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Search Results (6,402)

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Keywords = design research methodology

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19 pages, 2355 KB  
Article
Effects of Levels of Realism on Perceived Distance in Computer-Simulated Urban Spaces
by Majdi Alkhresheh
Buildings 2025, 15(19), 3565; https://doi.org/10.3390/buildings15193565 - 2 Oct 2025
Abstract
Today, as planners and urban designers increasingly rely on computational modeling to study complex urban systems, a methodological shift toward virtual experimentation is discernible because the real-world factors are difficult to control. This paper investigates the effect of the realism of computer simulations [...] Read more.
Today, as planners and urban designers increasingly rely on computational modeling to study complex urban systems, a methodological shift toward virtual experimentation is discernible because the real-world factors are difficult to control. This paper investigates the effect of the realism of computer simulations on distance perception in urban squares and streets. This study used Autodesk 3ds Max® for modeling and V-Ray for rendering to create systematic variations in distances, with 172 participants providing distance estimates for 216 images. Results indicated that realism had a significant effect on distance perception, increasing estimation accuracy from r = 0.8 to r = 0.94. Lower realism was always associated with an underestimation of the distance, whereas higher realism manifested both overestimation and underestimation. Underestimation is dominant at long distances (>20 m), attributable to a lack of cues, common in low realism; overestimation happens only for short distances (≤20 m) due to high realism. These findings underscore the importance of simulation fidelity for urban designers and planners, enhancing the validity of virtual tools in design, research, and decision-making. Full article
(This article belongs to the Section Architectural Design, Urban Science, and Real Estate)
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16 pages, 1031 KB  
Article
Analysis of Marginal Expansion in Existing Pressurised Water Installations: Analytical Formulation and Practical Application
by Alfonso Arrieta-Pastrana, Oscar E. Coronado-Hernández and Manuel Saba
Sci 2025, 7(4), 140; https://doi.org/10.3390/sci7040140 - 2 Oct 2025
Abstract
Water supply networks in both developed and developing major cities worldwide were constructed many years ago. Currently, these systems face numerous challenges, including population growth, climate change, emerging technologies, and the policies implemented by local governments. Such factors can impact the design life [...] Read more.
Water supply networks in both developed and developing major cities worldwide were constructed many years ago. Currently, these systems face numerous challenges, including population growth, climate change, emerging technologies, and the policies implemented by local governments. Such factors can impact the design life of water infrastructure, leading to service pressure deficiencies. Consequently, water infrastructure must be reinforced to ensure an adequate and reliable service. This research presents the development of an analytical formulation for hydraulic installations with a pumping station, enabling the calculation of requirements for a new parallel pipeline within an existing water system without altering the current pipe resistance class. To implement the proposed solution, it is essential to maintain the initial pump head by adjusting the impeller size. A construction cost assessment is also undertaken to identify the most cost-effective reinforcement strategy, acknowledging that pipe costs vary significantly with diameter and material, and are proportional to the square of the diameter. The proposed methodology is applied to a 30 km pipeline with a 10% increase in demand, showing that a new parallel pipe of the same diameter as the existing hydraulic installation must be installed to minimise construction costs. A multi-parametric analysis was conducted employing machine learning presets with 309 dataset points. Full article
44 pages, 80926 KB  
Article
Spatial Organization Patterns and Their Impact on Evacuation Efficiency: Evidence from Primary School Teaching Buildings
by Sen Cao, Wenjia Liu and Jiantao Zhang
Buildings 2025, 15(19), 3560; https://doi.org/10.3390/buildings15193560 - 2 Oct 2025
Abstract
Primary school teaching buildings represent a typical category of densely populated public architecture, where the safe evacuation of occupants is essential to ensuring their safety. The spatial organizational structure plays a pivotal role in determining overall evacuation efficiency. However, systematic research linking spatial [...] Read more.
Primary school teaching buildings represent a typical category of densely populated public architecture, where the safe evacuation of occupants is essential to ensuring their safety. The spatial organizational structure plays a pivotal role in determining overall evacuation efficiency. However, systematic research linking spatial organization with evacuation performance remains limited. This study addresses this gap by analyzing 102 real-world cases of primary school teaching buildings, identifying common spatial organizational patterns, and developing a spatial structural framework based on fundamental units and their organizational relationships. A hybrid methodology integrating weighted network analysis and evacuation simulation is employed to quantitatively evaluate the relationship between spatial organization types and evacuation performance, ultimately proposing three design principles—Integrity, Balance, and Stability—to guide evacuation efficiency optimization. The findings provide a methodological reference for evacuation research in public buildings and offer practical design guidance for optimizing primary school facility layouts. Full article
(This article belongs to the Section Building Energy, Physics, Environment, and Systems)
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23 pages, 12417 KB  
Article
Optimizing EDM of Gunmetal with Al2O3-Enhanced Dielectric: Experimental Insights and Machine Learning Models
by Saumya Kanwal, Usha Sharma, Saurabh Chauhan, Anuj Kumar Sharma, Jitendra Kumar Katiyar, Rabesh Kumar Singh and Shalini Mohanty
Materials 2025, 18(19), 4578; https://doi.org/10.3390/ma18194578 - 2 Oct 2025
Abstract
This study investigates the optimization of electric discharge machining (EDM) parameters for gunmetal using copper electrodes in two different dielectric environments, which are conventional EDM oil and EDM oil infused with Al2O3 nanoparticles. A Taguchi L27 orthogonal array design was [...] Read more.
This study investigates the optimization of electric discharge machining (EDM) parameters for gunmetal using copper electrodes in two different dielectric environments, which are conventional EDM oil and EDM oil infused with Al2O3 nanoparticles. A Taguchi L27 orthogonal array design was used to evaluate the effects of current, voltage, and pulse-on time on Material Removal Rate (MRR), Electrode Wear Rate (EWR), and surface roughness (Ra, Rq, and Rz). Analysis of Variance (ANOVA) was used to statistically evaluate the influence of each parameter on machining performance. In addition, machine learning models including Linear Regression, Ridge Regression, Support Vector Regression, Random Forest, Gradient Boosting, and Neural Networks were implemented to predict performance outcomes. The originality of this research is not only rooted in the introduction of new models; rather, it is also found in the comparative analysis of various machine learning methodologies applied to the performance of electrical discharge machining (EDM) utilizing Al2O3-enhanced dielectrics. This investigation focuses specifically on gunmetal, a material that has not been extensively studied within this framework. The nanoparticle-enhanced dielectric demonstrated improved machining performance, achieving approximately 15% higher MRR, 20% lower EWR, and 10% improved surface finish compared to conventional EDM oil. Neural Networks consistently outperformed other models in predictive accuracy. Results indicate that the use of nanoparticle-infused dielectrics in EDM, coupled with data-driven optimization techniques, enhances productivity, tool life, and surface quality. Full article
(This article belongs to the Special Issue Non-conventional Machining: Materials and Processes)
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10 pages, 946 KB  
Article
Diagnosing Colour Vision Deficiencies Using Eye Movements (Without Dedicated Eye-Tracking Hardware)
by Aryaman Taore, Gabriel Lobo, Philip R. K. Turnbull and Steven C. Dakin
J. Eye Mov. Res. 2025, 18(5), 51; https://doi.org/10.3390/jemr18050051 - 2 Oct 2025
Abstract
Purpose: To investigate the efficacy of a novel test for diagnosing colour vision deficiencies using reflexive eye movements measured using an unmodified tablet. Methods: This study followed a cross-sectional design, where thirty-three participants aged between 17 and 65 years were recruited. The participant [...] Read more.
Purpose: To investigate the efficacy of a novel test for diagnosing colour vision deficiencies using reflexive eye movements measured using an unmodified tablet. Methods: This study followed a cross-sectional design, where thirty-three participants aged between 17 and 65 years were recruited. The participant group comprised 23 controls, 8 deuteranopes, and 2 protanopes. An anomaloscope was employed to determine the colour vision status of these participants. The study methodology involved using an Apple iPad Pro’s built-in eye-tracking capabilities to record eye movements in response to coloured patterns drifting on the screen. Through an automated analysis of these movements, the researchers estimated individuals’ red–green equiluminant point and their equivalent luminance contrast. Results: Estimates of the red–green equiluminant point and the equivalent luminance contrast were used to classify participants’ colour vision status with a sensitivity rate of 90.0% and a specificity rate of 91.30%. Conclusions: The novel colour vision test administered using an unmodified tablet was found to be effective in diagnosing colour vision deficiencies and has the potential to be a practical and cost-effective alternative to traditional methods. Translation Relevance: The test’s objectivity, its straightforward implementation on a standard tablet, and its minimal requirement for patient cooperation, all contribute to the wider accessibility of colour vision diagnosis. This is particularly advantageous for demographics like children who might be challenging to engage, but for whom early detection is of paramount importance. Full article
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31 pages, 1144 KB  
Systematic Review
Smart Contracts, Blockchain, and Health Policies: Past, Present, and Future
by Kenan Kaan Kurt, Meral Timurtaş, Sevcan Pınar, Fatih Ozaydin and Serkan Türkeli
Information 2025, 16(10), 853; https://doi.org/10.3390/info16100853 - 2 Oct 2025
Abstract
The integration of blockchain technology into healthcare systems has emerged as a technical solution for enhancing data security, protecting privacy, and improving interoperability. Blockchain-based smart contracts offer reliability, transparency, and efficiency in healthcare services, making them a focal point of many studies. However, [...] Read more.
The integration of blockchain technology into healthcare systems has emerged as a technical solution for enhancing data security, protecting privacy, and improving interoperability. Blockchain-based smart contracts offer reliability, transparency, and efficiency in healthcare services, making them a focal point of many studies. However, challenges such as scalability, regulatory compliance, and interoperability continue to limit their widespread adoption. This study conducts a comprehensive literature review to assess blockchain-driven health data management, focusing on the classification of blockchain-based smart contracts in health policy and the health protocols and standards applicable to blockchain-based smart contracts. This review includes 80 core studies published between 2019 and 2025, identified through searches in PubMed, Scopus, and Web of Science using the PRISMA method. Risk of bias and methodological quality were assessed using the Joanna Briggs Institute tool. The findings highlight the potential of blockchain-enabled smart contracts in health policy management, emphasizing their advantages, limitations, and implementation challenges. Additionally, the research underscores their transformative impact on digital health policies in ensuring data integrity, enhancing patient autonomy, and fostering a more resilient healthcare ecosystem. Recent advancements in quantum technologies are also considered as they present both novel opportunities and emerging threats to the future security and design of healthcare blockchain systems. Full article
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12 pages, 765 KB  
Article
Optimising Ventilation System Preplanning: Duct Sizing and Fan Layout Using Mixed-Integer Programming
by Julius H. P. Breuer and Peter F. Pelz
Int. J. Turbomach. Propuls. Power 2025, 10(4), 32; https://doi.org/10.3390/ijtpp10040032 - 1 Oct 2025
Abstract
Traditionally, duct sizing in ventilation systems is based on balancing pressure losses across all branches, with fan selection performed subsequently. However, this sequential approach is inadequate for systems with distributed fans in the central duct network, where pressure losses can vary significantly. Consequently, [...] Read more.
Traditionally, duct sizing in ventilation systems is based on balancing pressure losses across all branches, with fan selection performed subsequently. However, this sequential approach is inadequate for systems with distributed fans in the central duct network, where pressure losses can vary significantly. Consequently, when designing the system topology, fan placement and duct sizing must be considered together. Recent research has demonstrated that discrete optimisation methods can account for multiple load cases and produce ventilation layouts that are both cost- and energy-efficient. However, existing approaches usually concentrate on component placement and assume that duct sizing has already been finalised. While this is sufficient for later design stages, it is unsuitable for the early stages of planning, when numerous system configurations must be evaluated quickly. In this work, we present a novel methodology that simultaneously optimises duct sizing, fan placement, and volume flow controller configuration to minimise life-cycle costs. To achieve this, we exploit the structure of the problem and formulate a mixed-integer linear program (MILP), which, unlike existing non-linear models, significantly reduces computation time while introducing only minor approximation errors. The resulting model enables fast and robust early-stage planning, providing optimal solutions in a matter of seconds to minutes, as demonstrated by a case study. The methodology is demonstrated on a case study, yielding an optimal configuration with distributed fans in the central fan station and achieving a 5 reduction in life-cycle costs compared to conventional central designs. The MILP formulation achieves these results within seconds, with linearisation errors in electrical power consumption below 1.4%, confirming the approach’s accuracy and suitability for early-stage planning. Full article
(This article belongs to the Special Issue Advances in Industrial Fan Technologies)
25 pages, 1417 KB  
Article
The What, Why, and How of Climate Change Education: Strengthening Teacher Education for Resilience
by Alex Lautensach, David Litz, Christine Younghusband, Hartley Banack, Glen Thielmann and Joanie Crandall
Sustainability 2025, 17(19), 8816; https://doi.org/10.3390/su17198816 - 1 Oct 2025
Abstract
This paper offers content priorities, justifications, and pedagogical approaches for the integration of climate change education into the training of teachers, and thus into public schooling. To meet urgent imperatives presented by the polycrisis of the Anthropocene, climate change education must be inclusive, [...] Read more.
This paper offers content priorities, justifications, and pedagogical approaches for the integration of climate change education into the training of teachers, and thus into public schooling. To meet urgent imperatives presented by the polycrisis of the Anthropocene, climate change education must be inclusive, comprehensive, flexible, and regionally responsive. Climate change education can be achieved by adapting regional programs for teacher education to meet those requirements. An example is the Climate Education in Teacher Education (CETE) project in northern British Columbia, Canada. Using the Education Design-Based Research methodology, the project addresses critical questions for curricular and pedagogical development of teachers to address the following three questions: (a) what content and outcomes to prioritize, (b) why these elements matter, and (c) how to implement them effectively. Over two years, CETE engaged pre-service and in-service teachers through workshops, reflective practices, and consultations with Indigenous communities. Our tentative answers emphasize the importance of adapting curriculum and pedagogy to foster community resilience, address climate anxiety, and promote an ethical renewal toward sustainability. The iterative development of objectives as “High-Level Conjectures” provides flexibility and reflexivity in the design process in the face of rapid contextual change. CETE developed practical pedagogical tools and workshop strategies that align educational priorities with local and global needs. This study offers a replicable framework to empower educators and communities in diverse locations to navigate the complexities of the climate crisis in their quest for a more secure and sustainable future. Full article
(This article belongs to the Special Issue Creating an Innovative Learning Environment)
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34 pages, 424 KB  
Review
Smartphone Addiction in Youth: A Narrative Review of Systematic Evidence and Emerging Strategies
by Daniele Giansanti
Psychiatry Int. 2025, 6(4), 118; https://doi.org/10.3390/psychiatryint6040118 - 1 Oct 2025
Abstract
Smartphone addiction has emerged as a significant public health concern, particularly among adolescents and young adults. This narrative review, conducted in line with the ANDJ checklist, synthesizes evidence from 25 systematic reviews and meta-analyses, complemented by randomized controlled trials and clinical studies, to [...] Read more.
Smartphone addiction has emerged as a significant public health concern, particularly among adolescents and young adults. This narrative review, conducted in line with the ANDJ checklist, synthesizes evidence from 25 systematic reviews and meta-analyses, complemented by randomized controlled trials and clinical studies, to provide a structured overview of the field. The study selection flow and publication trends reveal a rapidly expanding research landscape, with most evidence produced in the last decade, reflecting both the ubiquity of smartphones and increasing awareness of their health impacts. The synthesis highlights converging findings across reviews: excessive smartphone use is consistently associated with psychosocial, behavioral, and academic challenges, alongside sleep disturbances and mental health symptoms. Common messages include the recognition of smartphone addiction as a multidimensional phenomenon, while emerging themes point to heterogeneity in definitions, tools, and methodological approaches. Comparative analysis of reviews underscores both shared risk factors—such as emotional dysregulation and social isolation—and differences in study designs and target populations. Importantly, this review identifies critical gaps, including the lack of standardized definitions, limited longitudinal evidence, and scarce cross-cultural validation. At the same time, promising opportunities are noted, from lifestyle-based interventions (e.g., physical activity) to educational and policy-level strategies fostering digital literacy and self-regulation. The post-pandemic context further emphasizes the need for sustained monitoring and adaptive responses. Overall, this review calls for youth-centered, multi-sector interventions aligned with WHO recommendations, supporting coordinated, evidence-based action across health, education, and policy domains. Full article
24 pages, 6313 KB  
Article
Research on the Internal Force Solution for Statically Indeterminate Structures Under a Local Trapezoidal Load
by Pengyun Wei, Shunjun Hong, Lin Li, Junhong Hu and Haizhong Man
Computation 2025, 13(10), 229; https://doi.org/10.3390/computation13100229 - 1 Oct 2025
Abstract
The calculation of internal forces is a critical aspect in the design of statically indeterminate structures. Local trapezoidal loads, as a common loading configuration in practical engineering (e.g., earth pressure, uneven surcharge), make it essential to investigate how to compute the internal forces [...] Read more.
The calculation of internal forces is a critical aspect in the design of statically indeterminate structures. Local trapezoidal loads, as a common loading configuration in practical engineering (e.g., earth pressure, uneven surcharge), make it essential to investigate how to compute the internal forces of statically indeterminate structures under such loads by using the displacement method. The key to displacement-based analysis lies in deriving the fixed-end moment formulas for local trapezoidal loads. Traditional methods, such as the force method, virtual beam method, or integral method, often involve complex computations. Therefore, this study aims to derive a general formula for fixed-end moments in statically indeterminate beams subjected to local trapezoidal loads by using the integral method, providing a more efficient and clear theoretical tool for engineering practice while addressing the limitations of existing educational and applied methodologies. The integral method is employed to derive fixed-end moment expressions for three types of statically indeterminate beams: (1) a beam fixed at both ends, (2) an an-end-fixed another-end-simple-support beam, and (3) a beam fixed at one end and sliding at the other. This approach eliminates the redundant equations of the traditional force method or the indirect transformations of the virtual beam method, directly linking boundary conditions through integral operations on load distributions, thereby significantly simplifying the solving process. Three representative numerical examples validate the correctness and universality of the derived formulas. The results demonstrate that the solutions obtained via the integral method align with software-calculated results, yet the proposed method yields analytical expressions for structural internal forces. Comparative analysis shows that the integral method surpasses traditional approaches (e.g., force method, virtual beam method) in terms of conceptual clarity and computational efficiency, making it particularly suitable for instructional demonstrations and rapid engineering calculations. The proposed integral method provides a systematic analytical framework for the internal force analysis of statically indeterminate structures under local trapezoidal loads, combining mathematical rigor with engineering practicality. The derived formulas can be directly applied to real-world designs, substantially reducing computational complexity. Moreover, this method offers a more intuitive theoretical case for structural mechanics education, enhancing students’ understanding of the mathematical–mechanical relationship between loads and internal forces. The research outcomes hold both theoretical significance and practical engineering value, establishing a solving paradigm for the displacement-based analysis of statically indeterminate structures under complex local trapezoidal loading conditions. Full article
(This article belongs to the Section Computational Engineering)
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43 pages, 2230 KB  
Review
NGS Approaches in Clinical Diagnostics: From Workflow to Disease-Specific Applications
by Desiree Brancato, Simone Treccarichi, Francesca Bruno, Elvira Coniglio, Mirella Vinci, Salvatore Saccone, Francesco Calì and Concetta Federico
Int. J. Mol. Sci. 2025, 26(19), 9597; https://doi.org/10.3390/ijms26199597 - 1 Oct 2025
Abstract
Next-Generation Sequencing (NGS) techniques have become a cornerstone of molecular diagnostics, enabling high-throughput, parallel analysis of multiple disease-associated genes. Their targeted design allows streamlined interpretation and optimised diagnostic yield, especially in disorders with known genetic heterogeneity. In this review, we provide a comprehensive [...] Read more.
Next-Generation Sequencing (NGS) techniques have become a cornerstone of molecular diagnostics, enabling high-throughput, parallel analysis of multiple disease-associated genes. Their targeted design allows streamlined interpretation and optimised diagnostic yield, especially in disorders with known genetic heterogeneity. In this review, we provide a comprehensive overview of the clinical application of NGS techniques—targeted gene panels, whole exome sequencing (WES) and whole genome sequencing (WGS)—detailing the methodological workflow and the critical steps involved in their implementation. Particular emphasis is placed on the genes identified through NGS that are implicated in neurodevelopmental, neurodegenerative, psychiatric, neuromuscular, cardiovascular, and metabolic disorders. We also compare the advantages and limitations of panel-based diagnostics versus WES and WGS, and discuss future directions, including the integration of long-read sequencing technologies into multidisciplinary clinical practice. Finally, we consider how these advances may ultimately bridge biomedical research and clinical practise to improve the diagnosis and management of multifactorial diseases. Full article
(This article belongs to the Special Issue Molecular Progression of Genome-Related Diseases: 2nd Edition)
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50 pages, 4498 KB  
Review
Reinforcement Learning for Electric Vehicle Charging Management: Theory and Applications
by Panagiotis Michailidis, Iakovos Michailidis and Elias Kosmatopoulos
Energies 2025, 18(19), 5225; https://doi.org/10.3390/en18195225 - 1 Oct 2025
Abstract
The growing complexity of electric vehicle charging station (EVCS) operations—driven by grid constraints, renewable integration, user variability, and dynamic pricing—has positioned reinforcement learning (RL) as a promising approach for intelligent, scalable, and adaptive control. After outlining the core theoretical foundations, including RL algorithms, [...] Read more.
The growing complexity of electric vehicle charging station (EVCS) operations—driven by grid constraints, renewable integration, user variability, and dynamic pricing—has positioned reinforcement learning (RL) as a promising approach for intelligent, scalable, and adaptive control. After outlining the core theoretical foundations, including RL algorithms, agent architectures, and EVCS classifications, this review presents a structured survey of influential research, highlighting how RL has been applied across various charging contexts and control scenarios. This paper categorizes RL methodologies from value-based to actor–critic and hybrid frameworks, and explores their integration with optimization techniques, forecasting models, and multi-agent coordination strategies. By examining key design aspects—including agent structures, training schemes, coordination mechanisms, reward formulation, data usage, and evaluation protocols—this review identifies broader trends across central control dimensions such as scalability, uncertainty management, interpretability, and adaptability. In addition, the review assesses common baselines, performance metrics, and validation settings used in the literature, linking algorithmic developments with real-world deployment needs. By bridging theoretical principles with practical insights, this work provides comprehensive directions for future RL applications in EVCS control, while identifying methodological gaps and opportunities for safer, more efficient, and sustainable operation. Full article
(This article belongs to the Special Issue Advanced Technologies for Electrified Transportation and Robotics)
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21 pages, 1373 KB  
Article
Voices of the City: Understanding Hong Kong Residents’ Views on Smart City Transformation
by Alistair Cole, Dionysios Stivas, Emilie Tran and Calvin Ming Tsun Lai
Urban Sci. 2025, 9(10), 406; https://doi.org/10.3390/urbansci9100406 - 1 Oct 2025
Abstract
This study explores Hong Kong residents’ perceptions of their city’s smart city transformation, set against a backdrop of political and economic changes. It investigates residents’ awareness and support for Hong Kong’s development as a smart city and their familiarity with the Smart City [...] Read more.
This study explores Hong Kong residents’ perceptions of their city’s smart city transformation, set against a backdrop of political and economic changes. It investigates residents’ awareness and support for Hong Kong’s development as a smart city and their familiarity with the Smart City Blueprint. Despite the global emphasis on smart city initiatives, there is a significant gap in understanding residents’ perceptions, with the existing literature often focusing on technological and policy aspects while neglecting citizen voices. Employing a mixed-methods research design, the study integrates quantitative survey data (N = 808) with qualitative interviews (N = 25) and focus group discussions (4 groups, N = 43) to capture diverse perspectives. The findings reveal a generally low level of understanding of the Smart City Blueprint among residents, alongside a positive attitude towards its key dimensions like mobility, living, and the environment. Older citizens, those with lower educational attainment, and individuals from mainland China showed greater understanding and support. Interviews highlighted concerns about coordination, bureaucratic processes, data privacy, and public involvement. Focus group discussions revealed varied viewpoints, with some participants drawing comparisons to smart city developments in mainland China and expressing privacy concerns. The study underscores the importance of aligning smart city initiatives with residents’ needs and preferences through inclusive communication strategies and addressing concerns about data privacy and job displacement. Methodological triangulation enhances the validity and reliability of the research, revealing complex patterns and contradictions. Full article
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13 pages, 446 KB  
Systematic Review
Digital Enablement of Psychedelic-Assisted Therapy in Non-Clinical Settings: A Systematic Review of Safety, Efficacy, and Implementation Models
by Brendan Driscoll and Shaheen E. Lakhan
Psychoactives 2025, 4(4), 35; https://doi.org/10.3390/psychoactives4040035 - 1 Oct 2025
Abstract
Psychedelic-assisted therapy offers rapid and profound benefits for treatment-resistant psychiatric conditions but remains constrained by the need for intensive, clinic-based administration. Concurrently, advances in digital health technologies have introduced scalable tools. This systematic review evaluates the safety, efficacy, and implementation of digitally enabled [...] Read more.
Psychedelic-assisted therapy offers rapid and profound benefits for treatment-resistant psychiatric conditions but remains constrained by the need for intensive, clinic-based administration. Concurrently, advances in digital health technologies have introduced scalable tools. This systematic review evaluates the safety, efficacy, and implementation of digitally enabled psychedelic-assisted therapy delivered in non-clinical settings. A comprehensive search of five databases, registered in PROSPERO (CRD420251020968) and conducted in accordance with PRISMA guidelines, identified six eligible studies including real-world analyses, clinical trials, qualitative research, and case reports, representing a total of 12,731 participants. Most studies examined at-home ketamine or esketamine therapy supported by telehealth platforms or mobile applications. Data were synthesized narratively given the heterogeneity of designs and outcomes. Digital enablement was associated with high response rates (ranging from 56.4% to 62.8% for depression) and rapid symptom improvement, particularly in depression and anxiety. Remote monitoring and digital tools demonstrated feasibility and acceptability, but serious safety concerns—including psychiatric adverse events and one unintentional overdose—underscore the need for strict oversight. Risk of bias was moderate to serious across non-randomized studies, limiting confidence in the findings. One study on virtual ayahuasca rituals highlighted the sociocultural potential and limitations of online practices. Despite promising preliminary findings, the field is marked by low methodological rigor and absence of controlled trials. Digitally supported at-home psychedelic therapy represents a transformative but high-stakes frontier, requiring robust research and safeguards to ensure safe, equitable, and effective implementation. No funding was received for this review, and the authors declare no conflicts of interest. Full article
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37 pages, 1993 KB  
Systematic Review
Demand Response Potential Forecasting: A Systematic Review of Methods, Challenges, and Future Directions
by Ali Muqtadir, Bin Li, Bing Qi, Leyi Ge, Nianjiang Du and Chen Lin
Energies 2025, 18(19), 5217; https://doi.org/10.3390/en18195217 - 1 Oct 2025
Abstract
Demand response (DR) is increasingly recognized as a critical flexibility resource for modernizing power systems, enabling the large-scale integration of renewable energy and enhancing grid stability. While the field of general electricity load forecasting is supported by numerous systematic reviews, the specific subfield [...] Read more.
Demand response (DR) is increasingly recognized as a critical flexibility resource for modernizing power systems, enabling the large-scale integration of renewable energy and enhancing grid stability. While the field of general electricity load forecasting is supported by numerous systematic reviews, the specific subfield of DR potential forecasting has received comparatively less synthesized attention. This gap leaves a fragmented understanding of modeling techniques, practical implementation challenges, and future research problems for a function that is essential for market participation. To address this, this paper presents a PRISMA-2020-compliant systematic review of 172 studies to comprehensively analyze the state-of-the-art in DR potential estimation. We categorize and evaluate the evolution of forecasting methodologies, from foundational statistical models to advanced AI architectures. Furthermore, the study identifies key technological enablers and systematically maps the persistent technical, regulatory, and behavioral barriers that impede widespread DR deployment. Our analysis demonstrates a clear trend towards hybrid and ensemble models, which outperform standalone approaches by integrating the strengths of diverse techniques to capture complex, nonlinear consumer dynamics. The findings underscore that while technologies like Advanced Metering Infrastructure (AMI) and the Internet of Things (IoT) are critical enablers, the gap between theoretical potential and realized flexibility is primarily dictated by non-technical factors, including inaccurate baseline methodologies, restrictive market designs, and low consumer engagement. This synthesis brings much-needed structure to a fragmented research area, evaluating the current state of forecasting methods and identifying the critical research directions required to improve the operational effectiveness of DR programs. Full article
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