Search Results (9)

Compound T1089—a novel nitrogen mustard based on an indole-3-carboxylic acid derivative (ICAD)—has been synthesized. The ICAD used as the basis for T1089 is a TLR agonist capable of activating an antitumor immune response. This study describes the synthesis method and presents the results of preliminary investigations of this compound. This research included an assessment of acute toxicity in mice, in vivo clastogenic activity evaluated via the bone marrow chromosome aberration (BMCA) test in mice, in vitro cytotoxicity determined by the MTT assay against human lung carcinoma A549 cells, and in vivo antitumor effects (ATEs) in models of conventional chemotherapy (CCT) of solid tumors in mice. The bifunctional alkylating agent cyclophosphamide (CPA) was used as a reference drug. Toxicological studies revealed that T1089 belongs to toxicity class III (moderately toxic), with acute toxicity values (LD₁₆ and LD₅₀) in mice following intraperitoneal (i.p.) administration being 191 and 202 mg/kg, respectively. The alkylating activity and clastogenic potential of T1089 were demonstrated by its effects in the BMCA test, which were comparable to those of CPA. A single i.p. administration of CPA and T1089 at a dose of 0.064 mmol/kg induced similar stimulation of structural mutagenesis associated with DNA strand breaks. The frequency of karyocytes with aberrations increased 20-fold compared to the control, primarily due to a rise in chromatid breaks and fragments, and to a lesser extent, due to an increase in exchange-type aberrations. In vitro cytotoxicity studies indicated differences in the mechanisms of alkylating activity between CPA and T1089. According to the MTT assay, the cytotoxic effects of CPA were observed only at concentrations exceeding 2 mM (IC₅₀ = 4.2 ± 0.3 mM), corresponding to lethal in vivo doses, which is expected since the formation of CPA’s alkylating metabolite requires hepatic microsomal enzymes. In contrast, significant cytotoxic effects of T1089 were observed at much lower concentrations (15–50 μM, IC₅₀ = 33.4 ± 1.3 μM), corresponding to safe in vivo doses. Differences were also observed in the in vivo ATEs of CPA and T1089 in the Ehrlich solid carcinoma (ESC) CCT model. Following seven i.p. administrations at 48 h intervals (33 mg/kg), both compounds exhibited increasing toxicity, manifested as cumulative body weight loss in treated mice. However, despite the aggressive CCT regimen, ESC showed low sensitivity to CPA. The ATE of CPA developed slowly, reaching a significant level only after four injections, and even after seven administrations, tumor inhibition (TI) did not exceed 30%. In contrast, ESC was significantly more sensitive to T1089 under the same CCT conditions. The ATE of T1089 exhibited a cumulative pattern but developed more rapidly and to a greater extent. A significant antitumor effect was observed after just two injections, with maximal efficacy (TI = 53%) achieved after four injections and sustained until the end of the observation period. A high ATE of T1089 was also observed in the B-16 melanoma CCT model. Following six i.p. administrations at 48 h intervals (28 mg/kg), T1089 treatment was associated with minimal toxicity. Despite this mild CCT regimen, melanoma exhibited high sensitivity to T1089. Maximal ATE (TI = 56%) was achieved after two injections, and subsequent administrations maintained a consistently high efficacy (TI = 52–55%) until the end of the study. In summary, preliminary findings demonstrate that T1089 possesses alkylating activity characteristic of bifunctional agents, accompanied by high in vitro cytotoxicity and in vivo ATEs in CCT models (at high doses). Given that the ICAD used as the basis for T1089 is a TLR agonist capable of stimulating antitumor immunity, T1089 can be considered a dual-action alkylating agent with combined antitumor effects. These results justify further investigation of T1089 in conventional and metronomic chemotherapy regimens, particularly in combination with immune checkpoint inhibitors and antitumor vaccines. Full article

The integration of nonconventional energy sources such as solar, wind, and fuel cells into electrical power networks introduces significant challenges in maintaining frequency stability and consistent tie-line power flows. These fluctuations can adversely affect the quality and reliability of power supplied to consumers. This paper addresses this issue by proposing a Proportional–Integral–Derivative (PID) controller optimized through a hybrid Particle Swarm Optimization–Artificial Hummingbird Algorithm (PSO-AHA) approach. The PID controller is tuned using the Integral Time Absolute Error (ITAE) as a fitness function to enhance control performance. The PSO-AHA-PID controller’s effectiveness is evaluated in two networks: a two-area thermal tie-line interconnected power system (IPS) and a one-area multi-source power network incorporating thermal, solar, wind, and fuel cell sources. Comparative analyses under various operational conditions, including parameter variations and load changes, demonstrate the superior performance of the PSO-AHA-PID controller over the conventional PSO-PID controller. Statistical results indicate that in the one-area multi-source network, the PSO-AHA-PID controller achieves a 76.6% reduction in overshoot, an 88.9% reduction in undershoot, and a 97.5% reduction in settling time compared to the PSO-PID controller. In the dual-area system, the PSO-AHA-PID controller reduces the overshoot by 75.2%, reduces the undershoot by 85.7%, and improves the fall time by 71.6%. These improvements provide a robust and reliable solution for enhancing the stability of interconnected power systems in the presence of diverse and variable energy sources. Full article

A low-noise amplifier (LNA) design with the operation of concurrent dual-band for Global Navigation Satellite System (GNSS) receivers with single channel is presented in this work. This LNA structure has an inductively degenerated cascode architecture and is pseudo-differential, operating at two frequencies simultaneously (1.2 GHz and 1.57 GHz). Two noise reduction/cancellation techniques, using load capacitor and feedforward path, respectively, are proposed resulting in an excellent improvement in the noise figure (NF). The input matching circuit uses both series and parallel resonant components to enable concurrency. The adopted pseudo-differential structure results in input balun elimination. Inductively degenerated cascode topology provides both input impedance and optimum noise impedance matching. The soundness of the proposed approach has been demonstrated in a 0.18-µm CMOS technology by TSMC. Simulation results show that at 1.2 GHz and 1.57 GHz the LNA achieves −13 dB and −11 dB of input matching, 24.6 dB and 24.7 dB of gain, 1.47 dB and 1.43 dB of NF, respectively. The input-referred 1-dB compression point (IP_1dB) is around −16 dBm, while the input-referred third-order intercept point (IIP₃) achieves −2.2 dBm at 1.2 GHz and −0.6 dBm at 1.57 GHz. The LNA draws about 13 mA from a 1.8-V supply voltage. Full article

Epithermal deposits represent a significant category of gold occurrences, with their subsurface structure playing a key role in reserve assessments. Fujian Province, characterized by extensive Mesozoic volcanic activities, stands out as a noteworthy region for shallow hydrothermal mineralization in China. This paper focus on the Youxi area within Fujian Province, employing the dual-frequency induced polarization method (DFIP) and controlled-source audio-frequency magnetotelluric method (CSAMT) to investigate the target ore. The DFIP results revealed predominant northeast-oriented zones with high polarizability and notable apparent resistivity. The CSAMT data were inverted using the SCS2D software. Two-dimensional resistivity profiles reveal a three-layer electrical structure, comprising subsurface banded rhyolites influenced by fault zones, intermediate-low resistivity sandstone layers, and deep-seated high-resistivity conglomerates. The resistivity gradient zones and highly polarizable locations align closely with known local faults. We interpreted these resistivity gradient zones as prospective target areas for mineralization, a hypothesis subsequently validated by drilling results. Combining geochemical analyses of epithermal gold deposits with the electrical resistivity structure, we propose an explanatory model for the mechanism of the formation of epithermal gold–silver deposits in the Youxi area. The magmatic hydrothermal fluids ascended along the fault, underwent convection-driven interaction with meteoric waters, and subsequently metasomatized the host rocks. This integrated approach provides valuable insights into the geological processes governing epithermal gold–silver deposit formation in the Youxi region. Full article

The White Rabbit protocol allows synchronization and communication via an optical link in an integrated, modular, and scalable manner. It provides a solution to those applications that have very demanding requirements in terms of synchronization. Field-programmable gate arrays are used to implement the protocol; additionally, special hardware is needed to provide the necessary clock signals used by the dual-mixer time difference for precise phase measurement. In the present work, an expansion board that allows for White Rabbit functionality is presented. The expansion board contains the oscillators required by the White Rabbit protocol, one running at 125 MHz and another at 124.922 MHZ. The architecture of this board includes two oscillator systems for tests and comparison. One is based on VCOs and another on crystal oscillators running at the desired frequencies. In addition, it incorporates a temperature sensor, from where the medium access control address is extracted, an electrically erasable programmable read-only memory, a pulse-per-second output, and a USB UART to access the White Rabbit IP core at the field-programmable gate array. Finally, to ensure the quality of the layout design and guarantee the level of synchronization desired, the results of the power and signal integrity simulations are also presented. Full article

In order to reveal the migration process of chromium-contaminated sites, COMSOL5.6 software was used to build the initial model of the chromium pollution source and analyze the migration change characteristics over time based on the rule of groundwater movement and Convection–Dispersion equation. COMSOL provides fully coupled multiphysics modeling for most engineering fields. The results show that: the permeable layer with a high permeability coefficient during the migration of chromium pollutants has a strong adsorption effect on the heavily polluted part, and it will enhance the lateral diffusion of the polluted area within a short period. Based on the migration model, the intermediate gradient and the symmetrical quadrupole sounding model are built. The variation law of apparent amplitude frequency and apparent resistivity under flat and undulating terrain is analyzed based on the dual frequency IP (Induced Polarization) method. The results show that: The intermediate gradient detection is better than the symmetrical quadrupole sounding in the correspondence between the peak value of apparent amplitude frequency and the valley value of apparent resistivity. The arrangement of the bathymetric measurement point in the center of the projected edge of the pollution field can be a better way to monitor the pollution. Monitoring with the intermediate gradient detection device and the symmetrical quadrupole sounding device creates “multiple peaks” in the curve as it passes through the valley. Arranging the power supply electrodes on the mountain frontiers on both sides of the raised peaks and synthesizes the apparent amplitude frequency and apparent resistivity curves of the pollution field, which can effectively determine the specific orientation of the heavily polluted area of the pollution field. This research makes theoretical additions to the migration characteristics of the Cr pollution field. It provides technical guidance for the real-time monitoring of the pollution field, which is of positive significance for promoting ecological and environmental protection. Full article

The induced polarization (IP) effects in transient electromagnetic (TEM) responses pose difficulties to the TEM data interpretation and inversion. The IP effects break the monotony in TEM decay curves and can even cause sign reversals and lead to the singularity and non-monotony of inversion. The singularity problem is still urgent to be solved. In this paper, the forward modeling method of IP-affected TEM responses is developed using the Cole–Cole model and a frequency-time domain transformation. A TEM data acquisition scheme using a dual-source method without a significant increase in field work is proposed to weaken the singularity and improve the inversion quality finally. Based on the modeling and analysis, the dual-source scheme is designed to guarantee all stations be measured twice with different loops. The joint inversion of dual-source datasets is realized by using an objective combing function and the particle swarm optimization (PSO) algorithm. The synthetic data test proved the validity of the algorithm and illustrated that the joint dual-source method greatly weakened the singularity and stabilized the inversion. The field example of the Baiyun golden deposit showed well consistency with resistivity logging and TEM logging results and predicted the gold mineralization below 2000 m. Full article

The main requirement for using the Fluctuation Enhanced Sensing technique is the ability to perform low-frequency noise measurements. The portability of the measurement system is also a quite desirable feature not limited to this specific application. In this paper, an approach for the realization of a dual channel spectrum analyzer that is capable of exploring frequencies down to DC, although based on a USB sound card, is proposed. The lower frequency range of the input signals, which is outside the frequency range of the sound board, is upconverted to higher frequencies by means of a very simple modulation board. Then, the entire spectrum is reconstructed numerically by proper elaboration. With the exception of the modulation board, the approach we propose does not rely on any specific hardware. Thanks to the efficiency of the spectra estimation and reconstruction software, which is based on a public domain library, the system can be built on a low-cost computer single board computer, such as the Raspberry PI3. Moreover, when equipped with an optical TCP/IP link, it behaves as a compact spectrum analyzer that along with the device under test can be placed into a shielded environment, thus being isolated from external electromagnetic interferences. Full article

The electromagnetic (EM) method is commonly used in mineral exploration due to the method’s sensitivity to conductive targets. Controlled source audio-frequency magnetotellurics (CSAMT) is developed from magnetotelluric (MT) method with an artificial EM source to improve the signal amplitude. It has been used for mineral exploration for many years. In this study, we performed a case study of the CSAMT application for the Eagles-Nest lead–zinc (Pb–Zn) ore deposits in Jianshui, China. The Eagles-Nest deposit is located in southwest in China in forest-covered complex terrain, making it difficult to acquire the geophysical data. Based on the previous dual-frequency induced polarization (IP) results, we designed four profiles for the CSAMT data acquisition. After data processing and inversion, we mapped the subsurface resistivity distribution. From the CSAMT results, we inferred the location of the ore body, which was verified by the drilling wells. The Pb–Zn ore body was found at a depth between 373.70 m to 407.35 m in the well. Full article