Search Results (13,740)

In order to investigate the cumulative deformation characteristics of silt soil in highway subgrade engineering, dynamic triaxial tests were carried out to examine the influences of dynamic stress, confining pressure, and moisture content on the cumulative plastic strain of silt soil under traffic loading conditions. Particle Swarm Optimization (PSO) is employed to enhance the prediction performance of cumulative plastic strain in silt soils. Specifically, the architecture of the traditional Backpropagation (BP) neural network is optimized for its learning process, and weight parameters are introduced to achieve more effective control over the development and analysis of prediction results. Furthermore, this optimized neural network also enables more accurate predictions regarding multiple influencing factors, which further improves the overall accuracy of the prediction outcomes. The results show that. The cumulative deformation of the silt soil decreases gradually with increasing confining pressure. The cumulative deformation decreases from 3.32 percent to 2.82 percent when the confining pressure increases from 60 kPa to 150 kPa. With the increase in dynamic stress and moisture content, the cumulative deformation gradually increases. The cumulative deformation rate was derived from the cumulative deformation and the number of loading cycles, and it was found that the cumulative deformation rate decreases gradually with the increase in the number of cycles. Specifically, when the moisture content is 17.4%, the cumulative deformation rate decreases from 0.3912 to 4.54 × 10⁻⁵ as the number of cycles increases from 1 to 10,000. Based on the cumulative deformation test data of silt soil, the Monismith model was applied to predict plastic deformation. Meanwhile, a cumulative plastic deformation prediction model was constructed by leveraging the learning capability of the PSO-BP neural network, which incorporates multiple influencing factors including moisture content, confining pressure, and dynamic stress magnitude. By comparing the three cumulative deformation prediction models (i.e., the Monismith model, the traditional BP neural network model, and the PSO-BP neural network model), it was found that the PSO-BP neural network model exhibits the optimal prediction performance, with its correlation coefficient (R²) all exceeding 0.99. Full article

In consideration of the characteristics of two-stage (stable and degraded), nonlinearity and non-stationary randomness in the full life-cycle evolution process of the rolling bearing health indicator (HI), a novel remaining useful life (RUL) prediction method for rolling bearings is proposed based on long short-term memory network–Mahalanobis distance (LSTM-MD) and an incremental unscented Kalman filter (IUKF). First, an LSTM-MD hybrid algorithm is developed to precisely identify the critical change point (CP) between stable operation and incipient degradation in bearing HI trajectories, effectively mitigating the susceptibility of conventional threshold-based methods to HI fluctuations. Second, during the degradation stage, a degradation analysis model based on the nonlinear Wiener process is constructed. Simultaneously, an IUKF-based RUL prediction method for bearings is proposed, which overcomes the implicit assumption of the traditional UKF method that one-step prediction can replace state prediction, particularly in scenarios with significant HI fluctuations, thereby significantly reducing prediction errors. Finally, the proposed method is validated through comparisons with traditional methods using both the XJTU-SY public dataset and a self-built bearing test dataset. The results demonstrate that compared to traditional methods, the accuracy of initial degradation change point identification is improved by 32.6%, and the root mean square error (MSE) of RUL prediction is decreased by 41.8%. Full article

The present study explores the production of metallized titanomagnetite briquettes, with a view to addressing two key issues. Firstly, it seeks to address the growing shortage of high-quality iron-bearing raw materials. Secondly, it looks at how to meet the increasingly stringent environmental constraints. The conventional blast-furnace treatment of titanomagnetite is hindered by the formation of refractory Ti-rich slags. It is hereby proposed that a single-cycle briquetting process in conjunction with a thermal reduction route should be utilized. This approach enables precise regulation of the Fe/flux ratio. Experiments were conducted on a low-grade titanomagnetite concentrate (68.5% Fe) from the Pervouralsk deposit (Russia). Cylindrical briquettes (D 15–20 mm, h 8–10 mm) were subjected to a pressure of 300 MPa during the pressing process, with the utilization of diverse binders comprising rubber cement, CaO, graphite + water, and basic oxygen-furnace (BOF) slag + sodium silicate. Following an oxidative pre-heating process at 1300 °C for two hours, followed by a gas-based reduction process at 1050 °C for three hours, with a CO/N₂ ratio of 90/10, the products demonstrated an oxidation rate of 85–95% and a cold compression strength of 16–80 MPa. The highest observed strength (80 MPa) was obtained with a binder comprising CaO·MgO·2SiO₂ (diopside/merwinite), which forms a low-viscosity melt, fills 90% of pores and crystallizes as acicular Mg-SFCA-I during cooling. Conversely, the CaO·TiO₂ and FeO·TiO₂ + Fe₃C associations yield brittle structures and a maximum strength of 16 MPa. The optimum briquette (0.55% CaO, D/H = 20/10 mm) exhibited a 95.7% metallization degree, a compressive strength of 48.9 MPa, and dimensional changes within acceptable limits, thus fulfilling the requirements for electric arc furnace feedstock. Further research is required in the form of a full Life Cycle Assessment and pilot-scale testing. However, the results obtained thus far confirm that titanomagnetite briquettes with a binder consisting of CaO, MgO and SiO₂ are a promising alternative to pellets for low-carbon steelmaking. Full article

In this study, we investigate the mechanical energy absorption performance of reusable 3D-printed honeycomb structures fabricated using fused deposition modeling with three thermoplastic polyurethane variants: TPU 70A, TPU 85A, and TPU 95A. Prior to manufacturing, the mechanical properties of the TPU filaments were analyzed as a function of printing temperature to optimize tensile strength and layer adhesion. Four honeycomb configurations, including hexagonal and circular cell geometries, both with and without a 30° twist, were subjected to out-of-plane compression testing to evaluate energy absorption efficiency, specific energy absorption, and crushing load efficiency. The highest energy absorption efficiency, 47%, was achieved by the hexagonal honeycomb structure fabricated from TPU 95A, surpassing the expected values for expanded polystyrene and approaching the performance reported for high-cost advanced lattice structures. Additionally, twisted honeycomb configurations exhibited improved crushing load efficiency values (up to 73.5%), indicating better stress distribution and enhanced reusability. Despite variations in absorbed energy, TPU 95A demonstrated the best balance of elasticity, structural integrity, and reusability across multiple compression cycles. These findings suggest that TPU-based honeycomb structures could provide a viable, cost-effective alternative for energy-absorbing applications in impact protection systems, automotive safety, and sports equipment. Full article

The increasing occurrence of extreme rainfall events often leads to flash floods, infrastructure damage, loss of human life, and significant economic impacts. There is a pressing need for data-driven assessments and the application of robust analytical approaches to better understand these changes. Analyzing ground-level daily rainfall data from 1985 to 2023 from 26 monitoring stations, this study first employs the Mann–Kendall test using robust statistics including minimum, median, various quartiles, and maximum rainfall values for detecting long-term trends across Saudi Arabia. Next, the k-means clustering technique is applied to characterize the annual rainfall cycles across different regions of the country. Finally, the Peaks Over Threshold (POT) approach within Extreme Value Theory (EVT) is employed to identify site-specific thresholds for extreme rainfall using the Generalized Pareto Distribution (GPD). This automated, data-driven method offers a more objective alternative to the commonly used ad hoc percentile-based threshold selection, thereby enhancing the rigour and reproducibility of extreme rainfall analysis. Local specific thresholds were computed ranging from about 16 to 47 mm from Arar and Jazan, respectively. These thresholds were then used to calculate the frequency and intensity of extreme rainfall events. The fitted GPD parameters were further used to estimate return levels (RLs) for different return periods (2-, 5-, 10-, 20-, 50-, and 100-year) into the future. The results underscore considerable spatial variability in extreme rainfall behaviour across Saudi Arabia, with a higher likelihood of intense and infrequent precipitation events in the coming decades. Full article

One of the best-known flavonoid chrysin was coupled at position 7 with several trisubstituted phosphine derivatives with a flexible spacer, and their in vitro anticancer activities were investigated on 60 human tumor cell lines (NCI60) and on several gynecological cancer cells. The trisubstituted phosphines contained different substituents on the aromatic ring(s), e.g., methyl and methoxy groups or fluoro atoms. The phosphorus atom was substituted not only with aromatic rings but with cyclohexyl substituents. The ionic phosphonium building block is important because it allows the therapeutic agents to transfer across the cell membrane. Therefore, the pharmacophores linked to it can exert their effects in the mitochondria. Instead of the ionic phosphonium element, a neutral moiety, namely the triphenylmethyl group, was also added to the side chain, being sterically similar but without a charge and phosphorus atom. Most of the hybrids exhibited low micromolar growth inhibition (GI₅₀) values against the majority of the tested cell lines. Notably, conjugate 3f stood out, demonstrating nanomolar antitumor activity against the K-562 leukemia cell line (GI₅₀ = 34 nM). One selected compound (3i) with promising cancer selectivity elicited cell cycle disturbances and inhibited the migration of breast cancer. The tumor-selectivity of 3a and 3f was assessed based on their effects on non-tumor Chinese hamster ovary (CHO) cells using the CellTiter-Glo Luminescent Cell Viability Assay. Given their estimated half-maximal inhibitory concentration (IC₅₀) values on non-tumor CHO cells (2.65 µM and 1.15 µM, respectively), these conjugates demonstrate promising selectivity toward several cancer cell lines. The excellent results obtained may serve as good starting points for further optimization and the design of even more effective flavonoid- and/or phosphonium-based drugs. Full article

Silver and gold nanoparticles (NPs) have gained considerable attention in recent years due to their wide-ranging applications in medicine, agriculture, industry, and other fields where they may interact with the environment. Green synthesis of NPs supports sustainability by reducing chemical waste and energy use while improving their biocompatibility through plant phytochemicals. Accordingly, it is important to assess the effects of metal NPs on microorganisms, which play vital roles in ecosystems and biogeochemical cycles. This study aimed to investigate microbial growth dynamics in the presence of green-synthesized silver and gold NPs (using an aqueous extract of Mentha × piperita leaves) and to evaluate potential mechanisms of their interaction. Microorganisms were cultivated in 96-well microtiter plates, and growth curves were analyzed alongside bacterial enumeration on Petri plates. Silver NPs affected the growth of Brevundimonas vesicularis USM1, Pseudarthrobacter oxydans USM2, and Pseudomonas putida USM4, although these strains exhibited partial resistance. In contrast, gold NPs did not inhibit the growth of the tested strains. The ability of Brevundimonas vesicularis USM1 to precipitate metal NPs highlights its potential for sustainable bioremediation applications. The findings contribute to a better understanding of the environmental impact and sustainability aspects of silver and gold NPs in microbial systems. Full article

Music data exhibits numerous distinct symmetric and asymmetric patterns—ranging from symmetric pitch sequences and rhythmic cycles to asymmetric phrase structures and dynamic shifts. These varied and often subjective patterns present notable challenges for data analysis, such as distinguishing meaningful structural features from noise and adapting analytical methods to accommodate both regularity and irregularity. To tackle this challenge, we present a novel uncertain hypothesis test, referred to as the conservative hypothesis test, which is designed to assess the validity of statistical hypotheses associated with the symmetric and asymmetric patterns exhibited by two multivariate normal uncertain populations. Specifically, we extend the uncertain hypothesis test for the mean difference between two single-characteristic normal uncertain populations to the multivariate case, filling a research gap in uncertainty theory. Building on this two-population multivariate hypothesis test, we propose the conservative hypothesis test—a feasible uncertain hypothesis testing method for multivariable scenarios, developed based on multiple comparison procedures. To demonstrate the practical utility of these methods, we apply them to music-related statistical data, assessing whether two groups of evaluators use consistent criteria to score music. In essence, the hypothesis tests proposed in this paper hold significant value for social sciences, particularly music statistics, where data inherently contains ambiguity and uncertainty. Full article

West Nile fever is a mosquito-borne zoonotic disease caused by West Nile virus (WNV), maintained in an enzootic cycle between avian hosts and Culex mosquitoes. While birds are the principal reservoirs, WNV also infects a wide range of mammals, including humans, horses, and wildlife species. In this study, we assessed WNV seroprevalence in wild ungulates, wild boars, golden jackals, and the invasive rodent nutria in Serbia. A total of 522 serum samples from wild animals were tested. Antibodies against WNV were detected across all tested species, with seroprevalence rates of 37% in wild boars, 11.9% in nutrias, 32.4% in golden jackals, 50.6% in red deer, and 9.1% in roe deer. Detection of antibodies in both adults and juveniles provides evidence of recent transmission during the study period. These findings confirm widespread circulation of WNV in Serbian wildlife and suggest that wild ungulates, carnivores, and invasive rodents may serve as useful sentinel species for monitoring WNV prevalence and geographic spread in natural ecosystems. Full article

Under global warming, the rising frequency and intensity of extreme climate events pose challenges to disaster prevention and sustainable development. Based on daily meteorological observations from 1970 to 2020 in Jilin Province, this study analyzes the spatiotemporal evolution and driving mechanisms of extreme temperature and precipitation events. Linear trend analysis and the Mann–Kendall test were employed to examine temporal trends and abrupt change years in extreme temperature and precipitation indices. Wavelet analysis was used to identify dominant periodicities and multi-scale variability. Empirical Orthogonal Function Analysis (EOF) revealed the spatial distribution characteristics of variability in extreme precipitation and temperature across Jilin Province, identifying high-incidence zones for extreme temperature and precipitation events. Additionally, Pearson correlation analysis was to investigate the correlation patterns between extreme climate indices in Jilin Province and geographical environmental factors alongside atmospheric circulation indicators. Results show that: (1) Warm-related temperature indices display significant upward trends, while cold-related indices generally decline, with abrupt changes mainly occurring in the 1980s–1990s and dominant periodicities of 3–5 years. Precipitation indices, though variable, show general increases with 3–4year cycles. (2) Spatially, most indices follow an east–high to west–low gradient. Temperature indices exhibit spatial coherence, while precipitation indices vary, especially between the northwest and central-southern regions. (3) The Arctic Oscillation (AO) exhibits a significant negative correlation with the extreme cold index, with correlation coefficients ranging from −0.31 to −0.46. It shows a positive correlation with the extreme warm index, with correlation coefficients between 0.16 and 0.18, confirming its regulatory role in cold air activity over Northeast China, particularly elevation and latitude, influence the spatial distribution of precipitation. These findings enhance understanding of extreme climate behaviors in Northeast China and inform regional risk management strategies. Full article

To address the worsening energy crisis from rapid fossil fuel consumption, this study synthesized Ce-FeWO₄ composites and hydrophilic carbon nanotubes. XRD and other characterizations showed all intermediates had rough, porous nanosheet morphology; Ce-doping formed disordered porous structure in FeWO₄, increasing its specific surface area. Three-electrode tests confirmed optimal parameters: 0.5% Ce-doping and 12 h growth. Ce-FeWO₄ exhibited a specific capacity of 1875 ± 28 F/g at 1 A/g (based on five parallel samples), and retained 1807 F/g after 3000 cycles (exceeding previous studies) with excellent stability. The Ce-FeWO₄//CNTs asymmetric supercapacitor achieved 152 F/g specific capacity, 81.4 Wh/g energy density, and 768 W/kg power density. The simple, efficient, eco-friendly preparation process and the material’s high capacitance and stability offer broad application prospects in the electrode field. Full article

To improve the seismic performance of semi-rigid steel frame beam–column joints connected by T-stubs, reinforced T-stubs formed via wedge-shaped and thickening modifications are proposed. Taking the middle column joints in steel frames as the research objects, three types of beam–column joints are designed by adopting ordinary, wedge-shaped, and thickened wedge-shaped T-stubs. To conduct a comparative analysis of the seismic performance of the test specimens, this study imposes low-cycle cyclic loads on the column ends of each specimen along their major-axis and minor-axis in-planes. This loading protocol is adopted to simulate the dynamic responses of the specimens under bidirectional seismic action. Comparing the macroscopic failure phenomena of the specimens, the influence of reinforced T-stubs on the plastic development mode of the joints is analyzed. Based on seismic indicators such as hysteresis characteristics, skeleton curves, stiffness degradation, and energy dissipation capacity, the energy dissipation capacity of the specimens along the major-axis is greater than that along the minor-axis, but their deformation capacity is slightly reduced. The bearing capacity, energy dissipation, and rotational stiffness could be improved by reinforced T-stubs, but the deformation capacity is reduced to varying degrees. The stiffness degradation rate of the specimen adopting wedge-shaped T-stubs shows a more obvious accelerating trend. Through the comparative analysis of the three specimens based on the energy damage index, the results indicate that wedge-shaped T-stubs significantly increase the damage degree of the specimens, but thickened wedge-shaped T-stubs have a relatively small impact on the evolution of joint damage. Full article

In the saline, cold, and arid regions of Western China, the adhesive performance at the carbon fiber-reinforced polymer (CFRP)–concrete interface critically affects the long-term reliability of CFRP-strengthened structures. Replacing the organic epoxy resin (EP) with inorganic magnesium phosphate cement (MPC) has been proposed as an alternative. However, comparative studies on the deterioration of MPC- and EP-bonded CFRP–concrete under sulfate freeze–thaw cycles are limited. This study employed double-shear tests to systematically compare the failure modes, ductility, and bond performance of the CFRP–concrete interface bonded with MPC and EP after 25, 50, and 75 sulfate freeze–thaw cycles. The results indicate that, as the number of cycles increased, MPC-bonded specimens exhibited progressive interfacial peeling, whereas EP-bonded specimens underwent abrupt brittle fracture. At 0, 25, 50, and 75 cycles, the peak strains of MPC specimens exceeded those of EP specimens by 9.28%, 10.13%, 5.99%, and 0.86%, respectively, indicating greater ductility. Bond performance declined markedly for both groups as cycles increased, with MPC specimens showing greater deterioration. After 75 cycles, compared with EP-bonded specimens, MPC-bonded specimens showed a 16.56% lower interfacial load capacity, a 21.53% reduction in peak bond stress, and a 6.03% shorter effective bond length. This systematic comparison of MPC- and EP-bonded CFRP–concrete under sulfate freeze–thaw exposure provides guidance for adhesive selection and strengthening practices in saline, cold, and arid regions. Full article

Epilobium parviflorum Schreb. is used in folk and modern medicine for the treatment of prostate diseases. It is also known to alleviate gastrointestinal ailments. The aim of the present study is to define the chemical composition of diverse extracts from the herb, to test their inhibitory properties toward post-proline-specific peptidases and to elucidate the mechanisms of their antitumor activity on colorectal carcinoma cells in vitro. The extractions were performed using mono- or biphasic systems of solvents. Their chemical compositions were defined by LC-HRMS. Inhibitory properties towards prolyloligopeptidase (POP) and fibroblast activation protein (FAP) were studied by kinetic assays on human recombinant enzymes. Antioxidant activity was measured by three methods. Genotoxicity to HT-29 colorectal carcinoma cells was analyzed with the comet assay. FACS analyses and flow cytometry were used to evaluate the extracts effect on the cell cycle and their pro-apoptotic properties on HT-29 cells. The extract derived using 80% ethanol was chosen for the next studies due to its efficient and selective inhibition of POP. It contains mainly oenotein B and myricetin-3-O-rhamnoside. Its antioxidant and moderate genotoxic activities can contribute to the antitumor effect on HT-29 cells. The extract has a small effect on the cell cycle but a pronounced pro-apoptotic action on those cells. In conclusion, the 80% ethanol extract of E. parviflorum concentrates the ellagitannin oenotein B, which is a selective inhibitor of POP. Antitumor activity of the extract towards HT-29 cells may be due to the inhibition of POP, the antioxidant, genotoxic and pro-apoptotic activities. Full article

This study examines the seepage and damage behavior of coal under cyclic loading and unloading, typical in multi-layer coal seam mining. Four stress paths were designed: isobaric, stepwise, incrementally increasing, and cross-cyclic, based on real-time stress monitoring in protected coal strata. Seepage tests on gas-bearing coal were conducted using a fluid–solid coupled triaxial apparatus. The results show that axial compression most significantly affects axial strain, followed by volumetric strain, with minimal impact on radial strain. Permeability variation closely follows the stress–strain curve. Under isobaric cyclic loading (below specimen failure strength), specimens with higher initial damage (0.6) exhibit a sharp permeability decrease (75.47%) after the first cycle, with gradual recovery in subsequent cycles. In contrast, samples with lower initial damage (0.05) show higher permeability during loading, which eventually reverses, with unloading permeability surpassing loading permeability. Across all paths, a significant increase in residual deformation and permeability recovery exceeding 100% indicate the onset of instability. Continued cyclic loading increases damage accumulation, with different evolution patterns based on initial damage levels. These findings provide valuable insights into the pressure-relief permeability enhancement mechanism in coal seam mining and inform optimal gas drainage borehole design. Full article