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21 pages, 3358 KB  
Article
Wave-Induced Loads and Fatigue Life of Small Vessels Under Complex Sea States
by Pasqualino Corigliano, Claudio Alacqua, Davide Crisafulli and Giulia Palomba
J. Mar. Sci. Eng. 2025, 13(10), 1920; https://doi.org/10.3390/jmse13101920 (registering DOI) - 6 Oct 2025
Abstract
The Strait of Messina poses unique challenges for small vessels due to strong currents and complex wave conditions, which critically affect structural integrity and operational safety. This study proposes an integrated methodology that combines seakeeping analysis, a comparison with classification society rules, and [...] Read more.
The Strait of Messina poses unique challenges for small vessels due to strong currents and complex wave conditions, which critically affect structural integrity and operational safety. This study proposes an integrated methodology that combines seakeeping analysis, a comparison with classification society rules, and fatigue life assessment within a unified and computationally efficient framework. A panel-based approach was used to compute vessel motions and vertical bending moments at different speeds and wave directions. Hydrodynamic loads derived from Response Amplitude Operators (RAOs) were compared with regulatory limits and applied to fatigue analysis. A further innovative aspect is the use of high-resolution bathymetric data from the Strait of Messina, enabling a realistic representation of local currents and sea states and providing a more accurate assessment than studies based on idealized conditions. The results show that forward speed amplifies bending moments, reducing safe wave heights from 2 m at rest to about 0.5 m at 16 knots. Fatigue analysis indicates that aluminum hulls are highly vulnerable to 2–3 m waves, while steel and titanium show no significant damage. The proposed workflow is transferable to other vessel types and supports safer design and operation. The case study of the Strait of Messina, the busiest and most challenging maritime corridor in Italy, confirms the validity and practical importance of the approach. By combining hydrodynamic and structural analyses into a single workflow, this study establishes the foundation for predictive maintenance and real-time structural health monitoring, with significant implications for navigation safety in complex sea environments. Full article
(This article belongs to the Special Issue Advanced Studies in Marine Mechanical and Naval Engineering)
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29 pages, 3369 KB  
Article
Longitudinal Usability and UX Analysis of a Multiplatform House Design Pipeline: Insights from Extended Use Across Web, VR, and Mobile AR
by Mirko Sužnjević, Sara Srebot, Mirta Moslavac, Katarina Mišura, Lovro Boban and Ana Jović
Appl. Sci. 2025, 15(19), 10765; https://doi.org/10.3390/app151910765 (registering DOI) - 6 Oct 2025
Abstract
Computer-Aided Design (CAD) software has long served as a foundation for planning and modeling in Architecture, Engineering, and Construction (AEC). In recent years, the introduction of Augmented Reality (AR) and Virtual Reality (VR) has significantly reshaped the CAD landscape, offering novel interaction paradigms [...] Read more.
Computer-Aided Design (CAD) software has long served as a foundation for planning and modeling in Architecture, Engineering, and Construction (AEC). In recent years, the introduction of Augmented Reality (AR) and Virtual Reality (VR) has significantly reshaped the CAD landscape, offering novel interaction paradigms that bridge the gap between digital prototypes and real-world spatial understanding. These technologies have enabled users to engage with 3D architectural content in more immersive and intuitive ways, facilitating improved decision making and communication throughout design workflows. As digital design services grow more complex and span multiple media platforms—from desktop-based modeling to immersive AR/VR environments—evaluating usability and User Experience (UX) becomes increasingly challenging. This paper presents a longitudinal usability and UX study of a multiplatform house design pipeline (i.e., structured workflow for creating, adapting, and delivering house designs so they can be used seamlessly across multiple platforms) comprising a web-based application for initial house creation, a mobile AR tool for contextual exterior visualization, and VR applications that allow full-scale interior exploration and configuration. Together, these components form a unified yet heterogeneous service experience across different devices and modalities. We describe the iterative design and development of this system over three distinct phases (lasting two years), each followed by user studies which evaluated UX and usability and targeted different participant profiles and design maturity levels. The paper outlines our approach to cross-platform UX evaluation, including methods such as the Think-Aloud Protocol (TAP), standardized usability metrics, and structured interviews. The results from the studies provide insight into user preferences, interaction patterns, and system coherence across platforms. From both participant and evaluator perspectives, the iterative methodology contributed to improvements in system usability and a clearer mental model of the design process. The main research question we address is how iterative design and development affects the UX of the heterogeneous service. Our findings highlight important considerations for future research and practice in the design of integrated, multiplatform XR services for AEC, with potential relevance to other domains. Full article
(This article belongs to the Special Issue Extended Reality (XR) and User Experience (UX) Technologies)
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20 pages, 5333 KB  
Article
Shielded Capacitive Power Transmission (S-CPT) System Using Cast Iron
by Eiichi Tateishi, Hao Chen, Naoki Kojo, Yuta Ide, Nobuhiro Kai, Toru Hashimoto, Kota Uchio, Tatsuya Yamaguchi, Reiji Hattori and Haruichi Kanaya
Energies 2025, 18(19), 5288; https://doi.org/10.3390/en18195288 - 6 Oct 2025
Abstract
In this study, we investigate a shielded capacitive power transfer (S-CPT) system that employs cast iron road covers as transmission electrodes for both dynamic and static charging of electric vehicles. Coupling capacitance was evaluated from S-parameters using copper, aluminum, ductile cast iron, structural [...] Read more.
In this study, we investigate a shielded capacitive power transfer (S-CPT) system that employs cast iron road covers as transmission electrodes for both dynamic and static charging of electric vehicles. Coupling capacitance was evaluated from S-parameters using copper, aluminum, ductile cast iron, structural steel, and carbon steel electrodes, with additional comparisons of ductile iron surface conditions (casting, machining, electrocoating). In a four-plate S-CPT system operating at 13.56 MHz, capacitance decreased with electrode spacing, yet ductile cast iron reached ~70 pF at 2 mm, demonstrating a performance comparable to that of copper and aluminum despite having higher resistivity and permeability. Power transmission experiments using a Ø330 mm cast iron cover meeting road load standards achieved 58% efficiency at 100 W, maintained around 40% efficiency at power levels above 200 W, and retained 45% efficiency under 200 mm lateral displacement, confirming robust dynamic performance. Simulations showed that shield electrodes enhance grounding, stabilize potential, and reduce return-path impedance. Finite element analysis confirmed that the ductile cast iron electrodes can withstand a 25-ton design load. The proposed S-CPT concept integrates an existing cast iron infrastructure with thin aluminum receiving plates, enabling high efficiency, mechanical durability, EMI mitigation, and reduced installation costs, offering a cost-effective approach to urban wireless charging. Full article
(This article belongs to the Section E: Electric Vehicles)
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19 pages, 1201 KB  
Article
Sustainable Fashion in Slovenia: Circular Economy Strategies, Design Processes, and Regional Innovation
by Tanja Devetak and Alenka Pavko Čuden
Sustainability 2025, 17(19), 8890; https://doi.org/10.3390/su17198890 - 6 Oct 2025
Abstract
This study investigates sustainability-oriented design and production practices in Slovenia, focusing on brand-led approaches grounded in local innovation, cultural heritage and community engagement. Through mapping of Slovenian fashion enterprises, the research identifies and analyzes core sustainability and circularity strategies including zero- and low-waste [...] Read more.
This study investigates sustainability-oriented design and production practices in Slovenia, focusing on brand-led approaches grounded in local innovation, cultural heritage and community engagement. Through mapping of Slovenian fashion enterprises, the research identifies and analyzes core sustainability and circularity strategies including zero- and low-waste design, recycling, upcycling and the development of adaptable, long-lasting garments. Further attention is given to participatory design methods involving consumers, the strategic social media use for community building and service-based circular economy models such as lifetime garment repair. Technological and production innovations, localized supply chains and small-scale production models are assessed for their role in reducing environmental impact and advancing sustainable supply chain management. The study also analyzes initiatives to shorten the fashion loop, including dematerialization and production minimization, as pathways to reduce resource consumption. Methodologically, the study combines empirical fieldwork, participant observation and literature review to deliver a comprehensive analysis of Slovenia’s sustainable fashion sector. The findings contribute to the global discourse on regional and place-based sustainability in fashion demonstrating how design-driven, small- and medium-sized enterprises can integrate circular economy principles, cultural continuity and collaborative innovation to foster environmentally responsible and socially embedded fashion. Full article
(This article belongs to the Special Issue Sustainable Product Design, Manufacturing and Management)
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20 pages, 2587 KB  
Article
Load-Dedicated Fiber Reinforcement of Additively Manufactured Lightweight Structures
by Sven Meißner, Daniel Kalisch, Rezo Aliyev, Sebastian Scholz, Henning Zeidler, Sascha Müller, Axel Spickenheuer and Lothar Kroll
J. Compos. Sci. 2025, 9(10), 548; https://doi.org/10.3390/jcs9100548 - 6 Oct 2025
Abstract
This study focuses on a novel lightweight technology for manufacturing variable-axial fiber-reinforced polymer components. In the presented approach, channels following the load flow are implemented in an additively manufactured basic structure and impregnated continuous fiber bundles are pulled through these component-integrated cavities. Improved [...] Read more.
This study focuses on a novel lightweight technology for manufacturing variable-axial fiber-reinforced polymer components. In the presented approach, channels following the load flow are implemented in an additively manufactured basic structure and impregnated continuous fiber bundles are pulled through these component-integrated cavities. Improved channel cross-section geometries to enhance the mechanical performance are proposed and evaluated. The hypothesis posits that increasing the surface area of the internal channels significantly reduces shear stresses between the polymer basic structure and the integrated continuous fiber composite. A series of experiments, including analytical, numerical, and microscopic analyses, were conducted to evaluate the mechanical properties of the composites formed, focusing on Young’s modulus and tensile strength. In addition, an important insight into the failure mechanism of the novel fiber composite is provided. The results demonstrate a clear correlation between the channel geometry and mechanical performance, indicating that optimized designs can effectively reduce shear stress, thus improving load-bearing capacities. The findings reveal that while fiber volume content influences the impregnation quality, an optimal balance must be achieved to enhance mechanical properties. This research contributes to the advancement of production technologies for lightweight components through additive manufacturing and the development of new types of composite materials applicable in various engineering fields. Full article
(This article belongs to the Special Issue Additive Manufacturing of Advanced Composites, 2nd Edition)
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18 pages, 4521 KB  
Article
Lightweight Design and Research of Electric Towing Winch Based on Kriging-NSGA-III-TOPSIS Multi-Objective Optimization Technology
by Quanliang Liu, Lu Feng, Ya Wang, Ji Lin and Linsen Zhu
Machines 2025, 13(10), 922; https://doi.org/10.3390/machines13100922 - 6 Oct 2025
Abstract
To address the challenges of weight redundancy, low material utilization, and excessive performance margins in the design of electric cable-hauling machines, this study proposes a novel multi-objective optimization framework. The framework integrates Latin hypercube experimental design, Kriging surrogate modeling, a Non-dominated Sorting Genetic [...] Read more.
To address the challenges of weight redundancy, low material utilization, and excessive performance margins in the design of electric cable-hauling machines, this study proposes a novel multi-objective optimization framework. The framework integrates Latin hypercube experimental design, Kriging surrogate modeling, a Non-dominated Sorting Genetic Algorithm III (NSGA-III), and a coupled TOPSIS (Technique for Order Preference by Similarity to Ideal Solution) approach. A high-fidelity finite element model based on extreme operating conditions was established to simulate the performance of the electric towing winch. The Kriging model was employed to replace time-consuming finite element calculations, significantly improving computational efficiency. The NSGA-III algorithm was then utilized to search for the Pareto front, identifying a set of optimal solutions that balance multiple design objectives. Finally, the TOPSIS method was applied to select the most preferable solution from the Pareto front. The results demonstrate a 7.32% reduction in the overall mass of the towing winch, a 7.34% increase in the safety factor, and a 4.57% reduction in maximum structural deformation under extreme operating conditions. These findings validate the effectiveness of the proposed Kriging-NSGA-III-TOPSIS strategy for lightweight design of ship deck winch machinery. Full article
(This article belongs to the Section Machine Design and Theory)
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24 pages, 7261 KB  
Article
Coupling Rainfall Intensity and Satellite-Derived Soil Moisture for Time of Concentration Prediction: A Data-Driven Hydrological Approach to Enhance Climate Responsiveness
by Kasun Bandara, Kavini Pabasara, Luminda Gunawardhana, Janaka Bamunawala, Jeewanthi Sirisena and Lalith Rajapakse
Hydrology 2025, 12(10), 264; https://doi.org/10.3390/hydrology12100264 - 6 Oct 2025
Abstract
Accurately estimating the time of concentration (Tc) is critical for hydrological modelling, flood forecasting, and hydraulic infrastructure design. However, conventional methods often overlook the combined effects of rainfall intensity and antecedent soil moisture, thereby limiting their applicability under changing climates. This [...] Read more.
Accurately estimating the time of concentration (Tc) is critical for hydrological modelling, flood forecasting, and hydraulic infrastructure design. However, conventional methods often overlook the combined effects of rainfall intensity and antecedent soil moisture, thereby limiting their applicability under changing climates. This study presents a novel approach that integrates data-driven techniques with remote sensing data to improve Tc estimation. This method was successfully applied in the Kalu River Basin, Sri Lanka, demonstrating its performance in a tropical catchment. While an overall inverse relationship between rainfall intensity and Tc was observed, deviations in several events underscored the influence of initial soil moisture conditions on catchment response times. To address this, a modified kinematic wave-based equation incorporating both rainfall intensity and soil moisture was developed and calibrated, achieving high predictive accuracy (calibration: R2 = 0.97, RMSE = 1.1 h; validation: R2 = 0.96, RMSE = 0.01 h). A hydrological model was developed to assess the impacts of Tc uncertainties on design hydrographs. Results revealed that underestimating Tc led to substantially shorter lag times and significantly increased peak flows, highlighting the sensitivity of flood simulations to Tc variability. This study highlights the need for improved TC estimation and presents a robust, transferable methodology for enhancing hydrological predictions and climate-resilient infrastructure planning. Full article
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31 pages, 1677 KB  
Review
A Taxonomy of Robust Control Techniques for Hybrid AC/DC Microgrids: A Review
by Pooya Parvizi, Alireza Mohammadi Amidi, Mohammad Reza Zangeneh, Jordi-Roger Riba and Milad Jalilian
Eng 2025, 6(10), 267; https://doi.org/10.3390/eng6100267 - 6 Oct 2025
Abstract
Hybrid AC/DC microgrids have emerged as a promising solution for integrating diverse renewable energy sources, enhancing efficiency, and strengthening resilience in modern power systems. However, existing control schemes exhibit critical shortcomings that limit their practical effectiveness. Traditional linear controllers, designed around nominal operating [...] Read more.
Hybrid AC/DC microgrids have emerged as a promising solution for integrating diverse renewable energy sources, enhancing efficiency, and strengthening resilience in modern power systems. However, existing control schemes exhibit critical shortcomings that limit their practical effectiveness. Traditional linear controllers, designed around nominal operating points, often fail to maintain stability under large load and generation fluctuations. Optimization-based methods are highly sensitive to model inaccuracies and parameter uncertainties, reducing their reliability in dynamic environments. Intelligent approaches, such as fuzzy logic and ML-based controllers, provide adaptability but suffer from high computational demands, limited interpretability, and challenges in real-time deployment. These limitations highlight the need for robust control strategies that can guarantee reliable operation despite disturbances, uncertainties, and varying operating conditions. Numerical performance indices demonstrate that the reviewed robust control strategies outperform conventional linear, optimization-based, and intelligent controllers in terms of system stability, voltage and current regulation, and dynamic response. This paper provides a comprehensive review of recent robust control strategies for hybrid AC/DC microgrids, systematically categorizing classical model-based, intelligent, and adaptive approaches. Key research gaps are identified, including the lack of unified benchmarking, limited experimental validation, and challenges in integrating decentralized frameworks. Unlike prior surveys that broadly cover microgrid types, this work focuses exclusively on hybrid AC/DC systems, emphasizing hierarchical control architectures and outlining future directions for scalable and certifiable robust controllers. Also, comparative results demonstrate that state of the art robust controllers—including H∞-based, sliding mode, and hybrid intelligent controllers—can achieve performance improvements for metrics such as voltage overshoot, frequency settling time, and THD compared to conventional PID and droop controllers. By synthesizing recent advancements and identifying critical research gaps, this work lays the groundwork for developing robust control strategies capable of ensuring stability and adaptability in future hybrid AC/DC microgrids. Full article
(This article belongs to the Section Electrical and Electronic Engineering)
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11 pages, 354 KB  
Article
Development of a Tool to Assess the Severity of Pulmonary Hypertension in Patients with Interstitial Lung Disease: A Guide to Assist Therapeutic Choices
by Garrett Fiscus, Chebly Dagher, David O’Sullivan, Brett Carollo, Kristen Swanson, Harrison Farber and Raj Parikh
Adv. Respir. Med. 2025, 93(5), 41; https://doi.org/10.3390/arm93050041 - 6 Oct 2025
Abstract
Background: Pulmonary hypertension (PH) is a frequent complication in patients with interstitial lung disease (ILD); its occurrence results in significant morbidity and mortality. Currently approved treatment options for PH-ILD include inhaled prostacyclin therapy, although this approach may be insufficient in patients who have [...] Read more.
Background: Pulmonary hypertension (PH) is a frequent complication in patients with interstitial lung disease (ILD); its occurrence results in significant morbidity and mortality. Currently approved treatment options for PH-ILD include inhaled prostacyclin therapy, although this approach may be insufficient in patients who have developed simultaneous right ventricular failure. Moreover, there is no available treatment algorithm regarding the optimal therapy and timing of lung transplant referral for PH-ILD patients based on disease severity. Design/Methods: In this study, we created such a tool to guide PH-specific therapy in PH-ILD patients, especially as further treatment strategies are developed. We developed a 4-point PH-ILD Severity score that integrated both subjective and objective information (WHO FC, CI, TAPSE, PVR) from retrospective analysis of 57 PH-ILD patients. Results: A score of 3 or greater in the PH-ILD Severity score yielded an AUC of 0.831 (p < 0.001) for the composite endpoint of clinical worsening (hospitalization due to a cardiopulmonary indication; decrease in 6 min walk distance by >15% at 2 consecutive visits; all-cause mortality; lung transplantation). Conclusions: Further confirmation and evolution of this PH-ILD Severity score will assist in the development of optimal treatment plans in ILD patients diagnosed with concomitant PH. Full article
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32 pages, 5868 KB  
Review
A Review of Robotic Interfaces for Post-Stroke Upper-Limb Rehabilitation: Assistance Types, Actuation Methods, and Control Mechanisms
by André Gonçalves, Manuel F. Silva, Hélio Mendonça and Cláudia D. Rocha
Robotics 2025, 14(10), 141; https://doi.org/10.3390/robotics14100141 - 6 Oct 2025
Abstract
Stroke is a leading cause of long-term disability worldwide, with survivors often facing significant challenges in regaining upper-limb functionality. In response, robotic rehabilitation systems have emerged as promising tools to enhance post-stroke recovery by delivering precise, adaptable, and patient-specific therapy. This paper presents [...] Read more.
Stroke is a leading cause of long-term disability worldwide, with survivors often facing significant challenges in regaining upper-limb functionality. In response, robotic rehabilitation systems have emerged as promising tools to enhance post-stroke recovery by delivering precise, adaptable, and patient-specific therapy. This paper presents a review of robotic interfaces developed specifically for upper-limb rehabilitation. It analyses existing exoskeleton- and end-effector-based systems, with respect to three core design pillars: assistance types, control philosophies, and actuation methods. The review highlights that most solutions favor electrically actuated exoskeletons, which use impedance- or electromyography-driven control, with active assistance being the predominant rehabilitation mode. Resistance-providing systems remain underutilized. Furthermore, no hybrid approaches featuring the combination of robotic manipulators with actuated interfaces were found. This paper also identifies a recent trend towards lightweight, modular, and portable solutions and discusses the challenges in bridging research prototypes with clinical adoption. By focusing exclusively on upper-limb applications, this work provides a targeted reference for researchers and engineers developing next-generation rehabilitation technologies. Full article
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15 pages, 9047 KB  
Article
Comparative Chemical and Physical Characterization of Biomimetic Versus Commercial Hydroxyapatites for Tooth Enamel Repair
by Marco Lelli, Ismaela Foltran, Rossella Pucci and Fabrizio Tarterini
Biomimetics 2025, 10(10), 672; https://doi.org/10.3390/biomimetics10100672 - 6 Oct 2025
Abstract
Background: Substituted hydroxyapatites (HAps) are widely used in oral-care formulations for enamel repair; however, head-to-head comparisons among commercial grades remain limited. Objective: To compare four commercial HAps: A (Kal-HAp), B (FL-HAp), C (FL-HAp-SC), and D (microRepair®, a biomimetic Zn–carbonate-substituted HAp) and [...] Read more.
Background: Substituted hydroxyapatites (HAps) are widely used in oral-care formulations for enamel repair; however, head-to-head comparisons among commercial grades remain limited. Objective: To compare four commercial HAps: A (Kal-HAp), B (FL-HAp), C (FL-HAp-SC), and D (microRepair®, a biomimetic Zn–carbonate-substituted HAp) and to evaluate their ability to form an enamel-like coating in vitro. Methods: We characterized the powders by X-ray diffraction (crystalline phase, Landi crystallinity index), FTIR-ATR (phosphate/carbonate bands), SEM/EDS (morphology, surface Ca/P), and DLS (particles size, ζ-potential). In vitro, human enamel sections were treated with 5% slurries in artificial saliva; surface coverage was quantified by image analysis on SEM. Results: All commercial materials analyzed in this work were composed of HAp. Differences were observed between HApin terms of crystallinity-range [2 Theta 8.0–60.0°], carbonate substitution (ATR [carbonate group evaluated −870 cm−1]), and particle size (DLS [in a range 0.1–10,000 nm], Z-mean [mV]). On enamel, all samples form a hydroxyapatite layer; coverage differed between groups ([A] 28.83 ± 7.35% vs. [B] 31.11 ± 3.12% vs. [C] 57.20 ± 33.12% vs. [D] 99.90 ± 0.12%), with the biomimetic Zn-carbonate-substituted HAp showing the highest coverage, and the post-treatment Ca/P ratio approached values similar to those of dental enamel. Conclusions: Complementary physic-chemical signatures (crystallinity, carbonate substitution, and morphology) relate to enamel-surface coverage in vitro, providing evidence base for selecting HAp grades for enamel-repair formulations, which is a practical implication for product design. Full article
(This article belongs to the Special Issue Advances in Biomaterials, Biocomposites and Biopolymers 2025)
23 pages, 8816 KB  
Article
Error Correction in Bluetooth Low Energy via Neural Network with Reject Option
by Wellington D. Almeida, Felipe P. Marinho, André L. F. de Almeida and Ajalmar R. Rocha Neto
Sensors 2025, 25(19), 6191; https://doi.org/10.3390/s25196191 - 6 Oct 2025
Abstract
This paper presents an approach to error correction in wireless communication systems, with a focus on the Bluetooth Low Energy standard. Our method uses the redundancy provided by the cyclic redundancy check and leaves the transmitter unchanged. The approach has two components: an [...] Read more.
This paper presents an approach to error correction in wireless communication systems, with a focus on the Bluetooth Low Energy standard. Our method uses the redundancy provided by the cyclic redundancy check and leaves the transmitter unchanged. The approach has two components: an error-detection algorithm that validates data packets and a neural network with reject option that classifies signals received from the channel and identifies bit errors for later correction. This design localizes and corrects errors and reduces transmission failures. Extensive simulations were conducted, and the results demonstrated promising performance. The method achieved correction rates of 94–98% for single-bit errors and 54–68% for double-bit errors, which reduced the need for packet retransmissions and lowered the risk of data loss. When applied to images, the approach enhanced visual quality compared with baseline methods. In particular, we observed improvements in visual quality for signal-to-noise ratios between 9 and 11 dB. In many cases, these enhancements were sufficient to restore the integrity of corrupted images. Full article
(This article belongs to the Section Internet of Things)
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33 pages, 7256 KB  
Article
Exploring Bioinspired Climatic Design Strategies for a Low-Carbon Future: A Case Study of a Hot–Humid Climate in Sri Lanka
by Arosha Gamage, Anir Upadhyay and Richard Hyde
Biomimetics 2025, 10(10), 671; https://doi.org/10.3390/biomimetics10100671 - 6 Oct 2025
Abstract
Bioclimatic design, rooted in vernacular architecture, aims to create buildings that harmonise with their local climate and context. Over the past five decades, continuous advancements have strengthened its foundation for climate-responsive architecture. However, the development of bioinspired thinking extends new opportunities to enhance [...] Read more.
Bioclimatic design, rooted in vernacular architecture, aims to create buildings that harmonise with their local climate and context. Over the past five decades, continuous advancements have strengthened its foundation for climate-responsive architecture. However, the development of bioinspired thinking extends new opportunities to enhance ecological sustainability and innovation in bioclimatic design. This study introduces Bioinspired Climatic Design (BCD) as an advancement of bioclimatic design, integrating ecological processes, human behaviour, and high-resolution climate data to create sustainable, climate-responsive low-carbon architecture. Focusing on residential buildings in hot–humid climates, it categorises BCD strategies into primary and modifying adaptive approaches, examined through four case studies using observation and spatial analysis. Findings emphasise the importance of aligning design with climate, ecology, and occupant behaviour to achieve low-carbon, resilient architecture, especially in challenging conditions. The research calls for a paradigm shift from conventional climate-responsive design towards a holistic, ecologically integrated framework for future-oriented built environments. Full article
12 pages, 771 KB  
Review
Early Initiation of Biologic Therapies to Prevent Severe Asthma Progression
by Alessandra Tomasello, Alida Benfante, Stefania Principe and Nicola Scichilone
Medicina 2025, 61(10), 1797; https://doi.org/10.3390/medicina61101797 - 6 Oct 2025
Abstract
Asthma is a chronic inflammatory disease with a heterogeneous course, often progressing silently from mild symptoms to severe, treatment-refractory disease. Current guidelines recommend biologic therapies after failure of high-dose inhaled corticosteroids and additional controllers, typically in patients with frequent exacerbations. This reactive approach [...] Read more.
Asthma is a chronic inflammatory disease with a heterogeneous course, often progressing silently from mild symptoms to severe, treatment-refractory disease. Current guidelines recommend biologic therapies after failure of high-dose inhaled corticosteroids and additional controllers, typically in patients with frequent exacerbations. This reactive approach may delay intervention until irreversible airway remodeling has occurred, limiting the potential benefits of biologic therapy. Therefore, severe asthma may be envisioned as the consequence of missed opportunities for early interventions. Early initiation of biologic therapy—guided by biomarkers such as blood eosinophil count and fractional exhaled nitric oxide (FeNO), as well as symptom burden and risk of lung function decline—may prevent progression to severe asthma and improve remission rates. This position paper advocates for a shift from severity-based to risk-based treatment strategies, recommending earlier biomarker assessment, redefinition of escalation criteria, and clinical trials designed to evaluate biologics in symptomatic non-exacerbating patients. By recognizing persistent inflammation and progression risk earlier in the disease course, clinicians may have a critical opportunity to alter the trajectory of asthma, reduce long-term morbidity, and achieve sustained control before irreversible damage occurs. Full article
(This article belongs to the Special Issue Latest Advances in Asthma and COPD)
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22 pages, 1759 KB  
Review
Tumour-on-Chip Models for the Study of Ovarian Cancer: Current Challenges and Future Prospects
by Sung Yeon Lim, Lamia Sabry Aboelnasr and Mona El-Bahrawy
Cancers 2025, 17(19), 3239; https://doi.org/10.3390/cancers17193239 - 6 Oct 2025
Abstract
Ovarian cancer is a highly lethal malignancy, characterised by late-stage diagnosis, marked inter- and intra-tumoural heterogeneity, and frequent development of chemoresistance. Existing preclinical models, including conventional two-dimensional cultures, three-dimensional spheroids, and organoids, only partially recapitulate the structural and functional complexity of the ovarian [...] Read more.
Ovarian cancer is a highly lethal malignancy, characterised by late-stage diagnosis, marked inter- and intra-tumoural heterogeneity, and frequent development of chemoresistance. Existing preclinical models, including conventional two-dimensional cultures, three-dimensional spheroids, and organoids, only partially recapitulate the structural and functional complexity of the ovarian tumour microenvironment (TME). Tumour-on-chip (CoC) technology has emerged as a promising alternative, enabling the co-culture of tumour and stromal cells within a microengineered platform that incorporates relevant extracellular matrix components, biochemical gradients, and biomechanical cues under precisely controlled microfluidic conditions. This review provides a comprehensive overview of CoC technology relevant to ovarian cancer research, outlining fabrication strategies, device architectures, and TME-integration approaches. We systematically analyse published ovarian cancer-specific CoC models, revealing a surprisingly limited number of studies and a lack of standardisation across design parameters, materials, and outcome measures. Based on these findings, we identify critical technical and biological considerations to inform the rational design of next-generation CoC platforms, with the aim of improving their reproducibility, translational value, and potential for personalised medicine applications. Full article
(This article belongs to the Special Issue Advancements in Preclinical Models for Solid Cancers)
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