Search Results (243)

In recent years, there has been a growing recognition within the medical community that idiopathic pulmonary fibrosis (IPF) cannot be effectively managed through a singular focus on the disease itself. Instead, a dual approach is essential, one that not only aims to prolong survival by targeting the underlying pathological mechanisms of IPF but also addresses the numerous comorbidities that frequently complicate the clinical picture for affected individuals. This narrative review seeks to provide a detailed and comprehensive exploration of the various comorbid conditions associated with IPF, which may include cardiovascular disease (CVD), lung cancer (LC), gastroesophageal reflux disease (GERD), obstructive sleep apnea (OSA), and anxiety/depression, among others. By understanding the interplay between these comorbidities and IPF, healthcare providers can better tailor treatment regimens to meet the holistic needs of patients. Furthermore, this review delves into both current management strategies and emerging therapeutic approaches for these comorbidities, emphasizing the importance of interdisciplinary collaboration in clinical practice. By synthesizing the latest research and clinical insights, this review aims to enhance awareness and understanding of the complexities surrounding IPF management, ultimately guiding clinicians in developing more effective, individualized care plans that address not only the fibrotic lung disease but also the broader spectrum of health challenges faced by patients. Through this comprehensive overview, we hope to contribute to the ongoing dialogue about improving quality of life and survival rates for individuals living with IPF. Full article

The introduction of Christian angelology during the Ming and Qing dynasties was driven by strong practical needs. As intermediaries bridging the sacred and the secular, angels were endowed with crucial functions in core sacraments such as baptism and the Mass, including the purification of sins, protection, and the connection between God and humanity. Their participation in these rituals not only enhanced the sanctity of the ceremonies but also facilitated a dialogue with traditional Chinese spirits. Missionaries deliberately avoided abstract theological discussions about angels, instead emphasizing their role in accompanying and guiding believers in daily life. The concept of “guardian angels” addressed the spiritual needs of believers, while the imagery of angels in funeral rites helped reconstruct expressions of filial piety, thereby mitigating cultural conflicts between China and the West. At the same time, the localized understanding of angels among Chinese Catholics during this period focused on ritual practices and the affirmation of their own identity. The introduction of Christian angels during the Ming and Qing dynasties, with their practical dimensions, facilitated the indigenization process of Catholicism in China and provided new perspectives and pathways for interreligious and intercultural dialogue. Full article

This study evaluates the utility derived by policyholders in a Danish pension company, from their life insurance coverages. We quantify the relative importance policyholders assign to their existing coverages versus a hypothetical complete coverage scenario, thereby measuring the implicit priority of their current coverage. By analyzing these implicit priorities based on individual attributes such as age, financial situation, and company agreement limitations, we gain a comprehensive understanding of policyholders’ evaluations of their current life insurance coverage. Utilizing a continuous-time life cycle model, we optimize consumption and life insurance decisions during the accumulation phase, applying well-established theoretical findings to actual data. Our analysis identifies trends, outliers, and insights that can inform potential improvements in life insurance coverage. This tool aims to assist policyholders in prioritizing their coverage according to their life situations and provides a foundation for advisory dialogues and product development. Full article

Extended-reality (XR) tools are increasingly used to revitalise museum experiences, but typical head-mounted or smartphone solutions tend to fragment audiences and suppress the social dialogue that makes cultural heritage memorable. This article addresses that gap on two fronts. First, it proposes a four-phase design methodology—spanning artifact selection, narrative framing, tangible-interface fabrication, spatial installation, software integration, validation, and deployment—that helps curators, designers, and technologists to co-create XR exhibitions in which co-presence, embodied action, and multisensory cues are treated as primary design goals rather than afterthoughts. Second, the paper reports LanternXR, a proof-of-concept built with the methodology: visitors share a 3D-printed replica of the fourteenth-century Virgin of Boixadors while wielding a tracked “camera” and a candle-like lantern that lets them illuminate, photograph, and annotate the sculpture inside a life-sized Gothic nave rendered on large 4K displays with spatial audio and responsive lighting. To validate the approach, the article presents an analytical synthesis of feedback from curators, museologists, and XR technologists, underscoring the system’s capacity to foster collaboration, deepen engagement, and broaden accessibility. The findings show how XR can move museum audiences from isolated immersion to collective, multisensory exploration. Full article

Aboriginal and Torres Strait Islander ways of knowing, being and doing have fostered physical, social, and emotional wellbeing for millenia, forming a foundation of strength and resilience. However, colonisation, systemic violence and discrimination—including the forced removal of Aboriginal and Torres Strait Islander children, which continues today—have disrupted this foundation, leading to compounding cycles of intergenerational and complex trauma. The enduring impact of intergenerational and complex trauma is exemplified in increasing proportions of Aboriginal and Torres Strait Islander children being removed from their families and involved in the child protection and youth justice system—which represents a national crisis. Despite this crisis, the national response remains insufficient. To address these urgent issues, over 200 predominantly Aboriginal and Torres Strait Islander stakeholders, participated in Gathering the Seeds Symposium, the inaugural meeting for the Replanting the Birthing Trees project held in Perth in April 2023. This meeting marked the beginning of a public dialogue aimed at Closing the Gap by advancing community-led strategies to break cycles of trauma and foster cycles of nurturing, recovery, and wellbeing for Aboriginal and Torres Strait Islander parents and children across the first 2000 days. We outline critical shortcomings in the current child protection and youth justice systems, and the urgent need for child wellbeing reform. Importantly we highlight recommendations made in submissions in 2023 to two key Australian inquiries—the National Early Years Strategy and the Human Rights Commission inquiry into out of home care and youth justice systems. We argue that structural reforms and culturally safe and skillful care for parents experiencing trauma and violence is a serious gap, and a national priority. The first 2000 days represents a critical window of opportunity to transform cycles of trauma into cycles of healing. It is time to ‘replant the birthing trees’ and ensure that all Aboriginal and Torres Strait Islander babies and families can have the best possible start to life through comprehensive models of care grounded in recognition of the right to self-determination and culture. Full article

This article explores the dynamic interplay between theological and secular paradigms in shaping contemporary political movements and social justice discourse, with a particular focus on the Culture War surrounding reproductive rights and gender identity. It examines the historical transition from the Judeo–Christian tradition to modern secular frameworks, highlighting how core theological concepts—such as imago Dei, the sanctity of life, and divine sovereignty—have been reinterpreted and secularized. In the context of an increasingly secular world and the resurgence of religion in a post-secular society, the article leverages Eric Voegelin’s philosophical framework to deepen the dialogue on the Culture War and secularization. The analysis argues that modern social justice movements and ideology can be seen as immanentizing the eschaton and moral order, where transcendent values are reconfigured as temporal, political, and cultural constructs for ultimate justice and redemption. By tracing modern concepts of social justice back to their theological roots, this article aims to enrich debates on secularization and the ideological divisions fueling the Culture War, fostering pathways toward a more cohesive and less polarized political landscape. Full article

The Ukrainian Greek Catholic Church (UGCC) is an Eastern Catholic Church that lives according to the Ukrainian–Byzantine Christian theological, liturgical, canonical and spiritual tradition and is in full and visible communion with the successor of Peter. Unity with the Roman Apostolic See has become one of the most important foundations of the UGCC’s identity, enriching its church life and strengthening its ecumenical ministry. As a sui iuris Church in the “family” of Catholic communion, the UGCC actively develops its ecumenical commitments with the Orthodox Churches and Protestant ecclesial communities. In this article, we will briefly examine how the UGCC developed its communion with the Bishop of Rome and how communion with the Apostolic See was a blessing for this Church, but at the same time sometimes became a threat to its existence in times of persecution by totalitarian regimes. We will also present the current religious context in which the UGCC operates, analyze some of its most important ecumenical initiatives and examine its participation in the development of interfaith dialogue in Ukraine. We will consider the challenges that the Russian invasion has brought to the UGCC and other religions in Ukraine, and how the UGCC, by developing communion with Rome, manages to witness the Gospel of life in the difficult circumstances of war and death. Full article

This article reflects on six years of work that implemented various participatory research methods with young women linked to gangs in El Salvador. The reflection focuses on the fundamental role of emotions and trust in contexts marked by violence and social exclusion. From the Freirean perspective of popular education and the approaches of Haraway and Butler, it also analyzes how these participatory methodologies with an autobiographical focus contribute to the re-signification of identities, the construction of agency, and the creation of safe spaces for dialogue. Through methods such as the systematization of experiences, life narratives, and critical ethnography, not only was the complexity of the participants’ lived realities captured, but the investigative process also became a vehicle for empowerment and social transformation. This article highlights how the ethical management of emotions, combined with the construction of trust-based relationships and the use of an autobiographical approach in participatory methodologies, redefines research as a humanized and transformative practice in the study of stigmatized and excluded populations. The findings emphasize the recognition of the contribution participatory research makes in contexts of violence and exclusion for the design of public policies, programs, or reintegration strategies. This underscores the need to promote research lines and funding that advance such proposals from the social sciences, establishing them as key tools for structural transformation. Full article

This review highlights the emerging role of cross-kingdom RNA interference in plant–microbe interactions, particularly the transfer of sRNAs from microbes to plants and vice versa, emphasizing the importance of this mechanism in both mutualistic and pathogenic contexts. As plants adapted to terrestrial life, they formed symbiotic relationships with microbes, essential for nutrient uptake and defense. Emerging evidence underscores sRNAs, including small interfering RNAs (siRNAs) and microRNAs (miRNAs), as critical regulators of gene expression and immune responses in plant–microbe interactions. In mutualistic symbioses, such as mycorrhizal fungi and nitrogen-fixing bacteria associations, sRNAs are hypothesized to regulate nutrient exchange and symbiotic stability. In pathogenic scenarios, microbes utilize sRNAs to undermine plant defenses, while plants employ strategies like host-induced gene silencing (HIGS) to counteract these threats. We further explore the emerging role of extracellular vesicles (EVs) in sRNA transport, which is critical for facilitating interspecies communication in both pathogenic and mutualistic contexts. Although the potential of ckRNAi in mutualistic interactions is promising, the review highlights the need for further experimental validation to establish its true significance in these relationships. By synthesizing current research, this review highlights the intricate molecular dialogues mediated by sRNAs in plant–microbe interactions and identifies critical gaps, proposing future research directions aimed at harnessing these mechanisms for agricultural advancements. Full article

Chronic obstructive pulmonary disease (COPD) and type 2 diabetes mellitus (T2DM) are highly prevalent chronic conditions, frequently coexisting due to their shared pathophysiological mechanisms and risk factors. Epidemiological studies estimate that up to 30% of COPD patients have comorbid T2DM, contributing to worsened disease progression, more hospitalizations, and higher mortality rates. Systemic inflammation in COPD contributes to insulin resistance by increasing pro-inflammatory cytokines (TNF-α, IL-6, and CRP), which impair glucose metabolism and beta-cell function. Conversely, hyperglycemia in T2DM exacerbates oxidative stress, leading to endothelial dysfunction, reduced lung function, and impaired pulmonary repair mechanisms. A comprehensive narrative review was conducted to evaluate the interplay between COPD and T2DM, examining shared pathophysiological mechanisms, clinical consequences, and management strategies. The co-occurrence of COPD and T2DM accelerates disease development, elevates hospitalization rates, and deteriorates overall prognosis. Pharmacological interactions complicate illness treatment, requiring a multidisciplinary therapy strategy. Recent data underscore the need to integrate palliative care, facilitate shared decision-making, and provide psychological support to enhance patient outcomes. Efficient therapy of COPD-T2DM comorbidity necessitates a customized, interdisciplinary strategy that targets both respiratory and metabolic health. Preliminary prognostic dialogues, palliative care, and holistic lifestyle modifications can improve patient quality of life and clinical results. Full article

“Church’s law is first and foremost lex libertatis”—this proclamation by Pope Benedict XVI (2008) inspired the author, a Catholic canonist, to attempt an aspectual reflection on the question of the quality and relevance in Ecclesia of contemporary legislation, keeping in mind the universal (ecumenical) goal of Church law: salus animarum. For in the face of today’s “signs of the times”, it is impossible to avoid the question of how, in legislating this law, interpreting and applying it, to safeguard and optimize the operability of communion bonds (bonum commune) along with the realization of subjective rights (bonum personae)? It is necessary to ask what contemporary proposals for legislative activity can serve to stimulate “organic development in the life […] of the ecclesial society and of the individual persons who belong to it” (John Paul II)? The inescapable context for this reflection today is the epochal enunciation, according to some, of Pope Francis “it is clear that ecumenical dialogue […] enriches canon law”. In the author’s opinion, the last decade has brought two interesting answers to the questions formulated above. The two “ecumenical enterprises”—to use Ecumenical Patriarch Bartholomew’s apt phrase—“fill the historical juridical deficit”; especially since theologians and jurists from different traditions have not yet worked together to demonstrate the ecumenical potential of church law. The results of this work—offering original methodologies—are the idea of “receptive ecumenism”, by Catholic canonist Paul Murray, and Norman Doe’s project, culminating in the Statement of Principles of Christian Law, produced by the International Panel of Experts. Both “ecumenical enterprises” give new impetus to ecumenical initiatives, but also, according to Francis’ quoted words, carry with them the potential to enrich church law and serve its renewal. Full article

This article argues that indigenous knowledge is significantly resourceful for ecological sustainability, without which humanity will not survive. It addresses the intersection between the 15th United Nations Sustainable Development Goal (SGD) “Life on Land” and African indigenous knowledge systems, including the fundamental support system that can sustain the livelihoods of communities. It reconstructs the vision of ecological sustainability from the indigenous knowledge perspective by first analyzing the inadequacy of the United Nations carbon-pricing approach to reforestation and conservation in developing countries. Then, it uses the ethnosphere methodological approach, affirming the ecological ethical warrants found in indigenous epistemology and cosmology in regard to land protection in dialogue with the sustainability vision of Laudado Si’, Querida Amazonia, and Laudate Deum. This article explores indigenous knowledge’s wellspring for ecological sustainability and what it offers for a more sustainable “Life on Land”. It suggests an approach to ecological sustainability that goes beyond a market-based instrument to CO₂ reduction to embrace a view of the “sacramental universe” as essential theological input, without which sustainable “Life on Land” cannot be met. It concludes by showing how African mountain region conservancy practices are not essential in sustaining “Life on Land” not solely because they provide the earth’s freshwater but also because they contain valuable ecologically sensitive cultural and religious wisdom. Full article

The purpose of this paper is to demonstrate the priority of interior life for democracy, imagining a dialogue between Nicolai Berdyaev and Bernard Lonergan. My claim is that Berdyaev and Lonergan converge on the same perspective, while affirming that only a subject who considers the spiritual life as the source of her own life and actions and is open to conversion, is able to collaborate with others in building what Lonergan calls a cosmopolis, which represents a core aspect of democracy. Full article

This article aims to describe the value priorities of Kazakhstani student youth and explore their relationship with traditions, the culture of ethnic groups in Kazakhstan, state ideological attitudes, and the influence of external cultures. This paper addresses the impact of the multinational environment and globalization on the formation of values among students in Kazakhstan. This article analyzes empirical data collected through a mixed-methods questionnaire, developed in accordance with the well-known value measurement methodologies of M. Rokeach and Sh. Schwartz. The results show that although traditional values remain significant, the growing exposure of young people to global influences and socio-political changes indicates a dynamic evolution of their value system, reflecting both continuity and changes in the cultural landscape of Kazakhstan. The key value for Kazakhstani students is family, which suggests sufficient harmony in the life models chosen by these students. The significance of this study lies in its potential to contribute to the establishment of a system of relations in which different cultures can engage in dialogue, preserve their historical trajectories, and maintain mutual respect among representatives of diverse ethnicities and social groups. This study also holds implications for the development of legislative mechanisms aimed at respecting Kazakhstan’s national interests in international communication. Full article

Jason Allen-Paisant in Self-Portrait as Othello moves unflinchingly through complex histories and genealogies that widen to include Jamaica, Venice, Italy, France, and elsewhere and to locate the duppy manifestations of an unburied past in the pervasive precariousness of Black life. Across his poems, he tracks the chaotic reverberations of intergenerational traumas that persist across time, space and collective memory. This paper contends that the poet, through his use of allusion evident in his grafting and borrowings of other stories, literary syncretism, the symbolism of foreignness and its mysterious power, back and forth journeys through Europe and into homelands (Jamaica), procures an integrated circuit of Black meaning and kindred relations. This interconnectedness lays bare the sociohistorical conditions that have and continue to circumscribe and assault Black lives and deconstructs the perpetuity of anti-Black systems in the modern Western world. For all his worldly travels, the poet-narrator situates himself in an interstitial zone where each crossroad leads to new possibilities and affirmative energy. Allen-Paisant thus offers a way to reconcile a vicious history of Black xenophobia while procuring moments and processes to make peace with rupturous spaces, which necessitates a return to his homeland. However, homecoming complicates the search for self and the idea of return draws him into a dialogue with the fragmented inheritances of his past. He ultimately achieves coherence and fresh understandings through images of sterility and barrenness which he re-purposes as a foundation to make bold leaps of faith across uncertain chasms. This paper thus argues that for the poet of the African diaspora, who aspires to recover a long and complex spiritual history, the interface between domestic and international dramas highlights the luminous transcendence embodied in the journey along complicated routes and the steadfast pursuit of ideas that illuminate the deepest insights about identity, culture and the Black experience. Full article