Search Results (40)

Aspergillus spp., particularly A. fumigatus, are increasingly reported as emerging pathogens in cetaceans, yet their clinical and ecological relevance remains poorly characterized. This systematic review synthesizes evidence from 34 studies involving 106 animals, identifying respiratory, neurological, and otic infections as the most frequent presentations with potential interspecies tropism. Invasive disease, frequently fatal, was linked to co-infections—especially with morbillivirus—and environmental stressors such as pollution- and climate-related immune suppression. Despite cetaceans’ role as sentinel species, antifungal susceptibility testing and species-level identification were inconsistently performed. Additionally, azole-resistant A. fumigatus strains were isolated from wild porpoises, indicating environmental antifungal exposure and potential public health implications. Aspergillosis remains underdiagnosed in free-ranging populations, particularly in remote or pelagic species. Conservation implications were scarcely addressed, despite evidence suggesting that fungal disease may contribute to morbidity, stranding, and population impact. This review underscores the need for enhanced surveillance, integrative diagnostics, and recognition of fungal pathogens in a One Health framework. The growing intersection of climate change, emerging mycoses, and wildlife conservation positions Aspergillus infections in cetaceans as both a marine mammal health concern and an ecological indicator of broader environmental changes. Full article

During the Meiji period, the relationship between Confucianism and the indigenous Japanese religion of Shinto became more complex within the context of national culture and policy. The integration of Confucianism and Shinto became an important part of Japan’s modernization and ideological construction. However, this profound fusion did not emerge suddenly; as early as the Edo period, Confucianism and Shinto had already established a certain degree of interaction and influence. Therefore, this article attempts to outline an early example of the combination of Shinto and Confucianism (more specifically, Neo-Confucianism, which had a profound impact on modern and contemporary Japan) through the lens of the integrated thought of Shinto and Confucianism of the early Edo-period scholar, Kaibara Ekiken. Full article

Traditional Japanese architecture is known for its open, ambiguous spatial boundaries (“kyokai”), which integrate nature and dwelling through Zen/Shinto philosophies. Yet modern urban housing, driven by high-density minimalism, flattens spatial hierarchies and erodes these rich boundary concepts. This study aims to explore how Japanese architect Yoshiji Takehara reinterprets traditional spatial principles to reconstruct the interior–exterior relationships in modern housing through a mixed-methods approach—including a literature review, case studies, and semi-structured interviews—verifying the hypothesis that he achieves the modern translation of traditional “kyokai” through strategies of boundary expansion and ambiguity. Analyzing 78 independent residential projects by Takehara and incorporating his interview texts, the research employs spatial typology and statistical methods to quantify the characteristics of boundary configurations, such as building contour morphology, opening orientations, and transitional space types, to reveal the internal logic of his design strategies. This study identifies two core strategies through which Takehara redefines spatial boundaries: firstly, clustered building layouts, multi-directional openings, and visual connections between courtyards and private functional spaces extend interface areas, enhancing interactions between nature and daily life; secondly, in-between spaces like corridors and doma (earthen-floored transitional zones), double-layered fixtures, and floor-level variations blur physical and psychological boundaries, creating multilayered permeability. Case studies demonstrate that his designs not only inherit traditional elements such as indented plans and semi-outdoor buffers but also revitalize the essence of “dwelling” through contemporary expressions, achieving dynamic visual experiences and poetic inhabitation within limited sites via complex boundary configurations and fluid thresholds. This research provides reusable boundary design strategies for high-density urban housing, such as multi-directional openings and buffer space typologies, and fills a research gap in the systematic translation of traditional “kyokai” theory into modern architecture, offering new insights for reconstructing the natural connection in residential spaces. Full article

Colloidal quantum dots (QDs) and graphene hybrids have emerged as promising platforms for optoelectronic and biosensing applications due to their unique photophysical and electronic properties. This study investigates the fundamental mechanism underlying the photoluminescence (PL) quenching and recovery in graphene–QD hybrid systems using single-layer graphene field-effect transistors (SLG-FETs) and time-resolved photoluminescence (TRPL) spectroscopy. We demonstrate that PL quenching and its recovery are primarily driven by charge transfer, as evidenced by an unchanged fluorescence lifetime upon quenching. Density functional theory calculations reveal a significant charge redistribution at the graphene–QD interface, corroborating experimental observations. We also provide a simple analytical quantum mechanical model to differentiate charge transfer-induced PL quenching from resonance energy transfer. Furthermore, we leverage the charge transfer mechanism for ultrasensitive biosensing to detect biomarkers such as immunoglobulin G (IgG) at femtomolar concentrations. The sensor’s electrical response, characterized by systematic shifts in the Dirac point of SLG-FETs, confirms the role of analyte-induced charge modulation in PL recovery. Our findings provide a fundamental framework for designing next-generation graphene-based biosensors with exceptional sensitivity and specificity. Full article

This paper explores the scholarly discourse on the divinity of the emperor in postwar Japan to better understand Japanese conservative nationalism, which has been regaining momentum since the 1990s. Viewing the idea of the divinity of the emperor as ideologically fundamental to Japanese conservative nationalism, this paper looks at how conservative scholars from the 1970s developed a culturalist argument for the divinity of the emperor, first to negate the “humanity declaration”, i.e., the New Year’s greeting by the Showa emperor on 1 January 1946 renouncing his divinity, and then to reconfigure conservative ideology into a popular discourse on Japanese identity (i.e., the Nihonjin-ron), thereby making it more easily accepted by postwar society. Key to this culturalist argument is an essentialized dichotomy between Japanese culture and Western culture, more specifically a binary between Shinto kami and the Christian God—that the Japanese concept of kami is qualitatively different from that of the Christian God, so the emperor is not God but is kami; therefore, the emperor’s divinity is not really denied and he remains the spiritual pillar of the Japanese nation even under the postwar constitutional regime. Refashioning itself as part of the increasingly popular but depoliticized Nihonjin-ron discourse, the culturalist argument on the divinity of the emperor helped make the imperial house a popular topic of the discourse on Japanese identities, even while it completely circumvented the very issues of war responsibility and historical memory which gave rise to the “humanity declaration” in 1946 in the first place. In its depoliticized, popularly appealing form, the culturalist argument played a role in legitimating the regressive conservative nationalism that seeks to revive the pre-1945 divine emperor-centered political regime. Exploring the scholarly discourse on the divinity of the emperor, then, helps shed light on how and why conservative nationalism could persist and gain momentum in the 21st century. Full article

In a faraway apple orchard in Sannohe, a small town in Japan’s Aomori Prefecture, a zushi miniature wooden shrine at the Nose Kannon Hall caught the media’s attention with its unique adornment—the karuta playing cards with European-inspired abstract designs in bold red and black colors that were used during the early modern period for pastime and gambling. Because of this decoration, the Nose Kannon Hall is known by locals as the Karuta Hall, and the zushi that enshrines the Buddhist deity Bodhisattva Shō-Kanzeon is also believed to be the home of bakuchi no kamisama “the kami deity of gambling”. Little is known about the nature of devotion to this bakuchi no kamisama or how the playing cards that were used for frivolous games came to be sacralized as items worthy to be used as decoration of a Buddhist shrine. This article considers the slippage between prayer and play in the regional Buddhist devotion by focusing on the Nose Kannon Hall, which presided at a key intersection along the northern trade route where the local community and outside visitors, such as pilgrims and traders, converged, especially during the Edo period (1603–1868). Marshaling historical records, televised interviews, and images provided by the town officials and guardian family of Nose Kannon Hall, I argue that the use of karuta playing cards on the miniature shrine at Nose Kannon Hall epitomizes a kind of localized early modern Shinto–Buddhist syncretism at the margins of the urban culture that is simultaneously devotional and tongue-in-cheek sacrilegious in a quintessentially Edo-esque way. Full article

Tumor-infiltrating lymphocytes in the tumor microenvironment are important in the treatment of triple-negative breast cancer (TNBC). Cytotoxic T cells produce cytokines and cytotoxic factors, such as perforin and granzyme, which induce apoptosis by damaging target cells. To identify biomarkers of these cells, we investigated granzyme B (GZMB) in the tumor microenvironment as a biomarker of treatment response and prognosis in 230 patients with primary TNBC who underwent surgery without preoperative chemotherapy between January 2004 and December 2014. Programmed cell death ligand 1 (PD-L1) positivity was defined as a composite positive score ≥10 based on the PD-L1 immunostaining of tumor cells and immune cells. GZMB-high was defined as positivity in ≥1% of tumor-infiltrating lymphocytes (TILs). Among the 230 TNBC patients, 117 (50.9%) had CD8-positive infiltrating tumors. In the PD-L1-positive group, a Kaplan–Meier analysis showed that GZMB-high TNBC patients had better recurrence-free survival (RFS) and overall survival (OS) than GZMB-low patients and that OS was significantly longer (RFS: p = 0.0220, OS: p = 0.0254). A multivariate analysis also showed significantly better OS in PD-L1- and GZMB-high patients (hazard ratio: 0.25 (95% IC: 0.07–0.88), p = 0.03). Our findings indicate that GZMB is a useful prognostic biomarker in PD-L1-positive TNBC patients. Full article

Chronotype (morningness–eveningness) and social jetlag (SJL; discrepancy in the sleep pattern between the weekday and weekend) are related to eating behavior and health. The association between sleep behavior and the daily macro- and micronutrient eating pattern of each meal (breakfast, lunch, and dinner) have not been discussed well and need more evidence. Here, meal pattern datasets of Japanese participants aged 20–59 years were obtained as averages over 1 month from the data stored in the food-logging app “Asken”. We allocated three groups for each chronotype and SJL. Multiple regression analyses revealed that morning chronotype and small SJL were associated with higher total daily intake of potassium, fiber, magnesium, phosphorus, and vitamin K. Breakfast energy intake and consumption of nutrients, including protein, lipid, carbohydrate, and minerals, were higher in the morning chronotype or small SJL. Lunch intake of potassium, cholesterol, fiber, magnesium, and vitamin K was also higher in the morning chronotype or small SJL. Dinner energy intake and nutrient intake of proteins, lipids, carbohydrates, sodium, and saturated fatty acids were lower in the morning chronotype or small SJL. The current data would help to establish a detailed reference for dietary intake which considers eating patterns over a day. Full article

We retrospectively evaluated the impact of therapeutic modifications of atezolizumab (Atezo) plus bevacizumab (Bev) therapy (Atezo/Bev), including the interruption or discontinuation of both Atezo and Bev, and the reduction or discontinuation of Bev, on the outcome of patients with unresectable hepatocellular carcinoma (uHCC) (median observation period: 9.40 months). One hundred uHCC from five hospitals were included. Therapeutic modifications without discontinuation of both Atezo and Bev (n = 46) were associated with favorable overall survival (median not reached; hazard ratio (HR): 0.23) and time to progression (median: 10.00 months; HR: 0.23) with no therapeutic modification defined as the reference. In contrast, the discontinuation of both Atezo and Bev without other therapeutic modifications (n = 20) was associated with unfavorable overall survival (median: 9.63 months; HR: 2.72) and time to progression (median: 2.53 months; HR: 2.78). Patients with modified albumin–bilirubin grade 2b liver function (n = 43) or immune-related adverse events (irAEs) (n = 31) discontinued both Atezo and Bev without other therapeutic modifications more frequently (30.2% and 35.5%, respectively) than those with modified albumin–bilirubin grade 1 (10.2%) and without irAEs (13.0%). Patients with objective response (n = 48) experienced irAEs more frequently (n = 21) than those without (n = 10) (p = 0.027). Avoiding the discontinuation of both Atezo and Bev without other therapeutic modifications may be the optimal management of uHCC. Full article

Although conversion surgery has increasingly been performed for initially unresectable advanced pancreatic ductal adenocarcinoma (PDAC), the rate of conversion, including that for patients who do not undergo resection, remains unclear. Patients with PDAC who were treated between January 2013 and December 2018 were classified into three groups: resectable (R), borderline resectable (BR), and unresectable (UR). We analyzed patient outcomes, including the rate of surgical resection and survival, in each of these groups. In total, 211 patients (R, 118; BR, 22; UR, 81) were selected. Among them, 117 (99%), 18 (82%), and 15 (19%) patients in the R, BR, and UR groups, respectively, underwent surgical resection. R0 resection rates were 88, 78, and 67%, whereas median overall survival (OS) from treatment initiation were 31, 18, and 11 months (p < 0.0001) in the R, BR, and UR groups, respectively. In patients who underwent surgical resection, relapse-free survival (RFS) and OS were similar among the three groups (R vs. BR vs. UR; median RFS (months), 17 vs. 13 vs. 11, p = 0.249; median OS (months), 31 vs. 26 vs. 32, p = 0.742). Lymph node metastases and incomplete adjuvant chemotherapy were identified as independent prognostic factors for OS. Although the surgical resection rate was low, particularly in the BR and UR groups, the prognosis of patients who underwent surgical resection was similar irrespective of the initial resectability status. Full article

Microbiologically influenced corrosion (MIC) of metal alloys is promoted by biofilms formed on metal surfaces. In the marine environment, MIC causes serious metal infrastructure problems, which lead to significant economic losses. In this study, we used an enrichment culture approach to examine the bacterial community that grows on metal surface at levels below the detection limit as a preliminary study for developing guidelines to prevent biofilm formation. An enrichment culture approach was employed to analyze the bacterial community on metal surface without biofilms and corrosion. Genomic DNA was extracted from culture sample after incubation in the enrichment culture with a metal piece, and then the V3–V4 variable regions of the bacterial 16S rRNA gene were amplified using the extracted genomic DNA as the template. Subsequently, using a next-generation sequencing approach, the amplified V3–V4 regions were sequenced, and the bacterial community was analyzed using the QIIME 2 microbiome bioinformatics platform. Using this enrichment culture approach, more than 80 bacterial genera were detected with Sphingomonas bacteria exhibiting the highest relative abundance (44%). These results demonstrated that this method could be useful for bacterial community analysis for bacteria below detection limits, and will serve as a basis for the development of the guidelines. Full article

The wartime propaganda slogan Hakkō Ichiu 八紘一宇 (“Unify the whole world under one roof”) was loaded with historical meaning: Japan was glorifying the aggression and colonization of war by fostering a specific interpretation of the narrative about how Jimmu, the first emperor, founded the nation in State Shinto mythology. In this article, I consider this slogan as central to a religious rhetoric with nationalistic overtones and I analyze it in terms of etymology, connotation, and rhetorical devices. First, the expression Hakkō Ichiu originated in ancient East Asian cosmology, before becoming one of the rhetorical expressions of State Shinto, emphasizing the extent of the imperial reign. Second, the Nichirenist activist Tanaka Chigaku rediscovered it and gave it an expansionist connotation, fostering a syncretistic approach mixing Buddhist and Shinto features. Finally, during wartime, in official documents, lyrics, trademarks, etc., the slogan gave way to a number of graphic and monumental expressions, reinforcing its connections with militarism and ultranationalism. The most notable of these material expressions was the Hakkō Ichiu Tower, erected to commemorate the 2600th anniversary of the foundation of the nation and perpetuate the State Shinto rhetoric. Full article

(1) Background: From the perspective of patient-centered care, it is important for medical professionals involved in diabetes care to know the role of choice behavior when individuals with type 2 diabetes mellitus select their meals at home. In Japan, online meal management applications are widely used to help individuals to prepare healthy, colorful, and tasty meals. (2) Objective: To assess menu selection from an online diet management application in individuals with type 2 diabetes mellitus over a period of 24 months. (3) Method: The saved data of the selected food menus on the online diet management application were analyzed. We identified specific nutritional groups of the food menus, called nutritional clusters, by clustering the multidimensional data of the nutrients after de-dimensioning them. Then, we analyzed the constitutional nutrients of each nutritional cluster with the highest and lowest frequencies of selection by the users of the application. (4) Results: In all, 9674 food menus made by 3164 people were included in the analysis, and 12 nutritional clusters were identified. Low-carbohydrate and low-calorie food clusters showed the highest selection frequency. The average caloric value of 149.7 kcal and average carbohydrate ratio of 47% in the cluster with the highest selection frequency were significantly lower than the average caloric value of 435.2 kcal and carbohydrate ratio of 63% in the cluster with the lowest selection frequency (p < 0.001, respectively). (5) Conclusion: Individuals with type 2 diabetes in this population preferred to select lower-carbohydrate and lower-calorie food menus at home using online diet management applications. To improve sustained self-management and quality of life, medical professionals may consider incorporating preferred dietary behaviors into medical management of type 2 diabetes mellitus. Full article

Microbiologically influenced corrosion (MIC) is caused by biofilms formed on metal surfaces, and MIC of metal alloys on marine infrastructure leads to severe accidents and great economic losses. Although bacterial community analyses of the biofilms collected from corroded metal have been studied, the analyses of biofilms collected from uncorroded metal are rarely reported. In this study, a biofilm formed on an uncorroded metal joint attached to a metal dock mooring at Akitsu Port was used as a model for bacterial community analysis. The bacterial community was analyzed by high-throughput sequencing of the V3–V4 variable regions of the 16S rRNA gene. Bacterial species contained in the biofilms were identified at the genus level, and Alkanindiges bacteria were the dominant species, which have been not reported as the dominant species in previous research on MIC. The genome sequences of known Alkanindiges bacteria do not have conserved gene clusters required to cause metal corrosion, which suggests that Alkanindiges bacteria do not corrode metals but act on the formation of biofilms. Those findings indicated that the bacterial community may change significantly during the process from biofilm formation to the occurrence of metal corrosion. Full article

There is now a convincing body of evidence from observational studies that the majority of modifiable Alzheimer’s disease and related dementia (ADRD) risk factors are vascular in nature. In addition, the co-existence of cerebrovascular disease with AD is more common than AD alone, and conditions resulting in brain ischemia likely promote detrimental effects of AD pathology. Oxylipins are a class of bioactive lipid mediators derived from the oxidation of long-chain polyunsaturated fatty acids (PUFAs) which act as modulators of both vascular tone and inflammation. In vascular cognitive impairment (VCI), there is emerging evidence that oxylipins may have both protective and detrimental effects on brain structure, cognitive performance, and disease progression. In this review, we focus on oxylipin relationships with vascular and inflammatory risk factors in human studies and animal models pertinent to ADRD. In addition, we discuss future research directions with the potential to impact the trajectory of ADRD risk and disease progression. Full article