Search Results (8,259)

Epoxy resins used in reactors are prone to cracking and failure due to mechanical vibration, thermal stress, and ultraviolet radiation. Improving their resistance to damage is important to extend the service life of reactors. This investigation develops a self-healing imidazole-cured epoxy resin for reactors using epoxy microcapsules and amine microcapsules prepared by electrospraying-interfacial polymerization (ES-IP) microencapsulation technique. Firstly, this investigation studies the feasibility of using double nozzles for simultaneous spraying to improve the preparation of small-sized microcapsules. After successful synthesis, the healing performance of self-healing imidazole-cured epoxy based on the microencapsulated epoxy-amine chemistry was studied, focusing on the influence of the ratio, concentration, and size of the two microcapsules on the healing efficiency, and further exploring the thermal stability of the self-healing performance. The addition of microcapsules to the mechanical properties was also investigated. Results show that the double-nozzle technique can prepare microcapsules with controllable sizes (20~200 μm). The self-healing imidazole-cured epoxy exhibits high self-healing performance, reaching 100% at the optimal ratio with 10.0 wt% 50~100 μm microcapsules. Although the added microcapsules reduce the tensile strength of the material, they improve its high-temperature aging resistance. The above investigation is significant for developing self-healing fiber-reinforced epoxy-based composite materials for reactors. Full article

Pharmacotherapy in the geriatric population is one of the greatest challenges in modern medicine. Elderly patients, characterized by multimorbidity and the resulting polypharmacy, are significantly more exposed to adverse drug reactions (ADRs), which often lead to hospitalization and a decline in quality of life. Understanding the reasons for this difference requires an analysis of the physiological changes that occur during the aging process at the molecular level. This article presents a perspective on the molecular aspects of geriatric pharmacotherapy, focusing on the fundamental mechanisms that are modified with age. The analysis covers changes in pharmacokinetics, including the role and regulation of cytochrome P450 (CYP) enzymes, whose activity, especially in phase I reactions, is significantly reduced. The age-dependent dysfunction of drug transporters from the ABC (ATP-binding cassette) and SLC (solute carrier) families in key organs such as the intestines, liver and kidneys is discussed, which affects the absorption, distribution and elimination of xenobiotic compounds, including drugs. The article also provides a comprehensive analysis of the blood–brain barrier (BBB), describing changes in neurovascular integrity, including the dysfunction of tight junctions and a decrease in the activity of P-glycoprotein, sometimes referred to as multidrug resistance protein (MDR). This increases the susceptibility of the central nervous system to the penetration and action of drugs. In the realm of pharmacodynamics, changes in the density and sensitivity of key receptors (serotonergic, dopaminergic, adrenergic) are described based on neuroimaging data, explaining the molecular basis for increased sensitivity to certain drug classes, such as anticholinergics. The paper also explores new research perspectives, such as the role of the gut microbiome in modulating pharmacokinetics by influencing gene expression and the importance of pharmacoepigenetics, which dynamically regulates drug response throughout life via changes in DNA methylation and histone modifications. The clinical implications of these molecular changes are also discussed, emphasizing the potential of personalized medicine, including pharmacogenomics, in optimizing therapy and minimizing the risk of adverse reactions. Such an integrated approach, incorporating data from multiple fields (genomics, epigenomics, microbiomics) combined with a comprehensive geriatric assessment, appears to be the future of safe and effective pharmacotherapy in the aging population. Full article

With an aging population, the number of joint replacement surgeries is on the rise. One of the most common implant materials is cobalt–chromium–molybdenum (CoCrMo) alloy. Hence, the surface properties of this alloy have attracted increasing attention. In this study, nanosecond and femtosecond laser processing, followed by annealing, was employed to modify the CoCrMo surface. The effects of the treatment conditions on the surface morphology, structure, composition, hardness, roughness, contact angle, wear properties, and corrosion current were studied. Femtosecond laser processing with an energy density of 1273 mJ/cm², followed by heat treatment at 160 °C for 2 h, produced laser-induced periodic surface structures (LIPSS) without altering the chemical composition of the alloy and rendered the surface superhydrophobic. In contrast, nanosecond laser treatment at higher laser energy densities promoted the formation of an oxide layer, which improved the hardness and corrosion resistance of the substrate. Overall, the CoCrMo samples processed using the femtosecond laser system exhibited superior corrosion and wear resistance, with a protection efficiency of approximately 92%. Full article

Background: Vascular malformations are relatively common in children. Current therapeutic strategies include observation, medical therapy, sclerotherapy or embolization, laser therapy, cryoablation, and surgery, depending on the type and anatomical location of the malformation. Surgery is commonly limited to small and/or circumscribed lesions, to debulking in case of large volumes, or in drug-resistant cases. Sclerotherapy is a minimally invasive treatment generally used to treat dysplastic vasculature and to significantly improve patients’ symptoms. Herein, we describe our preliminary experience with bleomycin electrosclerotherapy (BEST) in the treatment of peripheral low-flow venous and lymphatic malformations in the pediatric population. Methods: We prospectively collected and analyzed data from patients who underwent BEST for peripheral low-flow vascular malformations (venous and lymphatic) and were treated at our institution from May 2022 onward. Results: Twelve patients (4 boys and 8 girls) with peripheral low-flow vascular malformations who underwent BEST were enrolled in this preliminary study. The median patient age at the first procedure was 81 months (IQR = 46–128). The most frequent anomaly was peripheral low-flow venous malformation. No relevant postoperative complications were encountered in any of the patients. All patients underwent a clinical evaluation of the malformation 1 month after the procedure. A clinical and ultrasonographic evaluation of the malformation was performed 2 months after the procedure to determine whether to repeat BEST. In cases of clinical resolution, a second ultrasonographic evaluation was performed 6 months after the procedure. Conclusions: BEST appears to be a promising and safe option for treating peripheral low-flow vascular malformations in children. Further studies with a greater number of patients and longer follow-up periods are needed to confirm our preliminary experience. Full article

This study systematically investigates the effects of aging treatment (AT) on the microstructure and properties of Cr/DLC coatings deposited via cathodic arc ion plating onto the surface of ECAP-7075 aluminum alloy. Utilizing a comprehensive approach combining performance tests (nanoindentation, nanoscratch testing, dynamic polarization analysis) with characterization tests (scanning electron microscopy, energy dispersive spectroscopy, X-ray diffraction, and X-ray photoelectron spectroscopy), the synergistic effects of equal channel angular pressing (ECAP) and aging treatment(AT) were elucidated. The results demonstrate that the combined ECAP and AT significantly enhance the coating’s performance. Specifically, AT promotes the precipitation of η’ phase within the 7075 aluminum alloy substrate, increases the size of Cr₇C₃ crystallites in the Cr-based interlayer, improves the crystallinity of the Cr₇C₃ phase on the (060) or (242) crystal planes, and elevates the sp³-C/sp²-C ratio in the diamond-like carbon(DLC) top layer, leading to partial healing of defects and a denser overall coating structure. These microstructural transformations, induced by AT, result in substantial improvements in the mechanical properties (hardness reaching 5.2 GPa, bond strength achieving 15.1 N) and corrosion resistance (corrosion potential increasing to -0.698 V) of the Cr/DLC-coated ECAP-7075 aluminum alloy. This enhanced combination of properties makes these coatings particularly well-suited for high-performance aerospace components requiring both wear resistance and corrosion protection in demanding environments. Full article

Calcium aluminate cement (CAC) offers rapid strength development, chemical durability in harsh environments, and high-temperature resistance, but its long-term performance may be compromised by the conversion of metastable hexagonal hydrates into stable cubic phases. Concurrently, recycling spent fluorescent lamp glass (SFLG) is limited because of its residual mercury content. This study investigates the use of manually (MAN) and mechanically (MEC) processed SFLG as partial CAC replacements (up to 50 wt.%). Both SFLG types had irregular morphologies with mean particle sizes of ~20 µm and mercury concentrations of 3140 ± 61 ppb (MAN) and 2133 ± 119 ppb (MEC). Moreover, the addition of SFLG reduced the initial and final setting times, whilst MEC waste notably extended the plastic state duration from 20 min (reference) to 69 min (50 wt.% MEC). Furthermore, strength development was accelerated, with SFLG/CAC mortars reaching peak strengths at 7–10 days versus 28 days as in the CAC reference. CAC and 15 wt.% SFLG mortars showed strength loss over time by reason of their phase conversion, whereas mortars with 25–50 wt.% SFLG experienced significant long-term strength gains, reaching ~60 MPa (25 wt.%) and ~45 MPa (35 wt.%), respectively, after 365 days, with strength activity indexes (SAI) near 90% and 70%, respectively. These improvements are attributed to the formation of strätlingite (C₂ASH₈), which stabilized hexagonal CAH₁₀ and mitigated conversion to cubic katoite (C₃AH₆). Mercury leaching remained below 0.01 mg/kg dry matter for all mixes and curing ages, classifying the mortars as non-hazardous and inert under Spanish Royal Decree 646/2020. The results suggest that SFLG can be safely reused as a sustainable admixture in CAC systems, enhancing long-term mechanical performance while minimizing environmental impact. Full article

Vector-borne diseases (VBDs) continue to pose a persistent global health challenge, disproportionately impacting low- and middle-income countries where surveillance and healthcare infrastructure are constrained. Within these countries, residents of remote island communities are particularly vulnerable to emerging VBD threats; however, they remain critically understudied. We conducted a community-based cross-sectional survey of 300 residents from Shahpori Island, Bangladesh, and Gaya Island, Malaysia, to assess knowledge, attitudes, and practices (KAP) related to VBDs. Using a structured questionnaire and mixed-effects Poisson regression modeling, we identified socio-demographic predictors of VBD-related knowledge and compared KAP outcomes across the two islands. Significant disparities were observed between the two settings: the Gaya Island residents demonstrated a higher level of awareness regarding VBDs and preventive practices compared to the Shahpori residents. Education was a strong predictor of VBD knowledge, with individuals possessing secondary education or above exhibiting significantly better knowledge (β = 0.2024, p = 0.0003). Marital status was also a significant factor, with unmarried respondents showing lower levels of knowledge (β = –0.1657, p = 0.0372). Age was positively correlated with VBD knowledge (β = 0.0051, p = 0.0119), indicating a gradual increase with age, while income, gender, occupation, and household size were not significantly associated. Despite basic awareness of VBD symptoms and transmission, detailed understanding of mosquito ecology, disease symptoms, and breeding prevention strategies was remarkably poor, especially among the Shahpori residents. Our findings highlight critical gaps in VBD-related knowledge and prevention behaviors shaped by socio-economic and educational disparities. Community-focused public health strategies including educational campaigns, establishment of health infrastructure, access to trained healthcare providers, and integrated vector control interventions are urgently needed to enhance resilience against emerging VBD threats such as drug-resistant malaria in remote island populations. Full article

Jordan’s aging population faces a critical challenge: a strong cultural preference for aging at home, rooted in Islamic ethics of familial care (birr al-wālidayn), conflicts with housing stock that is largely unsafe and inaccessible. This first national mixed-methods study examines the intersection of home modifications, socio-economic barriers, and cultural constraints to aging in place. Data from 587 surveys and 35 interviews across seven governorates were analyzed using chi-square tests, linear regression, and thematic coding. Results indicate that while physical modifications significantly improve accessibility to key spaces like kitchens and reception areas (majlis) (χ² = 341.86, p < 0.001), their adoption is severely limited. Socio-economic barriers are paramount, with 34% of households unable to afford the median modification cost of over $1500. Cultural resistance is equally critical; 22% of widows avoid modifications like grab bars to prevent the ‘medicalization’ of their home, prioritizing aesthetic and symbolic integrity over safety. The study reveals a significant gendered decision-making dynamic, with men controlling 72% of structural modifications (β = 0.27, p < 0.001). We conclude that effective policy must integrate universal design with Islamic care ethics. We propose three actionable recommendations: (1) mandating universal design in building codes (aligned with SDG 11), (2) establishing means-tested subsidy programs (aligned with SDG 10), and (3) launching public awareness campaigns co-led by faith leaders to reframe modifications as preserving dignity (karama) (aligned with SDG 3). This approach provides a model for other rapidly aging Middle Eastern societies facing similar cultural-infrastructural tensions. Full article

The use of Reclaimed Asphalt Pavement (RAP) in asphalt mixtures offers environmental and economic advantages by reducing reliance on virgin aggregates and minimizing construction waste. However, the aged binder in RAP increases mixture stiffness, which can compromise fatigue resistance. This systematic review evaluates the influence of RAP content on fatigue performance compared to conventional mixtures, with a focus on the Indirect Tensile Test (IDT) as the primary assessment method. Following the parameters of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, five studies published between 2014 and 2024 were identified through searches in Web of Science, ScienceDirect, ASCE, and Scopus. Study quality was assessed using the Cochrane Risk of Bias tool. The results indicate that although RAP enhances rutting resistance, higher contents (>30%) often lead to reduced fatigue performance due to binder hardening and reduced mixture flexibility. The incorporation of rejuvenators—such as heavy paraffinic extracts—and modifiers, including high-modulus agents, polymers, and epoxy binders, can partially restore aged binder properties and improve performance. Sustainable innovations, such as lignin-based industrial by-products and warm-mix asphalt technologies, show promise in balancing mechanical performance with reduced environmental impact. Variability in material sources, modification strategies, and test protocols limits direct comparability among studies, underscoring the need for standardized evaluation frameworks. Overall, this review highlights that optimizing RAP content and selecting effective rejuvenation or modification strategies are essential for achieving durable, cost-effective, and environmentally responsible asphalt pavements. Future research should integrate advanced laboratory methods with performance-based design to enable high RAP utilization without compromising fatigue resistance. Full article

Aminoglycoside antibiotics (AGs) are widely used in medicine and animal husbandry, but they pose significant risks due to residual toxicity and antibiotic resistance. In this study, a novel chemical sensor based on the laccase-like activity of CH₃COOAg was developed for the selective detection of AGs. CH₃COOAg exhibited varying degrees of laccase-like activity in different buffers (MES, HEPES, and NaAc) and H₂O, and five AGs showed distinct intensities of the inhibitory effect on the laccase-like activity of CH₃COOA in different buffers and H₂O. Therefore, a four-channel colorimetric sensor array was constructed in combination with the use of principal component analysis (PCA) and Hierarchical Cluster Analysis (HCA) for the efficient identification of five AGs (0.02–0.3 μM) in environment samples like tap and lake water. In addition, a colorimetric method was developed for kanamycin (KAN) detection in a honey sample with a linear range of 10–100 nM (R² = 0.9977). The method has excellent sensitivity with a limit of detection of 3.99 nM for KAN. This work not only provides a rapid and low-cost detection method for AG monitoring but also provides a reference for the design of non-copper laccase mimics. Full article

Background/Objective: Insulin resistance (IR) during pregnancy, even in women with normal body mass index (BMI), may affect maternal and fetal metabolic and immune status. This study aimed to evaluate neopterin (NPT), leptin, insulin, and ghrelin concentrations in maternal blood (MB) and umbilical cord blood (CB) in normoglycemic women with and without IR, all with normal BMI. Methods: Peripheral and cord blood was collected from 36 Caucasian women with term, uncomplicated vaginal deliveries. The participants were classified into control (n = 16; age = 30.81 ± 4.875 years) and IR (n = 20; age = 31.95 ± 4.979 years) groups based on a professional medical diagnosis. Anthropometric parameters were recorded, and metabolic/hormonal markers were measured using ELISA and RIA. Results: NPT concentrations in CB were significantly higher in the IR group (p < 0.05), correlated positively with MB NPT levels (r = 0.3809, p < 0.05). A significantly higher concentration of both insulin and leptin was observed in the MB of women with IR compared to the control group (p < 0.0001), whereas in CB, only insulin concentration was significantly higher in the IR group than in healthy controls (p < 0.05). Ghrelin levels did not differ between the groups. Conclusions: Insulin resistance in non-obese pregnant women is associated with increased NPT concentration in CB, which may suggest fetal immune activation. However, defining the role of NTP as a metabolic “messenger” between mother and child requires further study. Full article

Esophageal squamous cell carcinoma (ESCC) accounts for the majority of esophageal cancers worldwide, with a poor prognosis and increasing resistance to conventional treatments. Faced with these limitations, nanoparticles (NPs) are attracting growing interest as innovative therapeutic agents capable of improving specificity and efficacy and reducing systemic toxicity. This study critically examines the pharmacological effects, mechanisms of action, and toxicity profiles of different metallic or organic nanoparticles tested on ESCC cell lines. Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) 2020 guidelines were followed by a meticulous literature search of Google Scholar, Web of Science, PubMed/Medline, and Scopus databases to achieve this goal. The results show that the anti-tumor properties vary according to the type of nanoparticle (copper(II) oxide (CuO), silver (Ag), gold (Au), nickel(II) oxide (NiO), nano-curcumin, etc.), the synthesis method (chemical vs. green), and the biological activity assessment method (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), Bromodeoxyuridine (BrdU), Cell Counting Kit-8 (CCK8) assays, etc.). NPs derived from green synthesis, such as those based on Moringa oleifera, Photinia glabra, or pomegranate bark, exhibit moderate cytotoxic activity (50% inhibitory concentration (IC₅₀) between 92 and 500 µg/mL) but show good tolerance on normal cells. In contrast, chemically synthesized NPs, such as Cu(II) complexes with 1,3,5-benzenetricarboxylic acid (H₃btc) or 1,2,4-triazole (Htrz), show lower IC₅₀ (34–86 µM), indicating more marked cytotoxicity towards cancer cells, although data on their toxicity are sometimes lacking. In addition, multifunctional nanoparticles, such as gold-based nano-conjugates targeting Cluster of Differentiation 271 (CD271) or systems combined with doxorubicin, show remarkable activity with IC₅₀ below 3 µM and enhanced tumor selectivity, positioning them among the most promising candidates for future clinical application against ESCC. The most frequently observed mechanisms of action include induction of apoptosis (↑caspases, ↑p53, ↓Bcl-2), oxidative stress, and inhibition of proliferation. In conclusion, this work identifies several promising nanoparticles (silver nanoparticles derived from Photinia glabra (PG), gold-based nano-immunoconjugates targeting CD271, and silver–doxorubicin complexes) for future pharmaceutical exploitation against ESCC. However, major limitations remain, such as the lack of methodological standardization, insufficient in vivo and clinical studies, and poor industrial transposability. Future prospects include the development of multifunctional nanocomposites, the integration of biomarkers for personalized targeting, and long-term toxicological assessment. Full article

Background/Objectives: Malaria is a prominent vector-borne disease, with a high mortality rate, particularly in children under five years old. Despite the use of various insecticides for its control, the emergence of resistant mosquitoes poses a significant public health threat. Acetylcholinesterase (AChE) is a crucial enzyme in nerve transmission and a primary target for insecticide development due to its role in preventing repeated nerve impulses. Recent studies have identified difluoromethyl ketone (DFK) as a potent inhibitor of both sensitive and resistant Anopheles gambiae acetylcholinesterase (AgAChE). This study aimed to identify novel AgAChE inhibitors that could be explored for malaria prevention. Methods: We performed a virtual screening on the PubChem database using a pharmacophore model from difluoromethyl ketone-inhibited AgAChE’s crystal structure. The most promising compound was then subjected to molecular docking and dynamics studies with AgAChE to confirm initial findings. ADMET and agrochemical likeness (ag-like) properties were also analyzed to assess its potential as an agrochemical agent. Results: PubChem18463786 was identified as the most suitable compound from the virtual screening. Molecular docking and molecular dynamics studies confirmed its strong interaction with AgAChE. The ADMET and ag-like analyses indicated that PubChem18463786 possesses physicochemical properties suggesting a high probability of non-absorption in humans and meets the criteria for agrochemical similarity. Conclusions: Our findings suggest that PubChem18463786 is a potential AgAChE inhibitor candidate. After validation through in vitro and in vivo experiments, it could be exploited for malaria prevention and serve as a lead compound for the synthesis of new, more effective, and selective agrochemical agents. Full article

This study investigates the influence of time (ageing) on the uplift capacity of bored piles in cohesionless silty sand through a full-scale field testing programme. Four reinforced concrete piles, two shorter (16 m) and two longer (21 m), were installed and tested under axial tension at two different ageing intervals: 35 days and 165 days post-construction. The load-displacement behaviour, load transfer characteristics, and shaft friction mobilisation were monitored using load cells and embedded strain gauges. Results showed that while all piles exhibited similar ultimate capacities, the aged piles consistently demonstrated stiffer responses and earlier mobilisation of shaft resistance. Extrapolated estimates showed modest increases in estimated ultimate uplift capacity, ranging from 2% to 7%, with ageing. Strain gauge data also indicated more uniform load transfer in the aged piles, suggesting time-dependent improvements in pile-soil interface behaviour. The findings confirm that even in cohesionless silty sand, moderate ageing effects can enhance uplift performance, but the extent of improvement is small and variable. These findings provide a valuable reference for evaluating uplift design assumptions and interpreting field test behaviour in similar soil environments. Full article

Background: Metabolic-dysfunction-associated steatotic liver disease (MASLD) is a major global health concern associated with insulin resistance, metabolic syndrome, and cardiovascular morbidity. Early identification of at-risk individuals through simple, non-invasive methods is essential, particularly in working populations. Objectives: This study aimed to assess and compare the diagnostic accuracy of four widely used anthropometric and metabolic indicators—body mass index (BMI), waist-to-height ratio (WtHR), triglyceride–glucose index (TyG), and waist–triglyceride index (WTI)—in identifying individuals at risk of metabolic-dysfunction-associated steatotic liver disease (MASLD), as determined by the Fatty Liver Index (FLI) and the Lipid Accumulation Product (LAP), within a large sample of Spanish workers. Methods: A cross-sectional analysis was performed on data from 386,924 Spanish employees aged between 18 and 69 years. Standardized anthropometric and laboratory measurements were obtained as part of routine occupational medical examinations conducted from 2021 to 2023. The presence of NAFLD was inferred using two validated surrogate markers: FLI and LAP. Receiver operating characteristic (ROC) curves and area under the curve (AUC) values were used to assess the discriminatory ability of each index, stratified by sex. Results: WTI and TyG demonstrated the highest diagnostic accuracy for both FLI- and LAP-defined NAFLD, with AUC values >0.95 in both sexes. WTI showed the best overall performance, followed closely by TyG. WtHR outperformed BMI but was less accurate than the metabolic indices. Sex-stratified analyses confirmed consistent patterns, with slightly higher AUCs for TyG and WTI in women. BMI consistently yielded the lowest discriminatory performance. Conclusions: WTI and TyG are superior to BMI and WtHR for non-invasive screening of MASLD in occupational settings. Their simplicity, low cost, and strong predictive value support their integration into routine workplace health surveillance. Sex-specific thresholds and prospective validation are warranted to enhance clinical application. Full article