Search Results (8)

This essay seeks to stress the importance of the American poet Walt Whitman to Gilles Deleuze, using how love is variously explored to think about their methods in relationality. I firstly consider how many classic responses to Whitman express division regarding his work. This is indicated by how D.H. Lawrence stresses the satisfactions and exhilarations of reading Whitman but also refers to the sense of embarrassment and shame which readers might experience on doing so, not least because of Whitman’s own apparent shamelessness. For Lawrence, this is exemplified by Whitman’s proclamation that he “aches with amorous love”, as if he were a Deleuzian desiring machine existing only to ache and nothing but. Yet there is no such embarrassment detectable in Deleuze’s responses to Whitman’s work, and his responses are characterized by their insistence that Whitman always insists upon a dimension to experience beyond such conventional desires. He is more than a poet of the body with organs, which in turn enables an understanding of his work as an anticipation of Deleuze and Guattari’s body without organs as it was first expounded in Anti-Oedipus. To explore this further, direct and indirect correspondences between Deleuze and Whitman are explored, with particular attention to a range of poems from the 1855 Leaves of Grass. These readings show that if there is a conceptual relationship in their work, their style and syntax are also a way in which they relate thought and action. To triangulate the consideration of the varieties of love that are manifest in Deleuze and Whitman, I use Hannah Stark’s essay on Deleuze and love, showing how different aspects of Deleuze’s writing and thought either consciously or unconsciously relate to the American poet. I reflect upon Deleuze’s claim in his essay on the poet that Whitman’s sustained advocacy of “comradely love” represents a practice of radical relationality, and that this also offers a sense of social and political transformability that is key to both. To provide a final shape to this discussion, I refer to Fredric Jameson’s posthumously published seminars on Deleuze, in which he gives particular attention to the philosopher’s particular interest in American literature. Ultimately, the essay finds that Whitman is given a unique status in Deleuze, one which even threatens to jeopardize his own philosophical system, and that the reason for this may well be love. Full article

The increasing interest in bacteriophage technology has prompted its novel applications to treat different medical conditions, most interestingly cancer. Due to their high specificity, manipulability, nontoxicity, and nanosize nature, phages are promising carriers in targeted therapy and cancer immunotherapy. This approach is particularly timely, as current challenges in cancer research include damage to healthy cells, inefficiency in targeting, obstruction by biological barriers, and drug resistance. Some cancers are being kept at the forefront of phage research, such as colorectal cancer and HCC, while others like lymphoma, cervical cancer, and myeloma have not been retouched in a decade. Common mechanisms are immunogenic antigen display on phage coats and the use of phage as transporters to carry drugs, genes, and other molecules. To date, popular phage treatments being tested are gene therapy and phage-based vaccines using M13 and λ phage, with some vaccines having advanced to human clinical trials. The results from most of these studies have been promising, but limitations in phage-based therapies such as reticuloendothelial system clearance or diffusion inefficiency must be addressed. Before phage-based therapies for cancer can be successfully used in oncology practice, more in-depth research and support from local governments are required. Full article

In its meticulous, freewheeling adaptation of the life and work of celebrated poet Emily Dickinson, the television series Dickinson (Apple TV+, 2019–2021) manifests a twenty-first-century disruption of high and low culture afforded by digital media, including streaming video and music platforms. This article argues that the fanciful series models a mixed-media, multimodal aesthetic form that invites a diverse range of viewers to find pleasure in Dickinson’s poetry itself and in the foibles of its author, regardless of their familiarity with the literary or cultural histories of the US American 19th century. Dickinson showcases creator Alena Smith’s well-researched knowledge of the poet and her work, while simultaneously mocking popular (mis)conceptions about her life and that of other literary figures such as Walt Whitman and Sylvia Plath, all set to a contemporary soundtrack. This analysis of Dickinson proposes to bring into conversation shifting boundaries of high and low culture across generations and engage with critical debates about the utility of the popular (and of studies of the popular) in literary and cultural studies in particular. Full article

Built environment neighborhood characteristics are difficult to measure and assess on a large scale. Consequently, there is a lack of sufficient data that can help us investigate neighborhood characteristics as structural determinants of health on a national level. The objective of this study is to utilize publicly available Google Street View images as a data source for characterizing built environments and to examine the influence of built environments on chronic diseases and health behaviors in the United States. Data were collected by processing 164 million Google Street View images from November 2019 across the United States. Convolutional Neural Networks, a class of multi-layer deep neural networks, were used to extract features of the built environment. Validation analyses found accuracies of 82% or higher across neighborhood characteristics. In regression analyses controlling for census tract sociodemographics, we find that single-lane roads (an indicator of lower urban development) were linked with chronic conditions and worse mental health. Walkability and urbanicity indicators such as crosswalks, sidewalks, and two or more cars were associated with better health, including reduction in depression, obesity, high blood pressure, and high cholesterol. Street signs and streetlights were also found to be associated with decreased chronic conditions. Chain link fence (physical disorder indicator) was generally associated with poorer mental health. Living in neighborhoods with a built environment that supports social interaction and physical activity can lead to positive health outcomes. Computer vision models using manually annotated Google Street View images as a training dataset were able to accurately identify neighborhood built environment characteristics. These methods increases the feasibility, scale, and efficiency of neighborhood studies on health. Full article

What if encounters between modernist poetry and architecture exceed inspiration, imagery, and allusions? These two modes of making have crossed boundaries for over a century, from Walt Whitman’s ecstatic stanzas on Manhattan skyscrapers to architect John Hejduk’s poetry of memory and place. Buildings become materials for poetry, and poems become material for building. When a literary critic and an architect build on overlaps they have discovered in syllabi for American Poetry and Architecture Studio courses, their teaching collaboration becomes a sustainable maker-space for student work—and for the Humanities more generally. We found that linking a literature survey to an architectural design studio brings materiality and resourcefulness to working with poems and that interacting with the Humanities demonstrates praxis (theory + practice) from the perspective of architectural pedagogy. Our classes also engaged each other through The Repurpose Project, a community space that promotes reuse and diverts waste from the local landfill. The profusion of readily available materials at Repurpose afforded students with a rich sampling of architectural textures and languages, opening new possibilities for thinking and making. In an academic climate that groups literary studies and architecture as “not-STEM,” we designed sustainable and resilient pedagogies that go beyond problem solving. Finding the same quality of renewable resourcefulness in Wallace Stevens’s “Thirteen Ways of Looking at a Blackbird,” we offer 13 tactics for teaching poetry as architecture. Full article

What is often overstated by democratic theorists enthralled by the poetic vision of Walt Whitman is the extent to which he excised the self in order to exalt a world where the sensed and the sensing collapse into reversibility. Throughout “Song of Myself,” I argue, Whitman experiments with an arts of attention—which he describes as “witnessing and waiting”—that adapts the self to the surplus vitality immanent to perceptual and sensual experience. I contrast this with democratic theories of “relational surrender” that stress self-sacrifice as the precondition for democratic sovereignty. In particular, I contrast Whitman’s poetics of touch with Elaine Scarry’s theory of beauty, which favors what she calls “opiated adjacency,” a vivid pleasure experienced in self-loss. By contrast, Whitman discloses a vision of democracy that emphasizes “cleaving things asunder,” a sense of intensified awareness that forms in spaces of proximity that are also spaces of separation. Full article

Gold nanoparticles continue to generate interest for use in several biomedical applications. Recently, researchers have been focusing on exploiting their dual diagnostic/therapeutic theranostic capabilities. Before clinical translation can occur, regulatory agencies will require a greater understanding of their biodistribution and safety profiles post administration. Previously, the real-time identification and tracking of gold nanoparticles in free-flowing vasculature had not been possible without extrinsic labels such as fluorophores. Here, we present a label-free imaging approach to examine gold nanoparticle (AuNP) activity within the vasculature by utilizing multiphoton intravital microscopy. This method employs a commercially available multiphoton microscopy system to visualize the intrinsic luminescent signal produced by a multiphoton absorption-induced luminescence effect observed in single gold nanoparticles at frame rates necessary for capturing real-time blood flow. This is the first demonstration of visualizing unlabeled gold nanoparticles in an unperturbed vascular environment with frame rates fast enough to achieve particle tracking. Nanoparticle blood concentration curves were also evaluated by the tracking of gold nanoparticle flow in vasculature and verified against known pre-injection concentrations. Half-lives of these gold nanoparticle injections ranged between 67 and 140 s. This label-free imaging approach could provide important structural and functional information in real time to aid in the development and effective analysis of new metallic nanoparticles for various clinical applications in an unperturbed environment, while providing further insight into their complex uptake and clearance pathways. Full article

Spindly was originally identified as a specific regulator of Dynein activity at the kinetochore. In early prometaphase, Spindly recruits the Dynein/Dynactin complex, promoting the establishment of stable kinetochore-microtubule interactions and progression into anaphase. While details of Spindly function in mitosis have been worked out in cultured human cells and in the C. elegans zygote, the function of Spindly within the context of an organism has not yet been addressed. Here, we present loss- and gain-of-function studies of Spindly using transgenic RNAi in Drosophila. Knock-down of Spindly in the female germ line results in mitotic arrest during embryonic cleavage divisions. We investigated the requirements of Spindly protein domains for its localisation and function, and found that the carboxy-terminal region controls Spindly localisation in a cell-type specific manner. Overexpression of Spindly in the female germ line is embryonic lethal and results in altered egg morphology. To determine whether Spindly plays a role in post-mitotic cells, we altered Spindly protein levels in migrating cells and found that ovarian border cell migration is sensitive to the levels of Spindly protein. Our study uncovers novel functions of Spindly and a differential, functional requirement for its carboxy-terminal region in Drosophila. Full article