Search Results (494)

The interplay between the environmental exposome and the cancer genome remains a critical gap in precision oncology. While somatic mutational signatures—genomic fossils imprinted by exposures such as ultraviolet radiation; tobacco smoke; and industrial pollutants—are well characterised for their etiological significance; their functional impact on therapeutic efficacy remains largely unexplored. We hypothesised that these environmental genomic scars induce distinct pharmacogenomic vulnerabilities and resistance mechanisms that vary by geographical exposure patterns. This study employs two complementary analytical frameworks. First, a linear regression-based pharmacogenomic screen across four datasets (GDSC1, GDSC2, CTRP, CCLE; 1001 cell lines, 31 cancer types) identified 608 statistically significant (p < 0.01) mutational signature–drug interactions, revealing that UV-associated signature SBS7a is associated with broad-spectrum therapeutic resistance, including to BRAF inhibitors (PLX-4720, p < 10⁻⁴), while pollution-driven oxidative stress (SBS18) is associated with sensitivity to p38 MAPK inhibition (VX-702, r = −0.45, p < 10⁻⁹). Second, an XGBoost predictive model trained exclusively on 33,679 GDSC2 records using a 1265-feature matrix integrating 40 SBS signatures, drug chemistry descriptors, proteomic features, and two satellite-derived environmental variables (NASA PM_2.5 and UV)—achieved R² = 0.7973 on a 20% holdout set (grouped cross-validation R² = 0.7296). SHAP analysis revealed that satellite-derived PM_2.5 (Zone_PM25) ranked 7th of 1265 features, exceeding all 40 individual SBS mutational signatures. Synthesising these findings with satellite-derived atmospheric data, we constructed an exploratory spatially interpolated risk surface spanning 122 nations, generating the hypothesis that uniform drug efficacy assumptions may not apply globally. These findings suggest that a patient’s environmental exposure history may constitute a measurable pharmacogenomic variable. This exploratory framework warrants validation in independent datasets and with individual-level geographic data before clinical application. Full article

Acute lymphoblastic leukemia (ALL) is a malignant neoplasm of the blood and bone marrow characterized by the uncontrolled proliferation of precursor cells of B- or T-lymphocyte lineage. Usually, the disease arises because of spontaneous mutations in bone marrow cells. Risk factors include genetic predisposition, exposure to ionizing radiation, prior chemotherapy or radiotherapy, and certain environmental factors. Clinical manifestations may include recurrent infections, anemia, and an increased tendency toward bleeding and stroke. A 12-year-old boy presented to the emergency department with a sudden decrease in visual acuity in the right eye. Best-corrected visual acuity (BCVA) in the right eye was 0.02, and intraocular pressure (IOP) was 16 mmHg. Ophthalmologic examination revealed a macular hemorrhage in the right eye. Blood samples were obtained for laboratory analysis. Complete blood count demonstrated leukocytosis with a white blood cell (WBC) count of 362.58 × 10³/µL, thrombocytopenia with a platelet (PLT) count of 87 × 10³/µL, hemoglobin (Hgb) level of 8.7 g/dL, and a red blood cell (RBC) count of 3.46 × 10⁶/µL. The patient was subsequently referred to the Department of Pediatric Hematology, where the diagnosis of acute lymphoblastic leukemia of B-cell precursor origin was confirmed. Appropriate systemic therapy targeting the underlying disease was initiated. Full article

Radioactive Ba²⁺ poses significant risks to nuclear safety and environmental protection, yet its efficient removal from nuclear wastewater remains a considerable challenge. Herein, Mg-Al layered double hydroxides (LDHs) were synthesized via a co-precipitation method and systematically optimized by tuning the Mg/Al molar ratio and calcination temperature. The optimal material, obtained by calcining Mg-Al LDH with a Mg/Al ratio of 4:1 at 450 °C (denoted as HT-450), exhibited a high apparent Ba²⁺ uptake capacity of 416 mg g⁻¹ and reached equilibrium within 15 min. Structural and spectroscopic analyses indicate that Ba²⁺ immobilization is more appropriately described as a reconstruction-coupled, interfacially mediated mineralization process, in which insoluble BaCO₃ forms in close association with the reconstructed HT-450 surface rather than through simple reversible adsorption or ion exchange. HT-450 also exhibited stable performance over a wide pH range of 3–7, high selectivity toward Ba²⁺ in the presence of competing mono-, di-, and trivalent cations, and excellent radiation tolerance, retaining approximately 95% of its initial uptake capacity after exposure to 200 kGy high-energy electron irradiation. These results demonstrate that HT-450 is a promising candidate for the rapid and stable immobilization of Ba²⁺ from Ba-containing radioactive wastewater. Full article

This work presents the design and validation of a low-cost electronic architecture for nuclear pulse conditioning and radiation exposure measurement using a Geiger–Müller tube. The main contribution is a structured three-stage conditioning system capable of transforming high-voltage analog nuclear pulses into standardized TTL-compatible digital signals for real-time acquisition and pulse counting. The proposed architecture integrates a regulated 500 V high-voltage supply, voltage coupling and limitation, CMOS-based inversion, and monostable pulse shaping using a 555 timer to generate stable 5 V output pulses with approximately 1600 μs duration. Experimental evaluation included oscilloscope-based pulse characterization, plateau-region verification, and calibration tests performed with a certified gamma radiation source under controlled laboratory conditions. The measured exposure response followed the expected inverse-distance radiation behavior, with relative deviations within $\pm 13\%$ compared with certified reference values. The results demonstrate the feasibility of implementing reliable radiation instrumentation using commercially available electronic components, providing an accessible solution for environmental, laboratory, and educational monitoring applications. Full article

Background: Environmental ionizing radiation plays a major role in human radiation exposure. Natural background radiation originates from the Earth’s crust and outer space. The terrestrial component consists of primordial radioisotopes (⁴⁰K, ²³⁸U, ²³⁵U, ²³²Th), as well as elements of the uranium and thorium decay chains, of which, from a dosimetric perspective, ²²²Rn and its decay products carry the greatest weight. These account for more than half of the crustal component. Cosmic radiation consists of gamma rays, X-rays, and particles such as protons, electrons, neutrons, mesons, and hyperons. Methods: The main objective of our research is to determine the background radiation levels characteristic of various regions of Transylvania. In addition, we aim to determine the effects of local environmental, diurnal, and seasonal changes on radiation levels. Results: A statistically significant difference was observed between the values of the individual regions (p < 0.001). The values we measured ranged from 0.051 µSv/h to 0.285 µSv/h. Based on the results, we can conclude that there is a statistically significant difference (p < 0.05) between the median value dropped after ventilation (0.159 µSv/h), compared to the one before ventilation (0.164 µSv/h). According to our database, radiation levels are significantly (p < 0.01) higher during the fall and winter months. Conclusions: On this basis, Transylvania can be regarded as a safe and livable region in terms of natural background radiation levels. Nevertheless, it is important to maintain a healthy lifestyle, ventilate homes frequently, and spend as much time as possible outdoors in nature. Full article

Ageing radically alters the physicochemical properties of microplastics, significantly increasing their affinity for environmental pollutants. However, the slow nature of natural degradation necessitates the development of efficient laboratory protocols. This study establishes an accelerated ageing methodology that reflects natural dynamics by comparing Polyethene terephthalate microplastics (PET MPs) exposed to sunlight (3 months) with those exposed to laboratory UV-C radiation (varying lamp numbers and 24–336 h). scanning electron microscopy (SEM) imaging confirmed progressive surface degradation, including increased roughness, micro-cavities, and erosion. Photo-oxidation was evidenced by an increase in the carbonyl index (CI) from 7.43 ± 0.30 to 8.97 ± 0.35 (UV-aged) and 11.45 ± 0.45 (sun-aged). Furthermore, crystallinity significantly decreased from 59.5% to 54.4% and 16.6%, respectively, while the point of zero charge (pH_PZC) shifted from near neutral (6.5–7.0) to below 2.0. Notably, high-intensity, short-term UV-C exposure accelerated surface functionalization, enhancing cadmium adsorption capacity (q_e = 1.9 mg/g). The laboratory protocol provides rapid reactivation on the surface, serving as a proxy for prolonged sunlight exposure. Consequently, these findings offer a framework for assessing heavy metal uptake and the broader environmental implications of microplastics in aquatic environments. This understanding supports pollutant evaluation and sustainable water management for aquatic ecosystem protection. Full article

Glacial lake dynamics in high-mountain regions serve as a sensitive proxy for cryospheric responses to climate warming. This study utilizes multi-temporal Sentinel-2 imagery and digital elevation model (DEM) data to quantify glacial lake evolution in the Donglin Tsangpo Watershed, a strategically important section of the China–Nepal Economic Corridor, from 2016 to 2024. The results show a significant expansion in both the number (from 43 to 56) and total area (from 3.97 km² to 4.94 km², +24.43%) of glacial lakes, primarily driven by the rapid emergence of very small lakes (0.02–0.05 km²) and a clear upward shift in elevation distribution, with new lakes forming above 5300 m and extending to elevations exceeding 5500 m. Analysis of Moderate Resolution Imaging Spectroradiometer (MODIS) land surface temperature (LST) reveals that this expansion coincided with pronounced positive thermal anomalies, particularly the 2020 extreme warm event (daytime +3.88 °C, nighttime +1.61 °C). Mechanistic analysis using the ERA5-Land reanalysis dataset further demonstrates that persistent positive downward longwave radiation (LW) anomalies (peaking at +10.71 W/m² in 2021) effectively compensated for reduced shortwave input, inhibiting nocturnal refreezing and extending the effective ablation period. Furthermore, a rising liquid-to-solid precipitation ratio and extreme melt-day anomalies (up to +39.36 days) provided intensified hydrothermal inputs, driving the pronounced expansion of glacier-contact lakes despite non-linear interannual responses. This study also estimates individual lake volumes, identifying a transition toward rapid lake development that elevates potential downstream hazard exposure. These findings provide a high-resolution dataset and a robust physical framework for transboundary environmental monitoring and risk assessment in this climate-sensitive region. Full article

The dynamics of calcium carbonate structures in marine organisms (skeletons and shells) has become increasingly important due to heightened interest in marine environmental acidification. Research into molluscan shell corrosion and calcification in response to acidification is typically carried out in laboratory-controlled settings, which often overlooks the intricate interactions found in natural environments. Mollusks inhabiting intertidal zones are especially susceptible to intense shell weathering caused by tidal cycles of heating, cooling, wetting, and drying, exacerbated by solar radiation during periods of air exposure. We investigated the effect of sun exposure (solar radiative heating) on both outer shell corrosion and inner shell compensatory calcification in the tropical oyster, Saccostrea scyphophilla. Shell properties were compared between oysters from neighboring populations in sun-exposed and shaded habitats. Habitat temperatures were measured using iButtons, and right shell valve corrosion was quantified. Compensatory calcification was assessed through measurements of shell thickness, shell density, shell compression strength, and mineralogical properties. Our results revealed that oysters in the sun that experience global irradiance, higher temperature peaks and broader daily temperature ranges (averaging an increase of 10 °C) show considerably greater outer shell surface corrosion (87%) compared to shaded oysters (31%) that experience only diffuse irradiance. Sun-exposed shells also become thickened in the midsection and around the adductor muscle, and they are slightly stronger, indicating compensation for the outer shell loss. These findings highlight the need for caution when interpreting molluscan shell dynamics based on laboratory marine acidification protocols that fail to account for the many natural environmental factors influencing shell formation and dissolution. Full article

Background/Objectives: Radon is a naturally occurring radioactive gas and the leading source of natural radiation exposure worldwide; however, its systemic biological effects in children remain poorly understood. This study examined the association between cumulative indoor radon exposure and inflammatory biomarkers among children residing in rural communities of the Aqmola region in Kazakhstan. Methods: The study included 87 children and adolescents (42 exposed and 45 controls). Radon exposure was measured in residential and school environments, and a composite Radon Exposure Index (REI) was constructed to estimate cumulative exposure over time. Serum concentrations of inflammatory biomarkers, including C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), and interleukin-8 (IL-8), were measured using validated immunoassay methods. Multivariable linear regression models adjusted for age, sex, body mass index, pubertal development stage, and heating type were used to evaluate associations between REI and biomarker levels. Results: Children and adolescents living in the radon-exposed community had significantly higher REI values than controls (7.75 ± 0.85 vs.4.83 ± 0.41, respectively). Among the biomarkers examined, CRP, TNF-α, IL-1β, IL-8 and IL-6 were not significantly associated with radon exposure. Conclusions: These findings do not support the use of the evaluated inflammatory biomarkers as indicators of early biological effects of environmental radon exposure in this population. However, the clear exposure contrast observed between study settings underscores the ongoing public health relevance of radon as an environmental hazard. Continued efforts to monitor and mitigate radon exposure in high-risk regions remain essential, particularly in environments where children spend substantial amounts of time. Full article

Microplastics (MPs), i.e., plastic particles <5 mm, and nanoplastics (NPs), i.e., plastic particles <1 µm, are widespread in the environment. MPs and NPs (MNPs) have also been detected in human tissues. Environmental MNPs exhibit diverse physicochemical properties such as size, shape, and surface degradation. However, most experimental studies have used pristine MNPs, which poorly represent real-world conditions, and only a limited number of studies have focused on preparing environmentally relevant MNPs. Therefore, we focused on the key physicochemical properties of MNPs, particularly their shape, size, and surface degradation, using polyvinyl chloride (PVC) as the model polymer. In this study, fragment and spherical PVC-MNPs were utilized, and surface degradation was introduced through exposure to vacuum ultraviolet (VUV) radiation at a wavelength of 172 nm. Attenuated Total Reflectance-Fourier Transform Infrared (ATR-FTIR) analysis revealed the formation of additional carbonyl groups after VUV exposure. We investigated the cytotoxic effects of the degraded and non-degraded PVC-MNPs on A549, Caco-2, and THP-1 cells. The results indicated that the degraded PVC-MNP-treated groups induced higher cytotoxic effects than those in the non-degraded groups. Notably, the degraded PVC-NPs induced stronger cytotoxicity than the degraded PVC-MPs. These findings highlight the potential health risks associated with environmental MNPs. Full article

Optimizing solar access is fundamental for developing ‘Sustainable Healthy Cities’ and ensuring occupant well-being in high-radiation climates like Egypt. This study establishes an environmental methodology to enhance urban sustainability by controlling solar exposure to facades to mitigate health risks and reduce energy demand. The methodology involved a verified simulation using Autodesk Revit with Insight, followed by a comparative analysis of 45 scenarios. These scenarios evaluated the impact of orientation, geometry, urban spacing, etc., on solar performance. Additionally, the paper discusses the prospective integration of Generative AI and algorithmic engines to automate solar access layouts, proposing a roadmap for future AI-driven sustainable urban planning. The results indicate that strategic adjustments in urban morphology significantly improve solar access levels, directly influencing indoor environmental quality. The findings serve as a scalable framework applicable to regions like Kafr El-Sheikh or adaptable to extreme climates like Aswan, aligning with the UN Sustainable Development Goals (SDGs 3 and 11). In conclusion, this study demonstrates that environmental simulation provides a pragmatic pathway for architects to achieve integrated sustainability and healthy urban standards. This research offers a foundation for future sustainability investigations into thermal comfort and non-linear interactions between urban variables to refine solar access strategies in diverse contextual conditions. Full article

Cancer is a major public health challenge worldwide, with increasing incidence and a growing economic and societal burden. Despite therapeutic advances, prevention remains the most effective strategy to reduce its impact. The One Health approach, which recognizes the interconnection between human, animal, and environmental health, provides a valuable framework to address cancer risk factors in a more integrated and sustainable way. This narrative review addresses cancer through a One Health lens. Human health aspects include the global burden, major lifestyle and infectious risk factors, and key prevention strategies. Environmental determinants of cancer are summarized with emphasis on climate change, air pollution, occupational exposures, microplastics, ultraviolet radiation, and nutrition/food safety. Animal health contributions include insights from comparative oncology, which offer translational opportunities for prevention, diagnosis, and treatment, and from microbiome research revealing promising biomarkers for early detection and treatment response. Integrating cancer prevention into the One Health framework is essential for addressing the complex interplay between environmental, animal, and human health. A multidisciplinary approach can enhance public health policies, promote sustainable prevention measures, and improve early detection and treatment strategies, ultimately reducing healthcare costs and advancing global health outcomes. Full article

Chronic exposure to ionizing radiation from uranium legacy sites remains a significant public health concern in Northern Kazakhstan. This review evaluates epidemiological, clinical, and environmental evidence published between 2000 and 2025, with particular emphasis on studies conducted during 2014–2023 in the Stepnogorsk region among populations residing near former uranium mining sites. Residents were exposed to annual external gamma doses of approximately 1.0–3.5 mSv and radon-related doses of up to 1.2 mSv. Cancer registry analyses revealed 1913 malignancy cases in the exposed group (vs. 358 controls), with digestive (29%) and respiratory (17%) cancers predominating. Early signs of chronic radiation syndrome (CRS) were consistently observed, including olfactory dysfunction, immunosuppression, vestibular disturbances, hematologic anomalies, and elevated chromosomal aberrations (1.3–1.5× baseline). Non-cancer morbidity was also elevated, including hypertension (32% vs. 24%), chronic bronchitis (14% vs. 8%), and reduced forced expiratory volume in one second (FEV₁; −9.7%), indicating broader systemic effects. These results underscore the need for targeted public health strategies incorporating CRS biomarker screening, cancer surveillance, personal dosimetry, and environmental remediation in uranium-impacted communities. Full article

Magic lantern slides are fragile objects consisting of transparent images depicted on thin glass plates to be projected by magic lanterns. Despite their widespread presence in archives and museums, these collections are often undervalued and understudied. The Portuguese Cinematheque holds the most extensive collection of slides in Portugal. This article presents the first preventive conservation case study focused on the collection of painted slides, reflecting on the general origins of this collection, examining the challenges faced by caretakers when adapting historical buildings to accommodate collections of this nature. Environmental monitoring of light and radiation, temperature, and relative humidity in storage and exhibition rooms was combined with ultraviolet-visible spectroscopy to measure the fading of one of the most light-sensitive colours identified in these slides in previous studies, the pink eosin-based lake, by comparing a slide exhibited under the measured light conditions with one kept in storage during the same period. The results identified damaging light exposure in display areas with illuminance values far above the recommended levels for these materials, and significant RH fluctuations in both spaces. These conditions are consistent with deterioration factors known to affect the material that composes these fragile media (e.g., light-sensitive painting materials and organic frames, and unstable glass). This study also showcases how raising awareness on the fragility of this heritage stimulated discussions and encouraged small and feasible changes that can positively impact its preservation. Full article

Spaceflight exposes astronauts to multiple environmental stressors that promote oxidative stress, including ionizing radiation, microgravity, circadian rhythm disruption, and psychological stress. These factors increase the production of reactive oxygen species (ROS) and disturb redox homeostasis, potentially affecting multiple physiological systems during long-duration missions. In addition to environmental challenges, nutritional factors may further influence oxidative balance in space. Space food systems rely on long-term storage and processing, which can lead to degradation of antioxidant nutrients and alterations in dietary composition. Furthermore, spaceflight conditions may modify eating behaviors and disrupt gut microbiome composition, both of which are closely linked to host redox regulation. This review examines current knowledge on oxidative stress during spaceflight and discusses how space food systems, dietary composition, and microbiome alterations interact with spaceflight stressors to influence redox homeostasis. Potential strategies to mitigate oxidative stress are also discussed, including preservation of antioxidant nutrients, optimization of dietary composition, reduction in pro-oxidant exposures, and microbiome-targeted approaches to support astronaut health during long-duration missions. Full article