Search Results (3,977)

Vineyard cover crops deliver well-documented ecosystem services, yet consistent establishment, especially of perennial grasses and legumes, remains a primary barrier to adoption. This review reframes “companion (nurse) cropping” not as a new crop class but as a acilitative establishment strategy within the broader cover-/service-crop literature. We (i) position our contribution relative to recent syntheses, (ii) synthesize evidence on companion crops practices that reduce cover cropping early failure risk, and (iii) propose a testable research agenda. A focused scoping review of peer-reviewed and extension literature indexed in Web of Science and Google Scholar was conducted using search terms encompassing cover/service crops and nurse/companion/facilitation in viticulture systems. Across climates, fast-establishing cereals (Avena sativa, Hordeum vulgare, Secale cereale, × Triticosecale Wittmack) and short-cycle legumes (Vicia sativa, Pisum sativum, Trifolium incarnatum) can reliably “nurse” slower perennials and legumes by providing early groundcover, weeds control, and microclimate buffering when sown at reduced rates (≈25–50% of monoculture) and terminated on time to limit vine competition. Evidence gaps persist for in-row applications, water-use penalties under drought, and long-term effects on yield and grape composition. Companion cropping is argued to be a design principle in vineyard cover-crop programs rather than a separate category. A decision framework and research agenda are presented to quantify establishment reliability, resource trade-offs, and wine-relevant outcomes, and it is recommended that future decision tools make the companion-phase logic explicit to de-risk adoption and align with regional guidelines. Full article

Lung-protective ventilation and other experimental conditions raise arterial carbon dioxide tension (PaCO₂) and alter pH. Short-term benefits are reported in non-infectious settings, whereas infection and/or prolonged exposure are typically harmful. This scoping review systematically maps immune-mediated effects of hypercapnia on innate immunity and alveolar epithelial repair. Scoping review per Levac et al. and PRISMA Extension for Scoping Reviews (Open Science Framework protocol: 10.17605/OSF.IO/WV85T; post hoc). We searched original preclinical studies (in vivo/in vitro) in PubMed, Web of Science, ScienceDirect, Cochrane Reviews, and SciELO (2008–2023). PaCO₂ (mmHg) was prioritized; %Fraction of inspired Carbon Dioxide (%FiCO₂) was recorded when PaCO₂ was unavailable; pH was classified as buffered/unbuffered. Data were organized by context, PaCO₂, and exposure duration; synthesis used heat maps (0–120 h) and a narrative description for >120 h. Mechanistic axes extracted the following: NF-κB (canonical/non-canonical), Bcl-2/Bcl-xL–Beclin-1/autophagy, AMPK/PKA/CaMKKβ/ERK1/2 and ENaC/Na,K-ATPase trafficking, Wnt/β-catenin in AT2 cells, and miR-183/IDH2/ATP. Thirty-five studies met the inclusion criteria. In non-infectious models, a “protective window” emerged, with moderate PaCO₂ and brief exposure (65–95 mmHg; ≤4–6 h), featuring NF-κB attenuation and preserved epithelial ion transport. In infectious models and/or with prolonged exposure or higher PaCO₂, harmful signals predominated: reduced phagocytosis/autophagy (Bcl-2/Bcl-xL–Beclin-1 axis), AMPK/PKA/ERK1/2-mediated internalization of ENaC/Na,K-ATPase, depressed β-catenin signaling in AT2 cells, impaired alveolar fluid clearance, and increased bacterial burden. Chronic exposures (>120 h) reinforced injury. Hypercapnia is a context-, dose-, time-, and pH-dependent double-edged modulator. The safe window is narrow; standardized, parallel reporting of PaCO₂ and pH—with explicit comparisons of buffered vs. unbuffered hypercapnia—is essential to guide clinical translation. Full article

Introduction/Background: Maternal depression is a significant risk factor for infant emotion regulation (ER), often linked to detrimental mother–infant interactions. Individual effects of maternal depression and maternal sensitivity are known, but their combined influence on infant ER across different emotional contexts remains underexplored. This study investigates concurrent relations among maternal depression, maternal sensitivity, and infant ER in low- and high-arousal contexts in a matched sample of primarily White educated mothers. Methods: We examined 5-month-old infants of clinically depressed and nondepressed mothers. Maternal sensitivity was coded from home observations; infant ER behaviors (e.g., gaze aversion, object-attend, self-soothing) were assessed through observation during modified Still-Face Paradigm (SFP) and fear-eliciting tasks. Results: Clinically depressed mothers exhibited lower maternal sensitivity than nondepressed mothers. Infants of depressed mothers used adaptive ER strategies less—specifically, lower monitoring and gaze aversion in the SFP, and lower gaze aversion and object-attend in the Fear task. Maternal sensitivity moderated the association between maternal depression and infant gaze aversion during the SFP and both gaze avert and object-attend during the Fear task. There was a context-specific regulatory difference for self-soothing; only infants of depressed mothers used self-soothing significantly more during the high-arousal Fear task. Conclusions: These findings underscore the interplay between maternal clinical depression and sensitivity in affecting infant ER. Maternal sensitivity acts as a crucial buffer against the adverse effects of maternal depression on infant ER. The results also indicate that infant emotion regulation varies in different contexts of low and high arousal. Interventions that target maternal sensitivity could significantly improve emotion regulation in infants of depressed mothers. Full article

MXenes, a rapidly emerging family of two-dimensional transition metal carbides and nitrides, have attracted considerable attention in recent years for their potential in next-generation energy storage technologies. In solid-state batteries (SSBs), they combine metallic-level conductivity (>10³ S cm⁻¹), adjustable surface terminations, and mechanical resilience, which makes them suitable for diverse functions within the cell architecture. Current studies have shown that MXene-based anodes can deliver reversible lithium storage with Coulombic efficiencies approaching ~98% over 500 cycles, while their use as conductive additives in cathodes significantly improves electron transport and rate capability. As interfacial layers or structural scaffolds, MXenes effectively buffer volume fluctuations and suppress lithium dendrite growth, contributing to extended cycle life. In solid polymer and composite electrolytes, MXene fillers have been reported to increase Li⁺ conductivity to the 10⁻³–10⁻² S cm⁻¹ range and enhance Li⁺ transference numbers (up to ~0.76), thereby improving both ionic transport and mechanical stability. Beyond established Ti-based systems, double transition metal MXenes (e.g., Mo₂TiC₂, Mo₂Ti₂C₃) and hybrid heterostructures offer expanded opportunities for tailoring interfacial chemistry and optimizing energy density. Despite these advances, large-scale deployment remains constrained by high synthesis costs (often exceeding USD 200–400 kg⁻¹ for Ti₃C₂T_x at lab scale), restacking effects, and stability concerns, highlighting the need for greener etching processes, robust quality control, and integration with existing gigafactory production lines. Addressing these challenges will be crucial for enabling MXene-based SSBs to transition from laboratory prototypes to commercially viable, safe, and high-performance energy storage systems. Beyond summarizing performance, this review elucidates the mechanistic roles of MXenes in SSBs—linking lithiophilicity, field homogenization, and interphase formation to dendrite suppression at Li|SSE interfaces, and termination-assisted salt dissociation, segmental-motion facilitation, and MWS polarization to enhanced electrolyte conductivity—thereby providing a clear design rationale for practical implementation. Full article

Dry eye disease (DED) is a multifactorial condition characterized by insufficient tear film stability and ocular discomfort. Conventional artificial tears offer limited efficacy due to short precorneal residence time. This study aimed to develop and optimize ion-sensitive in situ gelling formulations based on low-acyl gellan gum (GG) and arabinogalactan (AG) to enhance retention and therapeutic efficacy in DED. Various buffer systems were screened to identify optimal gelation conditions upon interaction with artificial tear fluid (ATF). Formulations were characterized by pH, osmolality, wettability, thermal behavior, viscosity, and viscoelastic properties. A Design of Experiments (DoE) approach was employed to understand the influence of GG and AG concentrations on rheological behavior. The selected formulation, GG(0.1%)/AG(0.2%), demonstrated a significant viscosity increase upon ATF dilution, suitable viscoelastic properties, enhanced mucoadhesion compared to hyaluronic acid, improved ferning patterns, no cytotoxic effects, and stability over time. In vivo studies in rabbits confirmed prolonged precorneal retention of the fluorescently labeled formulation. These results suggest that the GG/AG-based hydrogel is a promising strategy for improving the performance of artificial tears in DED treatment. Full article

In the production of recombinant antibody/Fc-fusion proteins using mammalian cells, many aggregates often form alongside the target proteins, particularly with bispecific antibodies. To ensure the safety of biological products, it is essential to control the amount of aggregates within a specific range. A traditional downstream process typically involves using Protein A (ProA) resin to capture the target antibody, followed by two polishing steps to ensure purity; for instance, using an anion exchange chromatography (AEX) in flow-through mode and a cation exchange chromatography (CEX) in binding–elution mode. In this study, we choose a Dual Action Fab (DAF), which can bind two antigens and is prone to aggregation when expression in CHO (Chinese Hamster Ovary) cells. We introduce hydrophobic interaction membrane chromatography (HIMC) operating in flow-through mode, which enhances production efficiency while reducing costs and the risks associated with column packing. We evaluated the impact of the operating buffer system, as well as the pH and conductivity of the loading samples, on aggregate removal using HIMC. Additionally, we investigated the mechanism of aggregate binding and found that loading conditions had a limited impact on this process. Overall, our findings indicate that employing HIMC can achieve a 20% reduction in aggregate levels. These results demonstrate that HIMC in flow-through mode is an effective and robust approach for reducing aggregates during antibody purification. Full article

Background: Necrotizing enterocolitis (NEC) is a life-threatening condition characterized by necrosis of the gastrointestinal tract caused by hypoperfusion and hypoxia-induced inflammation. Surgical treatment often requires resection, with high morbidity and mortality. Intestinal tissue engineering using absorbable biomaterials represents a potential alternative. Small intestinal submucosa (SIS) is a biodegradable extracellular matrix (ECM) scaffold that may facilitate regeneration of the native tissue. Objectives: The aim of our study is to investigate the regenerative potential of SIS in a rat model with multiple gastrointestinal defects. Methods: In rats, after a midline laparotomy, an approximately 1 cm full-thickness incision was performed on the anterior gastric wall, on the antimesenteric side of the small and large intestine, each covered with an SIS patch. After three weeks, the graft sites and adjacent fragments were harvested and fixed in 10% neutral buffered formalin. Cross-sections of the grafted area were processed and stained with hematoxylin and eosin for histologic analysis. Results: Among the fifteen Wistar rats used in the study, the survival rate was 80% (12/15). Macroscopic examination of the abdominal cavity after the second surgery showed no complications. Adhesions were present in 92% (11/12). Histological examination demonstrated complete mucosal coverage in all stomach samples, nine of the small intestine, and ten of the large intestine. Mild fibrosis with minimal inflammatory infiltrates predominated. Ulceration with granulation tissue replacement was observed in three small intestine samples. Foreign body reactions were restricted to suture sites. Conclusions: In this multifocal injury model, SIS integrated effectively and supported early regenerative healing across gastric, small-intestinal, and colonic sites at 3 weeks. These data support further studies with longer follow-up, quantitative histology and functional assessment, and evaluation in neonatal-relevant large animal models to determine translational potential for NEC surgery. Full article

A substantial body of literature has examined the factors predicting happiness among various groups; however, few studies have systematically focused on happiness and related factors among Muslim Americans. Within the framework of the stress-process paradigm, this current study addresses fundamental arguments regarding job insecurity as a key predictor of happiness and the role of religious involvement as a buffering factor against the deleterious effects of job insecurity as a structural stressor. Thus, our work contributes to the literature by examining the potential relationships between religious covariates and job insecurity with happiness. Using data from the 2007 Pew Survey of Muslim Americans, we test the study hypotheses accordingly. Findings from the binary logistic regression models demonstrate that (a) job insecurity is a negative predictor of happiness for both males and females; (b) religious involvement is positively associated with happiness for both males and females; and remarkably (c) religious involvement buffers the adverse effects of job insecurity on happiness for females, not males. We discuss the study findings and address implications, limitations, and future research avenues. Full article

Rapid urbanization has resulted in widespread habitat loss and fragmentation, threatening global biodiversity. Urban parks serve as essential refuges for wildlife within cities, particularly for birds, which are sensitive indicators of ecosystem health and habitat quality. In recent years, numerous Chinese cities have begun integrating biodiversity-friendly design approaches into new park development. However, the effectiveness of these strategies remains insufficiently evaluated. This study assesses the ecological performance of newly built parks by examining 11 recently constructed parks (within the past decade) and 9 historical parks in Zhengzhou, China’s high-density urban area. Monthly bird surveys were conducted across all 20 parks from May to December 2020, covering breeding, post-breeding, and overwintering seasons. Our findings reveal that new parks significantly outperformed old parks in bird abundance, species richness, Shannon diversity index, and functional diversity. Analysis of environmental variables at both local (within-park) and landscape (1-km buffer) scales showed that habitat diversity and multi-layered vegetation structure were the most influential local factors promoting bird diversity, while green space connectivity was the primary landscape-scale contributor. Notably, neither park area nor age significantly predicted diversity patterns. Based on these results, we propose three key planning strategies: (1) enhancing habitat diversity within parks to support species from various ecological niches; (2) implementing multi-layered vegetation planting to provide diverse food resources and nesting opportunities; (3) improving green space connectivity to facilitate species movement and population persistence within urban environments. These findings provide valuable insights for designing more effective biodiversity-friendly urban green spaces. Full article

Background and Objectives: Dental anxiety can hinder both treatment delivery and dental education. Few studies have examined this issue among Romanian dental students. This study assessed the prevalence, intensity, and main procedural triggers of dental anxiety, with a focus on experiences related to local anesthesia. Methods: A cross-sectional survey was conducted (January–May 2024) among 122 fourth-year students using the validated Romanian version of the Modified Dental Anxiety Scale (MDAS) and additional items on demographics, prior anesthesia and perceived complications. Data analysis included descriptive statistics, chi-square tests, and t-tests. Results: Overall, 21.3% of respondents scored in the low anxiety range, 75.4% in the moderate range, and 3.3% in the severe range (MDAS ≥ 19). No significant gender differences were identified (p > 0.05). Injections with local anesthetic were rated as the most distressing procedure, followed by drilling, whereas scaling was reported as least stressful. The majority (86.9%) had undergone previous local anesthesia, with very few adverse events recalled. Conclusions: Romanian dental students reported moderate dental anxiety overall, with local anesthesia injections as the main trigger. The lack of gender differences points to a potential buffering effect of clinical exposure. Incorporating structured anxiety management into dental curricula may enhance both student well-being and patient care. Full article

Understanding the regulatory effects of lakes on land surface temperature is critical for assessing regional climatological and ecological dynamics on the Tibetan Plateau (TP). This study investigates the spatiotemporal variability in the thermal effect of lakes across the TP from 2000 to 2022 using the MODIS land surface temperature product and a model-based lake surface water temperature product. Our results show that the lake–land temperature difference (LLTD) within 10 km buffer zones surrounding lakes ranges from −2.8 °C to 3.4 °C. A declining trend in 79.2% of the lakes is detected during 2000–2022, with summer contributing most significantly to this decrease at a rate of −0.56 °C per decade. Assessments of the spatial extent of lake thermal effects show that the “warm island” effect in autumn (5.5 km) influences a larger area compared to the “cold island” effect in summer (1.3 km). Furthermore, southwestern lakes exhibit stronger warming intensities, while northwestern lakes show more pronounced cooling intensities. Correlation analyses indicate that lake thermal effects are significantly related to lake depth, freeze-up start date, and salinity. These findings highlight the importance of lake thermal regulation in heat balance changes and provide a foundation for further research into its climatic and ecological implications on the Tibetan Plateau. Full article

Background/Objectives: This study developed a targeted drug delivery nanoplatform for treating HER2-positive breast cancer. The nanoplatform encapsulated two hydrophobic anticancer agents, neratinib (NTB) and docetaxel (DTX), within nanoparticles (DTX+NTB−NP) functionalized for conjugation to trastuzumab to form trastuzumab-tagged nanoparticles (TRZ−NP). Trastuzumab is a HER2-specific monoclo-nal antibody that binds to HER2 receptors, blocking signal transduction and inducing an-tibody-dependent cellular cytotoxicity (ADCC). Upon receptor-mediated endocytosis, neratinib inhibits cytosolic HER2 signaling, while docetaxel disrupts mitotic cell division, collectively leading to tumor cell death. Methods: Nanoparticles were fabricated by the nanoprecipitation technique, followed by surface modification with a crosslinker and a targeting moiety. DTX+NTB−NP, TRZ−NP, and singly loaded nanoparticles (NTB−NP and DTX−NP) were characterized and their effects evaluated in HER2-positive cancer cell line and xenograft model. Results: In vitro antiproliferation assay in SKBR-3 cell line re-veals a dose and time-dependent cytotoxicity. There was no significant difference in cyto-toxicity observed between DTX+NTB−NP and its free form (DTX+NTB) [p = 0.9172], and between TRZ−NP and its free form (TRZ+DTX+NTB) [p = 0.6750]. However, TRZ−NP, at half the concentration of the singly loaded nanoparticles, significantly reduced the viabil-ity of SKBR-3 cells compared to pure trastuzumab (TRZ) [p < 0.001], NTB−NP [p = 0.0019], and DTX−NP [p = 0.0002]. In vivo evaluation in female athymic nude mice showed sig-nificant log relative tumor volume (%) reduction in groups treated with TRZ−NP and DTX+NTB−NP compared to PBS (phosphate-buffered saline) controls (p ≤ 0.001 and p ≤ 0.001), respectively. Notably, TRZ−NP demonstrated a statistically significant regression in the log relative tumor volume (%) compared to DTX+NTB−NP (p = 0.001). Conclusions: These findings underscore the therapeutic potential and suitability of these nanoplatforms for the precise and controlled targeting of HER2-positive tumors. This study is the first to synchronize the delivery of multiple agents-docetaxel, neratinib, and trastuzumab-within a nanoparticle system for treating HER2-positive tumors, offering a promising strategy to enhance treatment outcomes for HER2 positive breast cancer patients. Full article

This study aims to create environmentally comfortable building designs in hot and dry steppe climates using more effective approaches. The purpose of this study is to assess the relationship between mean radiant temperature (MRT) and indoor air temperature (Tia), taking into account the orientation of buildings, for better building thermal performance. For this purpose, residential buildings with different orientations were selected in the study region ‘Garmian—northern Iraq’, and their thermal performance was evaluated. The results show how MRT contributes to the buildings’ thermal comfort. The outcomes of this research provide innovative empirical quantification of the correlation of MRT-Tia, as the regression coefficient (β) represents the rate of change in Tia per unit increase in MRT and ranges by orientation in the study area. The findings demonstrate that north-facing buildings buffer radiant heat gain (β~0.52), resulting in a 0.5 °C increase in indoor air temperature for each 1 °C rise in MRT. Moreover, west orientation delivers promising winter passive heating (MRT up to 22 °C and indoor air temperature up to 22.8 °C with a β of ~0.82). However, south-facing buildings perform poorly in the winter, with low MRT and a weak β (~0.44), contrasting with passive solar design strategies that favor south-facing buildings in the northern hemisphere. Furthermore, in the summer, the MRT is always higher than Tia, while it is lower in winter, indicating poor envelope and fenestration thermal insulation properties, which lead to excessive energy usage to maintain thermal comfort. Finally, the study suggests the novel quantified MRT-Tia mathematical correlation responds to the orientations for such climates, offering both diagnostic and predictive tools for thermal comfort performance optimization. This study is the first to empirically quantify orientation-specific MRT–Tia relationships in BSh climates, offering a novel diagnostic tool for sustainable building design. This study involved field observations in 36 residential row houses across four orientations. Key environmental and personal variables measured included mean radiant temperature (MRT), indoor air temperature (Tia), air velocity, relative humidity, metabolic rate, and clothing insulation. Full article

Amid rapid industrialization and the growing integration of financial technologies, emerging economies face increasing pressure from rising ecological footprints (ECOF). This study examines the environmental impacts of natural resource rents (NRES) and digital financial technology (DFIN), emphasizing the moderating role of governance (INST), using data from the top 10 emerging economies between 1995 and 2023. The Method of Moments Quantile Regression (MMQR) approach is employed to capture heterogeneous effects across different levels of environmental stress. The results reveal that both NRES and DFIN exacerbate ECOF, particularly in economies facing higher ecological pressures. However, strong governance significantly reduces these adverse effects, especially at higher ECOF quantiles, highlighting its pivotal role in aligning resource management and digital innovation with environmental sustainability goals. Interaction terms further confirm that effective institutional quality can buffer the ecological risks associated with resource exploitation and FinTech expansion. Additionally, Dumitrescu–Hurlin panel causality tests reveal a unidirectional causality from NRES and economic growth (EGRO) to ECOF, while bidirectional relationships are observed between DFIN, INST, education, urbanization, renewable energy, and ECOF. These findings underscore the complex interlinkages between economic growth, technological advancement, and institutional frameworks. In the context of post-COP28 climate commitments and Sustainable Development Goals, this study provides timely policy recommendations to promote sustainable growth through robust governance, responsible resource utilization, and balanced FinTech integration. Full article

Understanding the societal impacts of armed conflict remains challenging due to limitations in current models, which often apply fixed-radius buffers or composite indices that obscure critical dynamics. These approaches struggle to account for indirect effects, cumulative damage, and context-specific vulnerabilities, especially the question of why similar events produce vastly different outcomes across regions. We introduce a novel computational framework that applies principles from engineering and material science to conflict analysis. Communities are modeled as elastic plates, “social fabrics”, whose physical properties (thickness, elasticity, coupling) are derived from spatial socioeconomic indicators. Conflict events are treated as external forces that deform this fabric, enabling the simulation of how repeated shocks propagate and accumulate. Using a custom Python-based finite element analysis implementation, we demonstrate how heterogeneous data sources can be integrated into a unified, interpretable model. Validation tests confirm theoretical behaviors, while a proof-of-concept application to Nigeria (2018) reveals emergent patterns of spillover, nonlinear accumulation, and context-sensitive impacts. This framework offers a rigorous method to distinguish structural vulnerability from external shocks and provides a tool for understanding how conflict interacts with local conditions, bridging physical modeling and social science to better capture the multifaceted nature of conflict impacts. Full article