Search Results (12,881)

Background: L-carnitine supplementation is thought to enhance exercise performance, particularly in moderate and high-intensity activities, but evidence supporting this is mixed. This study aimed to assess whether acute L-carnitine tartrate supplementation could improve CrossFit^® performance, specifically during the “Cindy” workout, a high-intensity exercise protocol. Methods: In a randomized, double-blind, placebo-controlled crossover design, 20 trained male recreational CrossFit^® athletes completed the “Cindy” workout within a 20 min period after ingesting either 3 g of L-carnitine tartrate or a placebo 90 min before exercise. Performance was measured by total repetitions completed. Secondary outcomes included ratings of perceived exertion (RPE), gastrointestinal issues, and blood pressure (BP) measurements. Results: The results showed that L-carnitine supplementation did not significantly affect the number of repetitions performed (202.4 ± 69.9 vs. 204.5 ± 78.8, p = 0.810) compared to the placebo. There were also no significant differences in RPE (6.3 ± 1.5 vs. 6.9 ± 1.4, p = 0.180) or BP changes between groups. However, 10% of participants reported difficulty sleeping after L-carnitine supplementation. Conclusions: The findings suggest that 3 g of L-carnitine tartrate does not enhance CrossFit^® performance in recreational athletes. Further research is needed to clarify its potential benefits, especially with larger samples and consideration of factors like sex and carbohydrate co-ingestion. Full article

Clubroot disease, caused by Plasmodiophora brassicae, poses a serious threat to global Brassica crop production. Orphan genes (OGs), which are species or lineage-specific and lack detectable homologs in other taxa, have been implicated in various biotic stress responses. Here, we identified a novel Brassica rapa-specific orphan gene, designated CROG1, that confers resistance to clubroot. Heterologous overexpression of CROG1 in Arabidopsis thaliana significantly enhanced resistance to P. brassicae. Transcriptomic profiling of CROG1-overexpressing lines highlighted the essential role of the phenylpropanoid biosynthesis pathway, showing upregulation of key lignin synthesis genes (including CCoAMT, CAD6, PER4, and AZI1) and defense-related regulators (RBOHC and WAKs). Weighted co-expression network analysis further corroborated the link between CROG1-mediated resistance and enhanced lignin deposition and cell wall reinforcement. Our findings establish CROG1 as a Brassica-specific orphan gene that enhances clubroot resistance via phenylpropanoid pathway activation. These results highlight the potential of orphan genes as novel genetic resources for breeding clubroot-resistant Brassica varieties, offering a sustainable strategy to mitigate yield losses caused by this devastating disease. Full article

High-entropy alloy (HEA) catalysts have attracted significant attention from researchers. In many cases, HEAs exhibit high activity and selectivity for catalytic reactions due to four “core effects”: high entropy effect, lattice distortion effect, slow diffusion effect, and mixing effect. However, a systematic summary of HEA catalyst design and understanding is lacking. In this review, the reasons for the outstanding performance of HEA catalysts are first discussed from multiple perspectives, such as excellent mechanical properties, ultra-high-performance stability, and the potential for compositional optimization. Furthermore, to deepen our understanding of HEA catalysts, the rational design of HEA catalysts is introduced, covering design principles, element selection, and the use of algorithms for prediction. Next, several common preparation methods for HEAs are introduced, including chemical co-reduction, solution combustion, mechanical alloying, and sol–gel methods. Finally, the research progress of HEA catalysts in hydrogen evolution reactions, oxygen evolution reactions, and oxygen reduction reactions is presented. Unlike existing reviews, this work establishes a unified framework connecting HEA fundamentals (entropy effects), computational design, scalable synthesis, and application-specific performance, while identifying underexplored pathways like lattice-oxygen-mediated mechanisms (LOM) for future research. Full article

In this study, the synergistic tuning mechanism of heat treatment (600, 800, and 1000 °C) and dealloying (40, 60, and 80 °C) on the microstructure and electrocatalytic performance of an FCC + BCC-type CoCrNi0.5Ti0.3V0.2Al0.4 eutectic high-entropy alloy (EHEA) was systematically investigated. The findings indicate that with an increase in heat treatment temperature, there is a gradual increase in grain size and a change in the fraction of the two phases. Notably, heat treatment at 800 °C resulted in an FCC-dominated dual-phase structure with uniformly refined grains. As the dealloying temperature increased, the pore size also increased, leading to a uniform distribution of the internal FCC and BCC phases. The sample subjected to heat treatment at 800 °C and dealloying at 80 °C exhibited an OER overpotential of only 265 mV and a Tafel slope of 67.84 mV/dec, significantly enhancing the electrocatalytic activity and stability of the alloy. This study elucidates the mechanism by which the combination of heat treatment and dealloying processes optimizes the electrocatalytic performance of eutectic high-entropy alloys, providing a novel strategy for the design of non-precious metal electrocatalysts. Full article

With the gradual rise of automation and human–robot collaboration (HRC), artificial intelligence (AI) is expected to significantly change the construction industry by automating design and decision-making processes, thus improving both productivity and safety. Despite the growing research trends in AI and HRC, no study has synthesized the existing studies of AI in HRC in the construction industry. This paper aims to conduct a review of AI in HRC in construction and summarize the current mainstream topics, research gaps, and future research directions. A scoping review and science mapping analysis were used to explore extant literature in the studied domain and conduct keyword co-occurrence analysis, respectively. In this study, 210 relevant articles were retrieved from the Scopus database from 1993 to July 2025. The results revealed five main clusters regarding the co-occurrence of keywords. Four mainstream research topics were discussed, including (1) AI techniques and applications, (2) the use of extended reality (XR) in HRC, (3) the challenges of HRC, and (4) the application of HRC in the architecture, engineering, and construction (AEC) sector. Moreover, this study provided a detailed summary of research gaps and future research directions. These findings offer researchers and practitioners a deeper understanding of AI applications in HRC for construction case studies and serve as actionable directions to advance this field. Full article

Sustainable shell structures are thin, curved systems such as domes, vaults, and cylindrical shells that achieve strength and stability primarily through membrane action, allowing significant material savings. Their sustainability lies in minimizing embodied energy and CO₂ emissions by using less material, integrating recycled or bio-based components, and applying optimization strategies to extend service life and enable reuse or recycling, all while maintaining structural performance and architectural quality. This review critically examines the state-of-the-art in sustainable shell structures, focusing on their buckling behavior and material-efficient design strategies. Integrating bibliometric analysis with thematic synthesis, the study identifies key research trends, theoretical advancements, and optimization tools that support structural efficiency. Emphasis is placed on recent developments in composite and bio-based materials, imperfection-sensitive buckling models, and performance-based design approaches. Advanced computational methods, including finite element analysis, machine learning, and digital twins, are highlighted as critical in enhancing predictive accuracy and sustainability outcomes. The findings underscore the dual challenge of achieving both structural stability and environmental responsibility, while outlining research gaps and future directions toward resilient, low-impact shell construction. Full article

Background/Objectives: The conventional treatment of glioblastoma (GBM) with alkylating agents is not curative. The protein O6-methylguanine DNA methyltransferase (MGMT) is a significant limitation, being able to repair drug-induced DNA damage. Thus, exploring non-alkylating agents already approved by the FDA is imperative. The antidepressant fluoxetine (FL) has been explored due to its anti-cancer properties. However, its first-pass effect and its non-targeted distribution to brain tissue are major limitations of FL’s administration, which is conventionally orally administered. Thus, the primary objective of this work was the development of poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) tailored with folic acid (FA) for FL delivery to GBM cells. Methods: A Central Composite Design (CCD) was applied to optimize the NPs. Results: The developed FA-functionalized PLGA NPs exhibited physicochemical properties suitable for brain-targeted delivery. The final formulation presented an average diameter of 167 ± 8 nm, a polydispersity index (PdI) of 0.23 ± 0.07, and a zeta potential of −22.2 ± 0.3 mV. The encapsulation efficiency (EE) and loading capacity (LC) values were 44.4 ± 3.8% and 3.1 ± 0.3%, respectively. In vitro studies demonstrated that the NPs are stable in storage and simulated physiological conditions and can maintain a controlled and slow-release profile of FL for 17 days. In vitro cell uptake experiments demonstrated that conjugation with FA enhances the NPs’ internalization in GBM cells overexpressing folate receptors through endocytosis mediated by this receptor. Furthermore, in vitro cytotoxicity experiments demonstrated that the FL encapsulation in the developed NPs maintains drug efficacy, as well as it was able to increase cell sensitivity to treatment with an alkylating agent. Conclusions: These results suggest that the developed NPs are effective nanocarriers, either as a standalone therapy or as a chemosensitizer in combination with the standard GBM treatment. Full article

Background/Objectives: Parents report unmet information needs relating to childhood brain tumors. Existing research shows that providing information to families supports self-efficacy and well-being. The project therefore aimed to co-design resources tailored to the informational needs of families navigating childhood brain tumors in Australia. Methods: Mixed methods were used across multiple phases. A landscape analysis in Phase 1 confirmed the gap in Australian resources as well as the identification of international resources suitable to inform local solutions. Following the Double Diamond Design Framework, subsequent phases of the project aimed to discover and define the problems faced by families before developing and delivering the solution. Parents of children with brain tumors participated in a journey mapping workshop, content adaptation through feedback, and an online survey to determine the preferred delivery mode of information. Clinicians provided iterative feedback as the resource was developed and refined. Results: Nine mothers participated in journey mapping and iterative adaptation of the resource along with twelve clinicians. There were 46 respondents to the survey, which identified a preference for multi-modal delivery of information, and 23 clinical and consumer reviewers in the final revision phase. The process of adaptation is presented, providing transparency on the development of this national resource. Conclusions: The use of self-efficacy theory and co-design was pivotal in this project. Integration of concepts from self-efficacy moves beyond simply presenting information to empowering the audience to feel capable of the task ahead of them. Co-design ensured the content and tone of the resulting resource are fit-for-purpose from the perspective of both clinicians and consumers. The resource is available as a physical book, digital resource, and audiobook and disseminated through children’s hospitals, professional networks, and brain tumor support groups. Full article

Meeting the International Maritime Organization’s (IMO) 2050 targets for reducing greenhouse gas (GHG) emissions requires cost-effective solutions that minimize wind resistance without compromising safety, particularly for medium-sized multipurpose vessels (MPVs), which have been underrepresented in prior research. This study numerically evaluates 20 bow-mounted NaviScreen configurations using a coupled high-fidelity computational fluid dynamics (CFD) and finite element analysis (FEA) approach. Key design variables—including contact angle (35–50°), lower-edge height (1.2–2.0 m), and horn position (3.2–5.3 m)—were systematically varied. The sloped Type-15 shield reduced aerodynamic resistance by 17.1% in headwinds and 24.5% at a 30° yaw, lowering total hull resistance by up to 8.9%. Nonlinear FEA under combined dead weight, wind loads, and Korean Register (KR) green-water pressure revealed local buckling risks, which were mitigated by adding carling stiffeners and increasing plate thickness from 6 mm to 8 mm. The reinforced design satisfied KR yield limits, ABS buckling factors (>1.0), and NORSOK displacement criteria (L/100), confirming structural robustness. This dual-framework approach demonstrates the viability of NaviScreens as passive aerodynamic devices that enhance fuel efficiency and reduce GHG emissions, aligning with global efforts to address climate change by targeting not only CO2 but also other harmful emissions (e.g., NOx, SOx) regulated under MARPOL. The study delivers a validated CFD-FEA workflow to optimize performance and safety, offering shipbuilders a scalable solution for MPVs and related vessel classes to meet IMO’s GHG reduction goals. Full article

Xanthones from mangosteen pericarp (MP) are bioactive compounds with promising pharmaceutical and nutraceutical applications. However, their efficient and selective extraction using environmentally friendly solvents remains a challenge. This study aimed to evaluate tricaprylin (C8) and tricaprin (C10) as novel green co-extractants in supercritical carbon dioxide (scCO₂) extraction for the recovery of xanthones from MP, using a mass ratio of C8:C10 = 0.64:0.36, hereafter referred to as C8/C10, and to model extraction kinetics for process design and scale-up. Extraction performance was investigated using different C8/C10–MP mass ratios and scCO₂ conditions at temperatures of 60 °C and 70 °C and pressures of 250 bar, 350 bar, and 450 bar. A pseudo-first-order kinetic model was applied to describe the extraction profile, and the kinetic parameters were generalized using second-order polynomial functions of temperature and pressure. The highest xanthone yield (39.93 ± 0.37%) and total xanthone content (51.44 ± 2.22 mg/g) were obtained at a 40% C8/C10–MP ratio under 70 °C and 350 bar, where the C8/C10 mixture outperformed other tested co-extractants in both efficiency and selectivity, particularly for α-mangostin. The extraction profiles were well described by the pseudo-first-order kinetic model, and the generalized model predicted the extraction yield with an uncertainty of 2.3%. C8/C10 is a highly effective and scalable co-extractant for scCO₂ extraction of xanthones, offering a foundation for industrial applications in food, nutraceutical, and pharmaceutical sectors. Full article

The purpose of this study was to design a Pt/TiO₂–ZrO₂ catalytic-based treatment system to remove ethanol and oxygen (O₂) from a gaseous feed stream. The ultimate target application was the conversion of ethanol and O₂ to carbon dioxide (CO₂) and water (H₂O) from a feed stream of CO₂ in a commercial beer brewing operation. Bench-scale reactions were performed at 250 °C and 300 °C, representing two temperatures under practical consideration for a full-scale catalytic reactor. The target gaseous feed stream would be expected to have a relatively low (near-stoichiometric) concentration of O₂, so the effect of O₂ concentration was also studied. On the bench scale, ethanol was completely converted to CO₂ under low flow rate conditions, and the reactions proceeded through volatile and non-volatile reaction intermediates. Results from the bench-scale tests were used to make predictions for designing a pilot-scale catalytic reactor under conditions of high and low O₂ concentration. A pilot-scale reactor was constructed and installed in a commercial brewing facility, and results from testing the pilot-scale reactor are also presented. The pilot-scale system reduced the feed stream ethanol concentrations by 99.9% while concomitantly reducing the O₂ concentrations over the course of a six-day demonstration period without generating unacceptable levels of byproducts. Full article

Municipal sewage sludge (S.S.) and abundant olive-tree pruning on Lesvos Island present both a disposal challenge and an untapped energy resource. This study proposes and evaluates on a preliminary level an integrated system that utilizes both sewage sludge and pruning. The integrated system converts sewage sludge into Hydrochar (HC) via Hydrothermal Carbonization (HTC), removes the aqueous phase using passive solar distillation, and co-gasifies the dried HC with olive pruning in an autothermal downdraft gasifier. HTC experiments on anaerobically digested sludge produced HC with higher heating values exceeding 20 MJ kg⁻¹ while reducing the chemical oxygen demand of the process liquor. Gasification modelling, using the MAGSY equilibrium model, demonstrated that replacing up to 50% of lignocellulosic biomass with HC increased hydrogen content and the Lower Heating Value (LHV) of syngas. Mass and energy balances suggest that the system could provide approximately 590 kW of continuous power, contributing around 4720 MWh to the island’s annual electricity generation. These results indicate that combining HTC, solar distillation, and co-gasification offers a viable pathway to close waste loops, reduce landfill needs, and deliver renewable energy. Future work will focus on Aspen Plus design and optimization, along with a life-cycle assessment in order to assess the environmental benefits. Full article

(1) Background: In today’s digital society, challenges like cyberbullying, harmful social media use, and unhealthy digital habits demand innovative and inclusive educational responses. This study investigates the potential of service-learning (SL) and electronic service-learning (e-SL) as experiential approaches to enhance digital well-being among youth. By actively engaging students, educators, and community stakeholders in co-designed projects, SL/e-SL promotes critical awareness, digital citizenship, and prosocial values while addressing digital risks. (2) Methods: This review offers a literature-based analysis of existing programs and good practices that apply experiential education to encourage responsible digital engagement. It explores SL and e-SL experiences across various educational settings. (3) Results: The findings show that SL and e-SL can be effective educational tools, creating meaningful opportunities for youth to participate in tackling digital issues and building inclusive spaces where students, faculty, and communities collaborate to foster digital literacy and well-being. The analysis also led to the development of quality standards for SL and e-SL practices that promote digital well-being. (4) Conclusions: This study highlights key implications for teaching, underscoring the value of integrative pedagogies that connect experiential learning to digital challenges, promoting a more inclusive and responsible digital culture. Full article

Cobalt-based bulk metallic glasses (Co-based BMGs) offer a combination of high strength, corrosion resistance, and soft magnetic properties, yet their limited glass-forming ability (GFA) and poor room-temperature ductility restrict broader application. In this study, a microalloying strategy was applied to the Co₆₁Nb₈B₃₁ base composition to develop Co-Nb-B-Si and Co-Fe-Nb-B-Si systems. The effects of Si addition and Fe substitution on GFA, thermal stability, and mechanical properties were systematically investigated. Si doping combined with Co/B ratio tuning broadened the supercooled liquid region and increased the critical glass-forming diameter from 1 mm to 3 mm. Further addition of 5 at.% Fe expanded the supercooled liquid region and enabled the fabrication of a fully amorphous plate with 1 mm thickness. The optimized Co₆₃Nb₈B₂₇Si₂ alloy exhibited a compressive strength of 5.18 GPa and a plastic strain of 3.81%. Fracture surface analysis revealed ductile fracture features in the Si-containing alloy and brittle characteristics in Fe-rich compositions. These results demonstrate that microalloying is effective in optimizing the balance between GFA and mechanical performance of Co-based BMGs, offering guidance for composition and processing design. Full article

Nanovaccines have emerged as a transformative platform in immunotherapy, distinguished by their capabilities in targeted antigen delivery, enhanced immunogenicity, and multifunctional integration. By leveraging nanocarriers, these vaccines achieve precise antigen transport, improve immune activation efficiency, and enable synergistic functions such as antigen protection and adjuvant co-delivery. This review comprehensively explores the foundational design principles of nanovaccines, delves into the diversity of nanovaccine design strategies—including the selection of primary carrier materials, functionalization modification, synergistic delivery of immune adjuvants, and self-assembled nano-delivery systems—and highlights their applications in cancer immunotherapy, infectious disease and autoimmune diseases. Furthermore, it critically examines existing technical challenges and translational barriers, providing an integrative reference to guide future research and development in this dynamic field. Full article