Search Results (531)

In this work, bemotrizinol (BMTZ), a broad-spectrum UV-filter, was loaded into nanostructured lipid carriers (NLC) whose lipid matrix contained different oils (isopropyl myristate, decyl oleate, caprylic/capric triglyceride) to assess the effects of the lipid core composition on the properties of the resulting NLC. Subsequently, the effects of incorporating different concentrations of optimized BMTZ-loaded NLC on the technological properties of O/W emulsions (pH, viscosity, spreadability, occlusion factor, in vitro BMTZ release, skin permeation, and in vitro sun protection factor) were assessed. The optimized BMTZ-loaded NLC contained 3.0% w/w of isopropyl myristate and showed mean size = 190.6 ± 9.8 nm, polydispersity index = 0.153 ± 0.013, ζ-potential = −10.6 ± 1.7 mV, and loading capacity = 8% w/w. The incorporation of increasing concentrations (5, 10, 20% w/w) of optimized BMTZ loaded into emulsions provided a slight increase in spreadability, lower viscosity, and no change in pH, occlusion factor, and BMTZ release compared to emulsions containing free BMTZ. No BMTZ skin permeation was observed from all formulations. About a 20% increase in sun protection factor values was obtained for vehicles containing BMTZ-loaded NLC compared with formulations incorporating the same amount of free BMTZ. Therefore, incorporating BMTZ-loaded NLC into emulsions could be a promising strategy to develop safer and more effective sunscreen formulations. Full article

This paper presents a literature review on the potential of jaboticaba (Myrciaria cauliflora) peel extracts for application in multifunctional dermocosmetic formulations, particularly as natural antioxidants and photoprotective agents. Utilizing the Methodi Ordinatio methodology, of a total of 1226, 90 scientific articles were selected from six major databases and analyzed through bibliometric mapping (VOSviewer) and qualitative data processing (MAXQDA). The results highlight research concentration in three key areas: (1) extraction methodologies for bioactive compounds, (2) identification and quantification techniques, and (3) biological activities (antioxidant and photoprotective effects). The most frequent compounds reported were anthocyanins (cyanidin-3-glucoside and delphinidin-3-glucoside), quercetin-derived flavonoids (rutin and myricetin), and phenolic acids (ellagic, gallic, and ferulic acids), which exhibit synergistic effects with conventional UV filters. Ultrasound-assisted extraction (UAE) using ethanol and emerging green solvents, like glycerol and deep eutectic solvents (DESs), was identified as an effective, sustainable alternative. Despite increasing evidence supporting the dermocosmetic potential of jaboticaba peel, studies remain scarce, with only one identified investigation using it in a topical formulation. This review provides a structured scientific foundation to encourage research aimed at developing multifunctional, eco-friendly, plant-based cosmetics aligned with the principles of the circular economy. Full article

Multiwavelength modelling of the light variations in the chemically peculiar star CU Vir is presented. The modelling is based on the recent Doppler Imaging of CU Vir, which provides maps of the surface distribution of Si, Fe, He, and Cr. Intensity maps in both individual photometric filters and in the wide wavelength range from UV to NIR were calculated, taking into account the individual chemical abundances on the stellar surface. Comparison with observations revealed good agreement of both the light curves and their amplitude along the spectrum. Additionally, we analysed changes in the photometric period of the CU Vir from 1955 to 2022, including TESS measurements. The data of the last decades clearly indicate a gradual decrease in this period. Measurements of the CU Vir period over the next two decades will be crucial for verifying or refuting the periodic nature of its variations. Full article

Endocrine-disrupting chemicals are substances capable of interfering with hormonal systems, potentially leading to adverse developmental, reproductive, neurological, and immune effects in both humans and wildlife. Various experimental models are currently available to assess the endocrine-disrupting potential of substances. However, in the context of cosmetic ingredients, the ban on animal testing for safety and efficacy evaluations in Europe and other regions necessitates the use of in vitro or in silico approaches. Concerns have been raised regarding the possible endocrine-disrupting properties of certain cosmetic compounds, prompting the development of a priority substance list that includes several ultraviolet (UV) filters. This review provides a comprehensive overview of the main methodologies employed to evaluate endocrine-disrupting effects, with a particular focus on different endocrine organs. It also compiles and analyzes literature data related to commonly used UV filters such as benzophenones, avobenzone, homosalate, octocrylene, octinoxate, and 4-methylbenzylidene camphor. A major limitation identified is the lack of validated in vitro methods for assessing disruptions in specific endocrine organs, such as the thyroid and pancreas. This gap hinders accurate interpretation of experimental results and highlights the urgent need for further research to clarify the safety profiles of UV filters and other cosmetic ingredients. Full article

This paper constitutes a preliminary study that evaluates the organic pollutants desorbed from “fresh” plastic litter, i.e., recently stranded items, on three beaches in Cadiz (SW Spain): Bajo de Guia, La Jara, and La Puntilla. Beach litter items were collected and classified in laboratory according to their composition and use. Leachates were obtained by stir bar sorptive extraction (SBSE) and analysed with gas chromatography–mass spectrometry (GC–MS). Fifty-five target organic compounds—including polycyclic aromatic hydrocarbons (PAHs), pesticides, fragrances, insect repellents, and UV filters—were quantified. Plastics accounted for the majority of litter by both number and weight. Cigarette butts and wipes were also prevalent and served as key sources of leachable PAHs. With respect to the main pollutants found in plastic films, hard plastics, and wipes, fragrances such as OTNE1 (1-Tetramethyl Acetyloctahydronaphthalene), OTNE2 (2-Tetramethyl Acetyloctahydronaphthalene), DEET (N, N-Diethyl-Meta-Toluamide), galaxolide, and tonalide were dominant, with concentrations exceeding 100 ng/g in some cases. DEET was the most common insect repellent detected. These findings underscore the role of beach litter, especially plastic waste, as a vector for persistent and emerging organic pollutants, highlighting the urgent need for improved waste management and monitoring practices to mitigate ecological risks associated with plastic pollution. Full article

This work demonstrates the potential of polydimethylsiloxane sponges for removing organic UV filter compounds such as octinoxate from aqueous solutions. The sponges were fabricated using simple templates made of hydrophilic fused or pressed particles (sugar or NaCl salt) with an approximate particle size of 0.4 mm. Among the prepared sponges, those templated with sugar cubes or coarse salt exhibited the highest adsorption capacity, effectively adsorbing up to 0.6% of their own mass in octinoxate. The PDMS sponges were fully regenerable, allowing for the complete removal of octinoxate without any detectable changes in their adsorption properties or dry weight. Due to their simple fabrication, ease of handling, ability to float, and reusability, PDMS sponges present an environmentally friendly and low-maintenance alternative to conventional filtration systems for the removal of octinoxate and potentially other UV filter compounds from environmental surface waters and recreational water bodies. Full article

Oxybenzone (OBZ), an organic ultraviolet filter, is an emerging contaminant posing severe threats to ecosystem health. Using tobacco (Nicotiana tabacum) as a model plant, this study investigated the alleviation mechanisms of exogenous silicon (Na₂SiO₃, Si) and bamboo-based biochar (Bc) under OBZ stress. We systematically analyzed physiological and biochemical responses, including phenotypic parameters, reactive oxygen species metabolism, photosynthetic function, chlorophyll synthesis, and endogenous hormone levels. Results reveal that OBZ significantly inhibited tobacco growth and triggered a reactive oxygen species (ROS) burst. Additionally, OBZ disrupted antioxidant enzyme activities and hormonal balance. Exogenous Bc mitigated OBZ toxicity by adsorbing OBZ, directly scavenging ROS, and restoring the ascorbate-glutathione (AsA-GSH) cycle, thereby enhancing photosynthetic efficiency, while Si alleviated stress via cell wall silicification, preferential regulation of root development and hormonal signaling, and repair of chlorophyll biosynthesis precursor metabolism and PSII function. The mechanisms of the two stress mitigators were complementary, Bc primarily relied on physical adsorption and ROS scavenging, whereas Si emphasized metabolic regulation and structural reinforcement. These findings provide practical strategies for simultaneously mitigating organic UV filter pollution and enhancing plant resilience in contaminated soils. Full article

The lips, due to their unique anatomical characteristics of a thin stratum corneum, the absence of sebaceous glands, and limited melanin content are particularly vulnerable to ultraviolet (UV) radiation, necessitating specialized photoprotective care. While facial sunscreens are widely available, the development of lip-specific sun protection products remains underexplored. This study aims to analyze technological trends and innovations in lip photoprotection by reviewing patents published between 2014 and 2024. A comprehensive patent search using the IPC code A61Q19 and the keywords “lip” and “sunscreen” identified 17 relevant patents across China, the United States, and Japan. The patents were examined for active ingredients, formulation strategies, and use of botanical or sustainable excipients. The findings revealed that patented formulations predominantly rely on well-established UV filters such as zinc oxide, titanium dioxide, octyl methoxycinnamate, and avobenzone, often combined with antioxidants like ferulic acid and rutin for enhanced efficacy. Lipid-based excipients were widely used to improve texture, hydration, and product stability. Although many formulations exhibit a conservative ingredient profile, the strategic combination of UV filters with natural antioxidants and moisturizing lipids demonstrates a multifunctional approach aimed at enhancing both protection and user experience. Full article

Graphene quantum dots (GQDs) obtained by microwave-induced pyrolysis of glutamic acid and triethylenetetramine (trien) are fairly stable, emissive, water-soluble, and positively charged nano-systems able to interact with negatively charged meso-tetrakis(4-sulfonatophenyl) porphyrin (TPPS₄). The stoichiometric control during the preparation affords a supramolecular adduct, GQDs@TPPS₄, that exhibits a double fluorescence emission from both the GQDs and the TPPS₄ fluorophores. These supramolecular aggregates have an overall negative charge that is responsible for the condensation of cations in the nearby aqueous layer, and a three-fold acceleration of the metalation rates of Cu²⁺ ions has been observed with respect to the parent porphyrin. Addition of various metal ions leads to some changes in the UV/Vis spectra and has a different impact on the fluorescence emission of GQDs and TPPS₄. The quenching efficiency of the TPPS₄ emission follows the order Cu²⁺ > Hg²⁺ > Cd²⁺ > Pb²⁺ ~ Zn²⁺ ~ Co²⁺ ~ Ni²⁺ > Mn²⁺ ~ Cr³⁺ >> Mg²⁺ ~ Ca²⁺ ~ Ba²⁺, and it has been related to literature data and to the sitting-atop mechanism that large transition metal ions (e.g., Hg²⁺ and Cd²⁺) exhibit in their interaction with the macrocyclic nitrogen atoms of the porphyrin, inducing distortion and accelerating the insertion of smaller metal ions, such as Zn²⁺. For the most relevant metal ions, emission quenching of the porphyrin evidences a linear behavior in the micromolar range, with the emission of the GQDs being moderately affected through a filter effect. Deliberate pollution of the samples with Zn²⁺ reveals the ability of the GQDs@TPPS₄ adduct to detect sensitively Cu²⁺, Hg^2+, and Cd²⁺ ions. Full article

Calcipotriol, a synthetic vitamin D₃ analogue widely used in psoriasis treatment, requires a detailed stability assessment due to its topical application and potential exposure to UV radiation. As a drug applied directly to the skin, calcipotriol is particularly susceptible to photodegradation, which may affect its therapeutic efficacy and safety profile. The present study focuses on the analysis of calcipotriol photostability. An advanced UHPLC/MS^E method was employed for the precise determination of calcipotriol and its degradation products. Particular attention was given to the effects of commonly used organic UV filters—approved for use in cosmetic products in both Europe and the USA (benzophenone-3, dioxybenzone, meradimate, sulisobenzone, homosalate, and avobenzone)—on the stability of calcipotriol. Unexpected degradation of calcipotriol was observed in the presence of sulisobenzone. Importantly, this effect was consistently detected in methanolic solution and in the pharmaceutical formulation containing calcipotriol and betamethasone, which is particularly significant from a practical perspective. This finding underscores the necessity of evaluating photostability under real-life conditions, as cosmetic ingredients, when co-applied with topical drugs on the skin, may substantially influence the stability profile of the pharmaceutical active ingredient. The research resulted in the first-time characterization of four degradation products of calcipotriol. The degradation process was found to primarily affect the E-4-cyclopropyl-4-hydroxy-1-methylbut-2-en-1-yl moiety, causing its isomerization to the Z isomer and the formation of diastereomers with either the R or S configuration. Computational analyses using the OSIRIS Property Explorer indicated that none of the five degradation products exhibit a toxicity effect, whereas molecular docking studies suggested possible binding of two of the five degradation products of calcipotriol with the VDR. Full article

Aloin, a kind of active phenolic component, is sourced from Aloe vera. Recently, the determination of aloin has received enormous attention, owing to its positive performance (including anti-tumor, antibacterial, detoxification, liver protection, anti-stomach damage, and skin protection activities) and painful side effects (increased carcinogenicity caused by excessive use of aloin) impacting human health. This investigation was inspired by the good fluorescence properties of carbon dots (CDs); CD-based sensors have aroused a great deal of interest due to their excellent sensitivity and selectivity. Thus, it is of great significance to develop novel CD-based sensors for aloin determination. Herein, N,F-CDs were designed and synthesized through a convenient hydrothermal strategy; the synthesized N,F-CDs possessed good fluorescence performance and a small particle size (near 4.3 nm), which demonstrated the successful preparation of N,F-CDs. The resulting N,F-CDs possessed a large Stokes shift and could emit a highly stable green fluorescence. The fluorescence of the N,F-CDs could be effectively quenched by aloin through the inner filter effect. Furthermore, the synthesis procedure was easy to operate. Finally, the N,F-CD-coated test strips were fabricated and combined with a miniaturized fluorimeter for the fluorescence detection of aloin via the inner filter effect for the first time. The N,F-CD-coated test strips were fabricated and used for the fluorescence sensing of aloin, and the results were compared with a typical ultraviolet (UV) method. The N,F-CD-coated test strips exhibited high recovery (96.9~106.1%) and sensitivity (31.8 nM, n = 3), good selectivity, low sample consumption (1 μL), high speed (5 min), good stability, and anti-interference properties. The results indicate that N,F-CD-coated test strips are applicable for the quantitative determination of aloin in bovine serum, orange juice, and urine samples. Full article

The widespread discharge of industrial and urban waste has led to significant increases in the environmental concentrations of numerous chemical substances. This work presents the development of a simple and environmentally friendly dispersive liquid–liquid microextraction (DLLME) method based on a hydrophobic natural deep eutectic solvent (NADES) for the determination of selected compounds from benzotriazole, benzothiazole, paraben, and UV filter families in wastewater samples. Of the twelve NADES formulations evaluated, those composed of a 4:1 molar ratio of thymol and menthol presented the highest extraction efficiencies. The influence of key experimental variables such as the pH of the aqueous sample, the ratio of NADES phase to sample volume, and the extraction time on the extraction efficiency was investigated using a multivariate optimization. Under optimal conditions, relative standard deviations below 15% and recoveries for spiked wastewater samples ranged between 82 and 108%, demonstrating the suitability of the method for routine water-quality monitoring. The sustainability and practicality of the developed method was evaluated using the assessment tools ChlorTox, AGREEprep, AGRRE, and BAGI, obtaining scores of 0.005 g in the NADES-DLLME method, 0.70, 0.52, and 72.5, respectively, demonstrating that the method is green and reliable. Full article

In clinical applications of surface-enhanced Raman spectroscopy (SERS) immunosensors, accurately determining analyte biomarker concentrations is essential. This study presents a non-invasive approach for quantifying various breast cancer biomarkers—including human epidermal growth factor receptor II (HER-II) (2+, 3+ (I), 3+ (II), 3+ (III), and positive IV) and CA 15-3—using a directional, plasmonically active, label-free SERS sensor. Each stage of sensor functionalization, conjugation, and biomarker interaction was verified by UV–Vis spectroscopy. Atomic force microscopy (AFM) characterized the morphology of gold nanourchin (GNU)-immobilized printed circuit board (PCB) substrates. An enhancement factor of ≈ 0.5 × 10⁵ was achieved using Rhodamine 6G as the probe molecule. Calibration curves were initially established using standard HER-II solutions at concentrations ranging from 1 to 100 ng/mL and CA 15-3 at concentrations from 10 to 100 U/mL. The SERS signal intensities in the 620–720 nm region were plotted against concentration, yielding linear sensitivity with R² values of 0.942 and 0.800 for HER-II and CA15-3, respectively. The same procedure was applied to breast cancer serum (BCS) samples, allowing unknown biomarker concentrations to be determined based on the corresponding calibration curves. SERS data were processed using the filtfilt filter from scipy.signal for smoothing and then baseline-corrected with the Improved Asymmetric Least Squares (IASLS) algorithm from the pybaselines.Whittaker library. Principal Component Analysis (PCA) effectively distinguished the sample groups and revealed spectral differences before and after biomarker interactions. Key Raman peaks were attributed to functional groups including N–H (primary and secondary amines), C–H antisymmetric stretching, C–N (amines), C=O antisymmetric stretching, NH₃⁺ (amines), carbohydrates, glycine, alanine, amides III, C=N stretches, and NH₂ in primary amides. Full article

The aim of this study was to elucidate all the degradation byproducts (DBPs) of bemotrizinol (BEMT) that are associated with sodium hypochlorite treatment. BEMT is a UV filter that is found not only in many personal care products, such as sunscreen and cosmetics, but also as an additive in plastics or clothing to protect them from damage that results from absorbed radiation. BEMT has been detected in wastewater, surface water, and some lake sediments, in quantities from a few ng/L to hundreds of ng/L, to such an extent that, today, it is considered an emerging pollutant. In this study, the UV filter was subjected to oxidation with sodium hypochlorite, which is an oxidant at the base of the disinfection process that is used in most wastewater treatment plants or in swimming pools. Using different chromatographic methods (CC, TLC, HPLC, and GC), the resulting DBP mixture was separated into its main components, which were then identified using one- and two-dimensional nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry. Nineteen DBPs were isolated, and a plausible reaction mechanism was proposed to explain how they were obtained. Full article

In high-resolution microscopic imaging, using shorter-wavelength ultraviolet (UV) lasers as illumination sources is a common approach. However, the high spatial coherence of such lasers, combined with the surface roughness of the sample, often introduces disturbances in the received optical field, resulting in strong speckle noise. This paper presents a novel speckle noise suppression method specifically designed for coherent laser-based microscopic imaging. The proposed approach integrates statistical physical modeling and image gradient discrepancy into the training of a Cycle Generative Adversarial Network (CycleGAN), capturing the perturbation mechanism of speckle noise in the optical field. By incorporating these physical constraints, the method effectively enhances the model’s ability to suppress speckle noise without requiring annotated clean data. Experimental results under high-resolution laser microscopy settings demonstrate that the introduced constraints successfully guide network training and significantly outperform traditional filtering methods and unsupervised CNNs in both denoising performance and training efficiency. While this work focuses on microscopic imaging, the underlying framework offers potential extensibility to other laser-based imaging modalities with coherent noise characteristics. Full article