Search Results (597)

Young people under the care of child protection agencies are at increased risk of entering the criminal justice system. Residential youth organisations support young people who are unable to reside with their families or in foster care. Youth workers in these environments ensure the safety and wellbeing of young people in their care, consequently supporting the wellbeing of the overall community. This research explored the views and experiences of Queensland residential youth workers via a focus group interview. The data captured a thick description of service delivery practices. Constructivist Grounded Theory was used to conceptualise a theoretical framework based on the various empirical realities of participants. The findings highlight occasions where complex power dynamics had damaging consequences for youth workers and young people. Participants explored systemic constraints and structural inequalities, thus detailing the implications of top-down organisational structures on their service delivery, safety, and outcomes for young people. Participants were concerned about the implications of interrupted attachment and young people’s progression into crime. Practice recommendations centre around improving the disconnection between front-line realities and systemic hierarchies. Residential out-of-home care service delivery should focus on building community connection and belonging; mental, emotional and physical safety; collaborative care; and support. Full article

Despite their crucial biological role as metabolites, reactive oxygen and reactive nitrogen species (ROS and RNS) can have a negative effect on organisms when their cellular contents overwhelm the normal equilibrium provided by antioxidant defenses. Important biomolecules, such as lipids, proteins, and nucleic acids (i.e., DNA), can be damaged by their oxidative effects, resulting in malfunction or a shorter lifespan of cells and, eventually, of the whole organism. Oxidative stress can be defined as the consequence of an imbalance of pro-oxidants and antioxidants due to external stress sources (e.g., exposure to xenobiotics, UV radiation, or thermic stress). It can be evaluated by monitoring specific biomarkers to determine the state of health of breathing organisms. Assessments of ROS, RNS, specific degenerative oxidative reaction products, and antioxidant system efficiency (antioxidant enzyme activities and antioxidant compound contents) have been extensively performed for this purpose. A wide variety of analytical methods for measuring these biomarkers exist in the literature; most of these methods involve indirect determination via spectrophotometric and spectrofluorometric techniques. This review reports a collection of studies from the last decade regarding contaminant-induced oxidative stress in insects, with a brief description of the analytical methods utilized. Full article

This study investigates the encroachment risk in the Makause informal settlement by analysing resident survey data to identify key contributing factors and build predictive models. Encroachment threatens the water infrastructure through damage, contamination, and service disruptions, highlighting the need for informed, community-based planning. The data was collected from 105 residents, with responses (“Yes,” “No,” “Unsure”) analysed using descriptive statistics and a one-way ANOVA to identify significant differences across categories. The ReliefF algorithm was used to rank the importance of features predicting the encroachment risk. These inputs were then used to train, validate, and test an Artificial Neural Network (ANN) model. The Artificial Neural Network demonstrated a high predictive accuracy, achieving correlation coefficients above 95% and low mean squared errors. The ANOVA identified statistically significant mean differences for selected variables, while ReliefF helped determine the most influential predictors. A high agreement level (p > 0.900) between predicted and actual responses confirmed the model’s validity. This research introduces an innovative, data-driven framework that integrates machine learning and a statistical analysis to support municipalities and utility providers in engaging informal communities to protect infrastructure. While this study is limited to Makause and may be affected by a self-reported bias, it demonstrates the potential of Artificial Neural Networks and ReliefF in enhancing the risk analysis and infrastructure management in informal settlements. Full article

Background and Objectives: Coronavirus Disease 2019 (COVID-19) may cause extensive multi-organ pathology, particularly in the lungs, heart, kidneys, and liver. While hypercoagulability—often signaled by elevated D-dimer—has been thoroughly investigated, the concurrent pathological findings across organs and their interrelation with distinct D-dimer levels remain incompletely characterized. This study aimed to evaluate the pathological changes observed in autopsied or deceased COVID-19 patients, focusing on the prevalence of organ-specific lesions, and to perform subgroup analyses based on three D-dimer categories. Methods: We conducted a retrospective review of 69 COVID-19 patients from a Romanian-language dataset, translating all clinical and pathological descriptions into English. Pathological findings (pulmonary microthrombi, bronchopneumonia, myocardial fibrosis, hepatic steatosis, and renal tubular necrosis) were cataloged. Patients were grouped into three categories by admission D-dimer: <500 ng/mL, 500–2000 ng/mL, and ≥2000 ng/mL. Laboratory parameters (C-reactive protein, fibrinogen, and erythrocyte sedimentation rate) and clinical outcomes (intensive care unit [ICU] admission, mechanical ventilation, and mortality) were also recorded. Intergroup comparisons were performed with chi-square tests for categorical data and one-way ANOVA or the Kruskal–Wallis test for continuous data. Results: Marked organ pathology was significantly more frequent in the highest D-dimer group (≥2000 ng/mL). Pulmonary microthrombi and bronchopneumonia increased stepwise across ascending D-dimer strata (p < 0.05). Myocardial and renal lesions similarly showed higher prevalence in patients with elevated D-dimer. Correlation analysis revealed that severe lung and heart pathologies were strongly associated with high inflammatory markers and a greater risk of ICU admission and mortality. Conclusions: Our findings underscore that COVID-19-related organ damage is magnified in patients with significantly elevated D-dimer. By integrating pathology reports with clinical and laboratory data, we highlight the prognostic role of hypercoagulability and systemic inflammation in the pathogenesis of multi-organ complications. Stratifying patients by D-dimer may inform more tailored management strategies, particularly in those at highest risk of severe pathology and adverse clinical outcomes. Full article

Objectives: COVID-19, caused by the SARS-CoV-2 virus, has infected over 777 million individuals and led to approximately 7 million deaths worldwide. Despite significant efforts to develop effective therapies, treatment remains largely supportive, especially for severe complications like acute respiratory distress syndrome (ARDS). Numerous compounds from diverse pharmacological classes are currently undergoing preclinical and clinical evaluation, targeting both the virus and the host immune response. Methods: Despite the large number of articles published and after a preliminary attempt was published, we discarded the option of a systematic review. Instead, we have done a description of therapies with these results and a tentative mechanism of action. Results: Preliminary studies and early-phase clinical trials have demonstrated the potential of Mesenchymal Stem Cells (MSCs) in mitigating severe lung damage in COVID-19 patients. Previous research has shown MSCs to be effective in treating various pulmonary conditions, including acute lung injury, idiopathic pulmonary fibrosis, ARDS, asthma, chronic obstructive pulmonary disease, and lung cancer. Their ability to reduce inflammation and promote tissue repair supports their potential role in managing COVID-19-related complications. This review demonstrates the utility of MSCs in the acute phase of COVID-19 and postulates the etiopathogenic role of mitochondria in Long-COVID. Even more, their combination with other therapies is also analyzed. Conclusions: While the therapeutic application of MSCs in COVID-19 is still in early stages, emerging evidence suggests promising outcomes. As research advances, MSCs may become an integral part of treatment strategies for severe COVID-19, particularly in addressing immune-related lung injury and promoting recovery. However, a full pathogenic mechanism may explain or unify the complexity of signs and symptoms of Long COVID and Post-Acute Sequelae (PASC). Full article

Background: Informal welders in Pretoria West face growing occupational safety risks due to hazardous working environments and limited regulatory oversight. Despite the high-risk nature of their work, many remain unaware of relevant safety legislation and inconsistently use personal protective equipment (PPE). This study aimed to investigate the occupational safety risks, challenges, and levels of compliance with safety practices among informal welders in Pretoria West, South Africa. Methods: A cross-sectional mixed-methods approach was employed, incorporating both qualitative and quantitative designs. Data were collected from 40 male welders (aged 20–55 years) using structured questionnaires, observational checklists, and semi-structured interviews. Descriptive statistics were generated using Microsoft Excel, while thematic content analysis was applied to the qualitative data. Results: Eighty-five percent (85%) of welders reported using gas welding, and more than half had received training in welding and PPE use; however, 47.5% had no formal training. A high prevalence of work-related injuries was reported, including burns, cuts, and eye damage. Common safety concerns identified were burns (42.5%), electric shocks (35%), and malfunctioning equipment. Observational data revealed inconsistent PPE use, particularly with flame-resistant overalls and eye protection. Qualitative insights highlighted challenges such as demanding client expectations, hazardous physical environments, and inadequate equipment maintenance. Many sites lacked compliance with occupational safety standards. Conclusion: The study reveals critical gaps in safety knowledge, training, and PPE compliance among informal welders. These deficiencies significantly elevate the risk of occupational injuries. Strengthening occupational health and safety regulations, improving access to PPE, and delivering targeted training interventions are essential to safeguard the well-being of welders and those in their surrounding communities. Full article

The accurate description of plasticity and fracture behavior is essential in numerically investigating the mechanical responses of high-strength bolts under tension, shear and coupling loads. However, based on the von Mises criterion, inputting the constitutive relation and damage model from the tensile coupon test into the finite element method cannot properly predict the shear behavior of high-strength bolts. Cylindrical tensile coupons and shear specimens of common and weathering high-strength bolts are tested to obtain the complete tensile and shear responses. The combined S-V model and the modified shear constitutive model are collaboratively used to calibrate and describe the tensile and shear constitutive relations of high-strength bolts, and then the Bao–Wierzbicki model is used to predict the tensile and shear fracture behaviors. Furthermore, the collaborating method is used to discuss the applicable range of tensile and shear constitutive models for high-strength bolts under a tensile–shear coupling load, based on numerical analysis against available experimental data in the literature. The loading angle of 30° along the bolt rod is defined as the cut-off to differentiate high-strength bolts under a tensile- or shear-dominated state, and the corresponding mechanical responses of high-strength bolts can be predicted well based on the tensile and shear constitutive models, respectively. Full article

Objectives: We wished to evaluate the safety profile of the Janus kinase (JAK) inhibitors used in the Spanish population; to study the onset of major adverse cardiovascular events (MACEs) and thrombotic events (arterial and venous); and to analyze the factors associated with the onset of these events. Methods: We conducted a retrospective observational study of a cohort of patients with rheumatoid arthritis (RA), spondyloarthritis (SpA), and psoriatic arthritis (PsA) included in the biological therapy registry of the Rheumatology Department of Virgen Macarena University Hospital (HUVM), Seville, Spain, who started targeted treatment between 2019 and late 2024. We collected data on disease activity, traditional cardiovascular risk factors, the Charlson comorbidity index, previous synthetic or biologic drug therapy, the use of corticosteroids (and their dose), severity data (structural damage, extra-articular manifestations), and adverse events at the end of follow-up (e.g., MACEs, infections, neoplasms, and herpes zoster). We performed a descriptive bivariate analysis and a multivariate logistic regression analysis (dependent variable: MACEs) to identify factors that were independently associated with MACEs. Results: The study population comprised 137 patients (110 with RA, 18 with PsA, and 9 with SpA) who were followed up for a mean of 3.9 (2.6) years. Most patients had received JAK inhibitors as their second-line or subsequent treatment. At the end of the follow-up, 82 patients (66.7%) continued their treatment. Nine patients (6.6%) experienced a MACE, and five experienced a heart attack. All of these patients had RA. We found no differences between JAK inhibitors in terms of the incidence of the adverse events studied. Patients who experienced MACEs were more often male and smokers (current or former) and more often had hypertension and diabetes. No significant differences were found in the association with disease activity or previous or concomitant treatment. The factors that were independently associated with MACEs were a previous cardiovascular event (OR, 10.74; 95%CI, 1.05–113.7; p = 0.036), male sex (OR, 9.7; 95%CI, 1.6–76.5; p = 0.016), diabetes mellitus (OR, 10.3; 95%CI, 1.75–83; p = 0.013), and the duration of treatment with JAK inhibitors (OR, 1.47; 95%CI, 1.13–2.01; p = 0.005). Conclusions: We found no differences in the onset of adverse events, specifically MACEs, between the different JAK inhibitors analyzed. These events are more common in patients who already have cardiovascular risk factors, such as diabetes mellitus, or who have already experienced a cardiovascular event. JAK inhibitors broadly suppress cytokines in patients whose disease is refractory to other treatments. However, we must continue to evaluate their long-term safety in real-world studies. Full article

The genus Tegonotus Nalepa (Acariformes: Eriophyidae: Phyllocoptinae) is recorded for the first time from Saudi Arabia with the description of a new species, T. saudiensis sp. nov., collected from the inner fronds of Phoenix dactylifera L. (Arecaceae), described and illustrated based on females. The individuals of the new species were vagrant on the abaxial leaf surface, causing no apparent damage to the host plant. The taxonomic status of the genus and its species was thoroughly assessed through the literature-based analysis of morphological characters. Consequently, the diagnosis of the genus Tegonotus is updated, and a key to 47 valid species is provided. Eight Tegonotus species are suggested to be transferred to three different genera within the tribe. A brief discussion on the taxonomic status of these species is provided. The position of scapular tubercles and setae (sc), and shape of the dorsal pedipalp genu seta (d), were found to be significant for the generic designation. Full article

Purpose: Standard automated perimetry (SAP) remains the gold standard functional test in glaucoma, used primarily for evaluating peripheral vision loss. Central contrast sensitivity (CCS) has emerged as a potential early functional marker of glaucomatous damage. This systematic review aimed to describe the different methods used to measure CCS in randomized controlled trials (RCT) involving glaucoma patients. Methods: We searched the MEDLINE, Embase, CINAHL, Cochrane Central Register of Controlled Trials, Epistemonikos, and ClinicalTrials.gov databases on 25 January 2023, and updated the search on 12 February 2025. Eligible studies comprised RCTs that reported CCS as an outcome in patients with glaucoma, suspected glaucoma, or ocular hypertension. No restrictions were placed on age, sex, ethnicity, geography, intervention, or publication year. Abstracts and full texts were screened independently by two reviewers. Descriptive statistics were used. No formal risk of bias assessment was performed, due to the descriptive nature of the review. Results: Of 1066 records screened, 31 studies met the eligibility criteria. The study sample size ranged from 7 to 207 (median: 23), with most studies involving primary open-angle glaucoma. Interventions were diverse, mainly involving topical medications, with timolol being the most frequent. Eleven CCS test methods were identified. Five studies did not report the method used. The CSV-1000 was the most commonly used test, being applied in 11 studies. Conclusions: CCS has been measured using a wide range of methods in glaucoma RCTs, with limited standardization. Most of the included studies were small, variably reported, and conducted over 10 years ago, suggesting a decreasing interest in CCS as an outcome measure in glaucoma RCTs. Funding: This review was funded by Oslo University Hospital and the Research Council of Norway. Registration: This review was registered on the OSF. Full article

Antioxidants are critical components of the body’s defense system, providing protection against cell-damaging free radicals responsible for oxidative damage of biomolecules. Humans benefit from the consumption of plants with high antioxidant content, which have been shown to positively impact health. In plant physiology, antioxidants provide protection from biotic and abiotic stress, particularly during the development of seeds and germination. Peanut seeds and seed coats have been shown to contain several beneficial antioxidants and are a good source of phytonutrients. Seed coat color can vary greatly and impact the antioxidant capacity of the edible portion of the peanut. Additionally, the seed coat can provide bitter notes in products, affecting their palatability and potentially negating the beneficial properties of the antioxidants present. A total of 42 accessions from the Germplasm Resource Information Network (GRIN) with a variety of seed coat colors were obtained and analyzed for total antioxidant capacity to provide a baseline assessment of the distribution of antioxidants in kernel versus seed coats. The results demonstrated that seed coat color somewhat impacts antioxidant capacity, and 56–88% of the total antioxidant capacity resides in the seed kernel. Three control samples, not part of the germplasm collection, were roasted and prepared for analysis by the descriptive sensory panel. Seed coats were added back to the roasted paste in increasing proportion for analysis by the panel, and perceptions regarding bitterness and overall organoleptic properties were noted. Based on the results of this study, several accessions were selected and then planted for increase and potential crossbreeding with appropriate commercial cultivars. This information could be used to selectively add antioxidant capacity to peanut breeding programs to provide additional health benefits to consumers without compromising the sensory perception and desirability and peanut products in nutrition. Full article

Unilateral renal agenesis (URA) is a urinary tract congenital anomaly characterized by a congenital absence or early developmental arrest of only one kidney. In the presence of a normal contralateral kidney, URA is typically considered a condition of minimal clinical significance as the solitary kidney often undergoes hypertrophy and can sufficiently perform the needed renal function after birth. However, postnatal studies suggest that URA has a significant association with other urinary and extra-urinary anomalies and may have implications for long-term health. This descriptive review focuses on the perinatal aspects of URA, emphasizing the main ultrasound findings to establish the prenatal diagnosis and to guide perinatal management. The pediatric implications of this diagnosis, particularly the high prevalence of long-term complications including hypertension, proteinuria, and a decreased glomerular filtration rate, are also briefly reviewed. URA is consistently associated with other ipsilateral urogenital anomalies. In females, there is a significant association with uterine anomalies that has significant implications for subsequent reproductive function. In males, the prevalence of both urinary and genital anomalies is also increased, which may also have implications for future fertility. Prenatal ultrasound offers the possibility of early diagnosis and parental counseling, which may result in timely intervention to reduce contralateral renal damage, prevent severe urogenital manifestations and co-morbidities, and improve fertility and the quality of life. Full article

The disturbance factor (D) in the Hoek–Brown criterion quantifies excavation-induced rock mass disturbance. Although D is conceptually defined as a continuous parameter ranging from 0 to 1, the most recent Hoek–Brown guidelines provide descriptions only for boundary conditions related to slopes and tunnels. In slope excavations, the degree of disturbance is governed not only by the excavation method but also by the thickness of the removed overburden, with its influence becoming particularly significant in deep excavations. In recent years, the concept of a transitional disturbance factor, varying with depth from the excavation surface, has gained increasing attention. To address this need, the EXCASS system, an empirical method for selecting appropriate excavation techniques based on the Geological Strength Index (GSI) and point load strength (I_s50) values, was integrated into the transitional disturbance factor framework in this study. EXCASS allows for the selection of stronger or weaker excavation methods, offering flexibility to control the degree of disturbance induced in the rock mass. Moreover, the disturbance factor at the excavation surface was determined by incorporating both the operational excavation power index and the thickness of the removed overburden. This integrated approach enables a more realistic evaluation of excavation-induced damage in slope stability analyses. Full article

Flood risk to rice production has previously been examined in terms of river basins or administrative units, incorporating data about the flood year, inundated area, precipitation, elevation, and impacts. However, there is limited knowledge about this topic, as most flood impact studies have focused on loss and damage to people and the economy. It remains important to identify how flood risk to rice production can be better identified within a long-term, community-based, analytical framework. In addition, flood risk studies in Sri Lanka tend to focus on single-year flood events within an administrative boundary, making it difficult to fully comprehend risks to rice production. This paper aims to fill these gaps by investigating long-term flood risk levels on rice production. With this aim, we collected and analyzed information about rice production, geospatial data, and 15-year precipitation records. Temporal-spatial maps were generated using Google Earth Engine JavaScript coding, Google Earth Pro, and OpenStreetMap. In addition, focus group discussions with farmers and key informant interviews were conducted to verify the accuracy of online information. The collected data were analyzed using descriptive statistics, GIS, and linear regression analysis methods. Regarding rice production impacts, we found that floods in the years 2006–2007, 2010–2011, and 2014–2015 had significant impacts on rice production with 20.5%, 75.8%, and 16.6% reductions, respectively. Flood risk maps identified low-, medium-, and high-risk areas based on 15-year flood events, elevation, proximity to water bodies, and 15-year flood-induced damage to rice fields. High risk areas were further studied through field discussions and interviews, showing the connection between past floods and poor water governance practices in terms of dam management. Our linear regression analysis found a marginal negative correlation between total seasonal rainfall and rice production. Full article

Chemosensory systems play a pivotal role in insect survival and reproduction by mediating the detection of volatile organic compounds in the environment. Protaetia brevitarsis (Coleoptera: Scarabaeidae), a phytophagous pest widely distributed across East Asia, poses a significant threat to agro-horticultural systems through crop damage. We conducted antennal transcriptome sequencing of adult beetles and identified 117 chemosensory-related genes, including 66 odorant receptors (ORs), 20 ionotropic receptors, 10 gustatory receptors, 13 odorant-binding proteins (OBPs), four chemosensory proteins, and four sensory neuron membrane proteins. Tissue-specific expression profiling revealed the antennal enrichment of five PbreOBP genes and twenty-three ORs. Notably, sexual dimorphism was observed in OR expression patterns. PbreOR1/6/17/18/21/22/30/32 exhibited male-biased antennal expression, whereas PbreOR25/26/29/38/41/44/61 demonstrated female-biased antennal expression, indicating their potential involvement in sex-specific behaviors, such as pheromone detection and oviposition site selection. A comprehensive description of the antenna chemosensory-related genes of P. brevitarsis has deepened our understanding of the olfactory mechanisms in coleopteran insects. This study also provides a basis for understanding the molecular mechanisms underlying olfaction in P. brevitarsis. Full article