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Keywords = Sarcococca hookeriana

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7 pages, 1568 KB  
Article
Two New Cytotoxic Steroidal Alkaloids from Sarcococca Hookeriana
by Shaojie Huo, Jichun Wu, Xicheng He, Lutai Pan and Jiang Du
Molecules 2019, 24(1), 11; https://doi.org/10.3390/molecules24010011 - 20 Dec 2018
Cited by 20 | Viewed by 4227
Abstract
Two new steroidal alkaloids, named hookerianine A (1) and hookerianine B (2) were isolated from the stems and roots of Sarcococca hookeriana Baill., along with two known compounds, sarcorucinine G (3) and epipachysamine D (4). [...] Read more.
Two new steroidal alkaloids, named hookerianine A (1) and hookerianine B (2) were isolated from the stems and roots of Sarcococca hookeriana Baill., along with two known compounds, sarcorucinine G (3) and epipachysamine D (4). On the basis of spectroscopic methods and by comparison with literature data, their structures were determined. As well as X-ray crystallography was performed to confirm compound 4. To identify novel antitumor inhibitors, all compounds were performed a CCK-8 assay against five human cancer cell lines SW480, SMMC-7721, PC3, MCF-7 and K562 in vitro. Compound 2 exhibited moderate cytotoxic activities to all cell lines with IC50 values in the range of 5.97–19.44 μM. Compound 3 was the most effective one against SW480 and K562 cell lines with IC50 values of 5.77 and 6.29 μM, respectively. Full article
(This article belongs to the Special Issue Advances in Plant Alkaloid Research)
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8 pages, 575 KB  
Article
Three New Cytotoxic Steroidal Alkaloids from Sarcococca hookeriana
by Kang He, Jinxi Wang, Juan Zou, Jichun Wu, Shaojie Huo and Jiang Du
Molecules 2018, 23(5), 1181; https://doi.org/10.3390/molecules23051181 - 15 May 2018
Cited by 20 | Viewed by 4061
Abstract
Three new steroidal alkaloids with an unusual 3α tigloylamide group, named sarchookloides A–C (13), were isolated along with four known compounds (47) from the roots of Sarcococca hookeriana. Their structures and relative configuration [...] Read more.
Three new steroidal alkaloids with an unusual 3α tigloylamide group, named sarchookloides A–C (13), were isolated along with four known compounds (47) from the roots of Sarcococca hookeriana. Their structures and relative configuration were elucidated on the basis of spectroscopic methods including MS, UV, IR, 1D, and 2D NMR data. The isolated compounds were evaluated for their cytotoxicity against five human cancer cell lines: Hela, A549, MCF-7, SW480, and CEM in vitro. All three amide substituted steroidal alkaloids exhibited significant cytotoxic activities with IC50 values of 1.05–31.83 μM. Full article
(This article belongs to the Special Issue Advances in Plant Alkaloid Research)
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