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Keywords = adipolin

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17 pages, 375 KB  
Article
Correlation between Overweight, Obesity, Gestational Diabetes Mellitus, Adipokines (Adipolin and Adiponectin), and Adverse Pregnancy Outcomes: A Pilot Study
by Muntean Mihai, Săsăran Vladut, Luca Sonia-Teodora, Suciu Laura Mihaela, Nyulas Victoria, Muntean Irina Elena and Mărginean Claudiu
Medicina 2024, 60(9), 1544; https://doi.org/10.3390/medicina60091544 - 20 Sep 2024
Cited by 6 | Viewed by 2352
Abstract
Background: The prevalence of overweight (OW), obesity (OB), and gestational diabetes mellitus (GDM) has been increasing worldwide in recent years. Adipolin is a new adipokine with reduced circulating levels in obesity and type 2 diabetes mellitus (T2DM). Objectives: Our prospective case-control [...] Read more.
Background: The prevalence of overweight (OW), obesity (OB), and gestational diabetes mellitus (GDM) has been increasing worldwide in recent years. Adipolin is a new adipokine with reduced circulating levels in obesity and type 2 diabetes mellitus (T2DM). Objectives: Our prospective case-control study aimed to evaluate the maternal serum levels of adipolin and adiponectin, metabolic parameters, and anthropometric characteristics at the time of oral glucose tolerance test (OGTT) in pregnant women with a pre-pregnancy body mass index (BMI) ≥ 25 Kg/m2 and correlate them with newborn adipolin, adiponectin levels, and anthropometric characteristics of the newborns, and secondly to evaluate pregnancy outcomes. Material and Methods: After the OGTT results, we had 44 OW/OB pregnant women with GDM, 30 OW/OB pregnant women without GDM, and 92 lean healthy (LH) pregnant women. Data were analyzed by ANOVA and correlation tests, with a p-value < 0.05 considered significant. Results: We found no differences between adipolin values of the OW/OB pregnant women with GDM and the LH group (p > 0.99), OW/OB without GDM and the LH group (p = 0.56), and between OW/OB groups (p = 0.57). OW/OB pregnant women with GDM had a higher rate of gestational hypertension compared with the LH group (p < 0.0001). Newborns from OW/OB pregnant women with GDM were more frequently diagnosed with jaundice (p = 0.02), and they required more frequent admission to the neonatal intensive care unit (NICU) for treatment of respiratory distress (p = 0.01) compared with newborns from LH mothers. Conclusions: Our study revealed that the serum levels of adipolin in the second trimester among the group of OW/OB pregnant women with GDM, matched for age and BMI with OW/OB pregnant women without GDM, were not significantly different. This suggests that adipolin may not play an essential role in the occurrence of GDM in these patients. Despite good glycemic control during pregnancy, OW/OB pregnant women with GDM and their newborns tend to have more complications (gestational hypertension, jaundice, NICU admission) than LH pregnant women and their newborns, highlighting the importance of weight control before pregnancy. Full article
21 pages, 364 KB  
Article
Serum Levels of Adipolin and Adiponectin and Their Correlation with Perinatal Outcomes in Gestational Diabetes Mellitus
by Mihai Muntean, Vladut Săsăran, Sonia-Teodora Luca, Laura Mihaela Suciu, Victoria Nyulas and Claudiu Mărginean
J. Clin. Med. 2024, 13(14), 4082; https://doi.org/10.3390/jcm13144082 - 12 Jul 2024
Cited by 5 | Viewed by 1996
Abstract
Objectives: This study aimed to investigate the serum level of adipolin and adiponectin in healthy pregnant women and pregnant women with gestational diabetes mellitus (GDM) during the second trimester, the prepartum period, and in the newborns of these patients. Methods: A [...] Read more.
Objectives: This study aimed to investigate the serum level of adipolin and adiponectin in healthy pregnant women and pregnant women with gestational diabetes mellitus (GDM) during the second trimester, the prepartum period, and in the newborns of these patients. Methods: A total of 55 women diagnosed with GDM and 110 healthy pregnant women were included in this study. Pearson’s and Spearman’s correlation coefficients were calculated to determine the association of adipolin and adiponectin with anthropometric markers of obesity (body mass index (BMI), mid-upper arm circumference (MUAC), tricipital skinfold thickness (TST)), inflammation markers (neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), C-reactive protein (CRP)), and maternal glucose homeostasis parameters (fasting glucose, insulin, C peptide, glycosylated hemoglobin A1c (HbA1c), Insulin Resistance—Homeostatic Model Assessment (IR HOMA)). Results: There were no statistical differences between the adipolin value in patients with GDM compared to healthy patients (p = 0.65 at diagnosis and p = 0.50 prepartum) and in newborns from mothers with GDM compared to healthy mothers (p = 0.24). Adipolin levels are significantly higher in patients with GDM who gave birth via cesarean section (p = 0.01). In patients with GDM, the adipolin level correlates positively with HgA1c in the prepartum period. We found a positive correlation between the maternal adipolin values at diagnosis and prepartum and neonatal adipolin (respectively: r = 0.556, p = 0.001; r = 0.332, p = 0.013). Adiponectin levels were significantly lower in patients with GDM at diagnosis and prepartum (p = 0.0009 and p = 0.02), but their levels increased prepartum (5267 ± 2114 ng/mL vs. 6312 ± 3150 ng/mL p = 0.0006). Newborns of mothers with GDM had lower adiponectin levels than newborns of healthy mothers (p < 0.0001). The maternal adiponectin value correlates negatively with maternal BMI, MUAC, and IR HOMA in both groups at diagnosis and prepartum. There were no differences between the groups in terms of cesarean rate (p > 0.99). The relative risk of occurrence of adverse events in patients with GDM compared to healthy ones was 2.15 (95% CI 1.416 to 3.182), and the odds ratio for macrosomia was 4.66 (95% CI 1.591 to 12.69). Conclusions: There was no difference in adipolin levels between mothers with GDM and healthy mothers during the second trimester and the prepartum period. Adipolin is known to enhance insulin sensitivity and reduce inflammation, but unlike adiponectin, it does not appear to contribute to the development of GDM. Full article
(This article belongs to the Special Issue Gestational Diabetes: Current Knowledge and Therapeutic Prospects)
9 pages, 280 KB  
Proceeding Paper
Comparative Evaluation of Adipolin Expression in Gingival Crevicular Fluid and Serum of Healthy Subjects and Periodontitis Patients with and without Type 2 Diabetes Mellitus
by Shruti Ligade, Anita Kulloli, Santosh Martande, Sharath K. Shetty, Ankita Mathur, Vini Mehta, Anisha Yadav, Francesca Gorassini and Luca Fiorillo
Eng. Proc. 2023, 56(1), 240; https://doi.org/10.3390/ASEC2023-15478 - 30 Oct 2023
Cited by 3 | Viewed by 1039
Abstract
Background: Adipokine is a huge family of cytokines which are cell-signaling proteins secreted by adipose tissue released by white adipose tissue (WAT), and adipolin (FAM132A/CTRP12 gene) is the newest member added to the adipokine family. This research marks the first attempt to estimate [...] Read more.
Background: Adipokine is a huge family of cytokines which are cell-signaling proteins secreted by adipose tissue released by white adipose tissue (WAT), and adipolin (FAM132A/CTRP12 gene) is the newest member added to the adipokine family. This research marks the first attempt to estimate and compare the gingival crevicular fluid (GCF) and serum levels of adipolin in healthy subjects and periodontitis patients with and without type-2 diabetes mellitus (T2DM). Methods: The study population consisted of 10 patients each with healthy subjects and periodontitis with and without T2DM. GCF and serum samples were collected from each patient before non-surgical periodontal therapy. All the samples underwent an enzyme-linked immunosorbent assay (ELISA) test with an antibody specific to adipolin. Results: The mean GCF and serum adipolin levels were high in Groups I and III compared with Groups II and IV. Comparison of adipolin levels between the groups showed no statistically significant difference either in GCF (p = 0.68) or serum (p = 0.85). The comparison between GCF and serum adipolin levels in Group IV showed a statistically significant difference (p < 0.031). The mean values showed a decrease in adipolin values as the disease rate progressed. A negative correlation was seen in serum and GCF adipolin with HbA1C. Conclusion: As the GCF and serum concentration of adipolin show a gradual positive relation with disease severity, within the limitations of the current study, it can be postulated adipolin could be a possible anti-inflammatory biomarker of periodontal disease. Full article
(This article belongs to the Proceedings of The 4th International Electronic Conference on Applied Sciences)
19 pages, 4692 KB  
Article
Adipolin, Chemerin, Neprilysin and Metabolic Disorders Associated with Obesity
by Marcelina Sperling, Teresa Grzelak, Marta Pelczyńska, Paweł Bogdański, Krystyna Czyżewska and Dorota Formanowicz
Appl. Sci. 2023, 13(14), 8005; https://doi.org/10.3390/app13148005 - 8 Jul 2023
Viewed by 2174
Abstract
Adipolin, neprilysin, and chemerin have pleiotropic properties; therefore, their concentrations may influence health complications associated with obesity. The study aimed to search the relationship between adipokine levels and anthropometric and metabolic parameters as well as blood pressure values, taking into account the influence [...] Read more.
Adipolin, neprilysin, and chemerin have pleiotropic properties; therefore, their concentrations may influence health complications associated with obesity. The study aimed to search the relationship between adipokine levels and anthropometric and metabolic parameters as well as blood pressure values, taking into account the influence of gender and age. The study group consisted of 88 people aged 30–60 years. It was found that chemerin concentration is positively correlated with glycaemia in the 120′ OGTT (rs = 0.412; p = 0.030) in obese women. There was a negative correlation between adipolin and LDL-C serum concentration (rs = −0.414; p = 0.044) in obese individuals with normal glucose tolerance and a positive correlation between chemerin concentration and triglyceridemia (rs = 0.333; p = 0.033) in the men. Moreover, high chemerin levels (above median values) were observed 3.79 times more frequently (OR = 3.79; 95% CI: 1.03–13.91; p = 0.040) in the male population characterized by elevated triglyceride levels (above 1.7 mmol/L). In the logistic regression analyses, we found that the frequency of high plasma adipolin concentrations increases with age (p = 0.005) only in people with a BMI < 30 kg/m2. It was also shown that the concentrations of the studied adipokines are interrelated. Adipolin, neprilysin and chemerin concentrations are associated with selected anthropometric and metabolism exponents. Full article
(This article belongs to the Section Chemical and Molecular Sciences)
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8 pages, 740 KB  
Article
Adipolin and IL-6 Serum Levels in Chronic Obstructive Pulmonary Disease
by Mohammad Reza Aslani, Mojtaba Amani, Faranak Moghadas and Hassan Ghobadi
Adv. Respir. Med. 2022, 90(5), 391-398; https://doi.org/10.3390/arm90050049 - 7 Sep 2022
Cited by 12 | Viewed by 3174
Abstract
Objective(s): One of the adipokines that have insulin-sensitizing properties is adipolin, whose reduced levels have been reported in obesity, oxidative stress, and inflammation. The present study investigated serum interleukin-6 (IL-6) and adipolin levels in chronic obstructive pulmonary disease (COPD) patients. Method: A control [...] Read more.
Objective(s): One of the adipokines that have insulin-sensitizing properties is adipolin, whose reduced levels have been reported in obesity, oxidative stress, and inflammation. The present study investigated serum interleukin-6 (IL-6) and adipolin levels in chronic obstructive pulmonary disease (COPD) patients. Method: A control case study included 60 COPD patients and 30 healthy subjects in the research and measured adipolin and IL-6 serum levels. In addition, serum adipolin levels in COPD patients were assessed according to the GOLD grade. The relationship between serum adipolin levels and study variables were also analyzed. Results: The results showed reduced adipolin levels in COPD patients compared with healthy individuals (p < 0.001). Furthermore, increased levels of IL-6 were evident in the COPD group compared to the control group (p < 0.001). Adipolin serum levels were positively correlated with PFTs and negatively correlated with IL-6 levels. Conclusion: Decreased adipolin levels enhanced disease severity in COPD patients. It seems that the existence of a significant relationship between adipolin and IL-6 may indicate the role of adipolin in the pathophysiology of COPD. Full article
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