Search Results (13,000)

Limited evidence exists on how teachers contribute to student learning gains in early childhood education. This study draws on the Dynamic Model of Educational Effectiveness (DMEE) and investigates the impact of teacher factors on pre-primary students’ mathematics achievement. It also examines whether the five proposed dimensions—frequency, quality, focus, stage, and differentiation—can clarify the conditions under which these factors influence learning. Using a stage sampling procedure, 463 students and 27 teachers from Greek pre-primary schools were selected. Mathematics achievement was assessed at the beginning and end of the school year, while external observations measured the DMEE factors. Analysis of observation data using multi-trait multilevel models provided support for the construct validity of the measurement framework. Teacher factors explained variation in student achievement gains in mathematics. The added value of using a multidimensional approach to measure the functioning of the teacher factor was identified. Implications of the findings are drawn. Full article

The global community remains significantly off track in achieving the United Nations Sustainable Development Goals (SDGs), prompting calls for not only stronger political commitments but also more effective and credible expert guidance. This paper contributes to this discourse by examining a critical form of global environmental expertise: the conduct of global environmental assessments. Such expertise has become a foundational component of the institutional architecture underpinning global sustainability governance. Focusing on the Intergovernmental Panel on Climate Change (IPCC), one of the most prominent and widely recognized international expert bodies, this study examines the challenges that researchers face when synthesizing research findings and making them policy-relevant within the IPCC’s assessment work. The empirical material consists of an interview study (N = 18) conducted with experts involved in the IPCC, from its first assessment (1990) to the most recent one (2023). The data were analyzed thematically using NVivo. The analysis reveals four key internal challenges that the IPCC must address to enhance its advisory capacity: epistemic hierarchies, leadership and management dynamics, the complexities of formulating recommendations, and inequities in recognition and reward systems. By identifying and analyzing these challenges, the paper contributes to ongoing discussions about the IPCC’s future development and offers broader insights into the evolving role of scientific expertise in global environmental governance. Full article

The article explores how the design of informational and promotional messages from financial institutions influences their reception by young people. The study combined eye tracking, individual in-depth interviews (IDIs), and text mining analysis to examine both visual attention and participants’ conscious reactions. The aim was to identify young users’ preferences, determine factors influencing content perception, and assess the effectiveness of visual and audiovisual communication strategies. The main hypothesis proposed that minimalistic and visually attractive messages, enhanced with dynamic graphics, more effectively shape attitudes and elicit positive emotions. Specific aspects examined included the role of infographics, color schemes, message dynamics, and references to financial institutions in attracting attention and engagement. The results indicate that young people operate primarily in virtual space and express limited interest in traditional media such as television or print. They favor short, clear, and visually structured messages. Excessive textual content and lack of clarity provoked negative reactions and discouraged further engagement. Elements like infographics, colors, and logos were found to be strongly associated with brand recognition and memorability. Full article

Jordan’s aging population faces a critical challenge: a strong cultural preference for aging at home, rooted in Islamic ethics of familial care (birr al-wālidayn), conflicts with housing stock that is largely unsafe and inaccessible. This first national mixed-methods study examines the intersection of home modifications, socio-economic barriers, and cultural constraints to aging in place. Data from 587 surveys and 35 interviews across seven governorates were analyzed using chi-square tests, linear regression, and thematic coding. Results indicate that while physical modifications significantly improve accessibility to key spaces like kitchens and reception areas (majlis) (χ² = 341.86, p < 0.001), their adoption is severely limited. Socio-economic barriers are paramount, with 34% of households unable to afford the median modification cost of over $1500. Cultural resistance is equally critical; 22% of widows avoid modifications like grab bars to prevent the ‘medicalization’ of their home, prioritizing aesthetic and symbolic integrity over safety. The study reveals a significant gendered decision-making dynamic, with men controlling 72% of structural modifications (β = 0.27, p < 0.001). We conclude that effective policy must integrate universal design with Islamic care ethics. We propose three actionable recommendations: (1) mandating universal design in building codes (aligned with SDG 11), (2) establishing means-tested subsidy programs (aligned with SDG 10), and (3) launching public awareness campaigns co-led by faith leaders to reframe modifications as preserving dignity (karama) (aligned with SDG 3). This approach provides a model for other rapidly aging Middle Eastern societies facing similar cultural-infrastructural tensions. Full article

This study uses a U-shaped aqueduct structure in a specific irrigation area as the research object to examine the damage patterns of large-span elevated U-shaped aqueduct structures under seismic action. A single-span aqueduct model that integrates fluid–structure interaction is created with the finite element program ANSYS. The incremental dynamic analysis approach is utilized to perform nonlinear dynamic time–history assessments for three types of bearings—plate rubber bearings, pot rubber bearings and lead-core rubber bearings—under conditions of an empty condition, a half-full condition and a design water level. Seismic fragility curves for the bearings and piers subjected to transverse seismic stress are developed using capacity–demand ratio models and specified damage limit states. The findings demonstrate that the likelihood of aqueduct components being damaged increases substantially as seismic intensity increases, with bearings failing before piers. Under the conditions of empty, half-full and design water levels, the structural mass increases as a result of higher water levels. This alters the dynamic response characteristics and increases the likelihood of failure in a variety of damage states. The probability of plate rubber bearings experiencing minor damage exceedance increases from 11.75% to 61.6% as the water level rises from vacant to design conditions. Lead-core rubber bearings provide better seismic isolation than plate rubber bearings and pot rubber bearings. This greatly lowers the aqueduct structure’s displacement response and damage likelihood. Under design water level circumstances, the chance of mild damage to lead rubber bearings is 8.64%, at a peak ground acceleration of 0.4 g. The damage probabilities for the pot rubber bearings and the plate rubber bearings are 80.68% and 97.45%, respectively. The research findings establish a theoretical foundation for the seismic design and damage evaluation of aqueduct structures in places with high seismic activity, ensuring the stable operation of water transfer projects and sustainable water resource utilization, presenting considerable technical applicability. Full article

The development of information technology allows firms to access consumer purchase records, enabling them to distinguish between new and old consumers. Firms can then provide these groups with respective product pricing and promised delivery time. This paper develops a two-period dynamic model based on game theory to examine the effects of behavior-based pricing and behavior-based promised delivery time strategies on product price, promised delivery time, firm profits, consumer surplus, and social welfare under conditions where consumers exhibit time-sensitive preferences. We find, first, when firms opt to implement behavior-based pricing and promised delivery time strategies, they should offer lower (higher) prices and longer (shorter) delivery times to new (old) consumers. Second, the implementation of behavior-based pricing and promised delivery time strategies may decrease firm profits while enhancing consumer surplus. Third, when consumers exhibit stronger time-sensitive preferences, behavior-based pricing and promised delivery time strategies can enhance social welfare; conversely, they may have a detrimental impact on social welfare. Finally, we extend the model into three aspects—asymmetric strategy selection, firm logistics service costs, and myopic consumer behavior—to enrich our research and test the robustness of the model. The results of this paper supply managerial implications and theoretical references for firms’ strategic implementation and policy-making by relevant government departments. Full article

As aquaculture expands globally, understanding immune responses in non-traditional farmed species like Octopus vulgaris under varying environmental conditions is increasingly important. This study investigated lysozyme activity, a key innate immune marker, in cell-free hemolymph of O. vulgaris following experimental challenge with four Gram-negative fish pathogens (Photobacterium damselae subsp. piscicida, P. damselae subsp. damselae, Vibrio alginolyticus, and V. anguillarum O1) at two temperatures (21 ± 0.5 °C and 24 ± 0.5 °C). These pathogens were selected because octopus farming frequently occurs near fish aquaculture facilities, raising the potential for pathogen crossover. A total of 216 wild octopuses were injected intramuscularly or intravenously and sampled on days 0, 3, and 7 post-challenge. Lysozyme activity varied by pathogen, injection route, sampling time, and temperature. A significant time- and temperature-dependent increase was observed, especially in IM-challenged groups exposed to Photobacterium species. Elevated temperatures supported a more prolonged immune response. These results highlight lysozyme as a responsive biomarker of innate immunity in O. vulgaris and emphasize the role of environmental factors in immune modulation. This work provides a foundation for disease monitoring and health management in cephalopod aquaculture. Future research should examine long-term lysozyme dynamics, broader pathogen exposure, molecular mechanisms, and additional environmental stressors such as salinity and pollution. Full article

To address the issue of uneven load and premature failure in ball–column composite bearings caused by ring deformation, this study develops a mechanical analysis model, considering ring deformation based on flexible ring theory and rolling bearing design. It systematically examines radial deflection of the ring and how key parameters affect load distribution and stress. The results demonstrate that the elastic deformation of the collar redistributes the load, reduces the roller column’s load-carrying efficiency, and disrupts the optimal load distribution mode. Increasing the number of loaded rolling elements significantly improves the load uniformity, reduces the peak contact stress, and enhances the overall load-carrying performance. By optimizing the clearance matching across three bearings rows, a load-adaptive gradient bearing mechanism is realized by dynamically transferring, 70–90% of the heavy-load optimal distribution. These findings address the domestic research gaps and offer theoretical support for the performance prediction and optimal design of integrated ball–column composite bearings. Full article

Alterations in gene expression induced by ionizing radiation (IR) were commonly explained by transcriptional activation. However, the weak correlation between mRNA and protein levels following IR indicates the significant role for post-transcriptional regulation. microRNAs (miRNAs) bound to AGO2 play a significant role in post-transcriptional regulation; however, their role in radiation response is not clear. miRNA sequencing was performed to analyze the miRNAome of glioma cells. The effect of IR on Let-7 miRNAs and their association with AGO2 was examined using RT-qPCR and RNA immunoprecipitation (RIP) assays. Clonogenic assays were performed to measure radiosensitivity following Let-7a overexpression or knockdown. DNA damage (γH2AX foci) and cell cycle distribution were analyzed by immunofluorescence and flow cytometry. Let-7 miRNA regulatory networks were identified through target prediction and pathway enrichment analysis. AGO2-Let-7 binding decreased post IR, indicating impaired RISC loading. Let-7 overexpression increased radiosensitivity, DNA damage and G2/M cell cycle arrest in glioma and other cells (HeLa and MDA-MB-231). Let-7 miRNAs mainly targeted cell cycle and DNA damage response (DDR) pathways. Our study showed radiation impairs AGO2-miRNA binding, while restoring Let-7-AGO2 interaction enhances radiosensitivity by modulating DNA repair and cell cycle checkpoint activation. Targeting AGO2-miRNA dynamics represents a promising approach to improve radiotherapy outcomes. Full article

Vertebrate embryonic development relies on tightly regulated signaling pathways that guide morphogenesis, cell fate specification, and tissue organization. Among these, the Wnt signaling pathway plays a central role, orchestrating key developmental events. The non-canonical Wnt pathways, including the Planar Cell Polarity and Wnt/Ca²⁺ branches, are especially critical for regulating cytoskeletal dynamics during gastrulation. Recent studies highlight that these pathways interface with cytoskeletal effectors to control actin remodeling in response to extracellular cues. One such effector is Profilin, a small, evolutionarily conserved actin-binding protein that modulates actin polymerization and cellular architecture. Profilins, particularly Profilin1 and 2, are known to interact with Daam1, a formin protein downstream of PCP signaling, thereby linking Wnt signals to actin cytoskeletal regulation. Emerging evidence suggests that Profilins are active signaling intermediates that contribute to morphogenetic processes. Their context-dependent interactions and differential expression across species also suggest that they play specialized roles in development and disease. This review synthesizes the current understanding of Profilin’s role in non-canonical Wnt signaling, examining its molecular interactions and contributions to cytoskeletal control during development. By integrating data across model systems, we aim to clarify how Profilins function at the intersection of signaling and cytoskeletal dynamics, with implications for both developmental biology and disease pathogenesis. Full article

The rapid expansion of transportation infrastructure on Hainan Island has intensified ecological pressures such as landscape fragmentation and decreased connectivity, threatening the environmental integrity of Hainan Tropical Rainforest National Park. As China’s only tropical island national park, it is important to maintain biodiversity and ecological resilience. Therefore, this study attempts to examine the park and its 5 km buffer zone to assess how transport expansion from 2003 to 2023 has altered land use patterns and landscape connectivity. Through the analysis of multi-period land use data, the land use changes are tracked by using ArcGIS and Fragstats 4.3 software, and the landscape dynamics are quantified. We linked these patterns to ecological processes via a resistance-surface model, which is further refined by spatial structural indices to better reflect ecological realism. Ecological sources were subsequently identified through morphological analysis and ecosystem service evaluation, and circuit theory was applied to delineate potential corridors and construct an ecological security network. The results indicate that (1) transportation development has significantly increased landscape fragmentation and ecological resistance, particularly along major highways; (2) while core forest areas inside the park remain relatively intact, the buffer zones show accelerating degradation; and (3) Although there are many ecological conflict points between the transportation network and the ecological corridor, the construction of animal channels in combination with bridges, tunnels and culverts can effectively improve ecological connectivity and protect the integrity of animal habitat. These findings highlight the vulnerability of ecological integrity as the network expands. The proposed modeling framework provides a more realistic assessment of infrastructure impact and offers a scientific basis for coordinating ecological protection and transport planning in tropical island national parks. Full article

In institutional environments characterized by ambiguity and contestation, the formation of sustainability capabilities poses significant interpretive and organizational challenges. Existing perspectives often assume clear mandates, strategic intent, and rational agency, yet such assumptions rarely hold in transitional or weakly institutionalized settings. This study adopts a constructivist grounded theory (CGT) approach to examine how sustainability-related routines emerge, stabilize, and contribute to capability formation under conditions of institutional complexity. Drawing from multiple organizational cases across East Asian contexts, this study identifies three interdependent categories of routines, including sensemaking, stabilization, and coordination, that interact recursively to generate sustainability capabilities. These routines function not as linear processes or technical tools, but as dynamic infrastructures of interpretation, consolidation, and alignment. Their recursive interplay enables organizations to translate ambiguous sustainability signals into patterned practices and symbolic legitimacy over time. We consolidate these insights into a mid-range theoretical framework, the Routines-as-Practice Configuration for Sustainability Structuring (RAPCSS). The RAPCSS explains how sustainability is not merely implemented but enacted and continually remade through situated, performative routines. By bridging strategic and practice-based perspectives, this study contributes to sustainability theory by theorizing capabilities as emergent configurations shaped through recursive routine work. This offers a situated, processual, and reflexive account of how sustainability unfolds under conditions of institutional ambiguity. Full article

Understanding the spatiotemporal dynamics of croplands is crucial for guiding agricultural transformation, food security, and sustainable land use in Africa. This study employs 30 m resolution land cover data and multi-source datasets to examine the spatiotemporal changes in rainfed and irrigated cropland and their driving factors in Tanzania from 1990 to 2020 through multiple GIS spatial analysis methods. The results indicate a net increase in Tanzania’s total cropland area, primarily driven by the expansion of irrigated cropland that has offset the volatile decline of rainfed cropland. From 1990 to 2000, rainfed cropland showed intense bidirectional conversion with shrubland and forest; thereafter, the scale of this conversion continued to decrease. In contrast, irrigated cropland expansion exhibited phased fluctuations. Spatially, rainfed cropland dominates the central, lake, and western zones, while irrigated cropland is predominantly concentrated in the western and southern highland. Hotspots of rainfed cropland shifted from extensive expansion in the central and western zones during the 1990s to localized growth in mountainous areas by the 2010s. Concurrently, irrigated cropland hotspots evolved from a lakeside-concentrated pattern to contiguous development in the central and western zones. Both cropland types exhibit a northwest–southeast spatial orientation. The center of rainfed cropland shifted northwest before moving southeast, while that of irrigated cropland migrated southeastward and then stabilized. Rainfall is a key determinant of rainfed cropland distribution, whereas river network and road network density exert a growing influence on irrigated cropland. Full article

p53 protein is a nuclear phosphoprotein that is a critical tumor suppressor, playing a key role in regulating the cell cycle and initiating apoptosis in response to DNA damage. As a transcription factor, it also activates genes involved in DNA repair and cell cycle arrest. H2AX is a histone H2A variant, which is vital for detecting DNA double-strand breaks. When phosphorylated at Serine 139, it forms γH2AX, which recruits DNA repair proteins to damage sites. The interaction between p53 and γH2AX is central to the DNA damage response, where p53 activates repair pathways and γH2AX flags the DNA lesions. It is known that impairing γH2AX while preserving p53 activity may slow cancer progression. Towards understanding this, graphene quantum dots (GQDs) offer a promising solution for tracking γH2AX and analyzing DNA damage, where they can help visualize it by investigating how p53 contributes to DNA repair at sites marked by γH2AX. This study examines the interactions between γH2AX and p53 with three different-sized two-layered GQDs (2 × 3 nm, 5 × 6 nm, and 8 × 9 nm) using the Molecular Dynamics (MD) approach. Our analysis revealed that both proteins adsorbed strongly to the 5 × 6 nm and 8 × 9 nm GQDs, with 5 × 6 nm GQD having the highest stability, making it a key candidate for future biosensing and cancer research, whereas the 8 × 9 nm GQD has the greatest potential to denature the proteins. Full article

Brinjal (Solanum melongena) is one of the most tropical vegetable crops cultivated worldwide. Rhizosphere microbial dynamics play a crucial role in plant nutrition, providing valuable insights into soil fertility and sustainable agricultural practices. This study aims to identify sustainable nutrient management practices for brinjal, focusing on the rhizosphere microbiome by examining various nutrient management approaches, including integrated nutrient management (INM), inorganic fertilization, and organic fertilization. Root architectural analysis, LC-MS-based metabolite profiling, and shotgun metagenomics were employed to assess the various nutrient management-induced changes in metabolites and the microbial community. The result suggested that superior root features, including volume (16.3 cm³), surface area (399.48 cm²), and total root length (794.89 cm), were achieved under INM. Additionally, it encompassed the highest number and diversity of root metabolites, including both primary and secondary compounds. This can be the reason for INM maintaining a balance between the representation of bacteria (87.4%) and fungi (12.4%), with Actinomycota and Ascomycota being the dominant groups. Further diversity analyses revealed that INM soils supported the highest microbial richness and OTU abundance, while inorganic fertilization favored greater evenness of taxa but lower richness. Organic soils harbored unique, less abundant taxa, reflected in higher Fisher’s alpha values. The beta diversity analysis indicated distinct microbial community structures across different treatments. Therefore, INM is a sustainable solution for brinjal cultivation, since it improves crop performance, soil health, and microbial ecosystem services. Full article