Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Journals

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Article Types

Countries / Regions

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Search Results (2,454)

Search Parameters:
Keywords = behavior classification

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
13 pages, 954 KB  
Article
Evaluation of the Relationship Between Straw Fouling Tendencies and Fuel Indices in CFB
by Rafał Rajczyk and Tomasz Idziak
Appl. Sci. 2025, 15(19), 10558; https://doi.org/10.3390/app151910558 (registering DOI) - 29 Sep 2025
Abstract
Biomass combustion for the production of electricity and heat remains one of the most widespread renewable energy technologies. Biomass is commonly utilized in fluidized bed combustion systems. Over the years, numerous issues related to the preparation and combustion of biomass in fluidized beds [...] Read more.
Biomass combustion for the production of electricity and heat remains one of the most widespread renewable energy technologies. Biomass is commonly utilized in fluidized bed combustion systems. Over the years, numerous issues related to the preparation and combustion of biomass in fluidized beds have been identified, including fouling and slagging, which involve the formation of deposits. These phenomena can be mitigated through various methods, including design modifications to boilers, the application of additives, and the careful selection and classification of fuel. Several fuel indices have been proposed to predict the behavior of fuels in terms of their tendency to cause fouling and slagging. Most of these indices were developed for fossil fuels, and the discrepancies between them suggest that although these indices are widely applied, their applicability to agricultural residues, such as straw, remains uncertain. Researchers working in this field emphasize the need for further research, particularly focusing on the comparison of developed indices with the results of biomass combustion at both laboratory and industrial scales. In this study, ten assortments of straw sourced from Poland were selected, and chemical composition analyses were conducted to determine selected fuel indices. The analyzed straw samples were then combusted in a 100 kWₜₕ laboratory-scale circulating fluidized bed unit. Using a specialized austenitic steel probe, the growth rate of the deposit was measured. The collected deposit masses for each straw type were then compared with the calculated fuel indices. The best correlation between the interpretation of the index values and the deposit mass on the probe was observed for the Rs index. However, due to the low sulfur content of straw, Rs numerical interpretation was not adequate. Overall, the indices indicating both good correlation coefficients and an appropriate numerical interpretation for fouling tendency were B/A, Fu, and Cl. Full article
(This article belongs to the Special Issue Novel Advances of Combustion and Its Emissions)
24 pages, 4667 KB  
Article
Fuzzy Rule-Based Interpretation of Hand Gesture Intentions
by Dian Christy Silpani, Faizah Mappanyompa Rukka and Kaori Yoshida
Mathematics 2025, 13(19), 3118; https://doi.org/10.3390/math13193118 - 29 Sep 2025
Abstract
This study investigates the interpretation of hand gestures in nonverbal communication, with particular attention paid to cases where gesture form does not reliably convey the intended meaning. Hand gestures are a key medium for expressing impressions, complementing or substituting verbal communication. For example, [...] Read more.
This study investigates the interpretation of hand gestures in nonverbal communication, with particular attention paid to cases where gesture form does not reliably convey the intended meaning. Hand gestures are a key medium for expressing impressions, complementing or substituting verbal communication. For example, the “Thumbs Up” gesture is generally associated with approval, yet its interpretation can vary across contexts and individuals. Using participant-generated descriptive words, sentiment analysis with the VADER method, and fuzzy membership modeling, this research examines the variability and ambiguity in gesture–intention mappings. Our results show that Negative gestures, such as “Thumbs Down,” consistently align with Negative sentiment, while Positive and Neutral gestures, including “Thumbs Sideways” and “So-so,” exhibit greater interpretive flexibility, often spanning adjacent sentiment categories. These findings demonstrate that rigid, category-based classification systems risk oversimplifying nonverbal communication, particularly for gestures with higher interpretive uncertainty. The proposed fuzzy logic-based framework offers a more context-sensitive and human-aligned approach to modeling gesture intention, with implications for affective computing, behavioral analysis, and human–computer interaction. Full article
24 pages, 4742 KB  
Article
Transfer Entropy and O-Information to Detect Grokking in Tensor Network Multi-Class Classification Problems
by Domenico Pomarico, Roberto Cilli, Alfonso Monaco, Loredana Bellantuono, Marianna La Rocca, Tommaso Maggipinto, Giuseppe Magnifico, Marlis Ontivero Ortega, Ester Pantaleo, Sabina Tangaro, Sebastiano Stramaglia, Roberto Bellotti and Nicola Amoroso
Technologies 2025, 13(10), 438; https://doi.org/10.3390/technologies13100438 - 29 Sep 2025
Abstract
Quantum-enhanced machine learning, encompassing both quantum algorithms and quantum-inspired classical methods such as tensor networks, offers promising tools for extracting structure from complex, high-dimensional data. In this work, we study the training dynamics of Matrix Product State (MPS) classifiers applied to three-class problems, [...] Read more.
Quantum-enhanced machine learning, encompassing both quantum algorithms and quantum-inspired classical methods such as tensor networks, offers promising tools for extracting structure from complex, high-dimensional data. In this work, we study the training dynamics of Matrix Product State (MPS) classifiers applied to three-class problems, using both fashion MNIST and hyperspectral satellite imagery as representative datasets. We investigate the phenomenon of grokking, where generalization emerges suddenly after memorization, by tracking entanglement entropy, local magnetization, and model performance across training sweeps. Additionally, we employ information-theory tools to gain deeper insights: transfer entropy is used to reveal causal dependencies between label-specific quantum masks, while O-information captures the shift from synergistic to redundant correlations among class outputs. Our results show that grokking in the fashion MNIST task coincides with a sharp entanglement transition and a peak in redundant information, whereas the overfitted hyperspectral model retains synergistic, disordered behavior. These findings highlight the relevance of high-order information dynamics in quantum-inspired learning and emphasize the distinct learning behaviors that emerge in multi-class classification, offering a principled framework to interpret generalization in quantum machine learning architectures. Full article
(This article belongs to the Section Quantum Technologies)
13 pages, 1159 KB  
Article
Spectrum of Various Mosaicism Types According to Female Age: An Analysis of 36,506 Blastocysts Using Preimplantation Genetic Testing for Aneuploidy
by Min Seo Jeon, Min Jee Kim, Nayeon Choi, Jiseon Hong, Rosa Choi, Yebin Jeong, Hyoung-Song Lee, Kyung Ah Lee, Eun Jeong Yu and Inn Soo Kang
Biomedicines 2025, 13(10), 2380; https://doi.org/10.3390/biomedicines13102380 - 28 Sep 2025
Abstract
Background/Objectives: Mosaicism in preimplantation embryos has important implications for embryo selection and reproductive outcomes. This study investigates the age-related frequency of mosaicism, analyzes its subtypes, and evaluates its clinical significance. Methods: A total of 36,506 blastocysts were analyzed using next-generation sequencing-based [...] Read more.
Background/Objectives: Mosaicism in preimplantation embryos has important implications for embryo selection and reproductive outcomes. This study investigates the age-related frequency of mosaicism, analyzes its subtypes, and evaluates its clinical significance. Methods: A total of 36,506 blastocysts were analyzed using next-generation sequencing-based preimplantation genetic testing for aneuploidy between January 2021 and December 2023. The overall frequencies of euploid, aneuploid, mosaic, and no-call embryos were 20%, 56%, 23%, and 1%, respectively. In this study, we propose a new classification. Embryos were classified into two categories: Mosaic-A, referring to embryos identified as mosaic in standard genetic testing reports, and Mosaic-B, which includes both Mosaic-A and aneuploid embryos containing mosaicism. Results: The proportion of Mosaic-A embryos significantly decreased with maternal age (31% in women <35 years, 30% at 35–37 years, 23% at 38–40 years, 16% at 41–42 years, and 10% in women >42 years). By contrast, Mosaic-B embryos, which include Mosaic-A and aneuploid embryos with mosaicism, increased with age (46%, 49%, 53%, 56%, and 62% across the same age groups). Notably, as maternal age advanced, low-level complex mosaicism decreased, whereas high-level complex mosaicism significantly increased (p < 0.001, chi-square test for trend). Other mosaicism subtypes followed similar trends. These findings suggest that the increase in high-level complex mosaicism resulted from a higher incidence of post-zygotic mitotic errors occurring earlier in development and affecting a larger proportion of cells in older women. Conclusions: This study underscores the significance of incorporating a broader classification of mosaicism, including Mosaic-A and B, to enhance understanding of the biological behavior of mosaic embryos according to age and highlights the clinical importance of cryopreserving high-level or complex mosaic embryos for transfer in women of advanced age. Full article
(This article belongs to the Section Molecular Genetics and Genetic Diseases)
Show Figures

Figure 1

20 pages, 7875 KB  
Article
SATSN: A Spatial-Adaptive Two-Stream Network for Automatic Detection of Giraffe Daily Behaviors
by Haiming Gan, Xiongwei Wu, Jianlu Chen, Jingling Wang, Yuxin Fang, Yuqing Xue, Tian Jiang, Huanzhen Chen, Peng Zhang, Guixin Dong and Yueju Xue
Animals 2025, 15(19), 2833; https://doi.org/10.3390/ani15192833 - 28 Sep 2025
Abstract
The daily behavioral patterns of giraffes reflect their health status and well-being. Behaviors such as licking, walking, standing, and eating are not only essential components of giraffes’ routine activities but also serve as potential indicators of their mental and physiological conditions. This is [...] Read more.
The daily behavioral patterns of giraffes reflect their health status and well-being. Behaviors such as licking, walking, standing, and eating are not only essential components of giraffes’ routine activities but also serve as potential indicators of their mental and physiological conditions. This is particularly relevant in captive environments such as zoos, where certain repetitive behaviors may signal underlying well-being concerns. Therefore, developing an efficient and accurate automated behavior detection system is of great importance for scientific management and welfare improvement. This study proposes a multi-behavior automatic detection method for giraffes based on YOLO11-Pose and the spatial-adaptive two-stream network (SATSN). Firstly, YOLO11-Pose is employed to detect giraffes and estimate the keypoints of their mouths. Observation-Centric SORT (OC-SORT) is then used to track individual giraffes across frames, ensuring temporal identity consistency based on the keypoint positions estimated by YOLO11-Pose. In the SATSN, we propose a region-of-interest extraction strategy for licking behavior to extract local motion features and perform daily behavior classification. In this network, the original 3D ResNet backbone in the slow pathway is replaced with a video transformer encoder to enhance global spatiotemporal modeling, while a Temporal Attention (TA) module is embedded in the fast pathway to improve the representation of fast motion features. To validate the effectiveness of the proposed method, a giraffe behavior dataset consisting of 420 video clips (10 s per clip) was constructed, with 336 clips used for training and 84 for validation. Experimental results show that for the detection tasks of licking, walking, standing, and eating behaviors, the proposed method achieves a mean average precision (mAP) of 93.99%. This demonstrates the strong detection performance and generalization capability of the approach, providing robust support for automated multi-behavior detection and well-being assessment of giraffes. It also lays a technical foundation for building intelligent behavioral monitoring systems in zoos. Full article
Show Figures

Figure 1

29 pages, 3308 KB  
Article
A Comparative Study of BERT-Based Models for Teacher Classification in Physical Education
by Laura Martín-Hoz, Samuel Yanes-Luis, Jerónimo Huerta Cejudo, Daniel Gutiérrez-Reina and Evelia Franco Álvarez
Electronics 2025, 14(19), 3849; https://doi.org/10.3390/electronics14193849 - 28 Sep 2025
Abstract
Assessing teaching behavior is essential for improving instructional quality, particularly in Physical Education, where classroom interactions are fast-paced and complex. Traditional evaluation methods such as questionnaires, expert observations, and manual discourse analysis are often limited by subjectivity, high labor costs, and poor scalability. [...] Read more.
Assessing teaching behavior is essential for improving instructional quality, particularly in Physical Education, where classroom interactions are fast-paced and complex. Traditional evaluation methods such as questionnaires, expert observations, and manual discourse analysis are often limited by subjectivity, high labor costs, and poor scalability. These challenges underscore the need for automated, objective tools to support pedagogical assessment. This study explores and compares the use of Transformer-based language models for the automatic classification of teaching behaviors from real classroom transcriptions. A dataset of over 1300 utterances was compiled and annotated according to the teaching styles proposed in the circumplex approach (Autonomy Support, Structure, Control, and Chaos), along with an additional category for messages in which no style could be identified (Unidentified Style). To address class imbalance and enhance linguistic variability, data augmentation techniques were applied. Eight pretrained BERT-based Transformer architectures were evaluated, including several pretraining strategies and architectural structures. BETO achieved the highest performance, with an accuracy of 0.78, a macro-averaged F1-score of 0.72, and a weighted F1-score of 0.77. It showed strength in identifying challenging utterances labeled as Chaos and Autonomy Support. Furthermore, other BERT-based models purely trained with a Spanish text corpus like DistilBERT also present competitive performance, achieving accuracy metrics over 0.73 and and F1-score of 0.68. These results demonstrate the potential of leveraging Transformer-based models for objective and scalable teacher behavior classification. The findings support the feasibility of leveraging pretrained language models to develop scalable, AI-driven systems for classroom behavior classification and pedagogical feedback. Full article
(This article belongs to the Section Artificial Intelligence)
Show Figures

Figure 1

35 pages, 3558 KB  
Article
Realistic Performance Assessment of Machine Learning Algorithms for 6G Network Slicing: A Dual-Methodology Approach with Explainable AI Integration
by Sümeye Nur Karahan, Merve Güllü, Deniz Karhan, Sedat Çimen, Mustafa Serdar Osmanca and Necaattin Barışçı
Electronics 2025, 14(19), 3841; https://doi.org/10.3390/electronics14193841 - 27 Sep 2025
Abstract
As 6G networks become increasingly complex and heterogeneous, effective classification of network slicing is essential for optimizing resources and managing quality of service. While recent advances demonstrate high accuracy under controlled laboratory conditions, a critical gap exists between algorithm performance evaluation under idealized [...] Read more.
As 6G networks become increasingly complex and heterogeneous, effective classification of network slicing is essential for optimizing resources and managing quality of service. While recent advances demonstrate high accuracy under controlled laboratory conditions, a critical gap exists between algorithm performance evaluation under idealized conditions and their actual effectiveness in realistic deployment scenarios. This study presents a comprehensive comparative analysis of two distinct preprocessing methodologies for 6G network slicing classification: Pure Raw Data Analysis (PRDA) and Literature-Validated Realistic Transformations (LVRTs). We evaluate the impact of these strategies on algorithm performance, resilience characteristics, and practical deployment feasibility to bridge the laboratory–reality gap in 6G network optimization. Our experimental methodology involved testing eleven machine learning algorithms—including traditional ML, ensemble methods, and deep learning approaches—on a dataset comprising 10,000 network slicing samples (expanded to 21,033 through realistic transformations) across five network slice types. The LVRT methodology incorporates realistic operational impairments including market-driven class imbalance (9:1 ratio), multi-layer interference patterns, and systematic missing data reflecting authentic 6G deployment challenges. The experimental results revealed significant differences in algorithm behavior between the two preprocessing approaches. Under PRDA conditions, deep learning models achieved perfect accuracy (100% for CNN and FNN), while traditional algorithms ranged from 60.9% to 89.0%. However, LVRT results exposed dramatic performance variations, with accuracies spanning from 58.0% to 81.2%. Most significantly, we discovered that algorithms achieving excellent laboratory performance experience substantial degradation under realistic conditions, with CNNs showing an 18.8% accuracy loss (dropping from 100% to 81.2%), FNNs experiencing an 18.9% loss (declining from 100% to 81.1%), and Naive Bayes models suffering a 34.8% loss (falling from 89% to 58%). Conversely, SVM (RBF) and Logistic Regression demonstrated counter-intuitive resilience, improving by 14.1 and 10.3 percentage points, respectively, under operational stress, demonstrating superior adaptability to realistic network conditions. This study establishes a resilience-based classification framework enabling informed algorithm selection for diverse 6G deployment scenarios. Additionally, we introduce a comprehensive explainable artificial intelligence (XAI) framework using SHAP analysis to provide interpretable insights into algorithm decision-making processes. The XAI analysis reveals that Packet Loss Budget emerges as the dominant feature across all algorithms, while Slice Jitter and Slice Latency constitute secondary importance features. Cross-scenario interpretability consistency analysis demonstrates that CNN, LSTM, and Naive Bayes achieve perfect or near-perfect consistency scores (0.998–1.000), while SVM and Logistic Regression maintain high consistency (0.988–0.997), making them suitable for regulatory compliance scenarios. In contrast, XGBoost shows low consistency (0.106) despite high accuracy, requiring intensive monitoring for deployment. This research contributes essential insights for bridging the critical gap between algorithm development and deployment success in next-generation wireless networks, providing evidence-based guidelines for algorithm selection based on accuracy, resilience, and interpretability requirements. Our findings establish quantitative resilience boundaries: algorithms achieving >99% laboratory accuracy exhibit 58–81% performance under realistic conditions, with CNN and FNN maintaining the highest absolute accuracy (81.2% and 81.1%, respectively) despite experiencing significant degradation from laboratory conditions. Full article
Show Figures

Figure 1

22 pages, 76121 KB  
Article
Nonlinear Wave Structures, Multistability, and Chaotic Behavior of Quantum Dust-Acoustic Shocks in Dusty Plasma with Size Distribution Effects
by Huanbin Xue and Lei Zhang
Mathematics 2025, 13(19), 3101; https://doi.org/10.3390/math13193101 - 27 Sep 2025
Abstract
This paper presents a detailed study of the (3+1)-dimensional Zakharov–Kuznetsov–Burgers equation to investigate shock-wave phenomena in dusty plasmas with quantum effects. The model provides significant physical insight into nonlinear dispersive and dissipative structures arising in charged-dust–ion environments, corresponding [...] Read more.
This paper presents a detailed study of the (3+1)-dimensional Zakharov–Kuznetsov–Burgers equation to investigate shock-wave phenomena in dusty plasmas with quantum effects. The model provides significant physical insight into nonlinear dispersive and dissipative structures arising in charged-dust–ion environments, corresponding to both laboratory and astrophysical plasmas. We then perform a qualitative, numerically assisted dynamical analysis using bifurcation diagrams, multistability checks, return maps, Poincaré sections, and phase portraits. For both the unperturbed and a perturbed system, we identify chaotic, quasi-periodic, and periodic regimes from these numerical diagnostics; accordingly, our dynamical conclusions are qualitative. We also examine frequency-response and time-delay sensitivity, providing a qualitative classification of nonlinear behavior across a broad parameter range. After establishing the global dynamical picture, traveling-wave solutions are obtained using the Paul–Painlevé approach. These solutions represent shock and solitary structures in the plasma system, thereby bridging the analytical and dynamical perspectives. The significance of this study lies in combining a detailed dynamical framework with exact traveling-wave solutions, allowing a deeper understanding of nonlinear shock dynamics in quantum dusty plasmas. These results not only advance theoretical plasma modeling but also hold potential applications in plasma-based devices, wave propagation in optical fibers, and astrophysical plasma environments. Full article
29 pages, 3761 KB  
Article
An Adaptive Transfer Learning Framework for Multimodal Autism Spectrum Disorder Diagnosis
by Wajeeha Malik, Muhammad Abuzar Fahiem, Jawad Khan, Younhyun Jung and Fahad Alturise
Life 2025, 15(10), 1524; https://doi.org/10.3390/life15101524 - 26 Sep 2025
Abstract
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition with diverse behavioral, genetic, and structural characteristics. Due to its heterogeneous nature, early diagnosis of ASD is challenging, and conventional unimodal approaches often fail to capture cross-modal dependencies. To address this, this study introduces [...] Read more.
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition with diverse behavioral, genetic, and structural characteristics. Due to its heterogeneous nature, early diagnosis of ASD is challenging, and conventional unimodal approaches often fail to capture cross-modal dependencies. To address this, this study introduces an adaptive multimodal fusion framework that integrates behavioral, genetic, and structural MRI (sMRI) data, addressing the limitations of unimodal approaches. Each modality undergoes a dedicated preprocessing and feature optimization phase. For behavioral data, an ensemble of classifiers using a stacking technique and attention mechanism is applied for feature extraction, achieving an accuracy of 95.5%. The genetic data is analyzed using Gradient Boosting, which attained a classification accuracy of 86.6%. For the sMRI data, a Hybrid Convolutional Neural Network–Graph Neural Network (Hybrid-CNN-GNN) architecture is proposed, demonstrating a strong performance with an accuracy of 96.32%, surpassing existing methods. To unify these modalities, fused using an adaptive late fusion strategy implemented with a Multilayer Perceptron (MLP), where adaptive weighting adjusts each modality’s contribution based on validation performance. The integrated framework addresses the limitations of unimodal approaches by creating a unified diagnostic model. The transfer learning framework achieves superior diagnostic accuracy (98.7%) compared to unimodal baselines, demonstrating strong generalization across heterogeneous datasets and offering a promising step toward reliable, multimodal ASD diagnosis. Full article
(This article belongs to the Special Issue Advanced Machine Learning for Disease Prediction and Prevention)
Show Figures

Figure 1

15 pages, 3510 KB  
Article
Real-Time Vehicle Emergency Braking Detection with Moving Average Method Based on Accelerometer and Gyroscope Data
by Hadi Pranoto, Abdi Wahab, Yoppy Yoppy, Muhammad Imam Sudrajat, Dwi Mandaris, Ihsan Supono, Adindra Vickar Ega, Tyas Ari Wahyu Wijanarko and Hutomo Wahyu Nugroho
Vehicles 2025, 7(4), 106; https://doi.org/10.3390/vehicles7040106 - 25 Sep 2025
Abstract
Emergency braking detection plays a vital role in enhancing road safety by identifying potentially hazardous driving behaviors. While existing methods rely heavily on artificial intelligence and computationally intensive algorithms, this paper proposes a lightweight, real-time algorithm for distinguishing emergency braking from non-emergency events [...] Read more.
Emergency braking detection plays a vital role in enhancing road safety by identifying potentially hazardous driving behaviors. While existing methods rely heavily on artificial intelligence and computationally intensive algorithms, this paper proposes a lightweight, real-time algorithm for distinguishing emergency braking from non-emergency events using accelerometer and gyroscope signals. The proposed approach applies magnitude calculations and a moving average filters algorithm to preprocess inertial data collected from a six-axis IMU sensor. By analyzing peak values of acceleration and angular velocity, the algorithm successfully separates emergency braking from other events such as regular braking, passing over speed bumps, or traversing damaged roads. The results demonstrate that emergency braking exhibits a unique short-pulse pattern in acceleration and low angular velocity, distinguishing it from other high-oscillation disturbances. Furthermore, varying the window length of the moving average impacts classification accuracy and computational cost. The proposed method avoids the complexity of neural networks while retaining high detection accuracy, making it suitable for embedded and real-time vehicular systems, such as early warning applications for fleet management. Full article
Show Figures

Figure 1

20 pages, 1418 KB  
Review
Artificial Intelligence-Driven Multi-Omics Approaches in Glioblastoma
by Giovanna Morello, Valentina La Cognata, Maria Guarnaccia, Giulia Gentile and Sebastiano Cavallaro
Int. J. Mol. Sci. 2025, 26(19), 9362; https://doi.org/10.3390/ijms26199362 - 25 Sep 2025
Abstract
Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults. It is characterized by a high degree of heterogeneity, meaning that although these tumors may appear morphologically similar, they often exhibit distinct clinical outcomes. By associating specific molecular fingerprints with [...] Read more.
Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults. It is characterized by a high degree of heterogeneity, meaning that although these tumors may appear morphologically similar, they often exhibit distinct clinical outcomes. By associating specific molecular fingerprints with different clinical behaviors, high-throughput omics technologies (e.g., genomics, transcriptomics, and epigenomics) have significantly advanced our understanding of GBM, particularly of its extensive heterogeneity, by proposing a molecular classification for the implementation of precision medicine. However, due to the vast volume and complexity of data, the integrative analysis of omics data demands substantial computational power for processing, analyzing and interpreting GBM-related data. Artificial intelligence (AI), which mainly includes machine learning (ML) and deep learning (DL) computational approaches, now presents a unique opportunity to infer valuable biological insights from omics data and enhance the clinical management of GBM. In this review, we explored the potential of integrating multi-omics, imaging radiomics and clinical data with AI to uncover different aspects of GBM (molecular profiling, prognosis, and treatment) and improve its clinical management. Full article
Show Figures

Figure 1

21 pages, 1577 KB  
Article
Development and Characterization of Sustainable Biocomposites from Wood Fibers, Spent Coffee Grounds, and Ammonium Lignosulfonate
by Viktor Savov, Petar Antov, Alexsandrina Kostadinova-Slaveva, Jansu Yusein, Viktoria Dudeva, Ekaterina Todorova and Stoyko Petrin
Polymers 2025, 17(19), 2589; https://doi.org/10.3390/polym17192589 - 24 Sep 2025
Viewed by 23
Abstract
Coffee processing generates large volumes of spent coffee grounds (SCGs), which contain 30–40% hemicellulose, 8.6–13.3% cellulose, and 25–33% lignin, making them a promising lignin-rich filler for biocomposites. Conventional wood composites rely on urea-formaldehyde (UF), melamine–urea–formaldehyde (MUF), and phenol–formaldehyde resins (PF), which dominate 95% [...] Read more.
Coffee processing generates large volumes of spent coffee grounds (SCGs), which contain 30–40% hemicellulose, 8.6–13.3% cellulose, and 25–33% lignin, making them a promising lignin-rich filler for biocomposites. Conventional wood composites rely on urea-formaldehyde (UF), melamine–urea–formaldehyde (MUF), and phenol–formaldehyde resins (PF), which dominate 95% of the market. Although formaldehyde emissions from these resins can be mitigated through strict hygiene standards and technological measures, concerns remain due to their classification as category 1B carcinogens under EU regulations. In this study, fiber-based biocomposites were fabricated from thermomechanical wood fibers, SCGs, and ammonium lignosulfonate (ALS). SCGs and ALS were mixed in a 1:1 ratio and incorporated at 40–75% of the oven-dry fiber mass. Hot pressing was performed at 150 °C under 1.1–1.8 MPa to produce panels with a nominal density of 750 kg m−3, and we subsequently tested them for their physical properties (density, water absorption (WA), and thickness swelling (TS)), mechanical properties (modulus of elasticity (MOE), modulus of rupture (MOR), and internal bond (IB) strength), and thermal behavior and biodegradation performance. A binder content of 50% yielded MOE ≈ 2707 N mm−2 and MOR ≈ 22.6 N mm−2, comparable to UF-bonded medium-density fiberboards (MDFs) for dry-use applications. Higher binder contents resulted in reduced strength and increased WA values. Thermogravimetric analysis (TGA/DTG) revealed an inorganic residue of 2.9–8.5% and slower burning compared to the UF-bonded panels. These results demonstrate that SCGs and ALS can be co-utilized as a renewable, formaldehyde-free adhesive system for manufacturing wood fiber composites, achieving adequate performance for value-added practical applications while advancing sustainable material development. Full article
(This article belongs to the Special Issue Advances in Cellulose-Based Polymers and Composites, 2nd Edition)
14 pages, 1507 KB  
Article
Diagnostic Efficacy of Olfactory Function Test Using Functional Near-Infrared Spectroscopy with Machine Learning in Healthy Adults: A Prospective Diagnostic-Accuracy (Feasibility/Validation) Study in Healthy Adults with Algorithm Development
by Minhyuk Lim, Seonghyun Kim, Dong Keon Yon and Jaewon Kim
Diagnostics 2025, 15(19), 2433; https://doi.org/10.3390/diagnostics15192433 - 24 Sep 2025
Viewed by 82
Abstract
Background/Objectives: The YSK olfactory function (YOF) test is a culturally adapted psychophysical tool that assesses threshold, discrimination, and identification. This study evaluated whether functional near-infrared spectroscopy (fNIRS) synchronized with routine YOF testing, combined with machine learning, can predict YOF subdomain performance in [...] Read more.
Background/Objectives: The YSK olfactory function (YOF) test is a culturally adapted psychophysical tool that assesses threshold, discrimination, and identification. This study evaluated whether functional near-infrared spectroscopy (fNIRS) synchronized with routine YOF testing, combined with machine learning, can predict YOF subdomain performance in healthy adults, providing an objective neural correlate to complement behavioral testing. Methods: In this prospective diagnostic-accuracy (feasibility/validation) study in healthy adults with algorithm development, 100 healthy adults completed the YOF test while undergoing prefrontal/orbitofrontal fNIRS during odor blocks. Feature sets from ΔHbO/ΔHbR included time-domain descriptors, complexity (Lempel–Ziv), and information-theoretic measures (mutual information); the identification task used a hybrid attention–CNN. Separate models were developed for threshold (binary classification), discrimination (binary classification), and identification (binary classification). Performance was summarized with accuracy, area under the curve (AUC), F1-score, and (where applicable) sensitivity/specificity, using participant-level cross-validation. Results: The threshold classifier achieved accuracy 0.86, AUC 0.86, and F1 0.86, indicating strong discrimination of correct vs. incorrect threshold responses. The discrimination model yielded accuracy 0.75, AUC 0.76, and F1 0.75. The identification model (attention–convolutional neural network [CNN]) achieved accuracy 0.88, sensitivity 0.86, specificity 0.91, and F1 0.88. Feature-attribution (e.g., SHapley Additive exPlanations [SHAP]) provided interpretable links between fNIRS features and task performance for threshold and discrimination. Conclusions: Olfactory-evoked fNIRS signals can accurately predict YOF subdomain performance in healthy adults, supporting the feasibility of non-invasive, portable, near–real-time olfactory monitoring. These findings are preliminary and not generalizable to clinical populations; external validation in diverse cohorts is warranted. The approach clarifies the scientific essence of the method by (i) aligning psychophysical outcomes with objective hemodynamic signatures and (ii) introducing a feature-rich modeling pipeline (ΔHbO/ΔHbR + Lempel–Ziv complexity/mutual information; attention–CNN) that advances prior work. Full article
(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
Show Figures

Figure 1

23 pages, 846 KB  
Article
A Biologically Informed Wavelength Extraction (BIWE) Method for Hyperspectral Classification of Olive Cultivars and Ripening Stages
by Miriam Distefano, Giovanni Avola, Claudio Cantini, Beniamino Gioli, Alice Cavaliere and Ezio Riggi
Remote Sens. 2025, 17(19), 3277; https://doi.org/10.3390/rs17193277 - 24 Sep 2025
Viewed by 140
Abstract
Reliable tools for cultivar discrimination and ripening stage evaluation are critical to optimize harvest timing and support milling process focused on olive oil quality. This research examines the spectral properties of olive drupes throughout different maturation stages, ranging from green to full purple-black [...] Read more.
Reliable tools for cultivar discrimination and ripening stage evaluation are critical to optimize harvest timing and support milling process focused on olive oil quality. This research examines the spectral properties of olive drupes throughout different maturation stages, ranging from green to full purple-black pigmentation, across 29 distinct cultivars. High-resolution spectrometric analysis was conducted within the 380–1080 nm wavelength range. Multiple analytical approaches were employed to optimize wavelength selection from hyperspectral reflectance data to obtain discriminating tools for olive classification. A Biologically Informed Wavelength Extraction method (BIWE) was developed, focusing on cultivar and ripening stages identification, and pivoted on biologically informed single wavelengths and Vegetation Indices (VIs) selection. The methodology integrated multi-scale spectral analysis with biochemically weighted scoring and a multi-criteria evaluation framework, employing a two-iteration refinement process to identify optimal spectral features with high discriminatory power and biological relevance. Analysis revealed spectral variations associated with maturation. A characteristic reflectance peak at approximately 550 nm observed during early ripening stages underwent a notable shift, developing into distinct spectral behavior within the 700–780 nm range in intermediate and advanced ripening stages and reaching a plateau for all the samples between 800 and 950 nm. The BIWE method achieved exceptional efficiency in olive classification, utilizing only 25 single wavelengths compared to 114 required by Principal Component Analysis (PCA) and 131 by Recursive Feature Elimination (RFE), representing 4.6-fold and 5.2-fold reductions, respectively. Despite this reduction, BIWE’s overall accuracy (0.5634) remained competitive compared to RFE (−10%) and PCA (−8%) alternative approaches requiring larger wavelengths dataset acquisition. The integration of biochemically relevant VIs enhanced accuracy across all methodologies, with BIWE demonstrating notable improvement (+19.2%). BIWE demonstrated effective olive identification capacity with a reduction in required wavelengths and VIs dataset, affecting the technological needs (spectrometer offset and real-time classification applications) for a tool oriented to olive cultivars and ripening stage discrimination. Full article
Show Figures

Graphical abstract

12 pages, 1074 KB  
Review
Genetic Markers and Mutations in Primary Spinal Cord Tumors and Their Impact on Clinical Management
by Rouzbeh Motiei-Langroudi
Brain Sci. 2025, 15(10), 1028; https://doi.org/10.3390/brainsci15101028 - 23 Sep 2025
Viewed by 74
Abstract
Primary spinal cord tumors are rare neoplasms representing 2–4% of central nervous system tumors. Despite their low incidence, their impact on neurological function is profound. Historically, tumor classification and management have relied primarily on histopathology. However, advances in molecular diagnostics have highlighted the [...] Read more.
Primary spinal cord tumors are rare neoplasms representing 2–4% of central nervous system tumors. Despite their low incidence, their impact on neurological function is profound. Historically, tumor classification and management have relied primarily on histopathology. However, advances in molecular diagnostics have highlighted the critical role of genetic alterations in tumor behavior, prognosis, and treatment response. This narrative review summarizes current evidence on genetic mutations in primary intramedullary spinal cord tumors, focusing on their prognostic value and implications for clinical management. Emphasis is placed on the integration of genetic features into diagnostic criteria and clinical practice, as distinct molecular profiles define many spinal cord tumor subtypes. Integration of molecular diagnostics into spinal cord tumor management represents a paradigm shift from morphology-based to biology-driven practice. Genetic alterations inform prognosis, refine risk stratification, and increasingly guide therapeutic decision-making, including the use of targeted therapies and adjuvant radiation. Despite progress, challenges remain due to the rarity of these tumors, small sample sizes, and limited access to molecular testing. Ultimately, molecular precision promises to enhance survival and quality of life for patients with these rare but impactful tumors. Full article
(This article belongs to the Special Issue Editorial Board Collection Series: Advances in Neuro-Oncology)
Show Figures

Figure 1

Back to TopTop