann,
  • Christiane Werckenthin,
  • Heike Weber,
  • Andrea Menrath and
  • Nicole de Buhr

20 November 2019

Swine stocks are endemically infected with the major porcine pathogen Streptococcus (S.) suis. The factors governing the transition from colonizing S. suis residing in the tonsils and the exacerbation of disease have not yet been elucidated. We analy...

  • Article
  • Open Access
11 Citations
2,744 Views
14 Pages

Aerococcus viridans Phage Lysin AVPL Had Lytic Activity against Streptococcus suis in a Mouse Bacteremia Model

  • Hengyu Xi,
  • Yao Fu,
  • Chong Chen,
  • Xin Feng,
  • Wenyu Han,
  • Jingmin Gu and
  • Yalu Ji

23 November 2023

Streptococcus suis (S. suis) is a swine pathogen that can cause sepsis, meningitis, endocarditis, and other infectious diseases; it is also a zoonotic pathogen that has caused a global surge in fatal human infections. The widespread prevalence of mul...

  • Article
  • Open Access
6 Citations
2,425 Views
15 Pages

Canagliflozin Inhibited the Activity of Hemolysin and Reduced the Inflammatory Response Caused by Streptococcus suis

  • Xiaodan Li,
  • Qingyuan Li,
  • Zhaoran Zhang,
  • Chenchen Wang,
  • Xinyu Huo,
  • Hongjiang Lai,
  • Hao Lu,
  • Wenjia Lu,
  • Yulin Qian and
  • Manli Liu
  • + 2 authors

22 August 2023

Highly virulent Streptococcus suis (S. suis) infections can cause Streptococcal toxic shock-like syndrome (STSLS) in pigs and humans, in which an excessive inflammatory response causes severe damage. Hemolysin (SLY) is a major virulence factor of S. ...

  • Article
  • Open Access
8 Citations
4,202 Views
11 Pages

1 August 2020

Tetracycline (TET) has been widely used in the treatment of Streptococcus suis (S. suis) infection. However, it was found that the efficacy of many antibiotics in S. suis decreased significantly, especially tetracycline. In this study, GML-12 (a nove...

  • Article
  • Open Access
10 Citations
2,929 Views
14 Pages

Suilyin Disrupts the Blood–Brain Barrier by Activating Group III Secretory Phospholipase A2

  • Yutong Sui,
  • Ying Chen,
  • Qingyu Lv,
  • Yuling Zheng,
  • Decong Kong,
  • Hua Jiang,
  • Wenhua Huang,
  • Yuhao Ren,
  • Peng Liu and
  • Yongqiang Jiang

20 June 2022

Serious diseases caused by Streptococcus suis serotype 2 (S. suis 2) include septicaemia and meningitis, which are associated with high morbidity and mortality. Proliferation in the blood can result in a breach of the blood–brain barrier (BBB)...

  • Article
  • Open Access
4 Citations
3,328 Views
17 Pages

2 September 2020

Streptococcus suis is a zoonotic pathogen causing serious infections in swine and humans. Although metals are essential for life, excess amounts of metals are toxic to bacteria. Transcriptome-level data of the mechanisms for resistance to metal toxic...

  • Article
  • Open Access
27 Citations
3,852 Views
21 Pages

Role of Bacterial and Host DNases on Host-Pathogen Interaction during Streptococcus suis Meningitis

  • Marita Meurer,
  • Sophie Öhlmann,
  • Marta C. Bonilla,
  • Peter Valentin-Weigand,
  • Andreas Beineke,
  • Isabel Hennig-Pauka,
  • Christian Schwerk,
  • Horst Schroten,
  • Christoph G. Baums and
  • Nicole de Buhr
  • + 1 author

Streptococcus suis is a zoonotic agent causing meningitis in pigs and humans. Neutrophils, as the first line of defense against S. suis infections, release neutrophil extracellular traps (NETs) to entrap pathogens. In this study, we investigated the...

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