Search Results (579)

Background/Objectives: Cardiorespiratory fitness (CRF) represents a strong and consistent predictor of mortality among adults. It is ideally expressed as the maximum or peak rate of oxygen consumption per kilogram of body mass (VO_2max) determined by the cardiopulmonary exercise test (CPX). Variance in CRF is mainly attributable to genetics and physical training; nevertheless, strong behavioral and socioeconomic confounders need to be considered. Among those, psychosocial stress may play an important role. Some papers show an association between low CRF and chronic stress conditions; nevertheless, CRF is generally estimated by indirect assessment and not directly measured by CPX. Methods: CRF was directly assessed by performing a CPX in 145 consecutive subjects (56 male, 89 female) (age 19–65 years) who attended our Exercise Medicine unit for health check-ups. Weekly total volume of physical activity (PA) was evaluated using a validated questionnaire (IPAQ); perceptions of stress, fatigue, and somatic symptoms were assessed using a self-administered questionnaire. Results: VO_2max was negatively correlated with perception of stress (p = 0.03), fatigue (p < 0.001), and somatic symptoms (p < 0.001); as expected, it was positively correlated with the weekly volume of PA (p < 0.001). This link was further evidenced by the observation that subjects who did not meet the PA goals as indicated by WHO guidelines presented a higher perception of stress, fatigue, and symptoms, as compared to physically active subjects. Conclusions: This direct link might, on the one hand, corroborate the role of exercise as a tool to manage stress and, on the other hand, focus on the role of stress as a possible determinant of CRF. Full article

(1) Background: The global increase in life expectancy has generated growing interest in strategies that support functional independence and quality of life among older adults. Functional fitness—including strength, mobility, flexibility, and aerobic endurance—is essential for preserving autonomy during aging. In this context, physical exercise, particularly High-Intensity Interval Training (HIIT), has gained attention for its time efficiency and physiological benefits. This randomized controlled trial aimed to evaluate the effects of a group-based HIIT program on functional fitness in older adults; (2) Methods: Functional outcomes were assessed before, during, and after a 65-week intervention using standardized field tests, including measures of upper and lower body strength, flexibility, aerobic endurance, and agility. This study was prospectively registered at ClinicalTrials.gov (NCT07170579); (3) Results: Significant improvements were observed in the HIIT group across multiple domains of functional fitness compared to the control group, notably in upper body strength, lower limb flexibility, cardiorespiratory endurance, and mobility; (4) Conclusions: These results suggest that HIIT is an effective and adaptable strategy for improving functional fitness in older adults, with the potential to enhance performance in daily activities and support healthy aging in community settings. Full article

Background: Rowing is a highly demanding endurance sport, requiring simultaneous work of approximately 70% of the body’s muscle mass and the combined contribution of aerobic and anaerobic energy systems. Objective: This study aimed to analyze the cardiorespiratory responses and performance characteristics of elite junior male and female rowers during maximal effort over 2000 m on a rowing ergometer. Methods: Fifteen junior rowers (six males aged 15–17 and nine females aged 15–18) participated in the study. Anthropometric data (body height, weight, and body surface area) were recorded. All participants performed a maximal 2000 m test on a Concept2 D-model ergometer. Throughout the test, oxygen uptake (VO₂), carbon dioxide production (VCO₂), heart rate, and ventilation parameters were continuously measured. Performance and physiological data were analyzed in three intensity zones, defined by ventilatory thresholds (VT1–VT3), as well as at peak exercise. Results: Significant anthropometric differences were observed between genders. In terms of performance, males completed the 2000 m test significantly faster than females (208.83 ± 87.66 s vs. 333.78 ± 97.51 s, p = 0.0253). Relative VO₂ at peak exercise was higher in males (58.73 ± 5.25 mL·kg⁻¹·min⁻¹) than females (48.32 ± 6.09 mL·kg⁻¹·min⁻¹, p = 0.0046). In most cardiorespiratory parameters, males outperformed females significantly, except for heart rate and ventilatory equivalents. Ranking analysis revealed that higher VO₂max values were generally associated with a better placement in both genders, though this relationship was not perfectly linear. Performance time was negatively correlated with VO₂Peak (r = −0.8286; p < 0.001), rVO₂Peak (r = −0.6781; p < 0.01), and O₂P_Peak (r = −0.7729; p < 0.01). Conclusions: The findings confirm significant gender differences in anthropometric and cardiorespiratory characteristics of elite junior rowers and reinforce VO₂max as a key determinant of performance. Yet, deviations from a direct VO₂max–rank correlation highlight the influence of tactical, psychological, and biomechanical factors. Future research should provide practical recommendations for monitoring performance and tailoring training to optimize adaptation and long-term athlete development. Full article

Background: Basketball is characterized as a high-intensity, intermittent sport that places considerable demands on the cardiorespiratory, neuromuscular, and mechanical systems. These physiological requirements are modulated by contextual variables and the athlete’s stage of biological maturation, both of which significantly influence physical fitness outcomes. Consequently, it is imperative to employ age- and development-specific assessment protocols. Objectives: This study aimed to evaluate the differences in physical fitness across competitive categories and to explore the interrelationships among the various physical assessment tests. Twenty-four male players (U14 = 12; U16 = 12) participated in this research. Methods: Athletes were monitored using WIMUPRO inertial measurement units and completed the SBAFIT test battery to evaluate physical fitness parameters. Statistical analyses included both inferential and correlational approaches, with effect sizes calculated for all relevant variables. The independent variable was the competitive age category of the players. Results: The results indicated notable differences in physical performance between developmental groups, primarily attributed to biological maturation. Significant disparities were observed in measures of aerobic capacity, linear speed, agility, and centripetal force. Conclusions: The comparative nature of this study across developmental categories offers novel insights and practical implications for talent development and training optimization. Full article

Background: Calcium is essential for maintaining bone health, facilitating muscle contractions, regulating body temperature, and supporting aerobic metabolism. While the relationship between physical activity and calcium metabolism is well established, the impact of calcium intake on cardiorespiratory fitness (CRF) remains underexplored. The main aim of this study was to assess the effects of calcium intake on CRF and the mediation effect of calcium intake on the relationship between vigorous physical activity participation and CRF. Methods: Analyses were performed on a sample of 576 adult participants (257 males and 319 females) from the Quebec Family Study (QFS) for whom data were available for calcium intake, CRF, and body composition. The effects of calcium intake on CRF and body composition were analyzed by comparing subjects classified into sex-specific tertiles of calcium intake using general linear mixed models. Pearson correlations were also used to document the associations between calcium intake, CRF, and body composition. A mediation analysis was used to determine the effect of calcium intake as a mediator of the association between vigorous physical activity and CRF. Results: The comparison of calcium-based tertiles revealed that low calcium consumers had lower CRF, especially in males. In both males and females, correlation analysis showed that calcium intake was positively associated (p < 0.05) with CRF. Mediation analyses revealed that calcium intake explains an insignificant fraction of the physical activity–CRF relationship. Between-tertile comparisons showed reduced body fat and increased fat-free mass levels when increasing calcium intake, although some of these effects were not statistically significant. Conclusions: The results of this study suggest that low calcium intake is associated with reduced aerobic capacity in adult males and females. While the positive relationship observed between calcium and aerobic fitness aligns with calcium’s known physiological roles, further research is needed to clarify the exact mechanisms by which this micronutrient may influence aerobic capacity. Full article

The vein of Galen malformations (VoGMs) is mainly correlated with the retention of an embryonic pattern of vascularity, inducer of vein of Galen dilation, and formation of arteriovenous communications that give rise to the risk of systemic shunting, causing cardiac dysfunction, vascular steal, and venous hypertension. This is a rare cerebral vascular malformation in the newborn, accounting for 1% of all cerebral arteriovenous malformations and occurring in approximately 1 in 25,000–50,000 live births. We review nine cases of newborns diagnosed with vein of Galen malformations (VoGMs) to assess whether this pathology demonstrates a marked improvement over the past 13 years in diagnostic accuracy, treatment approaches, and patient survival rates within our clinic. Medical treatment was focused on providing inotropic support and tightly controlled peripheral and pulmonary vasodilation with the aim of overriding the effects of high output heart failure. Most of the patients underwent liver failure and flow-mediated pulmonary hypertension, while half of the newborns expressed anomalies of the nervous system due to impaired cerebral hemodynamics. Given the unavailability of endovascular treatment in our unit, which predisposes the newborns to a higher vital risk, we recognize the importance of delivering tailored intensive care aimed at maintaining cardiorespiratory and hemodynamic stability until a curative intervention can be performed in a specialized center. Full article

Background: Taekwondo (TKD) and Tai Chi (TC) are promising interventions for enhancing health and physical function in older people, yet few studies have compared their effects across multiple domains. This study aimed to compare the effects of TKD versus TC on health status in independent older women. Methods: A randomized controlled trial was conducted with two parallel groups: TKD (n = 11) and TC (n = 10). Both groups trained three times per week for 8 weeks. Pre- and post-intervention assessments included anthropometry, submaximal CPX, 2-min step test, Timed Up-and-Go (TUG), isometric mid-thigh pull (IMTP), maximal isometric handgrip strength (MIHS), 30 s chair stand, 30 s arm curl, sit-and-reach, and back scratch. Results: Compared with TC, the TKD group showed significantly greater improvements in several cardiorespiratory outcomes, including VO₂ at VT1 and VT2, power output, VO₂/HR, OUES, and VE/VCO₂ slope (p < 0.05 to p < 0.001; d = 0.69–1.29). TKD participants also exhibited superior gains in maximal and relative IMTP, MIHS, relative MIHS, 30 s arm curl repetitions, and TUG performance (p < 0.05 to p < 0.001; d = 0.61–1.26). Both groups improved similarly in the 30 s chair stand test (p < 0.05). Flexibility outcomes diverged, with TKD improving sit-and-reach and TC showing greater gains in the back scratch test (p < 0.05). Conclusions: TKD was more effective than TC in improving cardiorespiratory fitness, muscle strength, and balance in older women and may represent a valuable health-oriented training strategy for this population. Full article

Background: This study aims to investigate and monitor cardiorespiratory fitness levels, measured by the 6-minute walk test (6MWT) and quality of life (QoL), assessed using the Short form-36 (SF-36), in patients with hypertension, both with and without coronavirus disease 2019 (COVID-19), at a 3-month follow-up. Methods: Sixty participants were recruited, comprising two groups: hypertensive patients with COVID-19 and hypertensive patients without COVID-19, with 30 individuals in each group. Cardiorespiratory response parameters were assessed before and after performing the 6MWT. QoL was evaluated using the SF-36 at baseline and again at 3 months. Results: Hypertensive patients who recovered from COVID-19 showed significant improvements, including reduced post-exercise HR, SBP, SpO₂, RPE, and leg fatigue, as well as increased 6MWT distance and enhanced QoL compared to baseline (p < 0.05). These parameters improved and returned to levels similar to those of hypertensive patients without COVID-19 by the 3-month follow-up. Conclusions: Hypertensive patients who have recovered from COVID-19 can achieve cardiorespiratory fitness and QoL levels comparable to those of hypertensive individuals who did not contract COVID-19 by the 3-month follow-up. Full article

High induction doses of propofol (PPF) may cause adverse effects. Co-induction protocols can reduce doses and enhance the beneficial profile of each drug. This study compared the induction quality, clinical, and echocardiographic effects of two rapid co-inductions in healthy, unpremedicated dogs. Baseline cardiorespiratory and echocardiographic variables were recorded. Dogs randomly received rapid intravenous PPF (2.2 mg/kg) with either dexmedetomidine (3 µg/kg) (PROPODEX; n = 12) or butorphanol (0.4 mg/kg) (PROPOBUT; n = 12). Induction quality, additional PPF dose, intubation time, cardiorespiratory parameters (2, 5, 10, 15, 20 min), and recovery quality were recorded. A second echocardiography was performed 5 min after induction. Induction quality was significantly higher in PROPODEX, with significantly lower additional PPF requirements and shorter intubation time. In PROPODEX, heart rate significantly decreased from baseline and was significantly lower than PROPOBUT, while arterial blood pressures significantly increased in PROPODEX and decreased in PROPOBUT from baseline. PROPOBUT significantly reduced left ventricular (LV) diastolic volumes and increased E/A ratio, while PROPODEX significantly increased LV systolic diameter and volumes, and significantly decreased fractional shortening. Recovery was significantly faster and better in PROPODEX. PROPOBUT preserved cardiac function but caused hypotension. PROPODEX provided superior induction and recovery quality, and cardiorespiratory stability, with only mild systolic function depression. Full article

Background: There is no information on how the dose of exercise training prior to myocardial infarction (MI) affects cardioprotection. Objective: This study aimed to evaluate the cardioprotective role of different volumes of exercise training prior to MI. Methods: Wistar female rats were allocated to one of the following groups: SHAM (not trained and undergoing simulated MI surgery), NT+MI (untrained and undergoing MI surgery), T60+MI (trained 60 min per session and undergoing MI surgery), T90+MI (trained 90 min per session and undergoing MI surgery), and T180+MI (trained 180 min per session and undergoing MI surgery). The training protocol was performed in a swimming pool for eight weeks. On the seventh day after MI, the animals underwent left ventricular (LV) structural and functional evaluation and were euthanized for molecular analyses. Results: Exercise training groups had greater VO₂peak and LV mass than did the SHAM group. The MI size did not differ statistically among the experimental groups. Compared with the SHAM group, all the MI groups presented a lower LV shortening fraction. LV systolic pressure was significantly lower in the T60+MI group than in the SHAM and T180+MI groups. The +dP/dt of the LV was significantly lower in the NT+MI, T60+MI, and T90+MI groups than in the SHAM group. We did not find significant changes in the inflammatory mediators and oxidative stress markers as well as proteins involved in calcium handling. Conclusions: Exercise training prior to MI enhanced cardiorespiratory fitness and induced LV hypertrophy, however, regardless of volume, was unable to counteract the detrimental effects of MI. Full article

Objectives: Adolescence is a pivotal stage of development characterized by significant physical, psychological, and social changes. Establishing healthy lifestyle habits during this period is crucial for long-term health and the prevention of chronic diseases. Despite this, global trends show a marked decline in physical activity among adolescents, particularly girls, who are more susceptible to sedentary behaviors. One potential site for intervention to eliminate physical inactivity at the population level is the school educational setting during childhood. Traditional school-based physical exercise programs often adopt a one-size-fits-all approach, which may not address the diverse needs and interests of students, leading to reduced motivation and participation. Personalized physical exercise programs, tailored to individual capabilities and preferences, offer a promising alternative to enhance physical fitness and foster lifelong engagement in physical activity. Methods: A total of 170 Hungarian high school girls (mean age ≈ 15.3 years) were randomly assigned to either a personalized physical exercise group or a control group following the standard curriculum. The intervention spanned two academic years and consisted of five traditional gym classes per week (control group) or three traditional and two individually tailored classes with cardiorespiratory and resistance training per week (intervention group), each lasting 45–60 min. Individual goals were set based on baseline assessments, emphasizing self-referenced progress. Results: The personalized physical exercise group showed significant improvements in body mass index (BMI), body fat percentage, maximum oxygen uptake capacity (VO₂max), muscular strength, and flexibility (p < 0.05), while the control group exhibited minimal or negative changes. Conclusions: The personalized physical exercise program has been shown to be more effective in achieving higher cardiorespiratory performance and favorable body composition among adolescent girls than a traditional school physical education class, highlighting its potential role in school settings. Full article

Background/Objectives: Vitamin D deficiency is a global epidemic. In certain populations, such as the United Arab Emirates (UAE), low nutritional intake of vitamin D, inadequate exposure to sunlight, and cultural dress codes can lead to deficiencies in blood vitamin D levels, predisposing them to musculoskeletal disorders, diabetes, and cardiovascular diseases. There are also notable associations between vitamin D deficiency, physical inactivity, and lower cognitive performance. The aim of this study was to determine how vitamin D status may affect physical inactivity and cognitive performance in a young UAE population. Methods: Primary data were obtained on vitamin D status, cardiorespiratory fitness, body composition, and blood profiles of students in the UAE. Following initial assessment, a cohort of vitamin D-deficient/insufficient individuals participated in a 10-week physical activity intervention (Group A), whilst another cohort was supplemented with 5000 IU vitamin D3 daily and an exercise intervention (Group B). Both groups underwent physiological and biochemical profiling, and the effects of vitamin D supplementation on cognitive function were assessed. Statistical analysis included paired samples t-tests between pre- and post-intervention values and the Wilcoxon signed rank test for within-group comparisons and the Mann–Whitney U test for between-group comparisons. Results: The findings suggest that physical exercise alone improves overall cardiorespiratory fitness, as shown by an increased VO₂ max (p < 0.05), while vitamin D supplementation combined with physical exercise did not significantly improve fitness over a 10-week period (p > 0.05). However, vitamin D combined with physical exercise significantly improved cognitive performance in Group B only, specifically in working memory, verbal memory, and cognitive flexibility (p < 0.05). Conclusions: This study highlights the need for targeted interventions such as physical exercise and vitamin D supplementation to be conducted at an early stage in order to improve physical and cognitive function and reduce the risk of disease. Full article

Background: Obesity affects over one billion people globally. Bariatric surgery is the most effective long-term intervention for severe obesity. However, postoperative outcomes can vary considerably, with such factors as baseline fitness and cardiorespiratory reserve influencing surgical outcomes. This systematic review aimed to evaluate the effects of preoperative exercise or physical activity, compared to standard care or no intervention, on preoperative fitness parameters and perioperative surgical outcomes in adults with obesity undergoing metabolic and bariatric surgery. Methods: A systematic review was conducted in accordance with the recommendations of the Cochrane Handbook and the PRISMA guidelines. Randomized controlled trials, non-randomized controlled trials, and cohort studies with control groups evaluating preoperative exercise interventions were included. Two independent reviewers conducted study selection, data extraction, and risk of bias assessment using Cochrane tools. Meta-analyses were performed using random effects models, with standardized mean differences calculated for continuous outcomes. Evidence certainty was assessed using the GRADE approach. Results: A total of 15 studies, including 1378 participants, were identified for qualitative synthesis, with 12 contributing data for quantitative meta-analysis. Preoperative exercise interventions significantly improved six-minute walk test distance (SMD 2.01; 95% CI: 0.51 to 3.50; p = 0.009) and VO₂ peak (SMD 1.02; 95% CI: 0.52 to 1.51; p < 0.0001). BMI reduction was significant (SMD −0.96; 95% CI: −1.75 to −0.16; p = 0.02), while weight change was not statistically significant (SMD −0.81; 95% CI: −1.72 to 0.09; p = 0.08). One study reported a reduction in hospital length of stay of 0.64 days (95% CI: −0.86 to −0.42; p < 0.00001). Evidence certainty was rated as very low to low across all outcomes. Conclusions: Preoperative exercise interventions have been shown to significantly improve cardiorespiratory fitness in bariatric surgery candidates, with large effect sizes for functional capacity measures. Despite the low certainty of the evidence, these findings suggest that supervised exercise programs should be incorporated into the preoperative care of bariatric surgery patients. Full article

Background/Objectives: This study aimed to identify the functional adaptations that enable competitive performance in a Paralympic cyclist with optimized bilateral transtibial prostheses compared to a conventional cyclist. Additionally, it describes the development of the prosthesis, designed through a user-centered engineering process incorporating Quality Function Deployment (QFD), Computer-Aided Design (CAD), Finite Element Analysis (FEA), Computational Fluid Dynamics (CFD), and topological optimization, with the final design (Design 1.4) achieving optimal structural integrity, aerodynamic efficiency, and anatomical fit. Methods: Both athletes performed a progressive cycling test with 50-watt increments every three minutes until exhaustion. Cardiorespiratory metrics, lactate thresholds, and joint kinematics were assessed. Results: Although the conventional cyclist demonstrated higher Maximal Oxygen Uptake (VO₂max) and anaerobic threshold, the Paralympic cyclist exceeded 120% of his predicted VO₂max, had a higher Respiratory Exchange Ratio (RER) [1.32 vs. 1.11], and displayed greater joint ranges of motion with lower trunk angular variability. Lactate thresholds were similar between athletes. Conclusions: These findings illustrate, in this specific case, that despite lower aerobic capacity, the Paralympic cyclist achieved comparable performance through efficient biomechanical and physiological adaptations. Integrating advanced prosthetic design with individualized evaluation appears essential to optimizing performance in elite adaptive cycling. Full article

Background: To evaluate and compare cardiorespiratory function, assessed by the 6-minute walk test (6MWT), and musculoskeletal function, assessed by the handgrip strength test and the sit-to-stand test (STS10) in post-coronavirus disease 2019 (COVID-19) patients. Participants were stratified based on the time since infection (≤6 months and >6 months) and compared with matched healthy controls. Methods: A total of 111 participants were recruited and divided into three groups (n = 37/group). Cardiorespiratory function was assessed using the 6MWT, while musculoskeletal function was evaluated through the handgrip strength test and the STS10. Results: All three groups had normal body mass index values. Group 2 demonstrated significantly lower handgrip strength and a shorter 6MWT distance compared to both Group 1 and Group 3. Additionally, Group 2 required significantly more time to complete the STS10 than Group 1. Following the 6MWT, Group 2 exhibited significantly higher heart rate and systolic blood pressure compared to both Group 1 and Group 3. Diastolic blood pressure was significantly lower in Group 3 compared to the other two groups. Furthermore, Group 2 had significantly lower pulse oxygen saturation than both Group 1 and Group 3. The rate of perceived exertion was significantly lower in Group 1 than in Group 2. Additionally, leg fatigue was significantly lower in Group 1 compared to both Group 2 and Group 3. Conclusions: These findings highlight significant differences in physical performance and physiological responses between post-COVID-19 patients and healthy individuals, emphasizing the potential long-term effects of SARS-CoV-2 infection on cardiorespiratory and musculoskeletal function. Full article