Search Results (4,245)

Background/Objectives: Glidants and lubricants are commonly used pharmaceutical excipients that enhance powder flowability and reduce inter-particle friction, respectively, but they also negatively impact critical quality attributes such as tablet tensile strength and drug release rate. Quantifying these effects is essential as the pharmaceutical industry transitions from batch to continuous manufacturing. Methods: This study develops a rational-function-based modeling approach to capture the effects of lubricants and glidants on tableting. The framework automatically identifies upstream critical material attributes and process parameters, such as excipient concentration and mixing time, and describes their coupling to first and second orders. Reduced-order models were constructed to evaluate the influence of these variables on the four stages of powder compaction—die filling, compaction, unloading, and ejection—using formulations composed of 10% acetaminophen, microcrystalline cellulose, and varying small concentrations of magnesium stearate or colloidal silica. Tablets were fabricated across a wide range of relative densities by varying dosing position and turret speed. Results: The modeling approach successfully quantified the effects of lubricant and glidant mixing conditions on each compaction stage, providing mechanistic insight into how upstream conditions propagate through the tableting process and influence critical quality attributes. Conclusions: Overall, the rational-function-based framework offers a systematic approach to quantify and predict the impact of lubricants and glidants on tablet performance, thereby enhancing product and process understanding in continuous manufacturing. Full article

This paper introduces a hypergraph-based formalism for modeling kinematic and dynamic structures in robotics, addressing limitations of the existing formats such as Unified Robot Description Format (URDF), MuJoCo-XML, and Simulation Description Format (SDF). Our method represents mechanical constraints and connections as hyperedges, enabling the native description of multi-joint closures, tendon-driven actuation, and multi-physics coupling. We present a tensor-based representation derived via star-expansion, implemented in the Hypergraph Model Cognition Framework (HyMeKo) language. Comparative experiments show a substantial reduction in model verbosity compared to URDF while retaining expressiveness for large-language model integration. The approach is demonstrated on simple robotic arms and a quarter vehicle model, with derived state-space equations. This work suggests that hypergraph-based models can provide a modular, compact, and semantically rich alternative for the next-generation simulation and design workflows. The introduced formalism reaches 50% reduction compared to URDF descriptions and 20% reduction compared to MuJoCo-XML descriptions. Full article

Urban growth models often prioritize environmental and accessibility factors while underestimating behavioral and functional dynamics. This study develops a POI-enhanced Cellular Automata (CA) framework to simulate urban expansion by incorporating three semantic indicators derived from Point-of-Interest (POI) data—density (PD), diversity (PDI), and functional centrality (FC). Taking Yan’an, China, as a case, the model integrates these indicators with terrain and infrastructure variables via logistic regression to estimate land-use transition probabilities. To ensure robustness, spatial block cross-validation was adopted to reduce spatial autocorrelation bias. Results show that the POI-based model outperforms the baseline in both Kappa and Figure of Merit metrics. High-density and mixed-function POI zones correspond with compact infill growth, while high-centrality zones predict decentralized expansion beyond administrative cores. These findings highlight how functional semantics sharpen spatial prediction and uncover latent behavioral demand. Policy implications include using POI-informed maps for adaptive zoning, ecological buffer protection, and growth hotspot management. The study contributes a transferable workflow for embedding behavioral logic into spatial simulation. However, limitations remain: the model relies on static POI data, omits vertical (3D) development, and lacks direct comparison with alternative models like Random Forest or SVM. Future research could explore dynamic POI trajectories, integrate 3D building forms, or adopt agent-based modeling for richer institutional representation. Overall, the approach enhances both the accuracy and interpretability of urban growth modeling, providing a flexible tool for planning in functionally evolving and ecologically constrained cities. Full article

As network automation and self-organizing networks (SONs) rapidly evolve, edge devices increasingly demand lightweight, real-time, and high-precision classification algorithms to support critical tasks such as traffic identification, intrusion detection, and fault diagnosis. In recent years, cross-entropy (CE) loss has been widely adopted in deep learning classification tasks due to its computational efficiency and ease of optimization. However, traditional CE methods primarily focus on class separability without explicitly constraining intra-class compactness and inter-class boundaries in the feature space, thereby limiting their generalization performance on complex classification tasks. To address this issue, we propose a novel classification loss framework—Contrastive Geometric Cross-Entropy (CGCE). Without incurring additional computational or memory overhead, CGCE explicitly introduces learnable class representation vectors and constructs the loss function based on the dot-product similarity between features and these class representations, thus explicitly reinforcing geometric constraints in the feature space. This mechanism effectively enhances intra-class compactness and inter-class separability. Theoretical analysis further demonstrates that minimizing the CGCE loss naturally induces clear and measurable geometric class boundaries in the feature space, a desirable property absent from traditional CE methods. Furthermore, CGCE can seamlessly incorporate the prior knowledge of pretrained models, converging rapidly within only a few training epochs (for example, on the CIFAR-10 dataset using the ViT model, a single training epoch is sufficient to reach 99% of the final training accuracy.) Experimental results on both text and image classification tasks show that CGCE achieves accuracy improvements of up to 2% over traditional CE methods, exhibiting stronger generalization capabilities under challenging scenarios such as class imbalance, few-shot learning, and noisy labels. These findings indicate that CGCE has significant potential as a superior alternative to traditional CE methods. Full article

Osseodensification (OD) compacts trabecular bone during implant site preparation rather than removing it, potentially enhancing primary stability versus conventional drilling. This review critically appraised clinical and preclinical evidence for OD’s biological and biomechanical efficacy in implant dentistry. We conducted electronic searches in seven databases (PubMed, Scopus, Web of Science, ScienceDirect, SciELO, LILACS, DOAJ) for the period January 2014 to March 2024. Studies comparing osseodensification with conventional drilling in clinical and large-animal models were included. Primary outcomes were insertion torque, implant stability quotient (ISQ), bone-to-implant contact (BIC), bone area fraction occupancy (BAFO), and complications. Of 75 retrieved records, 38 studies (27 clinical, 11 preclinical) provided analysable data. Based on descriptive averages from the narrative synthesis, osseodensification increased mean insertion torque by around 45% (range 32–59%) and initial ISQ by 3–10 units compared with conventional drilling. These gains permitted immediate loading in 78% of cases and shortened operating time (mean reduction 15–20 min). Animal studies demonstrated 12–28% higher BIC and increased peri-implant bone density at 4–12 weeks. No serious adverse events were recorded. Postoperative morbidity was similar between techniques. The collated evidence indicates that osseodensification significantly improves primary stability and may accelerate healing protocols, particularly in low-density (Misch D3–D4) bone. However, the predominance of short-term data and heterogeneity in surgical parameters limit definitive conclusions. Long-term randomised controlled trials with standardised protocols are needed before universal clinical recommendations can be established. Full article

Selective laser melting (SLM) builds metal parts layer by layer by locally melting powder with a fine laser beam, generating complex, geometry-dependent temperature gradients that govern density, microstructure, defects, and residual stresses. Resolving these gradients with high-fidelity finite-element (FE) models is prohibitively slow because the temperature field must be evaluated at dense points along every scan track across multiple layers, while the laser spot is orders of magnitude smaller than typical layer dimensions. This study replaces FE analysis with a deep neural network that predicts the end-of-build temperature field orders of magnitude faster. A benchmark part containing characteristic shape features is introduced to supply diverse training cases, and a novel control-volume-based geometry-abstraction scheme encodes arbitrary workpiece shapes into compact, learnable descriptors. Thermal simulation data from the benchmark train the network, which then predicts the residual temperature field of an unseen, geometrically dissimilar part with a mean absolute error of ~10 K and a mean relative error of ~1% across 500–1300 K. The approach thus offers a rapid, accurate surrogate for FE simulations, enabling efficient temperature-driven optimization of SLM process parameters and part designs. Full article

Wind turbine blade damage detection is crucial for advancing wind energy as a sustainable alternative to fossil fuels. Existing methods based on image processing technologies face challenges such as limited adaptability to complex environments, trade-offs between model accuracy and computational efficiency, and inadequate real-time inference capabilities. In response to these limitations, we put forward MSWindD-YOLO, a lightweight real-time detection model for wind turbine blade damage. Building upon YOLOv5s, our work introduces three key improvements: (1) the replacement of the Focus module with the Stem module to enhance computational efficiency and multi-scale feature fusion, integrating EfficientNetV2 structures for improved feature extraction and lightweight design, while retaining the SPPF module for multi-scale context awareness; (2) the substitution of the C3 module with the GBC3-FEA module to reduce computational redundancy, coupled with the incorporation of the CBAM attention mechanism at the neck network’s terminus to amplify critical features; and (3) the adoption of Shape-IoU loss function instead of CIoU loss function to facilitate faster model convergence and enhance localization accuracy. Evaluated on the Wind Turbine Blade Damage Visual Analysis Dataset (WTBDVA), MSWindD-YOLO achieves a precision of 95.9%, a recall of 96.3%, an mAP@0.5 of 93.7%, and an mAP@0.5:0.95 of 87.5%. With a compact size of 3.12 MB and 22.4 GFLOPs inference cost, it maintains high efficiency. After TensorRT acceleration on Jetson Orin NX, the model attains 43 FPS under FP16 quantization for real-time damage detection. Consequently, the proposed MSWindD-YOLO model not only elevates detection accuracy and inference efficiency but also achieves significant model compression. Its deployment-compatible performance in edge environments fulfills stringent industrial demands, ultimately advancing sustainable wind energy operations through lightweight lifecycle maintenance solutions for wind farms. Full article

This study focuses on enhancing the comprehensive utilisation of rice straw by proposing a vibration-assisted compression technology, with the aim of resolving inherent issues in traditional baling, such as uneven compression and low density. This study designed a multi-point vibration-assisted compression test rig and established a vibration-enhanced compression mechanical model based on the physical properties of rice straw. By integrating discrete element method (DEM) simulations with bench testing, the optimal length-to-width ratio of 1:1 was identified for achieving superior compaction quality. A systematic analysis was conducted to evaluate the effects of vibration point configuration, frequency, and amplitude control on straw bale integrity. The results of the DEM simulations demonstrated that vibration-assisted compression significantly enhanced the compaction uniformity and stability of rice straw. The dimensional stability coefficient and pressure transmission rates of the straw bales reached 88.25% and 58.04%, respectively, validating the efficacy of the vibration-assisted compression technique. This study provides innovative concepts and theoretical foundations for optimising the design of straw baling and in-field collection equipment. It holds critical significance for advancing the resource-efficient utilisation of agricultural residues and promoting sustainable agricultural practices. Full article

Cell towers play a key role in providing telecommunications infrastructure, especially in remote mountainous regions. This paper presents an approach to the efficient design of 42-metre-high cell towers intended to install high-power equipment in remote mountainous regions of the Carpathians (750 m above sea level). The region requires rapid deployment of many standardized towers adapted to geographical features. The main design challenges were the limited space available for the base, the impact of extreme weather conditions, and the need for a fast project implementation due to the critical importance of ensuring stable communication. Special methodological attention is given to how the transition between pyramidal and prismatic segments in cell tower shafts influences overall structural performance. The effect of this geometric boundary on structural efficiency and material usage has not been addressed in previous studies. A dedicated investigation shows that positioning the transition at a height of 33 m yields the best compromise between stiffness and weight, minimizing a generalized penalty function that accounts for both the horizontal displacement of the tower top and its total mass. Modal analysis confirms that the chosen configuration maintains a natural frequency of 1.68 Hz, ensuring a safe margin from resonance. For the final analysis of the behavior of towers with elements of different cross-sectional shapes, finite element modeling was used for a detailed numerical study of their structural and performance characteristics. This allowed us to assess the impact of geometric constraints of structures and take into account the most unfavorable combinations of static and dynamic loads. The study yields a concise rule of thumb for towers with compact foundations, namely that the pyramidal-to-prismatic transition should be placed at roughly 78–80% of the total tower height. Full article

The Bacillus anthracis pXO1 plasmid, encoding ~143 proteins, presents a compact model for exploring protein function and evolutionary patterns using protein language models. Due to the organism’s slow evolutionary rate, its limited amino acid variation enhances detection of physiologically relevant patterns in plasmid protein composition. In this study, we applied embedding-based analyses and machine learning methods to characterize pXO1 protein modules across diverse B. anthracis lineages. We generated protein sequence embeddings, constructed phylogenies, and compared plasmid content with whole genome variation. While whole genome and plasmid-based phylogenies diverge, the composition of proteins encoded along the pXO1 plasmid revealed lineage specific structure. Association rule mining combined with decision tree classification produced plasmid-encoded targets for assessing anthrax sublineage, which yielded functionally redundant protein modules that reflected geographic and phylogenetic patterns. A conserved DNA replication module exhibited both shared and B. anthracis lineage specific features. These results show that pXO1 plasmid protein modules contain biologically meaningful and evolutionarily informative signatures, exemplifying their value in phylogeographic characterizations of bacterial pathogens. This framework can be extended to study additional virulence plasmids across Bacillus and other environmental pathogens using scalable protein language model tools. Full article

Accurate estimation of chlorophyll and nitrogen content in tea leaves is essential for effective nutrient management. This study introduces a proof-of-concept dual-view RGB regression framework developed under controlled scanner conditions. Paired adaxial and abaxial images of Yun Kang 10 tea leaves were collected from four villages in Lincang, Yunnan, alongside corresponding soil and plant analyzer development (SPAD) and nitrogen measurements. A lightweight dual-input CoAtNet backbone with streamlined Bneck modules was designed, and three fusion strategies, Pre-fusion, Mid-fusion, and Late-fusion, were systematically compared. Ten-fold cross-validation revealed that Mid-fusion delivered the best performance ($R^2$ = 94.19% ± 1.75%, root mean square error ($RMSE$) = 3.84 ± 0.65, $MAE$ = 3.00 ± 0.45) with only 1.92 M parameters, outperforming both the single-view baseline and other compact models. Transferability was further validated on a combined smartphone–scanner dataset, where the framework maintained robust accuracy. Overall, these findings demonstrate a compact and effective system for non-destructive biochemical trait estimation, providing a strong foundation for future adaptation to field conditions and broader crop applications. Full article

Wi-Fi sensing has emerged as a powerful approach to Human Activity Recognition (HAR) by utilizing Channel State Information (CSI). However, current implementations face two significant challenges: reliance on firmware-modified hardware for CSI collection and dependence on GPU/cloud-based deep learning models for inference. To address these limitations, we propose a two-fold embedded solution: a novel CSI collection tool built on low-cost microcontrollers that surpass existing embedded alternatives in packet rate efficiency under standard baud rate conditions and an optimized DenseNet-based HAR model deployable on resource-constrained edge devices without cloud dependency. In addition, a new HAR dataset is presented. To deal with the scarcity of training data, an Empirical Mode Decomposition (EMD)-based data augmentation method is presented. With this strategy, it was possible to enhance model accuracy from 59.91% to 97.55%. Leveraging this enhanced dataset, a compact DenseNet variant is presented. An accuracy of 92.43% at 232 ms inference latency is achieved when implemented on an ESP32-S3 microcontroller. Using as little as 127 kB of memory, the proposed model offers acceptable performance in terms of accuracy and privacy-preserving HAR at the edge; it also represents a scalable and low-cost Wi-Fi sensing solution. Full article

The growing penetration of distributed photovoltaic (PV) systems presents significant operational challenges for power grids, driven by the scarcity of historical data and the high spatiotemporal variability of PV generation. To address these challenges, we propose Generative Reconstruction and Adaptive Identification via Latents (GRAIL), a unified, end-to-end framework that integrates generative modeling with adaptive clustering to discover latent structures and representative scenarios in PV datasets. GRAIL operates through a closed-loop mechanism where clustering feedback guides a cluster-aware data generation process, and the resulting generative augmentation strengthens partitioning in the latent space. Evaluated on a real-world, multi-site PV dataset with a high missing data rate of $45.4\%$, GRAIL consistently outperforms both classical clustering algorithms and deep embedding-based methods. Specifically, GRAIL achieves a Silhouette Score of 0.969, a Calinski–Harabasz index exceeding $4.132\times {10}^6$, and a Davies–Bouldin index of $0.042$, demonstrating superior intra-cluster compactness and inter-cluster separation. The framework also yields a normalized entropy of $0.994$, which indicates highly balanced partitioning. These results underscore that coupling data generation with clustering is a powerful strategy for expressive and robust structure learning in data-sparse environments. Notably, GRAIL achieves significant performance gains over the strongest deep learning baseline that lacks a generative component, securing the highest composite score among all evaluated methods. The framework is also computationally efficient. Its alternating optimization converges rapidly, and clustering and reconstruction metrics stabilize within approximately six iterations. Beyond quantitative performance, GRAIL produces physically interpretable clusters that correspond to distinct weather-driven regimes and capture cross-site dependencies. These clusters serve as compact and robust state descriptors, valuable for downstream applications such as PV forecasting, dispatch optimization, and intelligent energy management in modern power systems. Full article

Content delivery networks (CDNs) face steadily rising, uneven demand, straining heuristic cache replacement. Reinforcement learning (RL) is promising, but most work assumes a fully observable Markov Decision Process (MDP), unrealistic under delayed, partial, and noisy signals. We model cache replacement as a Partially Observable MDP (POMDP) and present the Miss-Triggered Cache Transformer (MTCT), a Transformer-decoder Q-learning agent that encodes recent histories with self-attention. MTCT invokes its policy only on cache misses to align compute with informative events and uses a delayed-hit reward to propagate information from hits. A compact, rank-based action set (12 actions by default) captures popularity–recency trade-offs with complexity independent of cache capacity. We evaluate MTCT on a real trace (MovieLens) and two synthetic workloads (Mandelbrot–Zipf, Pareto) against Adaptive Replacement Cache (ARC), Windowed TinyLFU (W-TinyLFU), classical heuristics, and Double Deep Q-Network (DDQN). MTCT achieves the best or statistically comparable cache-hit rates on most cache sizes; e.g., on MovieLens at $M=600$, it reaches $0.4703$ (DDQN $0.4436$, ARC $0.4513$). Miss-triggered inference also lowers mean wall-clock time per episode; Transformer inference is well suited to modern hardware acceleration. Ablations support $CL=50$ and show that finer action grids improve stability and final accuracy. Full article

This study focuses on the mathematical method developed by integrating the surrogate model as constraints for wall stability into the heuristic optimization algorithm to gain the optimum cost and ${\mathrm{CO}}_2$ emission value of the gabion retaining wall (GRW). This study also includes the comparison of optimum GRW results with optimum cantilever retaining wall (CRW) designs for different design cases. The Harmony Search Algorithm (HSA), which efficiently explores the design space and robustly reaches the optimum result in solving optimization problems, was used as the heuristic optimization algorithm. The primary construction scenario was considered as an optimization problem, which involved excavating the slope, constructing the wall, and compacting the backfill soil to minimize the cost and CO${}_2$ emissions for separate objective functions of GRW and CRW designs. Comparative results show that GRWs outperform CRWs in terms of sustainability and cost-efficiency, achieving 55% lower cost and 78% lower CO${}_2$ emissions on average, while the HSA–surrogate model provides a fast and accurate solution for geotechnical design problems. The surrogate models for sliding, overturning, and slope stability safety factors of GRW exhibited exceptional accuracy, characterized by minimal error values (MSE, RMSE, MAE, MAPE) and robust determination coefficients ($R^2\approx 0.99$), hence affirming their dependability in safety factor assessment. By integrating the surrogate model based on the statistical method into the optimization algorithm, a quick examination of the wall’s stability was performed, reducing the required computational power. Full article