Search Results (111,782)

Xylella fastidiosa was first detected in Portugal in 2019 in Lavandula dentata. In response, the national plant health authorities promptly established a Demarcated Zone in the affected area and implemented a series of eradication and control measures, including the systematic removal and destruction of infected and host plants. This study analyzes the economic and operational impacts of these eradication efforts in the northern region of Portugal, with a focus on Demarcated Zones such as the Porto Metropolitan Area, Sabrosa, Alijó, Baião, Mirandela, Mirandela II, and Bougado between 2019 and June 2023. During this period, about 412,500 plants were uprooted. The majority were Pteridium aquilinum (bracken fern), with 360,324 individuals (87.3%), reflecting its wide distribution and the large area affected. Olea europaea (olive tree) was the second most common species removed, with 7024 plants (1.7%), highlighting its economic relevance. Other notable species included Quercus robur (3511; 0.85%), Pelargonium graveolens (3509; 0.85%), and Rosa spp. (1106; 0.27%). Overall, destruction costs were estimated at about EUR 1.04 million, with replanting costs of roughly EUR 6.81 million. In parallel, prospection activities—conducted to detect early signs of infection and monitor disease spread—generated expenses of roughly EUR 5.94 million. While prospecting represents a significant financial investment, the results show that it is considerably more cost-effective than large-scale eradication. Prospection enables early detection and containment, preventing the widespread destruction of vegetation and minimizing disruption to agricultural production, biodiversity, and local communities. Importantly, our findings reveal a sharp decline in confirmed cases in the initial outbreak area—the Porto Demarcated Zone—from 124 cases in 2019 to just 5 in 2023, indicating the effectiveness of the eradication and monitoring measures implemented. However, the presence of 20 active Demarcated Zones across the country as of 2023 highlights the continued risk of spread and the need for sustained vigilance. The complexity of managing Xylella fastidiosa across ecologically and logistically diverse territories justifies the high costs associated with surveillance and targeted interventions. This study reinforces the strategic value of prospection as a proactive and sustainable tool for plant health management. Effective surveillance requires the integration of advanced methodologies aligned with the phenological stages of host plants and the biological cycle of vectors. Targeting high-risk locations, optimizing sample numbers, ensuring diagnostic accuracy, and maintaining continuous training for field teams are critical for improving efficiency and reducing costs. Ultimately, the findings underscore the need to refine and adapt monitoring and eradication strategies to contain the pathogen, safeguard agricultural systems, and prevent Xylella fastidiosa from becoming endemic in Portugal. Full article

Laboratory incubation experiments were conducted to investigate the effects of coal fly ash (FA) amendment (0%, 2.5%, 7.5%, and 15%) and moisture regimes (40%, 70%, and 100% water holding capacity (WHC)) on the mineralization of carbon (C) in an acidic agricultural soil. The results showed that the soil C mineralization intensity initially increased and subsequently decreased throughout the incubation period, with the mineralization dynamics well described by the first-order kinetic model (0.9633 ≤ R² ≤ 0.9972). Carbon mineralization increased with the application rate of FA, while moisture effect followed the order 70% WHC > 100% WHC > 40% WHC. Indicators showing highly significant correlations with total C mineralization amount included FA application rate, pH, water-soluble organic carbon, (WSOC) and cellulase (CEL) activity. Specific bacterial (Acidobacteriota, Gemmatimonadota, Pseudomonadota, and Actinobacteriota) and fungal phyla (Chytridiomycota, Glomeromycota, and Olpidiomycota) exhibited stronger correlations with C mineralization. The microbial taxa exhibiting significant responses to FA and moisture conditions were not consistent. Although the addition of high proportions of FA, especially with adequate moisture conditions, can enhance soil microbial activity and C mineralization, the potential risks of soil C loss and the accumulation of toxic elements necessitate the prudent implementation of elevated FA application rates in practical scenarios. Full article

This paper examines the evolving trajectory of the Social Determinants of Health (SDOH), tracing their development from early observational studies to contemporary, interdisciplinary frameworks that emphasize structural inequities and relational dynamics. It explores foundational milestones such as the Whitehall studies, the Heckler Report, and the World Health Organization’s conceptual models, which positioned SDOH as key drivers of population health. The paper highlights how upstream determinants—such as governance, policy, and socioeconomic systems—influence downstream health outcomes through mechanisms of social stratification and unequal access to resources. While SDOH are increasingly applied in clinical and educational settings, significant challenges persist, including underinvestment in community systems, fragmented care models, and political rollbacks of equity-centered policies. The paper critiques deterministic and deficit-focused framings of SDOH and underscores a shift toward more relational, context-sensitive, and agency-oriented approaches, reflected in the emerging concept of “social dynamics of health.” It highlights the importance of experiential education, competency-based curricula, and digital innovations in driving systemic transformation. Emphasis is placed on reimagining SDOH pedagogy and expanding interdisciplinary, data-driven research to bridge the gap between knowledge and practice. Amid shifting political landscapes, sustaining health equity efforts requires embracing adaptive, participatory models that acknowledge power, community agency, and structural change. Full article

Herbal medicinal products are increasingly used alongside conventional medicines, raising the risk of potential interactions such as pharmacodynamic drug–herb interactions (PD-DHIs) that can cause serious adverse drug reactions (ADRs). This review aims to present available pharmacological, clinical and pharmacoepidemiological literature regarding potential DHIs associated with serotonin syndrome or cardiac arrhythmias. Furthermore, it assesses the current evidence using the Oxford Centre for Evidence-Based Medicine (CEBM) 2009 framework. Serotonin syndrome most often results from combining serotonergic herbs (e.g., St. John’s wort) with antidepressants like serotonin reuptake inhibitors (SSRIs), as supported by repeated case reports and mechanistic plausibility (CEBM Level 3, Grade C). Other herbs such as black cohosh, ginseng, Syrian rue, turmeric, rhodiola, ashwagandha, and L-tryptophan/5-HTP have been linked to serotonin syndrome when used with SSRIs, serotonin-norepinephrine reuptake inhibitors (SNRIs), or monoamine oxidase inhibitors (MAOIs), but evidence is limited (Levels 4–5, Grade D). For cardiac arrhythmias, PD-DHIs arise when herbs interact with drugs that alter cardiac electrophysiology—such as QT-prolonging agents, psychotropics, antiarrhythmics or digoxin—thereby amplifying arrhythmogenic risk. Ephedra with sympathomimetics is strongly associated with arrhythmias (Level 2–3, Grade B). Licorice may potentiate digoxin and QT-prolonging drugs via hypokalemia (Level 4, Grade C). Other related PD-DHIs include aconite with antiarrhythmics, bitter orange or caffeine with QT-prolonging psychotropics, yohimbine with cardiovascular agents, and aloe or senna with digoxin. Overall, the evidence for PD-DHIs varies from moderate to weak but large-scale pharmacoepidemiological data is scarce. Future approaches, including artificial intelligence with explainable machine learning and network pharmacology, may integrate mechanistic, clinical, and real-world data to improve early detection or prediction of PD-DHIs. However, several specific challenges must be addressed. Therefore, it is crucial for healthcare providers in both clinical and community settings to increase their awareness of these interactions and ADRs to ensure the safe use of herbal remedies alongside conventional therapies. Full article

Background: Scientific literature highlights that practitioners and policymakers in social and educational fields can contribute to the inclusion and empowerment of vulnerable groups when developing actions grounded in scientific evidence of social impact, co-created through dialogic engagement with the concerned communities. This study, aligned with Sustainable Development Goals 4 (“Quality Education”) and 5 (“Gender Equality”), provides new evidence on the co-creation process between policymakers and practitioners and women without higher education degrees and its impact. Methods: A qualitative study was conducted through nine in-depth interviews with practitioners and policymakers engaged in the development of dialogic spaces in education, health, and equality. Results: Two key characteristics were identified: (1) a focus on the inclusion of women not yet involved, through the co-creation of egalitarian spaces for dialogue and decision-making, and (2) a commitment to implementing actions based on scientific evidence of social impact. These led to reported improvements in empowerment, education, well-being, health, and employability, not only for the women themselves but also for their families, schools, and communities. Conclusions: The findings support the promotion of co-creation processes with women without academic qualifications and in vulnerable situations, demonstrating their potential to foster sustainable social development. Full article

Rapid socio-spatial change in China’s traditional villages threatens living heritage and weakens locally grounded identity. This paper theorizes place identity as a dynamic, embodied and performative ecology and examines it in Dali Dong Village across four dimensions, emotional attachment, symbolic meaning, continuity and behavioural commitment, using a triangulated qualitative design that integrates interviews, spatial observation and visual ethnography. Findings show that identity is enacted around ritual architectures and everyday settings, particularly the Drum Tower, Flower Bridge, and Sa altar. Emotional attachment and symbolic meaning are expressed consistently across sources, whereas continuity and behavioural commitment are uneven, shaped by ritual fatigue (compressed rehearsal windows), symbolic commodification under tourism, and selective continuity in intergenerational transmission. These mechanisms identify where the identity fabric is most fragile and where intervention leverage lies. Conceptually, the study relocates place identity from cognition-centred, urban models to ritualized rural lifeworlds. Practically, it offers a portable framework for community-anchored stewardship that can be adapted to similar settlements and aligned with policy aims for safeguarding living heritage. Full article

As climate variability intensifies, its impacts are increasingly visible through disrupted agricultural systems and rising food insecurity, especially in climate-sensitive regions. This study explores the complex relationships between environmental stressors, such as rising temperatures, erratic rainfall, and soil degradation, with food insecurity outcomes in selected districts of Uttarakhand, India. Using the Fuzzy DEMATEL method, this study analyzes 19 stressors affecting the food supply chain and identifies the nine most influential factors. An Environmental Stressor Index (ESI) is constructed, integrating climatic, hydrological, and land-use dimensions. The ESI is applied to three districts—Rudraprayag, Udham Singh Nagar, and Almora—to assess their vulnerability. The results suggest that Rudraprayag faces high exposure to climate extremes (heatwaves, floods, and droughts) but benefits from a relatively stronger infrastructure. Udham Singh Nagar exhibits the highest overall vulnerability, driven by water stress, air pollution, and salinity, whereas Almora remains relatively less exposed, apart from moderate drought and connectivity stress. Simulations based on RCP 4.5 and RCP 8.5 scenarios indicate increasing stress across all regions, with Udham Singh Nagar consistently identified as the most vulnerable. Rudraprayag experiences increased stress under the RCP 8.5 scenario, while Almora is the least vulnerable, though still at risk from drought and pest outbreaks. By incorporating crop yield models into the ESI framework, this study advances a systems-level tool for assessing agricultural vulnerability to climate change. This research holds global relevance, as food supply chains in climate-sensitive regions such as Africa, Southeast Asia, and Latin America face similar compound stressors. Its novelty lies in integrating a Fuzzy DEMATEL-based Environmental Stressor Index with crop yield modeling. The findings highlight the urgent need for climate-informed food system planning and policies that integrate environmental and social vulnerabilities. Full article

Background: Clinician empathy is associated with family satisfaction and reduced anxiety, but quantitative data from the parents’ perspective in pediatric psychiatry are limited. Objective: To assess parent-perceived physician empathy in pediatric psychiatry consultations and explore its associations with clinical and demographic factors. Methods: Cross-sectional, consecutive sample of parents attending an outpatient pediatric psychiatry clinic (n = 163 parents). A 10-item behavioral empathy scale (range 10–40) was used. Analyses included reliability testing, group comparisons, correlations, OLS regression, and exploratory PCA. Results: The mean total empathy score was 34.5 (SD 4.2); most parents rated physicians as highly empathic (65%). Parents of children with ASD reported lower empathy compared to those with anxiety/depression. Empathy increased modestly with child age and was associated with a calmer state at the end of the visit. PCA suggested exploratory evidence of potential subdimensions, including child-centered communication and listening/facilitation. Conclusions: Parent-perceived empathy in this sample was generally high; however, behaviors that directly involve and facilitate the child (listening, encouraging questions) may need strengthening, particularly for children with ASD. Results should be interpreted in light of the single-center design, the absence of a recorded participation rate, parent-proxy reporting, and the exploratory nature of the PCA. Full article

Spatial density, as a key indicator of the quality of the urban residential environment, comprises both physical and perceived dimensions. Physical density refers to objective spatial characteristics (e.g., building density and population density), whereas perceived density denotes residents’ perceptual evaluations (e.g., perceived crowding, visual openness, and overall environmental quality). Clarifying the relationship between physical and perceived density is therefore critical for advancing livability-oriented urban planning and design. This study examines the relationship through an empirical analysis of 50 representative high-density communities in Guangzhou. Using morphological classification, descriptive statistics, and multiple linear regression, the analysis compares objective density indicators with residents’ perceptual evaluations and identifies key environmental factors that shape perceived density. Findings indicate that physical and perceived density are not fully aligned: compact but coherent spatial forms can enhance residents’ perceptual evaluations, whereas overcrowded and deteriorating environments intensify negative perceptions. The identified community typologies—for example, urban villages, traditional walk-up estates, and modern high-rise complexes—exhibit distinct perceptual patterns and influencing factors. These results highlight the need for density regulation to move beyond conventional physical indicators and to incorporate perceptual dimensions into planning frameworks. Overall, the study provides theoretical insights and practical guidance for tailored strategies in the renewal and management of high-density communities. Full article

Driving-impairing medicines (DIMs) are associated with an increased risk of traffic accidents. While Dutch pharmacy staff are expected to counsel patients at the first and second dispense of DIMs, current practice suggests that second-dispense consultations are underutilized. This study explored pharmacy staff’s experiences and perceived barriers in addressing driving impairment during the second dispense. Qualitative, semi-structured interviews were performed with 17 staff members in community pharmacies across the Netherlands. Transcripts were coded using thematic analysis in Atlas.ti, applying both deductive and inductive coding strategies to explore current practices and improvement needs. Participants reported that they provided detailed information on medication use, side effects, and driving impairment during the first dispense. In contrast, driving fitness was only discussed during the second dispense when patients initiated the topic, which rarely happened. Barriers to discuss DIMs included time constraints, a lack of protocols or prompts in pharmacy software, limited privacy, and patients’ reluctance to communicate about this topic. Many pharmacy technicians relied on closed questioning and observed a lack of patient initiative. Facilitators included strong patient relationships, access to medical records, and a desire for training in consultation skills. Pharmacy staff expressed the need for improved protocols, better ICT (Information and Communication Technology) integration, and targeted communication tools to support safe use of DIMs. In conclusion, second-dispense consultations for DIMs are underused and can support patients in safer medication use. Improved implementation will lead to better-informed choices about medicines and driving, and strengthen the pharmacy’s contribution to traffic safety. Full article

In the long-term evolutionary process, species maintain a natural balance within certain limits through communication. As plants grow and function as producers, root enrichment fosters a dynamic rhizosphere microbiome, which serves not only as a disintegrator within the ecological niche but also as a medium for interaction between the host and the soil environment. The life cycle of fungi within the microbiome alternates between single-cell resting spores and multicellular trophic mycelia. This cycle not only establishes a stable rhizosphere environment but also plays a crucial role in regulating both intra- and interspecific information transmission, significantly impacting the environment and plant health. The rhizosphere microbiome, particularly the fungi it contains, can be harnessed to repair environmental damage and either promote the growth of the plant host or inhibit pathogens. However, the mechanisms underlying these actions remain inadequately understood, hindering the advancement of artificial regulation. Additionally, the variability of influencing factors, along with unstable genes and traits, poses challenges to industrial development. In conclusion, this paper focuses on the fungal components of the rhizosphere microbiome, introduces the mechanisms of communication and current applications, and further analyzes existing bottlenecks and potential solutions. The aim is to provide theoretical support for achieving green, sustainable agriculture through biological means. Full article

Drawing upon the works of Kazadi wa Mukuma, Gerhard Kubik, Carlos de Lima, Vivian Gotheim, Wilson Nogueira, Temitope Fagunwa, and Alaba Simpson, this study traced the evolution of Bumba-Meu-Boi from its regional origins in Maranhao, Brazil, to its adaptation in Lagos, Nigeria, as an Afro-Brazilian returnee festival within the context of Lagos carnival. Beyond serving as a crucible for the historical return of repatriated Africans from Brazil following abolition of slavery in Brazil, the study also documents how the Afro-Brazilian community has been fully integrated into the Nigerian society. Through the formation of a thriving Brazilian Descendants Association, the Brazilian community has been able to sustain their Afro-Brazilian heritage through social events and community impact by preserving Brazilian architecture, culinary knowledge, festivals, teaching of Portuguese language, and the celebration of their Afro-Brazilian genealogical past. Full article

The NewEcoSmart project addresses the need to foster inclusive green and digital transitions in rural habitat sectors by systematically assessing local socio-technical readiness and tailoring capacity-building interventions. We adapted the validated SCIROCCO Exchange Maturity Self-Assessment Tool—selecting eight dimensions relevant to environmental, technological and social innovation—and conducted a two-phase evaluation across three pilot sites in Italy, Portugal and Spain. Phase 1 mapped stakeholder evidence against predefined criteria; Phase 2 engaged local actors (45+ adults, SMEs and micro-firms) in a self-assessment to determine digital, green and entrepreneurial skill gaps. For each domain of the SCIROCCO Tool, local actors can assign a minimum of 0 to a maximum of 5. The final score of the SCIROCCO tool can be a minimum of 0 to a maximum of 40. Quantitative maturity scores revealed heterogeneous profiles (Pacentro and Majella Madre = 5; Yecla = 10; Adelo Area = 23), underscoring diverse ecosystem strengths and limitations. A qualitative analysis, framed by Smart Healthy Age-Friendly Environments (SHAFE) domains, identified emergent training needs that are clustered at three levels: MACRO (community-wide awareness and engagement), MESO (decision-maker capacity for strategic planning and governance) and MICRO (industry-specific practical skills). The adapted SCIROCCO tool effectively proposes the assessment of socio-technical maturity in rural contexts and guides the design of a modular, multi-layered training framework. These findings support the need for scalable deployment of interventions that are targeted to the maturity of the local ecosystems to accelerate innovations through equitable green and digital transformations in complex socio-cultural settings. Full article

The formation of an emotional bond with young people’s parents is crucial for healthy development and serves as a model for future relationships. Disruptions to this bond can result in neurobiological consequences, manifesting as problematic behaviours and social deficits. Social-educational work in re-education facilities in Slovakia focuses on supporting and rehabilitating young people in conflict with the law, aiming for their reintegration into society. This study presents a qualitative analysis of social workers’ activities across 11 re-education facilities in Slovakia, utilizing semi-structured interviews, document analysis, and field observation. The findings reveal that social workers play an indispensable role in the re-education and resocialization process, providing emotional support, professional counselling, and coordination with multidisciplinary teams. Despite differences in client typology and methodologies among facilities, a shared emphasis exists on restoring social ties and personal development. The effectiveness of social work is influenced by adequate staffing, methodological support, and inter-ministerial cooperation. Implementing targeted recommendations could significantly enhance the effectiveness of the system and improve outcomes for children and young people in institutional care. This study contributes vital insights into how social workers must balance competing interests—such as individual therapeutic needs, institutional constraints, and family and community involvement—to successfully facilitate youth reintegration into society. Full article

As cities strive for human-centered and fine-tuned development, Agent-Based Modeling (ABM) has emerged as a powerful tool for simulating pedestrian behavior and optimizing walkable neighborhood design. This study presents a comparative bibliometric analysis of ABM applications in block-scale walkability research from 2015 to 2024, drawing on both Chinese- and English-language literature. Using visualization tools such as VOSviewer, the analysis reveals divergences in national trajectories, methodological approaches, and institutional logics. Chinese research demonstrates a policy-driven growth pattern, particularly following the introduction of the “15-Minute Community Life Circle” initiative, with an emphasis on neighborhood renewal, age-friendly design, and transit-oriented planning. In contrast, international studies show a steady output driven by technological innovation, integrating methods such as deep learning, semantic segmentation, and behavioral simulation to address climate resilience, equity, and mobility complexity. The study also classifies ABM applications into five key application domains, highlighting how Chinese and international studies differ in focus, data inputs, and implementation strategies. Despite these differences, both research streams recognize the value of ABM in transport planning, public health, and low-carbon urbanism. Key challenges identified include data scarcity, algorithmic limitations, and ethical concerns. The study concludes with future research directions, including multimodal data fusion, integration with extended reality, and the development of privacy-aware, cross-cultural modeling standards. These findings reinforce ABM’s potential as a smart urban simulation tool for advancing adaptive, human-centered, and sustainable neighborhood planning. Full article