Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline

Journals

Article Types

Countries / Regions

Search Results (1)

Search Parameters:
Keywords = fitonutrients

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
15 pages, 487 KB  
Review
Celiac Disease, Inflammation and Oxidative Damage: A Nutrigenetic Approach
by Gianna Ferretti, Tiziana Bacchetti, Simona Masciangelo and Letizia Saturni
Nutrients 2012, 4(4), 243-257; https://doi.org/10.3390/nu4040243 - 27 Mar 2012
Cited by 132 | Viewed by 25401
Abstract
Celiac disease (CD), a common heritable chronic inflammatory condition of the small intestine caused by permanent intolerance to gluten/gliadin (prolamin), is characterized by a complex interplay between genetic and environmental factors. Developments in proteomics have provided an important contribution to the understanding of [...] Read more.
Celiac disease (CD), a common heritable chronic inflammatory condition of the small intestine caused by permanent intolerance to gluten/gliadin (prolamin), is characterized by a complex interplay between genetic and environmental factors. Developments in proteomics have provided an important contribution to the understanding of the biochemical and immunological aspects of the disease and the mechanisms involved in toxicity of prolamins. It has been demonstrated that some gliadin peptides resistant to complete proteolytic digestion may directly affect intestinal cell structure and functions by modulating gene expression and oxidative stress. In recent years, the creation of the two research fields Nutrigenomics and Nutrigenetics, has enabled the elucidation of some interactions between diet, nutrients and genes. Various dietary components including long chain ω-3 fatty acids, plant flavonoids, and carotenoids have been demonstrated to modulate oxidative stress, gene expression and production of inflammatory mediators. Therefore their adoption could preserve intestinal barrier integrity, play a protective role against toxicity of gliadin peptides and have a role in nutritional therapy of celiac disease. Full article
(This article belongs to the Special Issue Foodomics 2011)
Show Figures

Figure 1

Back to TopTop