Search Results (305)

Sucralose, a persistent and widely used artificial sweetener, has emerged as a significant contaminant in aquatic environments, raising concerns about its ecological and physiological effects on aquatic species. This study investigates the impact of environmentally relevant concentrations of sucralose on the muscle quality of common carp (Cyprinus carpio), a bioindicator species. Using High-Performance Liquid Chromatography (HPLC), sucralose was quantified in water and fish muscle tissues, revealing its persistence and bioaccumulation. Sucralose exposure disrupted critical physicochemical, textural, and structural properties of fish muscle. Protein carbonyl content increased up to 10-fold, while lipid peroxidation levels rose significantly, indicating oxidative stress. Sulfhydryl groups were reduced by more than 40%, and water-holding capacity decreased by 12%, compromising muscle functionality. Textural profile analysis revealed alterations in hardness, cohesiveness, and elasticity, linked to covalent bond formation induced by protein oxidation. Furthermore, electrophoretic analysis confirmed myosin degradation, underscoring sucralose’s role as a pro-oxidant, even at low concentrations. These findings demonstrate that sucralose can adversely affect aquatic organisms by impairing muscle integrity, with potential consequences for their survival, ecological roles, and food web dynamics. This study underscores the urgent need to regulate and monitor artificial sweeteners in aquatic systems to mitigate long-term ecological impacts. Full article

Microcellular thermoplastic polyurethane (TPU) foams with dynamic covalent bonds demonstrating exceptional self-healing capabilities, coupled with precisely controlled micron-scale cellular architectures, present a promising solution for developing advanced materials that simultaneously achieve damage recovery and low density. In this study, a series of self-healable materials (named as PU-S) with high light transmittance possessing two dynamic covalent bonds (oxime bond and disulfide bond) in different ratios were fabricated by the one-pot method, and then the prepared PU-S were foamed utilizing the green and efficient supercritical carbon dioxide (scCO₂) foaming technology. The PU-S foams possess multiple dynamic covalent bonds as well as porous structures, and the effect of the dynamic covalent bonds endows the materials with excellent self-healing properties and recyclability. Owing to the tailored design of dynamic covalent bonding synergies and micron-sized porous structures, PU-S₅ exhibits hydrophobicity (97.5° water contact angle), low temperature flexibility (T_g = −30.1 °C), high light transmission (70.6%), and light weight (density of 0.12 g/cm³) together with high expansion ratio (~10 folds) after scCO₂ foaming. Furthermore, PU-S₅ achieves damage recovery under mild thermal conditions (60 °C). Accordingly, self-healing PU-S based on multiple dynamic covalent bonds will realize a wide range of potential applications in biomedical, new energy automotive, and wearable devices. Full article

Non-covalent and dynamic covalent interactions enable supramolecular systems to function as adaptive platforms in biomedical research, offering novel strategies for precision medicine applications. This review examines five-year developments in supramolecular applications across precision medical domains, including disease diagnosis, bioimaging, targeted drug delivery, tissue engineering, and gene therapy. The review begins by systematically categorizing supramolecular structures into dynamic covalent systems (e.g., disulfide bonds, boronate esters, and hydrazone bonds) and dynamic non-covalent systems (e.g., host–guest interactions, hydrogen-bond networks, metal coordination, and π–π stacking), highlighting current strategies employed to optimize their responsiveness, stability, and targeting efficiency. Representative case studies, such as cyclodextrin-based nanocarriers and metal–organic frameworks (MOFs), are thoroughly analyzed to illustrate how supramolecular systems can enhance precision in drug delivery and improve biocompatibility. Furthermore, this article critically discusses major challenges faced during clinical translation, encompassing structural instability, inadequate specificity of environmental responsiveness, pharmacokinetic and toxicity concerns, and difficulties in scalable manufacturing. Potential future directions to overcome these barriers are proposed, emphasizing biomimetic interface engineering and dynamic crosslinking strategies. Collectively, the continued evolution in structural optimization and functional integration within supramolecular systems holds great promise for achieving personalized diagnostic and therapeutic platforms, thereby accelerating their translation into clinical practice and profoundly shaping the future landscape of precision medicine. Full article

Using molecular dynamics (MDs) simulations with Materials Studio 8.0 software, we systematically investigated the adsorption and aggregation behaviors of silicon, tin, and copper atoms on the surface of (7,7) single-walled carbon nanotubes (SWCNTs). Silicon, tin, and copper were selected due to their distinct bonding characteristics—covalent (Si), semi-metallic (Sn), and metallic (Cu)—and their relevance in potential composite interface applications such as energy storage, thermal management, and electronics. The results indicate that silicon atoms form multi-layered concentric shells; however, the rigidity of their covalent bonds makes the resulting structures susceptible to disruption by local density fluctuations. Tin atoms form a limited number of stable concentric shells benefiting from the flexibility of their semi-metallic bonds. In contrast, copper atoms rapidly aggregate into disordered clusters due to their high diffusivity and metallic bonding. Within the confined geometry of the carbon nanotubes, all three types of atoms exhibit a tendency toward spiral growth, but their regularity depends on the properties of their chemical bonds, leading to distinct spiral features. These findings are further supported by linear density and radial distribution function (RDF) analyses. Full article

Traditional petroleum engineering materials have problems such as single functionality and poor environmental adaptability in terms of lost circulation control and enhanced oil recovery. Supramolecular gels, with their dynamic reversible non-covalent network structure, demonstrate unique advantages in this regard. This paper classifies supramolecular gels into hydrogen bond type, metal coordination type, host–guest type, and electrostatic interaction type based on differences in crosslinking structures. It explains the construction principles and characteristics of each type of gel and analyses their application progress in petroleum engineering fields, such as lost circulation control in drilling, temporary plugging in fracturing, and profile control in enhanced oil recovery. It also discusses the advantages and disadvantages of different systems and future development directions. Research has shown that the molecular design strategy of supramolecular gels can effectively address technical challenges under complex conditions, offering new insights for oil and gas field development. Further optimization of their long-term stability and large-scale production technology is needed to advance their practical application. Full article

Electroconductive, self-healing hydrogels have surfaced as a versatile tool for advanced wound care applications, since they combine classic hydrogels’ moist and biomimetic environment with the dynamic electrical responsiveness that can function as an accelerator of tissue repair processes. Recent advances report the automatic restoration of materials after mechanical disruption through various mechanisms, such as ionic or covalent bonds and supramolecular interactions. This property is crucial for biomaterials, as they are often applied in skin regions with high motility and, therefore, a high risk of breakage. By integrating within these networks compounds that are electrically active—polymers such as PEDOT:PSS or polypyrrole, or 2D nanomaterials such as graphene—it is possible to confer responsiveness to these hydrogels, which can lead to increases in fibroblast proliferation, antimicrobial properties, and angiogenesis. Furthermore, these biomaterials must have skin-mimicking mechanical properties and can also be loaded with drugs to improve their healing properties even further. This review synthesizes the chemistry behind the self-healing and electroconductive properties of these materials and expands on the available literature on this field and their biological outcomes, while also providing a look into the future of these promising materials, aiming at their integration in standard wound care strategies. Full article

Molecular dynamics (MD) simulations have been performed on the energetics, mechanical properties, and irradiation response of seventy-three 3C-SiC symmetric tilt grain boundaries (STGBs) with three tilt axes (<100>, <110> and <111>). The effect of GB characteristics on the STGB properties has been investigated. The GB energy is positively and linearly correlated with the excess volume, but the linearity in SiC is not as good as in metals, which stems from the inhomogeneous structural relaxation near GBs induced by orientation-sensitive covalent bonding. For <110>STGBs, the shear strength exhibits symmetry with respect to the misorientation angle of 90°, which is consistent with ab initio calculations for Al in similar shear orientations. Cascades are performed with 8 keV silicon as the primary knock-on atom (PKA). No direct correlation is found between the sink efficiency of GBs for defects and GB characteristics, which comes from the complexity of the diatomic system during the recovery phase. For GBs with smaller values of Σ, the GBs exhibit a weaker blocking effect on the penetration of irradiated defects, resulting in a lower number of defects in GBs and a higher number of total surviving defects. In particular, it is seen that the percentage decrease in tensile strength after irradiation is positively correlated with the Σ value. Taken together, these results help to elucidate the impact of GB behavior on the mechanical properties of as well as the primary irradiation damage in SiC and provide a reference for creating improved materials through GB engineering. Full article

Background/Objectives: Oncogenic KRAS drives ~30% of solid tumours, yet the only approved G12C-specific drugs benefit ≈ 13% of KRAS-mutant patients, leaving a major clinical gap. We sought mutation-agnostic natural ligands from Ziziphus lotus, whose stereochemically rich phenolics may overcome this limitation by occupying the SI/II (Switch I/Switch II) groove and locking KRAS in its inactive state. Methods: Phytochemical mining yielded five recurrent phenolics, such as (+)-catechin, hyperin, astragalin, eriodictyol, and the prenylated benzoate amorfrutin A, benchmarked against the covalent inhibitor sotorasib. An in silico cascade combined SI/II docking, multi-parameter ADME/T (Absorption, Distribution, Metabolism, Excretion, and Toxicity) filtering, and 100 ns explicit solvent molecular dynamics simulations. Pharmacokinetic modelling predicted oral absorption, Lipinski compliance, mutagenicity, and acute-toxicity class. Results: Hyperin and astragalin showed the strongest non-covalent affinities (−8.6 kcal mol⁻¹) by forging quadridentate hydrogen-bond networks that bridge the P-loop (Asp30/Glu31) to the α3-loop cleft (Asp119/Ala146). Catechin (−8.5 kcal mol⁻¹) balanced polar anchoring with entropic economy. ADME ranked amorfrutin A the highest for predicted oral absorption (93%) but highlighted lipophilic solubility limits; glycosylated flavonols breached Lipinski rules yet remained non-mutagenic with class-5 acute-toxicity liability. Molecular dynamics trajectories confirmed that hyperin clamps the SI/II groove, suppressing loop RMSF below 0.20 nm and maintaining backbone RMSD stability, whereas astragalin retains pocket residence with transient re-orientation. Conclusions: Hyperin emerges as a low-toxicity, mutation-agnostic scaffold that rigidifies inactive KRAS. Deglycosylation, nano-encapsulation, or soft fluorination could reconcile permeability with durable target engagement, advancing Z. lotus phenolics toward broad-spectrum KRAS therapeutics. Full article

Biogenic silver nanoparticles (AgNPs) were synthesized via a green chemistry strategy using wheat extract and subsequently functionalized with a carboxymethyl chitosan–cinnamaldehyde (CMC=CIN) conjugate through covalent imine bonding. The resulting nanohybrid (AgNP–CMC=CIN) was extensively characterized to confirm successful biofunctionalization: UV–Vis spectroscopy revealed characteristic cinnamaldehyde absorption peaks; ATR-FTIR spectra confirmed polymer–terpene bonding; and TEM analysis evidenced uniform nanoparticle morphology. Dynamic light scattering (DLS) measurements indicated an increase in hydrodynamic size upon coating (from 59.46 ± 12.63 nm to 110.17 ± 4.74 nm), while maintaining low polydispersity (PDI: 0.29 to 0.27) and stable surface charge (zeta potential ~ −30 mV), suggesting colloidal stability and homogeneous polymer encapsulation. Antifungal activity was evaluated against Fusarium oxysporum, Penicillium citrinum, Aspergillus niger, and Aspergillus brasiliensis. The minimum inhibitory concentration (MIC) against F. oxysporum was significantly reduced to 83 μg/mL with AgNP–CMC=CIN, compared to 708 μg/mL for uncoated AgNPs, and was comparable to the reference fungicide tebuconazole (52 μg/mL). Seed priming with AgNP–CMC=CIN led to improved germination (85%) and markedly reduced fungal colonization, while maintaining a favorable phytotoxicity profile. These findings highlight the potential of polysaccharide-terpene-functionalized biogenic AgNPs as a sustainable alternative to conventional fungicides, supporting their application in precision agriculture and integrated crop protection strategies. Full article

This study presents a comprehensive evaluation of starch-based gel formulations enriched with proteins and hydrocolloids for extrusion-based 3D food printing (3DFP). Food inks were prepared using corn or potato starch, protein concentrates (fava, whey, rice, pea and soya), and hydrocolloids (κ-carrageenan, arabic gum, xanthan gum, and carboxy methylcellulose). Their rheological, mechanical, and textural properties were systematically analyzed to assess printability. Among all formulations, those containing κ-carrageenan consistently demonstrated superior viscoelastic behavior (G′ > 4000 Pa), optimal tan δ values (0.096–0.169), and yield stress conducive to stable extrusion. These inks also achieved high structural fidelity (93–96% accuracy) and favourable textural attributes such as increased hardness and chewiness. Computational Fluid Dynamics (CFD) simulations further validated the inks’ performances by linking pressure and velocity profiles with rheological parameters. FTIR analysis revealed that gel strengthening was primarily driven by non-covalent interactions, such as hydrogen bonding and electrostatic effects. The integration of empirical measurements and simulation provided a robust framework for evaluating and optimizing printable food gels. These findings contribute to the advancement of personalized and functional 3D-printed foods through data-driven formulation design. Full article

Traditional covalently cross-linked solid-state electrolytes exhibit desirable mechanical durability but suffer from limited processability and recyclability due to their permanent network structures. Incorporating dynamic covalent bonds offers a promising solution to these challenges. In this study, we report a reprocessable and recyclable polymer electrolyte based on a dynamic ester bond network, synthesized from commercially available materials. Polyethylene glycol diglycidyl ether (PEGDE) and glutaric anhydride (GA) were cross-linked and cured in the presence of benzyl dimethylamine (BDMA), forming an ester-rich polymer backbone. Subsequently, 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) was introduced as a transesterification catalyst to facilitate network rearrangement. Lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) was incorporated to establish efficient ion transport pathways. By tuning the cross-linking density and catalyst ratio, the electrolyte achieved an ionic conductivity of 1.89 × 10⁻⁵ S/cm at room temperature along with excellent reprocessability. Full article

Research on phase change materials (PCMs) is booming in the context of global energy structure transitions and the challenge of dealing with temperature fluctuations in engineering materials. Polyurethane solid–solid phase change materials (PUSSPCMs) show great potential for thermal energy storage and temperature regulation because of their designable molecular structure, no risk of leakage, and high bulk stability. In this paper, the recent research progress on PUSSPCMs is systematically reviewed. Starting from the material system, the core preparation process of the PUSSPCMs was elucidated. At the performance improvement level, related performance studies on PUSSPCMs are systematically summarized, focusing on the introduction of dynamic covalent bonds and a nanofiller composite strategy to enhance the thermophysical properties of the materials. At the application level, innovative studies and thermomodulation advantages of PUSSPCMs in different fields are summarized. Finally, for green development, multifunctionalization, and bottlenecks in the scale-up preparation of PUSSPCMs, future research directions for balancing the performance requirements, conducting multi-scale simulations, and exploring green materials are proposed to provide theoretical references for the development and application of high-performance PUSSPCMs. Full article

Background: Chitosan (CS) crosslinked with genipin (GNP) provides a mild, non-toxic route to generate nanogels (NGs) with enhanced integrity and colloidal stability. Objectives: To develop and characterise CS-GNP NG as a novel platform for targeted cellular delivery, optimising design through physicochemical characterisation and biocompatibility evaluation. Methods: NGs were synthesised under optimised conditions by adjusting the pH of the CS solution, followed by high-intensity ultrasound (HIUS) to achieve disaggregation. Physicochemical characterisation was carried out using UV-Vis spectroscopy, FTIR, dynamic light scattering (DLS), and scanning electron microscopy (SEM). Rheological studies and SAXS analysis assessed structural properties. Biocompatibility was evaluated via MTT assay, and internalisation was monitored by fluorescence microscopy on mammalian cell lines. Results: NG formation was highly pH-dependent, with optimal configuration at pH 4.5, yielding stable, uniformly sized particles (~200 nm, ζ-potential +29 mV). Kinetic modelling showed a sigmoidal formation pattern, suggesting nucleation, growth, and stabilisation. FTIR confirmed covalent bonding between CS and GNP via primary amide bonds and Schiff bases. Rheology indicated pseudoplastic behaviour, and SAXS revealed a compact network formation. Biocompatibility assays confirmed non-cytotoxicity below 100 µg/mL and efficient cellular uptake. Conclusions: This study presents a rapid, reproducible protocol for generating colloidally stable, biocompatible NGs suitable for drug delivery. Full article

Background/Objectives: The increasing prevalence of multidrug-resistant bacteria presents a major global health challenge, prompting a search for innovative antimicrobial strategies. This study aimed to develop and evaluate a novel nanobiostructure combining alumina nanoparticles (NPs) with the antimicrobial peptide lunatin-1 (Lun-1), forming peptide-functionalized nanofilaments. The main objective was to investigate how the site of peptide functionalization (C-terminal vs. N-terminal) affects membrane interactions and antibacterial activity. Methods: NP–peptide conjugates were synthesized via covalent bonding between lun-1 and alumina NP and characterized using transmission electron microscopy (TEM), X-ray diffraction (XRD), zeta potential analysis, dynamic light scattering (DLS), Fourier-transform infrared (FTIR), and solid-state ¹³C NMR. Antibacterial activities were assessed against different Gram-positive and Gram-negative strains. Biophysical analyses, including circular dichroism (CD), isothermal titration calorimetry (ITC), differential scanning calorimetry (DSC), and solid-state ²H NMR, were employed to evaluate peptide–membrane interactions in the presence of membrane-mimetic vesicles composed of POPC:POPG (3:1) and DMPC:DMPG (3:1). Results: Characterization confirmed the successful formation of NP–peptide nanofilaments. Functionalization at the N-terminal significantly influenced both antibacterial activity and peptide conformation compared to C-terminal attachment. Biophysical data demonstrated stronger membrane interaction and greater membrane disruption when lun-1 was conjugated at the N-terminal. Conclusions: The site of peptide conjugation plays a crucial role in modulating the biological and biophysical properties of NP–lunatin-1 conjugates. C-terminal attachment of lunatin-1 retains both membrane interaction and antibacterial efficacy, making it a promising strategy for the design of peptide-based nanotherapeutics targeting resistant pathogens. Full article

To overcome the shortcomings of traditional polyurethane, such as poor weather resistance and susceptibility to hydrolysis, this study systematically explores the preparation techniques of organic silicon-modified polyurethane and its application in intelligent sports fields. By introducing siloxane into the polyurethane matrix through copolymerization, physical blending, and grafting techniques, the microphase separation structure and interfacial properties of the material are effectively optimized. In terms of synthesis processes, the one-step method achieves efficient preparation by controlling the isocyanate/hydroxyl molar ratio (1.05–1.15), while the prepolymer chain extension method optimizes the crosslinked network through dual reactions. The modified material exhibits significant performance improvements: tensile strength reaches 60 MPa, tear resistance reaches 80 kN/m, and the elastic recovery rate ranges from 85% to 92%, demonstrating outstanding weather resistance. In sports field applications, the 48% impact absorption rate meets the requirements for athletic tracks, wear resistance of <15 mg suits gym floors, and the impact resistance for skate parks reaches 55%–65%. Its environmental benefits are notable, with volatile organic compounds (VOC) <50 g/L and a recycling rate >85%, complying with green building material standards. However, its development is still constrained by multiple factors: insufficient material interface compatibility, a comprehensive cost of 435 RMB/m², and the lack of a quality evaluation system. Future research priorities include constructing dynamic covalent crosslinked networks (e.g., self-healing systems), adopting bio-based raw materials to reduce carbon footprint by 30%–50%, and integrating flexible sensing technologies for intelligent responsiveness. Through multidimensional innovation, this material is expected to evolve toward multifunctionality and environmental friendliness, providing core material support for the intelligent upgrading of sports fields. Full article