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17 pages, 4081 KB  
Article
Neural Network-Based Atlas Enhancement in MPEG Immersive Video
by Taesik Lee, Kugjin Yun, Won-Sik Cheong and Dongsan Jun
Mathematics 2025, 13(19), 3110; https://doi.org/10.3390/math13193110 - 29 Sep 2025
Abstract
Recently, the demand for immersive videos has surged with the expansion of virtual reality, augmented reality, and metaverse technologies. As an international standard, moving picture experts group (MPEG) has developed MPEG immersive video (MIV) to efficiently transmit large-volume immersive videos. The MIV encoder [...] Read more.
Recently, the demand for immersive videos has surged with the expansion of virtual reality, augmented reality, and metaverse technologies. As an international standard, moving picture experts group (MPEG) has developed MPEG immersive video (MIV) to efficiently transmit large-volume immersive videos. The MIV encoder generates atlas videos to convert extensive multi-view videos into low-bitrate formats. When these atlas videos are compressed using conventional video codecs, compression artifacts often appear in the reconstructed atlas videos. To address this issue, this study proposes a feature-extraction-based convolutional neural network (FECNN) to reduce the compression artifacts during MIV atlas video transmission. The proposed FECNN uses quantization parameter (QP) maps and depth information as inputs and consists of shallow feature extraction (SFE) blocks and deep feature extraction (DFE) blocks to utilize layered feature characteristics. Compared to the existing MIV, the proposed method improves the Bjontegaard delta bit-rate (BDBR) by −4.12% and −6.96% in the basic and additional views, respectively. Full article
(This article belongs to the Special Issue Coding Theory and the Impact of AI)
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32 pages, 20144 KB  
Article
Spatiotemporal Distribution and Driving Factors of Historic and Cultural Villages in China
by Shuna Jiang, Naigao Lu, Zhongqian Zhang, Huanli Pan, Guoyang Lu and Shuangqing Sheng
Buildings 2025, 15(19), 3507; https://doi.org/10.3390/buildings15193507 - 28 Sep 2025
Abstract
Historic and cultural villages in China are increasingly challenged by rapid urbanization, uneven commercial development, and fragmented preservation mechanisms. Understanding their spatiotemporal distribution and the factors shaping it is crucial for advancing the integrated development of cultural heritage conservation, ecological sustainability, and socio-economic [...] Read more.
Historic and cultural villages in China are increasingly challenged by rapid urbanization, uneven commercial development, and fragmented preservation mechanisms. Understanding their spatiotemporal distribution and the factors shaping it is crucial for advancing the integrated development of cultural heritage conservation, ecological sustainability, and socio-economic growth. This study examines 487 historic and cultural villages using the nearest neighbor index (NNI) and kernel density analyses to reveal spatial differentiation patterns. Vector buffer analysis and the geographic detector method were further employed to identify the key drivers of village distribution. The results indicate that: (1) historic and cultural villages exhibit a distinctly clustered spatial pattern, characterized by “more in the southeast, fewer in the northwest; more in the northeast, fewer in the southwest” (NNI = 0.44, Z = –23.52, p = 0.00); (2) provincial-level spatial density demonstrates clear stratification, with high-density clusters concentrated in the Yangtze River Delta, southern Anhui, the Fujian–Zhejiang–Jiangxi junction, and along the Yellow River in Shanxi–Shaanxi–Henan. From the fifth to seventh designation batches, kernel density peaks (maximum ~0.11 × 10−2) increased significantly, reflecting stronger spatial clustering; and (3) the spatial distribution of villages is jointly shaped by natural geography, socio-economic conditions, transportation infrastructure, visitor markets, and tourism resources. Among these, nighttime light intensity was identified as the most influential individual factor (q = 0.6132), while the combination of slope aspect and per capita disposable income emerged as the dominant factor pair (q = 0.966). Full article
(This article belongs to the Special Issue New Challenges in Digital City Planning)
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18 pages, 4016 KB  
Article
Evaluating Station–City Integration Performance in High-Speed Rail Station Areas: An NPI Model and Case Study in the Yangtze River Delta, China
by Yunli Zhai, Degen Wang, Meifeng Zhao and Leran Liangtang
Land 2025, 14(10), 1959; https://doi.org/10.3390/land14101959 - 28 Sep 2025
Abstract
Effective station–city integration is crucial for sustainable development around high-speed rail stations. However, research assessing public preferences regarding the aspects of this integration remains limited. We constructed a performance evaluation model for station–city integration in high-speed rail station areas. By considering the high-speed [...] Read more.
Effective station–city integration is crucial for sustainable development around high-speed rail stations. However, research assessing public preferences regarding the aspects of this integration remains limited. We constructed a performance evaluation model for station–city integration in high-speed rail station areas. By considering the high-speed rail station area in the Yangtze River Delta region as a research object, which is located in the metropolitan cities centered on Shanghai, China, we dissected the five dimensions of population, industry, land use, function, and environment into 15 indicators that flow into the three value objectives of attraction–retention–integration (NPI). Subsequently, we systematically analyzed the performance differentiation characteristics of station–city integration in the Yangtze River Delta region’s high-speed rail station areas by employing a multiple regression model to delve into the influence mechanisms affecting the performance differentiation patterns of station–city integration. Our findings indicate the following. (1) Regarding station–city integration performance grade differentiation, a few high-speed rail station areas in the Yangtze River Delta region exhibit a high-efficiency integration level, whereas more areas fall within the higher and general integration levels. (2) Spatially, the station–city integration performance in high-speed rail station areas within the Yangtze River Delta region exhibits a distinct distribution characterized by “high-grade point-block dependence and low-grade concentrated contiguous patches.” (3) The spatial distribution of the five dimensions of station–city integration performance exhibits significant disparities. (4) Regarding the development types of station–city integration performance advantages, efficient integration of stations and cities represents a multidimensional advantageous development type and higher integration falls into the same category. (5) Station–city integration performance results from the comprehensive effects of four factors: government policy inducement, station energy level attraction, station–city relationship adhesion, and urban energy level promotion. This study advances a systematic framework—encompassing performance measurement, mechanistic inquiry, and strategy formulation—for examining station–city integration in HSR station areas. By integrating the perspective of cyclical cumulative development into the node–place model from urban planning and geographical viewpoints, we articulate a new performance model that clarifies critical influencing factors and mechanisms, thus broadening the theoretical scope of HSR station area research. We believe that the NPI evaluation model can provide valuable insights for guiding the integrated development of high-speed rail station areas and enhancing the quality of urban development. Full article
(This article belongs to the Section Land Use, Impact Assessment and Sustainability)
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13 pages, 1107 KB  
Article
ACE2-Mediated Infection of Immortalized Human Visceral Adipocytes by SARS-CoV-2
by Francoise A. Gourronc, Megan I. Ahmann, Michael R. Rebagliati and Aloysius J. Klingelhutz
Viruses 2025, 17(10), 1311; https://doi.org/10.3390/v17101311 - 27 Sep 2025
Abstract
Adipocytes can be infected by SARS-CoV-2, potentially contributing to the obesity-associated severity of COVID-19. Circumstantial evidence points to angiotensin-converting enzyme 2 (ACE2) as the necessary receptor for adipocyte infection, but this has not been demonstrated experimentally. Using differentiated immortalized human preadipocyte lines that [...] Read more.
Adipocytes can be infected by SARS-CoV-2, potentially contributing to the obesity-associated severity of COVID-19. Circumstantial evidence points to angiotensin-converting enzyme 2 (ACE2) as the necessary receptor for adipocyte infection, but this has not been demonstrated experimentally. Using differentiated immortalized human preadipocyte lines that we developed, we found that visceral adipocytes express higher levels of ACE2 and are more susceptible to SARS-CoV-2 spike (S)-mediated luciferase-VSV infection than subcutaneous adipocytes. Overexpression of ACE2 significantly increased infection, whereas knockout of ACE2 significantly decreased S-mediated infection. Visceral adipocytes at baseline were susceptible to infection by SARS-CoV-2 (Delta variant); however, increased levels of viral transcript with time were not apparent. ACE2 knockout significantly decreased the susceptibility of visceral adipocytes to SARS-CoV-2, whereas overexpression of ACE2 resulted in increased SARS-CoV-2 infection and was associated with increased viral transcript levels with time, as well as induction of IL6, a marker of the proinflammatory response. Our results demonstrate that ACE2 confers susceptibility to SARS-CoV-2 infection of visceral adipocytes. Higher levels of ACE2 in these cells may play a role in establishment of infection and a proinflammatory response, potentially leading to pathogenesis. Full article
(This article belongs to the Section Human Virology and Viral Diseases)
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21 pages, 22622 KB  
Article
Comparison of FNR and GNR Based on TROPOMI Satellite Data for Ozone Sensitivity Analysis in Chinese Urban Agglomerations
by Jing Fan, Chao Yu, Yichen Li, Ying Zhang, Meng Fan, Jinhua Tao and Liangfu Chen
Remote Sens. 2025, 17(19), 3321; https://doi.org/10.3390/rs17193321 - 27 Sep 2025
Abstract
Currently, ozone (O3) has become one of the primary air pollutants in China, underscoring the importance of analyzing ozone formation sensitivity (OFS) for effective pollution control. Ozone sensitivity indices serve as effective tools for OFS identification. Among them, the ratio of [...] Read more.
Currently, ozone (O3) has become one of the primary air pollutants in China, underscoring the importance of analyzing ozone formation sensitivity (OFS) for effective pollution control. Ozone sensitivity indices serve as effective tools for OFS identification. Among them, the ratio of volatile organic compounds (VOCs) to nitrogen oxides (NOx)—such as the formaldehyde-to-nitrogen dioxide ratio (FNR, defined as HCHO/NO2, where HCHO represents VOCs and NO2 represents NOx)—is one of the most widely used satellite-based indicators. Recent studies have highlighted glyoxal (CHOCHO) as another critical ozone precursor, prompting the proposal of the glyoxal-to-nitrogen dioxide ratio (GNR, CHOCHO/NO2) as an alternative metric. This study systematically compares the performance of FNR and GNR across four major urban agglomerations in China: Beijing–Tianjin–Hebei (BTH), the Yangtze River Delta (YRD), the Pearl River Delta (PRD), and the Chengdu–Chongqing (CY) region, by integrating satellite remote sensing with ground-based observations. Results reveal that both indices exhibit consistent spatial trends in OFS distribution, transitioning from VOC-limited regimes in urban centers to NOx-limited regimes in surrounding suburban areas. However, differences emerge in threshold values and classification outcomes. During summer, FNR identifies urban areas as transitional regimes (or VOC-limited in regions such as YRD and PRD), while suburban areas are classified as NOx-limited. In contrast, GNR, which shows heightened sensitive to anthropogenic VOCs (AVOCs), exhibits a more restricted spatial extent in the transition regimes. By autumn, most urban areas shift toward VOC-limited regimes, while suburban regions remain NOx-limited. Thresholds for both VOCs and NOx increase during this period, with GNR demonstrating stronger sensitivity to NOx. These findings underscore that the choice between FNR and GNR directly influences OFS determination, as their differing responses to biogenic and anthropogenic emissions lead to different conclusions. Future research should focus on integrating the complementary strengths of both indices to develop a more robust OFS identification method, thereby providing a theoretical basis for formulating effective ozone control strategies. Full article
(This article belongs to the Special Issue Remote Sensing Applications for Trace Gases and Air Quality)
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23 pages, 17838 KB  
Article
Integrating Multi-Temporal Sentinel-1/2 Vegetation Signatures with Machine Learning for Enhanced Soil Salinity Mapping Accuracy in Coastal Irrigation Zones: A Case Study of the Yellow River Delta
by Junyong Zhang, Tao Liu, Wenjie Feng, Lijing Han, Rui Gao, Fei Wang, Shuang Ma, Dongrui Han, Zhuoran Zhang, Shuai Yan, Jie Yang, Jianfei Wang and Meng Wang
Agronomy 2025, 15(10), 2292; https://doi.org/10.3390/agronomy15102292 - 27 Sep 2025
Abstract
Soil salinization poses a severe threat to agricultural sustainability in the Yellow River Delta, where conventional spectral indices are limited by vegetation interference and seasonal dynamics in coastal saline-alkali landscapes. To address this, we developed an inversion framework integrating spectral indices and vegetation [...] Read more.
Soil salinization poses a severe threat to agricultural sustainability in the Yellow River Delta, where conventional spectral indices are limited by vegetation interference and seasonal dynamics in coastal saline-alkali landscapes. To address this, we developed an inversion framework integrating spectral indices and vegetation temporal features, combining multi-temporal Sentinel-2 optical data (January 2024–March 2025), Sentinel-1 SAR data, and terrain covariates. The framework employs Savitzky–Golay (SG) filtering to extract vegetation temporal indices—including NDVI temporal extremum and principal component features, capturing salt stress response mechanisms beyond single-temporal spectral indices. Based on 119 field samples and Variable Importance in Projection (VIP) feature selection, three ensemble models (XGBoost, CatBoost, LightGBM) were constructed under two strategies: single spectral features versus fused spectral and vegetation temporal features. The key results demonstrate the following: (1) The LightGBM model with fused features achieved optimal validation accuracy (R2 = 0.77, RMSE = 0.26 g/kg), outperforming single-feature models by 13% in R2. (2) SHAP analysis identified vegetation-related factors as key predictors, revealing a negative correlation between peak biomass and salinity accumulation, and the summer crop growth process affects soil salinization in the following spring. (3) The fused strategy reduced overestimation in low-salinity zones, enhanced model robustness, and significantly improved spatial gradient continuity. This study confirms that vegetation phenological features effectively mitigate agricultural interference (e.g., tillage-induced signal noise) and achieve high-resolution salinity mapping in areas where traditional spectral indices fail. The multi-temporal integration framework provides a replicable methodology for monitoring coastal salinization under complex land cover conditions. Full article
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20 pages, 3590 KB  
Article
Effect of Relative Wavelength on Excess Pore Water Pressure in Silty Seabeds with Different Initial Consolidation Degrees
by Hongyi Li, Yaqi Zhang, Aidong Ma, Mingzheng Wen, Zixi Zhao and Shaotong Zhang
Water 2025, 17(19), 2829; https://doi.org/10.3390/w17192829 - 26 Sep 2025
Abstract
Wave-induced silty seabed liquefaction is one of the key threats to offshore infrastructure stability. The excess pore pressure (EPP) response is the key parameter for judging seabed liquefaction. Many studies have examined the EPP response to surface waves in initially well-consolidated seabed; few [...] Read more.
Wave-induced silty seabed liquefaction is one of the key threats to offshore infrastructure stability. The excess pore pressure (EPP) response is the key parameter for judging seabed liquefaction. Many studies have examined the EPP response to surface waves in initially well-consolidated seabed; few works have explored initially less-consolidated seabed, which is widely distributed in estuaries due to the massive river sediment discharge and, thereafter, rapid accumulation. Here, we investigate the EPP response of silty seabed with various initial consolidation degrees using wave flume experiments. We found that (1) in initially liquefied seabed, the EPP magnitude monotonically increases with wavelength, while in initially consolidated seabed, there is a maximal response wavelength which is inversely related to consolidation degree. (2) Furthermore, we found two opposite EPP responses to cyclic surface wave loading under varying seabed conditions in initially liquefied and consolidated seabeds. That is, under the same waves, the EPP magnitude is inversely related to the consolidation degree in initially liquefied seabed, while the EPP magnitude is positively related to the consolidation degree in initially consolidated seabed. In other words, the influence of initial seabed consolidation degree on EPP magnitude behaves like a “√” shaped curve. Our findings provide some implications for further understandings of wave-induced silty seabed liquefaction. Full article
(This article belongs to the Special Issue Advanced Research on Marine Geology and Sedimentology)
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25 pages, 5749 KB  
Article
Study on Low-Carbon Design Strategy of Block-Scale Science and Technology Industrial Park Based on Solar Energy Utilization Potential and Heat Island Effects
by Hai Ye, Yiying Cao and Mingqi Ding
Energies 2025, 18(19), 5127; https://doi.org/10.3390/en18195127 - 26 Sep 2025
Abstract
This study aims to establish an energy assessment system and provide low-carbon design strategies for block-scale science and technology industrial parks in the Yangtze River Delta region of China. To investigate low-carbon design strategies for these parks, the impact of solar energy utilization [...] Read more.
This study aims to establish an energy assessment system and provide low-carbon design strategies for block-scale science and technology industrial parks in the Yangtze River Delta region of China. To investigate low-carbon design strategies for these parks, the impact of solar energy utilization potential and heat island effect on the energy consumption of buildings is taken as the entry point. Through an analysis of the spatial characteristics of twenty block-scale science and technology industrial parks in the Yangtze River Delta region of China, two types of idealized park models comprising a total of eighteen variations were established. The simulation process involved six key morphological parameters to describe the specific shape of the parks quantitatively. The Ladybug Tools 1.6.0, Radiance 5.4a, and URBANopt v0.9.2 software were used to simulate the potential for photovoltaic power generation and the energy consumption of the parks. Net Energy Use Intensity (NEUI) and Potential Utilization Ratio of Renewable Energy (PURRE) were selected as the final evaluation indexes to represent the integrated energy performance of the park. The results show that for the park with a circular layout, the optimal integrated energy performance is achieved when the building density is between 35% and 40%; the average building height is designed with lower values within the range of 20 m to 24 m, and the height-to-depth ratio is around 0.3. Finally, based on the results of the analysis, four major low-carbon design strategies were proposed: high-density development, courtyard layout, supporting-function centralized layout, and carbon sink enhancement. Full article
(This article belongs to the Section G: Energy and Buildings)
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24 pages, 1300 KB  
Article
On the Construction and Analysis of a Fractional-Order Dirac Delta Distribution with Application
by Muhammad Muddassar, Adil Jhangeer, Nasir Siddiqui, Malik Sajjad Mehmood, Liaqat Khan and Tahira Jabeen
Axioms 2025, 14(10), 728; https://doi.org/10.3390/axioms14100728 - 26 Sep 2025
Abstract
We introduce the generalized fractional-order Dirac delta distribution δGFODDF, defined by applying the generalized fractional derivative (GFD) operator to the Heaviside function. This construction extends the classical Dirac delta to non-integer orders, allowing modeling of systems with memory and non-local effects. [...] Read more.
We introduce the generalized fractional-order Dirac delta distribution δGFODDF, defined by applying the generalized fractional derivative (GFD) operator to the Heaviside function. This construction extends the classical Dirac delta to non-integer orders, allowing modeling of systems with memory and non-local effects. We establish fundamental properties—including shifting, scaling, evenness, derivative, and convolution—within a rigorous distributional framework and present explicit proofs. Applications are demonstrated by solving linear fractional differential equations and by modeling drug release with fractional kinetics, where the new delta captures impulse responses with long-term memory. Numerical illustrations confirm that δGFODDF reduces to the classical delta when η=1, while providing additional flexibility for 0<η<1. These results show that δGFODDF is a powerful tool for fractional-order analysis in mathematics, physics, and biomedical engineering. Full article
(This article belongs to the Special Issue Special Functions and Related Topics, 2nd Edition)
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19 pages, 5264 KB  
Article
Integrated Allocation of Water-Sediment Resources and Its Impacts on Socio-Economic Development and Ecological Systems in the Yellow River Basin
by Lingang Hao, Enhui Jiang, Bo Qu, Chang Liu, Jia Jia, Ying Liu and Jiaqi Li
Water 2025, 17(19), 2821; https://doi.org/10.3390/w17192821 - 26 Sep 2025
Abstract
Both water and sediment resource allocation are critical for achieving sustainable development in sediment-laden river basins. However, current understanding lacks a holistic perspective and fails to capture the inseparability of water and sediment. The Yellow River Basin (YRB) is the world’s most sediment-laden [...] Read more.
Both water and sediment resource allocation are critical for achieving sustainable development in sediment-laden river basins. However, current understanding lacks a holistic perspective and fails to capture the inseparability of water and sediment. The Yellow River Basin (YRB) is the world’s most sediment-laden river, characterized by pronounced ecological fragility and uneven socio-economic development. This study introduces integrated water-sediment allocation frameworks for the YRB based on the perspective of the water-sediment nexus, aiming to regulate their impacts on socio-economic and ecological systems. The frameworks were established for both artificial units (e.g., irrigation zones and reservoirs) and geological units (e.g., the Jiziwan region, lower channels, and estuarine deltas) within the YRB. The common feature of the joint allocation of water and sediment across the five units lies in shaping a coordinated water–sediment relationship, though their focuses differ, including in-stream water-sediment processes and combinations, the utilization of water and sediment resources, and the constraints imposed by socio-economic and ecological systems on water-sediment distribution. In irrigation zones, the primary challenge lies in engineering-based control of inflow magnitude and spatiotemporal distribution for both water and sediment. In reservoir systems, effective management requires dynamic regulation through density current flushing and coordinated operations to achieve water-sediment balance. In the Jiziwan region, reconciling socio-economic development with ecological integrity requires establishing science-based thresholds for water and sediment use while ensuring a balance between utilization and protection. Along the lower channel, sustainable management depends on delineating zones for human activities and ecological preservation within floodplains. For deltaic systems, key strategies involve adjusting upstream sediment and refining depositional processes. Full article
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21 pages, 16110 KB  
Article
Integrating Sentinel-1/2 Imagery and Climate Reanalysis for Monthly Bare Soil Mapping and Wind Erosion Modeling in Shandong Province, China
by Aobo Liu and Yating Chen
Remote Sens. 2025, 17(19), 3298; https://doi.org/10.3390/rs17193298 - 25 Sep 2025
Abstract
Accurate identification of bare soil exposure and quantification of associated dust emissions are essential for understanding land degradation and air quality risks in intensively farmed regions. This study develops a monthly monitoring and modeling framework to quantify bare soil dynamics and wind erosion-induced [...] Read more.
Accurate identification of bare soil exposure and quantification of associated dust emissions are essential for understanding land degradation and air quality risks in intensively farmed regions. This study develops a monthly monitoring and modeling framework to quantify bare soil dynamics and wind erosion-induced particulate matter (PM) emissions across Shandong Province from 2017 to 2024. By integrating Sentinel-1/2 imagery, climate reanalysis, terrain and soil data, and employing a stacking ensemble classification model, we mapped bare soil areas at 10 m resolution with an overall accuracy of 93.1%. The results show distinct seasonal variation, with bare soil area peaking in winter and early spring, exceeding 25,000 km2 or 15% of the total area, which is far above the 6.4% estimated by land cover products. Simulations using the CLM5.0 dust module indicate that annual PM10 emissions from bare soil averaged (2.72 ± 1.09) × 105 tons across 2017–2024. Emissions were highest in March and lowest in summer months, with over 80% of the total emitted during winter and spring. A notable increase in emissions was observed after 2022, likely due to more frequent extreme wind events. Spatially, emissions were concentrated in coastal lowlands such as the Yellow River Delta and surrounding saline–alkali lands. Our approach explicitly advances traditional methods by generating monthly 10 m bare soil maps and linking satellite-derived dynamics with process-based dust emission modeling, providing a robust basis for targeted dust control and land management strategies. Full article
(This article belongs to the Section Environmental Remote Sensing)
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25 pages, 2019 KB  
Article
Statistical Convergence for Grünwald–Letnikov Fractional Differences: Stability, Approximation, and Diagnostics in Fuzzy Normed Spaces
by Hasan Öğünmez and Muhammed Recai Türkmen
Axioms 2025, 14(10), 725; https://doi.org/10.3390/axioms14100725 - 25 Sep 2025
Abstract
We present a unified framework for fuzzy statistical convergence of Grünwald–Letnikov (GL) fractional differences in Bag–Samanta fuzzy normed linear spaces, addressing memory effects and nonlocality inherent to fractional-order models. Theoretically, we establish the uniqueness, linearity, and invariance of fuzzy statistical limits and prove [...] Read more.
We present a unified framework for fuzzy statistical convergence of Grünwald–Letnikov (GL) fractional differences in Bag–Samanta fuzzy normed linear spaces, addressing memory effects and nonlocality inherent to fractional-order models. Theoretically, we establish the uniqueness, linearity, and invariance of fuzzy statistical limits and prove a Cauchy characterization: fuzzy statistical convergence implies fuzzy statistical Cauchyness, while the converse holds in fuzzy-complete spaces (and in the completion, otherwise). We further develop an inclusion theory linking fuzzy strong Cesàro summability—including weighted means—to fuzzy statistical convergence. Via the discrete Q-operator, all statements transfer verbatim between nabla-left and delta-right GL forms, clarifying the binomial GL↔discrete Riemann–Liouville correspondence. Beyond structure, we propose density-based residual diagnostics for GL discretizations of fractional initial-value problems: when GL residuals are fuzzy statistically negligible, trajectories exhibit Ulam–Hyers-type robustness in the fuzzy topology. We also formulate a fuzzy Korovkin-type approximation principle under GL smoothing: Cesàro control on the test set {1,x,x2} propagates to arbitrary targets, yielding fuzzy statistical convergence for positive-operator sequences. Worked examples and an engineering-style case study (thermal balance with memory and bursty disturbances) illustrate how the diagnostics certify robustness of GL numerical schemes under sparse spikes and imprecise data. Full article
(This article belongs to the Special Issue Advances in Fractional-Order Difference and Differential Equations)
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28 pages, 11489 KB  
Article
Long-Term Responses of Crustacean Zooplankton to Hydrological Alterations in the Danube Inland Delta: Patterns of Biotic Homogenization and Differentiation
by Pavel Beracko, Igor Kokavec and Igor Matečný
Diversity 2025, 17(10), 670; https://doi.org/10.3390/d17100670 - 25 Sep 2025
Abstract
Our study addresses how large-scale hydrological alterations shape zooplankton biodiversity in floodplain ecosystems, which are highly sensitive to changes in river connectivity. Following the operation of the Gabčíkovo hydroelectric power plant in the Danube inland delta, we examined the long-term responses of crustacean [...] Read more.
Our study addresses how large-scale hydrological alterations shape zooplankton biodiversity in floodplain ecosystems, which are highly sensitive to changes in river connectivity. Following the operation of the Gabčíkovo hydroelectric power plant in the Danube inland delta, we examined the long-term responses of crustacean zooplankton communities, as these organisms are key indicators of hydromorphological disturbance. Based on previous evidence that river regulation often reduces habitat heterogeneity, we hypothesized that hydrological alterations in the Danube riverscape would promote increasing taxonomic and functional homogenization within sites, while simultaneously enhancing differentiation between sites over the past three decades. A total of 121 planktonic crustacean species were recorded across six monitored sites between 1991 and 2020, comprising 49 copepods and 72 cladocerans. Communities showed rising species richness, especially during the first decade of the hydropower plant’s operation. While overall richness increased, dam-induced hydromorphological changes triggered habitat-specific community shifts. In the main channel and adjacent parapotamal arm, taxonomic and functional homogenization occurred, dominated by resilient tychoplanktonic species with a gathering or secondary filter-feeding strategy. In contrast, isolated side arms experienced gradual eutrophication, favoring euplanktonic and primary filter-feeding taxa. The observed taxonomic and functional convergence within both habitat groups reflects the loss of connectivity and the cessation of artificial flooding. Full article
(This article belongs to the Special Issue Aquatic Biodiversity and Habitat Restoration)
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13 pages, 347 KB  
Review
Second-Line Therapies in Primary Biliary Cholangitis: A Comparative Review of Obeticholic Acid, Fibrates, Seladelpar, and Elafibranor
by Fares Jamal, Amani Elshaer, Mayar H. Alatout, Nour B. Odeh, Amal Youssef, Humam Abo Abdullah, Sandra Elmasry, Tala Shahin, Hussein Abdul Nabi, Astin R. Worden, Talha A. Malik and Blanca C. Lizaola-Mayo
Biomedicines 2025, 13(10), 2335; https://doi.org/10.3390/biomedicines13102335 - 24 Sep 2025
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Abstract
Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease marked by cholestasis and progressive fibrosis. While ursodeoxycholic acid (UDCA) remains the first-line therapy, approximately 30–40% of patients have an inadequate biochemical response, increasing the risk of disease progression. Obeticholic acid (OCA), a [...] Read more.
Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease marked by cholestasis and progressive fibrosis. While ursodeoxycholic acid (UDCA) remains the first-line therapy, approximately 30–40% of patients have an inadequate biochemical response, increasing the risk of disease progression. Obeticholic acid (OCA), a potent farnesoid X receptor (FXR) agonist, was the first second-line agent approved by the only Food and Drug Administration (FDA) and has demonstrated moderate biochemical efficacy but limited tolerability due to dose-dependent pruritus and safety concerns in cirrhosis. Fenofibrate, a peroxisome proliferator-activated receptor alpha (PPAR-α) agonist, showed substantial alkaline phosphatase (ALP) reductions when added to UDCA, although its long-term benefit remains unconfirmed in large-scale trials and its use remains off-label in the United States, unlike FDA-approved agents. Seladelpar, a selective peroxisome proliferator-activated receptor delta (PPAR-δ) agonist, and elafibranor, a dual PPAR-α/δ agonist, have both recently received FDA accelerated approval after demonstrating significant improvements in ALP, biochemical response rates, and pruritus relief in phase 3 trials. This review summarizes these second-line therapies’ mechanisms, efficacy, safety, and limitations emphasizing the need for individualized treatment decisions and ongoing research into long-term clinical outcomes. Full article
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21 pages, 2734 KB  
Article
Spatiotemporal Variation of Soil Enzyme Activities and Their Dominant Drivers in Salinized Wheat Fields of the Yellow River Delta
by Minghui Li, Sijia Guo, Jikun Xu, Sai Guan, Deyong Zhao, Yuxia Wang, Xianrui Song, Jian Li, Jianlin Wang and Shuaipeng Zhao
Sustainability 2025, 17(19), 8566; https://doi.org/10.3390/su17198566 - 24 Sep 2025
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Abstract
Soil salinization is one of the most important factors limiting the sustainable development of global agriculture. As the core driving force of the soil carbon cycle, soil-carbon-metabolism-related enzyme activity is very important for soil ecological balance and fertility enhancement. To explore the spatial [...] Read more.
Soil salinization is one of the most important factors limiting the sustainable development of global agriculture. As the core driving force of the soil carbon cycle, soil-carbon-metabolism-related enzyme activity is very important for soil ecological balance and fertility enhancement. To explore the spatial and temporal variation characteristics and coupling mechanisms of soil water, salt, nutrients and enzyme activities in different salinized wheat fields in the Yellow River Delta, field experiments were conducted in Dongying City, Shandong Province. The results showed that the soil moisture content of the low-salt wheat field was higher and that the salt content of three wheat fields was concentrated in the 0–20 cm and 80–100 cm soil layers. Here, soil nutrients and enzyme activities are concentrated in the 0–20 cm topsoil, with significant differences in different degrees among salinized wheat fields at the different growth stages of wheat. Overall, invertase activity (S-SC) and amylase activity (S-AL) presented a trend of low salt > high salt > medium salt, while cellulase activity (S-CL) presented a trend of medium salt > low salt > high salt. Redundancy analysis showed that available potassium (AK) (67.6%) and electric conductivity (EC) (21.2%) in the low-salinity wheat field, total nitrogen (TN) (48.6%) and AK (28.8%) in the medium-salinity wheat field, and EC (67%) and soil organic matter (SOM) (19%) in the high-salinity wheat field contributed the most to soil enzyme activity. This study provides a theoretical basis for the management and sustainable development of different salinized wheat fields in the Yellow River Delta. Full article
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