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  • Review
  • Open Access
15 Citations
12,049 Views
15 Pages

Imaging of Cartilage and Chondral Defects: An Overview

  • Neha Nischal,
  • Karthikeyan P. Iyengar,
  • Deepak Herlekar and
  • Rajesh Botchu

28 January 2023

A healthy articular cartilage is paramount to joint function. Cartilage defects, whether acute or chronic, are a significant source of morbidity. This review summarizes various imaging modalities used for cartilage assessment. While radiographs are i...

  • Review
  • Open Access
12 Citations
5,230 Views
31 Pages

7 October 2023

This review presents the changes that the imaging of articular cartilage has undergone throughout the last decades. It highlights that the expectation is no longer to image the structure and associated functions of articular cartilage but, instead, t...

  • Article
  • Open Access
7 Citations
2,738 Views
17 Pages

A Cationic Contrast Agent in X-ray Imaging of Articular Cartilage: Pre-Clinical Evaluation of Diffusion and Attenuation Properties

  • Simone Fantoni,
  • Ilenia Gabucci,
  • Paolo Cardarelli,
  • Gianfranco Paternò,
  • Angelo Taibi,
  • Virginia Cristofori,
  • Claudio Trapella,
  • Armando Bazzani,
  • Marta Assenza and
  • Fabio Baruffaldi
  • + 2 authors

The aim of this study was the preliminary assessment of a new cationic contrast agent, the CA4+, via the analysis of spatial distribution in cartilage of ex vivo bovine samples, at micrometer and millimeter scale. Osteochondral plugs (n = 18) extract...

  • Article
  • Open Access
7 Citations
3,197 Views
13 Pages

A Useful Combination of Quantitative Ultrashort Echo Time MR Imaging and a Probing Device for Biomechanical Evaluation of Articular Cartilage

  • Takehito Hananouchi,
  • Yanjun Chen,
  • Saeed Jerban,
  • Masaru Teramoto,
  • Yajun Ma,
  • Erik W. Dorthe,
  • Eric Y. Chang,
  • Jiang Du and
  • Darryl D. D’Lima

17 February 2021

In this study, we combined quantitative ultrashort echo time (UTE) magnetic resonance (MR) imaging and an investigation by a probing device with tri-axial force sensor to seek correlations with mechanical properties of human patellar cartilage for in...

  • Review
  • Open Access
1 Citations
2,365 Views
28 Pages

Computational and Imaging Approaches for Precision Characterization of Bone, Cartilage, and Synovial Biomolecules

  • Rahul Kumar,
  • Kyle Sporn,
  • Vibhav Prabhakar,
  • Ahab Alnemri,
  • Akshay Khanna,
  • Phani Paladugu,
  • Chirag Gowda,
  • Louis Clarkson,
  • Nasif Zaman and
  • Alireza Tavakkoli

Background/Objectives: Degenerative joint diseases (DJDs) involve intricate molecular disruptions within bone, cartilage, and synovial tissues, often preceding overt radiographic changes. These tissues exhibit complex biomolecular architectures and t...

  • Article
  • Open Access
2 Citations
2,736 Views
13 Pages

14 July 2023

Background: The purpose of the study was to determine the diagnostic performance of computed tomographic arthrography (CTA) and 3-Tesla magnetic resonance imaging (MRI) for detecting artificial cartilage lesions in equine femorotibial and femoropatel...

  • Feature Paper
  • Article
  • Open Access
3 Citations
1,840 Views
13 Pages

17 January 2025

Background/Objectives: After open-wedge high tibial osteotomy (OWHTO), the patella is displaced distally, causing patellofemoral joint degeneration. The objective of this study was to ascertain whether the combination of OWHTO and lateral retinacular...

  • Article
  • Open Access
6 Citations
2,622 Views
12 Pages

Usefulness of T2-Weighted Images with Deep-Learning-Based Reconstruction in Nasal Cartilage

  • Yufan Gao,
  • Weiyin (Vivian) Liu,
  • Liang Li,
  • Changsheng Liu and
  • Yunfei Zha

25 September 2023

Objective: This study aims to evaluate the feasibility of visualizing nasal cartilage using deep-learning-based reconstruction (DLR) fast spin-echo (FSE) imaging in comparison to three-dimensional fast spoiled gradient-echo (3D FSPGR) images. Materia...

  • Article
  • Open Access
9 Citations
3,895 Views
38 Pages

Performance and Robustness of Regional Image Segmentation Driven by Selected Evolutionary and Genetic Algorithms: Study on MR Articular Cartilage Images

  • Jan Kubicek,
  • Alice Varysova,
  • Martin Cerny,
  • Kristyna Hancarova,
  • David Oczka,
  • Martin Augustynek,
  • Marek Penhaker,
  • Ondrej Prokop and
  • Radomir Scurek

23 August 2022

The analysis and segmentation of articular cartilage magnetic resonance (MR) images belongs to one of the most commonly routine tasks in diagnostics of the musculoskeletal system of the knee area. Conventional regional segmentation methods, which are...

  • Article
  • Open Access
20 Citations
8,687 Views
19 Pages

Simultaneous Magnetic Resonance Imaging and Consolidation Measurement of Articular Cartilage

  • Robert Mark Wellard,
  • Jean-Philippe Ravasio,
  • Samuel Guesne,
  • Christopher Bell,
  • Adekunle Oloyede,
  • Greg Tevelen,
  • James M. Pope and
  • Konstantin I. Momot

5 May 2014

Magnetic resonance imaging (MRI) offers the opportunity to study biological tissues and processes in a non-disruptive manner. The technique shows promise for the study of the load-bearing performance (consolidation) of articular cartilage and changes...

  • Article
  • Open Access
5 Citations
2,734 Views
26 Pages

Novel Hybrid Optimized Clustering Schemes with Genetic Algorithm and PSO for Segmentation and Classification of Articular Cartilage Loss from MR Images

  • Jan Kubicek,
  • Alice Varysova,
  • Martin Cerny,
  • Jiri Skandera,
  • David Oczka,
  • Martin Augustynek and
  • Marek Penhaker

17 February 2023

Medical image segmentation plays an indispensable role in the identification of articular cartilage, tibial and femoral bones from magnetic resonance imaging (MRI). There are various image segmentation strategies that can be used to identify the knee...

  • Article
  • Open Access
2 Citations
1,828 Views
13 Pages

Optimization of Traction Magnetic Resonance Imaging to Improve Visibility of the Elbow Cartilage

  • Sho Kohyama,
  • Kazuhiro Ikeda,
  • Yoshikazu Okamoto,
  • Naoyuki Ochiai and
  • Yuichi Yoshii

We previously reported that elbow magnetic resonance imaging (MRI) with 7 kg traction increases the joint space width of the radiocapitellar joint and improves articular cartilage visibility without arthrography. However, the optimal traction weight...

  • Review
  • Open Access
6 Citations
4,226 Views
21 Pages

Beyond the Surface: Nutritional Interventions Integrated with Diagnostic Imaging Tools to Target and Preserve Cartilage Integrity: A Narrative Review

  • Salvatore Lavalle,
  • Rosa Scapaticci,
  • Edoardo Masiello,
  • Valerio Mario Salerno,
  • Renato Cuocolo,
  • Roberto Cannella,
  • Matteo Botteghi,
  • Alessandro Orro,
  • Raoul Saggini and
  • Francesco Pegreffi
  • + 4 authors

This narrative review provides an overview of the various diagnostic tools used to assess cartilage health, with a focus on early detection, nutrition intervention, and management of osteoarthritis. Early detection of cartilage damage is crucial for...

  • Article
  • Open Access
19 Citations
6,432 Views
21 Pages

Protocols for Culturing and Imaging a Human Ex Vivo Osteochondral Model for Cartilage Biomanufacturing Applications

  • Serena Duchi,
  • Stephanie Doyle,
  • Timon Eekel,
  • Cathal D. O’Connell,
  • Cheryl Augustine,
  • Peter Choong,
  • Carmine Onofrillo and
  • Claudia Di Bella

20 February 2019

Cartilage defects and diseases remain major clinical issues in orthopaedics. Biomanufacturing is now a tangible option for the delivery of bioscaffolds capable of regenerating the deficient cartilage tissue. However, several limitations of in vitro a...

  • Article
  • Open Access
1 Citations
1,866 Views
11 Pages

23 November 2023

Background. Osteoarthritis of the hand joints in systemic sclerosis (SSc) patients might be an independent manifestation leading to limitation of upper extremity function. There is no publication quantitatively assessing the thickness of articular ca...

  • Article
  • Open Access
3,883 Views
15 Pages

Assessment of CA4+ Impact on Mechanical Properties of Articular Cartilage

  • Matteo Berni,
  • Simone Fantoni,
  • Roberta Fognani,
  • Paolo Cardarelli,
  • Fabio Baruffaldi and
  • Massimiliano Baleani

21 June 2025

X-ray imaging of articular cartilage could be a breakthrough for the early diagnosis of tissue degeneration. This approach relies on radiopaque contrast agents to enhance the visualization of soft tissues. The potential impact of contrast agents on t...

  • Article
  • Open Access
1,546 Views
17 Pages

(1) Background: Osteoarthritis is a degenerative disease of the whole joint marked by cartilage–bone interface (CBI) remodeling, but methods to monitor subtle changes in mineralization are lacking. We optimized a non-destructive ultrasound imag...

  • Article
  • Open Access
10 Citations
3,073 Views
10 Pages

DGEMRIC in the Assessment of Pre-Morphological Cartilage Degeneration in Rheumatic Disease: Rheumatoid Arthritis vs. Psoriatic Arthritis

  • Daniel B. Abrar,
  • Christoph Schleich,
  • Miriam Frenken,
  • Stefan Vordenbäumen,
  • Jutta Richter,
  • Matthias Schneider,
  • Benedikt Ostendorf,
  • Sven Nebelung and
  • Philipp Sewerin

Background: Even though cartilage loss is a known feature of psoriatic (PsA) and rheumatoid arthritis (RA), research is sparse on its role in the pathogenesis of PsA, its potential use for disease monitoring and for differentiation from RA. We theref...

  • Article
  • Open Access
1 Citations
1,918 Views
12 Pages

13 September 2024

Background: Osteoarthritis (OA) is a complex disease marked by the degradation of articular cartilage. Objective: This study aimed to explore the relationship between cartilage volume/thickness and clinical outcomes in knee OA patients treated with i...

  • Article
  • Open Access
31 Citations
19,566 Views
15 Pages

Oral Supplementation with Hydrolyzed Fish Cartilage Improves the Morphological and Structural Characteristics of the Skin: A Double-Blind, Placebo-Controlled Clinical Study

  • Patrícia Maria Berardo Gonçalves Maia Campos,
  • Rodolfo Scarpino Barboza Franco,
  • Letícia Kakuda,
  • Gabriel Fernandes Cadioli,
  • Gabriela Maria D’Angelo Costa and
  • Elodie Bouvret

12 August 2021

Collagen and its peptides are natural ingredients used in food supplements and nutricosmetics with the claim of providing benefits for skin health and beauty. In this context, the aim of the present study was to evaluate the clinical efficacy of oral...

  • Article
  • Open Access
14 Citations
6,292 Views
14 Pages

Mosaicplasty versus Matrix-Assisted Autologous Chondrocyte Transplantation for Knee Cartilage Defects: A Long-Term Clinical and Imaging Evaluation

  • Stefano Zaffagnini,
  • Angelo Boffa,
  • Luca Andriolo,
  • Davide Reale,
  • Maurizio Busacca,
  • Alessandro Di Martino and
  • Giuseppe Filardo

3 July 2020

Different surgical procedures have been proposed over the past few years to treat cartilage lesions. The aim of this study was to compare mosaicplasty and matrix-assisted autologous chondrocyte transplantation (MACT) at long-term follow-up. Forty-thr...

  • Article
  • Open Access
3 Citations
2,081 Views
13 Pages

19 December 2023

The objective of this study was to compare articular cartilage thickness observed in the different 2D and 3D sequences to the cartilage thickness of the equine stifle in cadavers to determine the accuracy of each sequence. The study was conducted as...

  • Article
  • Open Access
3 Citations
1,921 Views
10 Pages

24 August 2023

Objectives: The main aims of the study were the evaluation of stress-related effects (strenuous vs. non-strenuous sport vs. nonathletes) in stimulating or reducing influences on cartilage volume in the ankle joint and the evaluation of the image qual...

  • Article
  • Open Access
28 Citations
5,191 Views
15 Pages

5 June 2020

A deeper understanding of the cartilage-bone mechanics is fundamental to unravel onset and progression of osteoarthritis, enabling better diagnosis and treatment. The aim of this study is therefore to explore the capability of X-ray computed (XCT) ph...

  • Article
  • Open Access
1 Citations
1,843 Views
13 Pages

Insights into the Age Dependency of Compositional MR Biomarkers Quantifying the Health Status of Cartilage in Metacarpophalangeal Joints

  • Miriam Frenken,
  • Karl Ludger Radke,
  • Emilia Louisa Ernestine Schäfer,
  • Birte Valentin,
  • Lena Marie Wilms,
  • Daniel Benjamin Abrar,
  • Sven Nebelung,
  • Petros Martirosian,
  • Hans-Jörg Wittsack and
  • Anja Müller-Lutz

(1) Background: We aim to investigate age-related changes in cartilage structure and composition in the metacarpophalangeal (MCP) joints using magnetic resonance (MR) biomarkers. (2) Methods: The cartilage tissue of 90 MCP joints from 30 volunteers w...

  • Article
  • Open Access
1,199 Views
17 Pages

Traction MRI of the Elbow: Age-Based Effects and Implications

  • Sho Kohyama,
  • Kazuhiro Ikeda,
  • Yoshikazu Okamoto and
  • Yuichi Yoshii

28 September 2024

Background/Objectives: We previously reported that traction magnetic resonance imaging (MRI) of the elbow without arthrography increases the width of the radiocapitellar joint (RC) and improves articular cartilage visibility. However, the effects of...

  • Article
  • Open Access
10 Citations
3,455 Views
16 Pages

27 January 2022

The use of imaging devices to assess directional mechanics of tissues is highly desirable. This is because the directional mechanics depend on fiber orientation, and altered directional mechanics are closely related to the pathological status of tiss...

  • Article
  • Open Access
10 Citations
2,906 Views
32 Pages

Dense Multi-Scale Graph Convolutional Network for Knee Joint Cartilage Segmentation

  • Christos Chadoulos,
  • Dimitrios Tsaopoulos,
  • Andreas Symeonidis,
  • Serafeim Moustakidis and
  • John Theocharis

In this paper, we propose a dense multi-scale adaptive graph convolutional network (DMA-GCN) method for automatic segmentation of the knee joint cartilage from MR images. Under the multi-atlas setting, the suggested approach exhibits several noveltie...

  • Article
  • Open Access
8 Citations
3,585 Views
20 Pages

Long-Term Tri-Modal In Vivo Tracking of Engrafted Cartilage-Derived Stem/Progenitor Cells Based on Upconversion Nanoparticles

  • Chu-Hsin Chen,
  • Na Tang,
  • Ke Xue,
  • Hui-Zhong Zhang,
  • Ya-Hong Chen,
  • Peng Xu,
  • Kang Sun,
  • Ke Tao and
  • Kai Liu

29 June 2021

Cartilage-derived stem/progenitor cells (CSPCs) are a potential choice for seed cells in osteal and chondral regeneration, and the outcomes of their survival and position distribution in vivo form the basis for the investigation of their mechanism. H...

  • Article
  • Open Access
9 Citations
7,005 Views
17 Pages

A Comprehensive Framework to Evaluate the Effects of Anterior Cruciate Ligament Injury and Reconstruction on Graft and Cartilage Status through the Analysis of MRI T2 Relaxation Time and Knee Laxity: A Pilot Study

  • Gregorio Marchiori,
  • Giorgio Cassiolas,
  • Matteo Berni,
  • Alberto Grassi,
  • Giacomo Dal Fabbro,
  • Milena Fini,
  • Giuseppe Filardo,
  • Stefano Zaffagnini and
  • Nicola Francesco Lopomo

10 December 2021

Background: Anterior cruciate ligament (ACL) tear represents a common orthopedic traumatic issue that often leads to an early development of osteoarthritis. To improve the diagnostic and prognostic techniques involved in the assessment of the joint a...

  • Review
  • Open Access
63 Citations
8,723 Views
31 Pages

9 February 2021

Advances in vibrational spectroscopy have propelled new insights into the molecular composition and structure of biological tissues. In this review, we discuss common modalities and techniques of vibrational spectroscopy, and present key examples to...

  • Feature Paper
  • Article
  • Open Access
29 Citations
6,921 Views
13 Pages

Estimation of Articular Cartilage Surface Roughness Using Gray-Level Co-Occurrence Matrix of Laser Speckle Image

  • Doaa Youssef,
  • Hatem El-Ghandoor,
  • Hamed Kandel,
  • Jala El-Azab and
  • Salah Hassab-Elnaby

28 June 2017

The application of He-Ne laser technologies for description of articular cartilage degeneration, one of the most common diseases worldwide, is an innovative usage of these technologies used primarily in material engineering. Plain radiography and mag...

  • Review
  • Open Access
1 Citations
1,691 Views
63 Pages

26 November 2025

Osteoarthritis (OA) is a leading cause of pain, disability, and healthcare utilization worldwide, yet clinical diagnosis commonly occurs after irreversible structural damage, limiting opportunities for prevention. Advances in molecular profiling, qua...

  • Article
  • Open Access
2 Citations
3,519 Views
11 Pages

Knee Diameter and Cross-Sectional Area as Biomarkers for Cartilage Knee Degeneration on Magnetic Resonance Images

  • Elias Primetis,
  • Dionysios Drakopoulos,
  • Dominik Sieron,
  • Hugo Meusburger,
  • Karol Szyluk,
  • Paweł Niemiec,
  • Verena C. Obmann,
  • Alan A. Peters,
  • Adrian T. Huber and
  • Andreas Christe
  • + 2 authors

23 December 2022

Background and Objectives: Osteoarthritis (OA) of the knee is a degenerative disorder characterized by damage to the joint cartilage, pain, swelling, and walking disability. The purpose of this study was to assess whether demographic and radiologic p...

  • Article
  • Open Access
27 Citations
4,031 Views
18 Pages

In Vitro Study of Extracellular Vesicles Migration in Cartilage-Derived Osteoarthritis Samples Using Real-Time Quantitative Multimodal Nonlinear Optics Imaging

  • Leonardo Mortati,
  • Laura de Girolamo,
  • Carlotta Perucca Orfei,
  • Marco Viganò,
  • Marco Brayda-Bruno,
  • Enrico Ragni and
  • Alessandra Colombini

Mesenchymal stromal cells (MSCs)-derived extracellular vesicles (EVs) are promising therapeutic nano-carriers for the treatment of osteoarthritis (OA). The assessment of their uptake in tissues is mandatory but, to date, available technology does not...

  • Article
  • Open Access
1 Citations
3,211 Views
15 Pages

Two for One—Combined Morphologic and Quantitative Knee Joint MRI Using a Versatile Turbo Spin-Echo Platform

  • Teresa Lemainque,
  • Nicola Pridöhl,
  • Marc Huppertz,
  • Manuel Post,
  • Can Yüksel,
  • Robert Siepmann,
  • Karl Ludger Radke,
  • Shuo Zhang,
  • Masami Yoneyama and
  • Sven Nebelung
  • + 3 authors

Quantitative MRI techniques such as T2 and T1ρ mapping are beneficial in evaluating knee joint pathologies; however, long acquisition times limit their clinical adoption. MIXTURE (Multi-Interleaved X-prepared Turbo Spin-Echo with IntUitive RElaxo...

  • Article
  • Open Access
2 Citations
2,195 Views
20 Pages

19 October 2022

Background: Comparing to anterior cruciate ligament reconstructions (ACLR) with free hamstring tendon (FHT), ACLR with preserved tibial-insertion hamstring tendon (HT-PTI) could ensure the blood supply of the graft and avoid graft necrosis. Yet, whet...

  • Article
  • Open Access
12 Citations
2,974 Views
13 Pages

21 March 2021

This study tested for longitudinal changes in femoral cartilage T2 relaxation time and thickness in fast-progressing medial femorotibial osteoarthritis (OA). From the Osteoarthritis Initiative (OAI) database, nineteen knees fulfilled the inclusion cr...

  • Article
  • Open Access
6 Citations
3,802 Views
11 Pages

Evaluating Lumbar Intervertebral Disc Degeneration on a Compositional Level Using Chemical Exchange Saturation Transfer: Preliminary Results in Patients with Adolescent Idiopathic Scoliosis

  • Lena M. Wollschläger,
  • Sven Nebelung,
  • Christoph Schleich,
  • Anja Müller-Lutz,
  • Karl L. Radke,
  • Miriam Frenken,
  • Matthias Boschheidgen,
  • Max Prost,
  • Gerald Antoch and
  • Daniel B. Abrar
  • + 1 author

Lumbar intervertebral disc (IVD) degeneration is characterized by structural and compositional changes. This study aimed to assess the glycosaminoglycan (GAG) content of IVDs of patients with adolescent idiopathic scoliosis (AIS) and healthy controls...

  • Article
  • Open Access
11 Citations
5,128 Views
13 Pages

Exploratory Full-Field Mechanical Analysis across the Osteochondral Tissue—Biomaterial Interface in an Ovine Model

  • Jeffrey N. Clark,
  • Agathe Heyraud,
  • Saman Tavana,
  • Talal Al-Jabri,
  • Francesca Tallia,
  • Brett Clark,
  • Gordon W. Blunn,
  • Justin P. Cobb,
  • Ulrich Hansen and
  • Jonathan R. T. Jeffers
  • + 1 author

4 September 2020

Osteochondral injuries are increasingly prevalent, yet success in articular cartilage regeneration remains elusive, necessitating the development of new surgical interventions and novel medical devices. As part of device development, animal models ar...

  • Article
  • Open Access
3,156 Views
17 Pages

17 November 2022

Late diagnosis and treatment of septic arthritis (SA) after anterior cruciate ligament reconstruction (ACL-R) can lead to graft and cartilage damage. Pathogen eradication time may be the key to preventing the development of osteoarthritis. The purpos...

  • Article
  • Open Access
14 Citations
14,772 Views
34 Pages

Windows on the Human Body – in Vivo High-Field Magnetic Resonance Research and Applications in Medicine and Psychology

  • Ewald Moser,
  • Martin Meyerspeer,
  • Florian Ph. S. Fischmeister,
  • Günther Grabner,
  • Herbert Bauer and
  • Siegfried Trattnig

8 June 2010

Analogous to the evolution of biological sensor-systems, the progress in “medical sensor-systems”, i.e., diagnostic procedures, is paradigmatically described. Outstanding highlights of this progress are magnetic resonance imaging (MRI) and spectrosco...

  • Systematic Review
  • Open Access
420 Views
18 Pages

Comparison of Diagnostic Performance Between CT and MRI for Detection of Cartilage Invasion and Tumor Staging in Patients with Laryngeal Cancer: A Systematic Review and Meta-Analysis

  • Ingrid-Denisa Barcan,
  • Dan Ionel Orbulescu,
  • Andreea-Mihaela Banța,
  • Alexandru Catalin Motofelea,
  • Dana Emilia Movila,
  • Razvan Gheorghe Diaconescu,
  • Emanuela Stan,
  • Eugen Radu Boia and
  • Delia Ioana Horhat

10 February 2026

Background: Laryngeal cancer constitutes a major burden. Accurate staging is important to determine the optimal treatment approach. However, a head-to-head comparison of diagnostic performance between CT and MRI in patients with laryngeal cancer is l...

  • Article
  • Open Access
519 Views
16 Pages

Serum COMP and Vitamin D as a Biomarker for Articular Cartilage Degeneration in Knee Osteoarthritis: Correlation with USG and MRI Findings

  • Radiyati Umi Partan,
  • Agus Mahendra,
  • Murti Putri Utami,
  • Khoirun Mukhsinin Putra,
  • Surya Darma,
  • Muhammad Reagan,
  • Putri Muthia,
  • Afifah Salshabila Radiandina,
  • Hermansyah Hermansyah and
  • Ziske Maritska

Background/Objectives: Osteoarthritis (OA) remains a global health problem, as it can cause permanent joint damage, leading to irreversible disability. Therefore, there is a need for accessible and non-invasive alternative examinations, such as USG,...

  • Review
  • Open Access
5 Citations
4,898 Views
9 Pages

Calcium-containing crystal deposition diseases are a common cause of pain and disability but remain relatively under-investigated. No drug has been identified that can prevent deposition or effect dissolution of either calcium pyrophosphate (CPP) or...

  • Review
  • Open Access
76 Citations
15,243 Views
19 Pages

Ear Reconstruction Simulation: From Handcrafting to 3D Printing

  • Elisa Mussi,
  • Rocco Furferi,
  • Yary Volpe,
  • Flavio Facchini,
  • Kathleen S. McGreevy and
  • Francesca Uccheddu

Microtia is a congenital malformation affecting one in 5000 individuals and is characterized by physical deformity or absence of the outer ear. Nowadays, surgical reconstruction with autologous tissue is the most common clinical practice. The procedu...

  • Article
  • Open Access
13 Citations
8,840 Views
15 Pages

Quantification of Sodium Relaxation Times and Concentrations as Surrogates of Proteoglycan Content of Patellar CARTILAGE at 3T MRI

  • Benedikt Kamp,
  • Miriam Frenken,
  • Jan M. Henke,
  • Daniel B. Abrar,
  • Armin M. Nagel,
  • Lena V. Gast,
  • Georg Oeltzschner,
  • Lena M. Wilms,
  • Sven Nebelung and
  • Anja Müller-Lutz
  • + 2 authors

8 December 2021

Sodium MRI has the potential to depict cartilage health accurately, but synovial fluid can influence the estimation of sodium parameters of cartilage. Therefore, this study aimed to reduce the impact of synovial fluid to render the quantitative compo...

  • Feature Paper
  • Review
  • Open Access
51 Citations
8,963 Views
16 Pages

6 November 2015

There is an increasing body of evidence establishing the advantages of dual-energy CT (DECT) for evaluation of head and neck squamous cell carcinoma (HNSCC). Focusing on a single-source DECT system with fast kVp switching, we will review the principl...

  • Review
  • Open Access
9 Citations
6,880 Views
15 Pages

6 June 2017

Since articular cartilage has a limited regeneration potential, for developing biological therapies for cartilage regeneration it is important to study the mechanisms underlying chondrogenesis of stem cells. Bioluminescence assays can visualize a wid...

  • Review
  • Open Access
7 Citations
8,899 Views
21 Pages

Quantitative and Compositional MRI of the Articular Cartilage: A Narrative Review

  • Domenico Albano,
  • Umberto Viglino,
  • Francesco Esposito,
  • Aldo Rizzo,
  • Carmelo Messina,
  • Salvatore Gitto,
  • Stefano Fusco,
  • Francesca Serpi,
  • Benedikt Kamp and
  • Philipp Sewerin
  • + 3 authors

24 June 2024

This review examines the latest advancements in compositional and quantitative cartilage MRI techniques, addressing both their potential and challenges. The integration of these advancements promises to improve disease detection, treatment monitoring...

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