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19 pages, 919 KB  
Article
A Sequential Kalman-Newton-KM Framework for AIS and Radar Data Fusion in Restricted Inland Waterways
by Huixia Shi, Dejun Wang, Longting Wei and Shan Liang
Sensors 2026, 26(7), 2255; https://doi.org/10.3390/s26072255 - 6 Apr 2026
Viewed by 55
Abstract
This paper presents a novel data fusion framework that integrates Automatic Identification System (AIS) data with radar surveillance for real-time vessel monitoring in inland restricted waterways. The approach exploits the complementarity between heterogeneous sensors: AIS provides semantic information with temporal sparsity, while radar [...] Read more.
This paper presents a novel data fusion framework that integrates Automatic Identification System (AIS) data with radar surveillance for real-time vessel monitoring in inland restricted waterways. The approach exploits the complementarity between heterogeneous sensors: AIS provides semantic information with temporal sparsity, while radar offers high-frequency observations without vessel identity. The proposed solution combines Kalman filtering and Newton interpolation (K-N) for high-resolution AIS resampling, followed by optimal data association using the Kuhn-Munkres (KM) algorithm. By formulating data association as a global optimization problem, the framework achieves globally optimal sensor fusion while effectively handling data imbalance through virtual point augmentation. Experimental validation using real-world data demonstrates a matching accuracy of 94.2% in low-density scenarios and 80.1% in high-traffic conditions, with computational efficiency suitable for real-time deployment. The system performs consistently across different waterway geometries, although performance varies slightly between curved and straight channels. By fusing the high temporal resolution of radar data with the rich identity information from AIS, this framework enables more accurate and reliable vessel tracking, providing waterway authorities with enhanced situational awareness for improved traffic management and scheduling in restricted waterways. Full article
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22 pages, 7072 KB  
Article
Parameter Inversion of Water Injection-Induced Fractures in Tight Oil Reservoirs Based on Embedded Discrete Fracture Model and Intelligent Optimization Algorithm
by Xiaojun Li, Chunhui Zhang, Bao Wang, Jing Yang, Zhigang Wen and Shaoyang Geng
Processes 2026, 14(7), 1176; https://doi.org/10.3390/pr14071176 - 6 Apr 2026
Viewed by 99
Abstract
In water injection development of tight oil reservoirs (TORs), the complex fracture network formed by hydraulic fracturing and water injection induction is the key factor determining the development effectiveness. Accurate inversion of water injection-induced fracture parameters holds significant importance for enhancing reservoir development [...] Read more.
In water injection development of tight oil reservoirs (TORs), the complex fracture network formed by hydraulic fracturing and water injection induction is the key factor determining the development effectiveness. Accurate inversion of water injection-induced fracture parameters holds significant importance for enhancing reservoir development outcomes. This paper innovatively proposes a parameter inversion framework that integrates the Embedded Discrete Fracture Model (EDFM) with intelligent optimization algorithms. EDFM efficiently characterizes complex unstructured fracture systems while maintaining mass conservation between the matrix and fractures; intelligent optimization algorithms automatically invert parameters such as fracture half-length, orientation, and conductivity. First, a three-dimensional geological model of the TOR is constructed, utilizing EDFM to handle the impact of fractures on the seepage field. Based on considerations of fracture geometry, conductivity, and stress sensitivity, a coupled fluid dynamics model for fractures and matrix is developed. Subsequently, an objective function is built based on water injection production dynamic data, and the Projection-Iterative-Methods-based Optimizer (PIMO) algorithm is employed to achieve efficient inversion of fracture parameters. Taking a TOR in the Ordos Basin as an example for verification, through synthetic model validation, this method significantly improves the accuracy and efficiency of history matching, with inversion results reliably guiding numerical simulation predictions. The results demonstrate that this method can effectively enhance the precision of fracture parameter identification, offering clear advantages in inversion speed and accuracy over traditional trial-and-error approaches. This study provides new insights for modeling induced fractures in TORs and optimizing water injection development strategies. Full article
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34 pages, 7125 KB  
Article
Integrated Design and Performance Validation of an Advanced VOC and Paint Mist Recovery System for Shipbuilding Robotic Spraying
by Kunyuan Lu, Yujie Chen, Lei Li, Yi Zheng, Jidai Wang and Yifei Pan
Processes 2026, 14(7), 1047; https://doi.org/10.3390/pr14071047 - 25 Mar 2026
Viewed by 341
Abstract
Volatile organic compounds (VOCs, dominated by xylene, toluene, and benzene) and paint mist emissions from ship painting represent a major environmental and health concern, posing a critical bottleneck to the green transformation of the shipbuilding industry. To tackle this challenge, this study presents [...] Read more.
Volatile organic compounds (VOCs, dominated by xylene, toluene, and benzene) and paint mist emissions from ship painting represent a major environmental and health concern, posing a critical bottleneck to the green transformation of the shipbuilding industry. To tackle this challenge, this study presents an integrated recovery system designed specifically for ship automatic-spraying robots. Guided by the synergistic principle of “air-curtain containment, multi-stage adsorption, and negative-pressure recovery,” the system features a modular design that ensures full compatibility with the robots’ spraying trajectory without operational interference. Core adsorption materials, namely glass fiber filter cotton and honeycomb activated carbon fiber, were selected to suit the high-humidity and high-pollutant-concentration environment typical of ship painting. An appropriately matched axial flow fan maintains stable negative pressure throughout the system. Furthermore, the design integrates an air curtain isolation subsystem and an automated control subsystem, enabling coordinated operation and real-time adjustment. Using ANSYS Fluent, geometric and flow field simulation models were established to analyze airflow distribution and pollutant adsorption behavior, which led to the optimization of key structural and material parameters. Field experiments conducted in shipyard environments demonstrated the system’s superior performance: it achieved a VOC removal efficiency of 88.4% and a paint mist capture efficiency of 85.7% under optimal working conditions, with a maximum simulated paint mist capture efficiency of 86.2%. The system maintained stable performance under complex vertical and overhead spraying conditions, with an efficiency attenuation of less than 1.5%, and its outlet emissions fully complied with the mandatory limits specified in the Emission Standard of Air Pollutants for the Shipbuilding Industry (GB 30981.2-2025). The relative error between experimental data and simulation results is less than 2%, confirming the reliability and practicality of the proposed system. This research provides an efficient and adaptable pollution control solution for green shipbuilding and offers valuable technical insights for the sustainable upgrading of automated painting processes in heavy industries. Full article
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24 pages, 5780 KB  
Article
A Deep Learning-Guided Ensemble Empirical Mode Decomposition Method for Single-Channel Fetal Electrocardiogram Extraction
by Xiaojian Xu, Yifan Zhang, Yufei Rao, Yinru Xu, Yang Gao and Huating Tu
Sensors 2026, 26(7), 2037; https://doi.org/10.3390/s26072037 - 25 Mar 2026
Viewed by 252
Abstract
The fetal electrocardiogram (FECG) is critical for assessing fetal cardiac electrophysiology and detecting fetal distress and arrhythmias. Single-channel abdominal electrocardiogram (AECG) enables home-based monitoring but faces challenges posed by weak fetal signals, maternal interference, and the lack of spatial information. Ensemble Empirical Mode [...] Read more.
The fetal electrocardiogram (FECG) is critical for assessing fetal cardiac electrophysiology and detecting fetal distress and arrhythmias. Single-channel abdominal electrocardiogram (AECG) enables home-based monitoring but faces challenges posed by weak fetal signals, maternal interference, and the lack of spatial information. Ensemble Empirical Mode Decomposition (EEMD) is suitable for nonstationary AECG signals but relies on accurate selection of intrinsic mode functions (IMFs). In this study, a deep learning-guided method was proposed: a one-dimensional convolutional neural network (1D CNN) scored and selected EEMD-derived IMFs, followed by maternal QRS template subtraction and secondary EEMD purification to achieve automatic FECG extraction. Leave-one-subject-out (LOSO) cross-validation was performed on 15 simulated cases and 5 ADFECGDB records, yielding a mean AUC of 0.9282 ± 0.0189 for the IMF classifier. On the independent DaISy and NIFEA arrhythmia datasets, the proposed CNN-2×EEMD method achieved correlation coefficients of 0.94–0.96, F1-scores of 0.8372–0.9565 for fetal R-peak detection, and SNR improvements of 13.39–15.88 dB. This method outperformed conventional automatic selection methods and matched the performance of manual selection. Ablation studies validated the optimal network design and IMF selection strategy, while complexity analysis (0.08 GFLOPs, 2.24 ms latency) confirmed its suitability for real-time wearable deployment. Full article
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13 pages, 656 KB  
Article
Quantitative and Qualitative MRI Assessment of Perivascular Spaces in Parkinson’s Disease Patients
by Evelina Stagisa, Arturs Silovs, Gvido Karlis Skuburs, Nauris Zdanovskis, Aleksejs Sevcenko, Janis Mednieks, Edgars Naudins, Santa Bartusevica, Solvita Umbrasko, Liga Zarina, Laura Zelge, Agnese Anna Pastare, Jelena Smilga, Jurgis Skilters, Baingio Pinna and Ardis Platkajis
Medicina 2026, 62(4), 613; https://doi.org/10.3390/medicina62040613 - 24 Mar 2026
Viewed by 259
Abstract
Background and Objectives: Enlarged perivascular spaces (ePVS) demonstrated by MRI have recently been associated with cerebral small vessel disease and glymphatic dysfunction, implicated in Parkinson’s disease (PD) pathophysiology. This study aimed to quantify the burden of ePVS in PD patients versus healthy [...] Read more.
Background and Objectives: Enlarged perivascular spaces (ePVS) demonstrated by MRI have recently been associated with cerebral small vessel disease and glymphatic dysfunction, implicated in Parkinson’s disease (PD) pathophysiology. This study aimed to quantify the burden of ePVS in PD patients versus healthy controls and to examine associations with cognitive performance. Materials and Methods: A total of 51 participants underwent 3T MRI, including a T2-weighted sequence. Twenty-one patients with Parkinson’s disease and 21 age-matched healthy controls were included in the final analysis. The ePVS burden was assessed quantitatively by counting visible PVS in the basal ganglia and centrum semiovale, and qualitatively using Potter and Heier rating scales. Cognitive function was measured with the Montreal Cognitive Assessment (MoCA). Statistical analyses used Mann–Whitney U tests and Spearman correlations. Results: PD patients had significantly higher total PVS counts in the basal ganglia (84.8 vs. 48.0; p < 0.001) and centrum semiovale (290.6 vs. 143.9; p < 0.001). Potter scale ratings were higher in PD across regions (p ≤ 0.025). Largest per-slice PVS counts negatively correlated with MoCA scores in right basal ganglia (ρ = −0.362, p = 0.012) and bilateral centrum semiovale (right: ρ = −0.421, p = 0.003; left: ρ = −0.431, p = 0.002). Heier scale differences were significant only in the right centrum semiovale (p = 0.023). PVS diameters were larger in PD only in the centrum semiovale (right: p = 0.010; left: p = 0.040). Conclusions: In this cohort, increased ePVS burden in the basal ganglia and centrum semiovale was associated with cognitive impairment in PD patients. Qualitative and quantitative PVS assessment, notably the largest-per-slice counts, may serve as a sensitive, non-invasive imaging biomarker for neurodegeneration and cognitive decline in PD. Larger group studies and longitudinal data are needed to assess their prognostic value in the long term, as well as the development of automatic quantification applications for better reproducibility. Full article
(This article belongs to the Special Issue Diagnostic Imaging: Recent Advancements and Future Developments)
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26 pages, 1035 KB  
Article
Time-Aware Construction Site Risk Prediction Based on Sentence-BERT and 7-Day Window Aggregation with Unlabeled Data
by Shu Liu, Weidong Yan, Guoqi Liu and Rui Zhang
Buildings 2026, 16(6), 1243; https://doi.org/10.3390/buildings16061243 - 21 Mar 2026
Viewed by 176
Abstract
Construction safety texts are commonly used only for descriptive statistical analysis, and systematic approaches for uncovering latent semantic risk correlations remain limited. In particular, risk identification and prioritization under unlabeled conditions remain challenging. To address this issue, this study proposes a semantic risk [...] Read more.
Construction safety texts are commonly used only for descriptive statistical analysis, and systematic approaches for uncovering latent semantic risk correlations remain limited. In particular, risk identification and prioritization under unlabeled conditions remain challenging. To address this issue, this study proposes a semantic risk association and ranking framework based on Sentence-BERT (SBERT). First, a domain-specific keyword library is constructed, and representative risk terms are extracted through tokenization, stop-word removal, and TF-IDF weighting. A fine-tuned SBERT model is then employed to generate sentence embeddings. FAISS-based similarity search is applied to match safety inspection records with historical accident reports, enabling automatic identification and ranking of the most relevant accident types. In addition, a seven-day inspection window is introduced to capture the temporal accumulation effect of hazards and support risk assessment without explicit labels. Experiments conducted on 1368 accident reports and 484 inspection records show that the proposed framework achieves an accuracy of 0.75, a recall of 1.00, and an F1-score of 0.8571. Cross-project validation yields an F1-score of 0.5607, and the performance remains stable under 10% noise interference. The results demonstrate that the proposed semantic risk association and ranking framework is effective and robust for practical construction safety management. Full article
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20 pages, 5729 KB  
Article
Who Do We Remember? Facial Anomalies, Race, and Sex in Social Categorization
by Soma Chaudhuri, Isabella Bobrow and Anjan Chatterjee
Behav. Sci. 2026, 16(3), 462; https://doi.org/10.3390/bs16030462 - 20 Mar 2026
Viewed by 316
Abstract
Social categorization often occurs automatically, shaping whom we notice, remember, and group together. The present study examined how visual cues indicative of sex, race, and facial anomaly guide spontaneous categorization, testing the hypothesis that anomaly-based categorization is more malleable than categorization by race [...] Read more.
Social categorization often occurs automatically, shaping whom we notice, remember, and group together. The present study examined how visual cues indicative of sex, race, and facial anomaly guide spontaneous categorization, testing the hypothesis that anomaly-based categorization is more malleable than categorization by race or sex. Using a within-subjects Who-Said-What (WSW) paradigm, participants viewed faces that varied by sex, race, and presence of a facial scar, each paired with self-descriptive statements. A surprise recall task required matching statements to faces. Categorization strength was computed from recall errors. Participants showed the strongest categorization by sex, weak categorization by race, and very weak categorization by facial anomaly. Regression analyses revealed that scar-based categorization was negatively associated with sex- and race-based categorization. When sex or race was strongly encoded, scar-based categorization was sharply diminished, and the cue appeared only under relatively weak and infrequent conditions. Thus, although visually salient, facial anomalies did not function as an independent or stable basis for social grouping. These findings demonstrate that the categorization system prioritizes evolutionarily primary cues such as sex, treats race as a comparatively weaker cue, and assigns facial anomalies to a minimal and malleable role. Overall, the results highlight the fragile, low-priority, and easily overshadowed nature of anomaly-based categorization in social memory. Importantly, the fragility of scar-based categorization suggests that negative evaluations of anomalous faces (anomalous-is-bad stereotyping) are not automatically translated into robust memories or categorical organization. Full article
(This article belongs to the Special Issue Emotions and Stereotypes About People with Visible Facial Difference)
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12 pages, 2082 KB  
Article
Design and Experimental Validation of a Dynamic Frequency Sweeping Algorithm for Optimized Impedance Matching in Semiconductor RF Power Systems Under Pulse-Mode Operation
by Zhaolong Fan, Zhifeng Wang, Long Xu, Lili Hou, Long Yao, Siao Zeng and Mingqing Liu
Micromachines 2026, 17(3), 376; https://doi.org/10.3390/mi17030376 - 20 Mar 2026
Viewed by 332
Abstract
The design and implementation of a dynamic frequency sweeping algorithm for a 3 kW RF power source are underpinned by theoretical principles aimed at optimizing impedance matching under pulse-mode operation. The algorithm dynamically adjusts the output frequency within a predefined range to align [...] Read more.
The design and implementation of a dynamic frequency sweeping algorithm for a 3 kW RF power source are underpinned by theoretical principles aimed at optimizing impedance matching under pulse-mode operation. The algorithm dynamically adjusts the output frequency within a predefined range to align the source impedance Zsource with the conjugate of the load impedance Z*load, maximizing the power transfer efficiency and minimizing the reflection coefficient Γ. This is achieved by leveraging the maximum power transfer theorem and adapting to dynamic load variations, such as those induced by the plasma state transitions. The algorithm incorporates adaptive step size adjustments based on the rate of change of Γ, predictive frequency initialization using historical data, and real-time impedance monitoring to ensure efficient convergence within the constrained pulse “ON” time (TON). Integration with pulse mode requires synchronization with the pulse signal, fast convergence, and optimized search strategies. Experimental validation on a 13.56 MHz, 3 kW Automatic Sweep Generator testbed operating at 20 kHz pulse modulation with a 50% duty cycle demonstrates a linear and stable sweep, achieving impedance matching and low reflected power within 5.0172 ms. These findings highlight the algorithm’s potential for high-precision applications, such as RF plasma excitation, and underscore the importance of adaptive techniques in dynamic RF systems. Full article
(This article belongs to the Special Issue Emerging Technologies and Applications for Semiconductor Industry)
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15 pages, 3189 KB  
Article
Label-Free Microfluidic Modulation Spectroscopy Monitors RNA Origami Structure and Stability
by Phoebe S. Tsoi, Lathan Lucas, Allan Chris M. Ferreon, Ewan K. S. McRae and Josephine C. Ferreon
Biosensors 2026, 16(3), 166; https://doi.org/10.3390/bios16030166 - 16 Mar 2026
Viewed by 396
Abstract
RNA origami enables genetically encoded, single-stranded RNA nanostructures that can self-assemble through co-transcriptional folding and are increasingly deployed as scaffolds for biosensing, synthetic biology, and nanomedicine. A recurring practical bottleneck is scalable, solution-phase readout of whether a designed scaffold has reached its intended [...] Read more.
RNA origami enables genetically encoded, single-stranded RNA nanostructures that can self-assemble through co-transcriptional folding and are increasingly deployed as scaffolds for biosensing, synthetic biology, and nanomedicine. A recurring practical bottleneck is scalable, solution-phase readout of whether a designed scaffold has reached its intended base-paired architecture, whether it undergoes slow maturation or kinetic trapping, and how its stability is distributed across motifs. Here, we adapt microfluidic modulation spectroscopy (MMS) as a label-free structural biosensor for RNA folding by exploiting the rich 1760–1600 cm−1 vibrational fingerprints of RNA bases and base pairs. MMS alternates between sample and composition-matched buffer measurements in a microfluidic transmission cell to automatically subtract the solvent background, enabling high-quality spectral measurement from microliter volumes under native solution conditions. Using a six-helix-bundle-with-clasp (6HBC) RNA origami as a model, we established an analysis workflow (baselined second derivative and constrained deconvolution) to quantify paired versus unpaired populations. Thermal ramping resolves multiple unfolding events and yields an unfolding barcode that differs between young and mature ensembles. Importantly, MMS tracks post-transcriptional maturation from a kinetically trapped young conformer toward a more compact, base-paired mature state, consistent with prior cryo-EM/SAXS observations for 6HBC RNA origami. Together, these results position MMS as a rapid, automated, and scalable complement to high-resolution structure determination for engineering dynamic RNA origami biosensors. Full article
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32 pages, 10642 KB  
Article
Dynamic Beam Control-Based Neighbor Discovery Protocol for Underwater Acoustic Networks with Multi-Parallel Transceiver
by Jianjun Zhang, Lin Zhou, Haijun Wang, Zhiyong Zeng and Qing Hu
Sensors 2026, 26(6), 1855; https://doi.org/10.3390/s26061855 - 15 Mar 2026
Viewed by 289
Abstract
Neighbor discovery in underwater acoustic networks (UANs) faces challenges such as high propagation delay and limited spectrum resources. This study proposes a dynamic beam control-based multi-parallel transceiver neighbor discovery protocol (DBCB), which improves node discovery efficiency by dynamically matching transmission beams and optimizing [...] Read more.
Neighbor discovery in underwater acoustic networks (UANs) faces challenges such as high propagation delay and limited spectrum resources. This study proposes a dynamic beam control-based multi-parallel transceiver neighbor discovery protocol (DBCB), which improves node discovery efficiency by dynamically matching transmission beams and optimizing spatiotemporal frequency resource allocation. During node initialization, the master node broadcasts omnidirectionally to quickly capture coarse-grained neighbor parameters. After obtaining these parameters, the master node dynamically allocates orthogonal frequency bands for directional multi-beam validation and optimizes beam alignment, resource allocation, and topology stability through real-time feedback. The protocol adaptively optimizes transmission power and continues the discovery task, while nodes that remain undiscovered for extended periods automatically adjust their receiving gain. The adaptive power control mechanism adjusts the transmission power based on node distance and azimuth, enabling the protocol to maintain low power consumption and enhance interference resilience. Simulation results show that the DBCB protocol outperforms similar neighbor discovery protocols based on directional transmission-reception (DTR) and random two-way (RTW) mechanisms, with improvements of 7.84% and 28.17% in average discovery rate, and reductions of 28.13% and 59.06% in average discovery delay, respectively. The anechoic tank experiment demonstrates that multi-beam parallel transmission effectively improves underwater node discovery efficiency, with simulation results aligning with experimental data, confirming the stability and high efficiency of the system. Full article
(This article belongs to the Section Sensor Networks)
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15 pages, 667 KB  
Article
Speech-to-Sign Gesture Translation for Kazakh: Dataset and Sign Gesture Translation System
by Akdaulet Mnuarbek, Akbayan Bekarystankyzy, Mussa Turdalyuly, Dina Oralbekova and Alibek Dyussemkhanov
Computers 2026, 15(3), 188; https://doi.org/10.3390/computers15030188 - 15 Mar 2026
Viewed by 382
Abstract
This paper presents the first prototype of a speech-to-sign language translation system for Kazakh Sign Language (KRSL). The proposed pipeline integrates the NVIDIA FastConformer model for automatic speech recognition (ASR) in the Kazakh language and addresses the challenges of sign language translation in [...] Read more.
This paper presents the first prototype of a speech-to-sign language translation system for Kazakh Sign Language (KRSL). The proposed pipeline integrates the NVIDIA FastConformer model for automatic speech recognition (ASR) in the Kazakh language and addresses the challenges of sign language translation in a low-resource setting. Unlike American or British Sign Languages, KRSL lacks publicly available datasets and established translation systems. The pipeline follows a multi-stage process: speech input is converted into text via ASR, segmented into phrases, matched with corresponding gestures, and visualized as sign language. System performance is evaluated using word error rate (WER) for ASR and accuracy metrics for speech-to-sign translation. This study also introduces the first KRSL dataset, consisting of 1200 manually recreated signs, including 95% static images and 5% dynamic gesture videos. To improve robustness under resource-constrained conditions, a Weighted Hybrid Similarity Score (WHSS)-based gesture matching method is proposed. Experimental results show that the FastConformer model achieves an average WER of 10.55%, with 7.8% for isolated words and 13.3% for full sentences. At the phrase level, the system achieves 92.1% accuracy for unigrams, 84.6% for bigrams, and 78.3% for trigrams. The complete pipeline reaches 85% accuracy for individual words and 70% for sentences, with an average latency of 310 ms. These results demonstrate the feasibility and effectiveness of the proposed system for supporting people with hearing and speech impairments in Kazakhstan. Full article
(This article belongs to the Special Issue Machine Learning: Innovation, Implementation, and Impact)
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14 pages, 12306 KB  
Article
Quantitative Autofluorescence Imaging of Oral Mucosa and Lesions: A Proof-of-Concept Study
by Keerthi Gurushanth, Sumsum P. Sunny, Shubha Gurudath, Harshita Thakur, Kripa Adlene Edith, Keerthi Krishnakumar, Shikha Jha, Pavitra Chandrashekhar, Satyajit Topajiche, Lynette Linzbuoy, Sanjana Patrick, Ramyashree Rao, Simranjeet Kaur, Umeshgouda Patil, Ananya Nagaraj, Bofan Song, Rongguang Liang, Shubhasini Raghavan, Anupama Shetty, Amritha Suresh, Moni Abraham Kuriakose and Praveen Birur Nagarajadd Show full author list remove Hide full author list
Diagnostics 2026, 16(6), 857; https://doi.org/10.3390/diagnostics16060857 - 13 Mar 2026
Viewed by 412
Abstract
Background/Objectives: This study aimed to quantitatively assess site-specific mean autofluorescence intensity across normal oral mucosal subsites and to evaluate the effectiveness of Autofluorescence Imaging (AFI) as an adjunct tool for distinguishing benign lesions, OPMDs, and oral cancers by comparing lesion intensity with anatomically [...] Read more.
Background/Objectives: This study aimed to quantitatively assess site-specific mean autofluorescence intensity across normal oral mucosal subsites and to evaluate the effectiveness of Autofluorescence Imaging (AFI) as an adjunct tool for distinguishing benign lesions, OPMDs, and oral cancers by comparing lesion intensity with anatomically matched healthy subsites. Methods: This observational study employed dual-mode imaging, comprising paired White Light Imaging (WLI) and AFI, captured from different oral cavity subsites using a smartphone-based point-of-care device. The Region of Interest (ROI) was annotated on WLI and automatically mapped to the corresponding AFI for both normal mucosa and lesions. WLI and AFI images were separated into their constituent red, green, and blue (RGB) channels, and AFI intensity was quantified via ImageJ. Results: A total of 1380 dual-mode images were acquired from 86 healthy participants. AFI intensities were comparable across most oral subsites, except for the lateral and ventral tongue. The lateral border showed the lowest fluorescence (Green channel-GC: 68.12 ± 28.27; Blue channel-BC: 25.29 ± 7.93), whereas the ventral tongue showed the highest (GC: 98.89 ± 42.22; BC: 37.08 ± 11.04; both p < 0.001). Among 611 lesions, predominantly from the buccal mucosa, AFI intensity declined progressively with increasing disease severity. Homogeneous leukoplakia (n = 149; GC: 38.62 ± 25.05; BC: 21.60 ± 9.50), non-homogeneous leukoplakia (n = 25; GC: 30.42 ± 18.66; BC: 18.25 ± 7.17) and oral cancer (n = 21; GC: 23.39 ± 15.53; BC: 15.82 ± 7.15; all p < 0.001) showed markedly reduced fluorescence, while benign lesions (n: 44; GC: 66.99 ± 30.88; BC: 32.01 ± 13.62) exhibited intermediate intensities, supporting AFI’s discriminative potential. Conclusions: This phase-1, proof-of-concept study highlights subsite-specific variations in autofluorescence intensity within healthy oral mucosa, providing an essential baseline for objective interpretation of lesion-associated fluorescence changes. AFI has the potential to be used as a non-invasive adjunct for monitoring OPMDs. Further validation in larger and more diverse cohorts is required before clinical implementation. Full article
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26 pages, 3165 KB  
Article
Analysis of Fundamental Frequency Changes in Astronaut Speech in Microgravity and in Terrestrial Conditions
by Natalia Repyuk, Anton Konev, Vladimir Faerman, Dmitry Rulev and Grigory Yashchenko
Acoustics 2026, 8(1), 18; https://doi.org/10.3390/acoustics8010018 - 13 Mar 2026
Viewed by 323
Abstract
This study investigates the influence of microgravity on the fundamental frequency (F0) of astronauts’ speech. A speech corpus was compiled, including recordings in microgravity and on Earth, matched by speaker and content. The signal processing methodology included filtering with consideration of human auditory [...] Read more.
This study investigates the influence of microgravity on the fundamental frequency (F0) of astronauts’ speech. A speech corpus was compiled, including recordings in microgravity and on Earth, matched by speaker and content. The signal processing methodology included filtering with consideration of human auditory perception, segmentation of speech fragments, F0 estimation using digital signal processing techniques, and visualization through fundamental frequency dynamics plots. Results revealed a consistent increase in F0 for most astronauts under microgravity, with maximum values of 450 Hz for female speakers and 245 Hz for male speakers. Elevated F0 levels were observed for approximately 86% of the total duration of speech fragments recorded in microgravity, compared with 14% on Earth. These findings confirm that microgravity affects the speech apparatus and acoustic characteristics of voice. Practical implications include adapting voice-controlled systems and automatic speech recognition for space environments, monitoring crew condition, and studying speech physiology under extreme conditions. Full article
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45 pages, 2436 KB  
Article
Grounded Knowledge Graph Extraction via LLMs: An Anchor-Constrained Framework with Provenance Tracking
by Yuzhao Yang, Genlang Chen, Binhua He and Yan Zhao
Computers 2026, 15(3), 178; https://doi.org/10.3390/computers15030178 - 9 Mar 2026
Viewed by 648
Abstract
Knowledge graphs represent real-world facts as structured triplets and underpin a wide range of applications, including question answering, recommendation, and retrieval-augmented generation. Automatically extracting such triplets from unstructured text is essential for scalable knowledge base construction. Traditional extraction methods require task-specific training data [...] Read more.
Knowledge graphs represent real-world facts as structured triplets and underpin a wide range of applications, including question answering, recommendation, and retrieval-augmented generation. Automatically extracting such triplets from unstructured text is essential for scalable knowledge base construction. Traditional extraction methods require task-specific training data and struggle to generalize across domains. Large language models (LLMs) offer an alternative through in-context learning, enabling flexible extraction without fine-tuning. However, LLMs frequently hallucinate—generating plausible triplets unsupported by the source text. The root cause is the lack of provenance: existing methods produce triplets without explicit links to their textual origins, making faithfulness unverifiable. This paper presents Anchor-Extraction-Verification-Supplement (AEVS), a framework that grounds every triplet element to the source text. AEVS operates in three stages: (1) anchor discovery identifies entities, relation phrases, and attribute values with precise positions, forming a constrained extraction vocabulary; (2) grounded extraction generates triplets linked to discovered anchors; and (3) restoration-based verification validates triplets through hierarchical matching, with a coverage-aware supplement ensuring comprehensive extraction. Experiments on WebNLG, REBEL, and Wiki-NRE demonstrate consistent improvements over both trained models and LLM-based baselines. Ablation studies confirm that anchor-based constraints are the primary mechanism for hallucination reduction. Dedicated analyses of anchor discovery quality, computational cost (2.83–4.28 LLM calls per sample), and hallucination rates (0.23–20.23% across model–dataset configurations) provide insights into the framework’s practical applicability and limitations. Full article
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11 pages, 5084 KB  
Article
AI-Assisted OCT Imaging for Core Needle Biopsy Guidance: The 1st in Humans Study
by Nicusor Iftimia, Poonam Yadav, Michael Primrose, Gopi Maguluri, Jack Jones, John Grimble and Rahul Anil Sheth
Diagnostics 2026, 16(5), 811; https://doi.org/10.3390/diagnostics16050811 - 9 Mar 2026
Viewed by 449
Abstract
Background: The heterogeneous nature of cancer with varying degrees of fat, necrosis, fibrosis, and varying degrees of tissue repair severely impacts the success of acquiring adequate tissue samples during percutaneous image-guided biopsy. Although ultrasound or CT fluoroscopy are used to identify tumor [...] Read more.
Background: The heterogeneous nature of cancer with varying degrees of fat, necrosis, fibrosis, and varying degrees of tissue repair severely impacts the success of acquiring adequate tissue samples during percutaneous image-guided biopsy. Although ultrasound or CT fluoroscopy are used to identify tumor location and thus to guide biopsy needle insertion, these technologies do not provide the necessary resolution to determine tissue composition and enable the selection of the most appropriate location for biopsy specimen extraction. As a result, biopsy must be repeated, leading to significant cost to the health care system. Methods: In this study, we introduce a combined optical imaging/artificial intelligence (OI/AI) methodology for the real-time assessment of tissue morphology at the tip of the biopsy needle, prior to the collection of a biopsy specimen. Addressing a significant clinical challenge, this approach aims to reduce the proportion of biopsy cores—currently as high as 40%—that yield low diagnostic value due to elevated adipose or low tumor content. Our methodology employs micron-scale optical coherence tomography (OCT) imaging to obtain detailed structural tissue information using a minimally invasive needle probe. The OCT images are automatically analyzed using a convolutional neural network (CNN)-driven AI software developed by our team. A U-net style architecture was used to segment regions of tumor from the OCT scans. U-Net is a specialized convolutional neural network (CNN) architecture designed for fast, precise image segmentation, which involves classifying each pixel in an image to outline objects. This streamlined approach shows promise to provide clinicians with real-time results, supporting more accurate and informed decisions regarding biopsy site selection. To evaluate this technology, we conducted a clinical study using a custom-made OCT imager and recorded OCT images from patients diagnosed with liver cancers. Expert OCT interpreters supplied annotated reference images that were used to train a custom AI algorithm. Results: OCT imaging with ~10 mm axial and 20 mm lateral resolution enabled the collection of high-quality images of the tissue. The AI analysis was performed offline. UNet achieved an AUC of ~0.877 on the validation dataset, indicating promising performance for the relatively small data set used to train the model. The AI model matched human interpretations approximately 90% of the time, highlighting its promise for making biopsy procedures both more accurate and more efficient. Conclusions: A novel OCT instrument and AI software were evaluated for assessing tissue composition at the tip of biopsy needle. The OCT instrument produced micron-scale resolution images of the tissue, enabling AI analysis and accurate real-time discrimination of tissue type. This preliminary study demonstrated the clinical potential of this technology for improving biopsy success. Full article
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