Search Results (711)

The large environmental and economic impact of sea lice infestation in the salmon industry has encouraged the development of non-medical methods and preventive strategies to combat sea lice infestation. Sea lice (Lepeophtheirus salmonis and Caligus elongatus) are sensitive to low salinities, and using fresh water as protection against infection may thus significantly reduce sea lice infestation of salmon while reducing the costs and impacts of traditional delousing methods. A new concept presented here is based on the manipulation of salinity within cages by adding fresh water to create an unfavourable environment for sea lice infestation. A full-scale set-up was tested in a salmon farm in northern Norway: two commercial-size cages with Atlantic salmon (Salmo salar) were enclosed with a 2 m deep tarpaulin skirt and supplied with fresh water at the centre to establish a surface layer with reduced salinity. Two reference cages had no skirt or fresh water supply. Time series of CTD-data showed that the fresh water supply caused a shallow and unstable salinity gradient, with salinities lower than 10 ppt measured for short periods in the upper 0.5 m. Despite these instabilities, significantly lower sea lice infestation in cages supplied with fresh water was observed, as infestation rates for pre-adult and adult stages of L. salmonis were reduced by 48% and 57%, respectively, in the treatment cages compared to controls. This preventive strategy is therefore very promising and deserves further development under more stable and controlled conditions. Future studies should focus on improving freshwater regulation, ensuring higher spatial resolution of salinity data in surface layers and documenting the effect on the more salinity-sensitive planktonic stages of L. salmonis. In addition, there is a need to examine the effectiveness of the technique at multiple sites and under a wide range of site conditions, especially various current rates through the site. Full article

Recycling of lithium-ion batteries (LIBs) requires efficient separation of active material from current collectors to enable high-quality recovery of both the coating and the metal foil. In this study, a water-based delamination process for anode foils was systematically investigated under variations in temperature, particle size, ultrasonic power, and prior mechanical stressing of the particles. Mechanically cut and pre-folded foil pieces were treated in a batch setup at different temperatures (room temperature to 100 °C) and ultrasonic power levels (50 and 100%). Results show that higher temperatures strongly promote delamination, with 100% removal of the active layer achieved on the smooth foil side at 80 °C without ultrasonic treatment. Ultrasonic treatment at moderate power (50%) yielded greater delamination than at full power (100%), likely due to more effective cavitation dynamics at moderate intensity. Mechanical pre-stressing by folding significantly reduced delamination, with three folds effectively preventing separation. In comparison, mechanically comminuted particles from a granulator achieved similar delamination to three-folded particles after 5 min treatment, and higher delamination after 30 min. These findings highlight the importance of process parameters in achieving efficient aqueous delamination, providing insights for scaling low-energy recycling processes for LIB production scrap. Full article

Antimicrobial resistance is a global threat to public health. The growing resistance of bacteria to commonly used antibiotics necessitates the search for and development of alternative treatments. Bacteriophage (or phage) therapy fits this trend perfectly. Phages that selectively infect and kill bacteria might represent, in some cases, the last therapeutic option. This overview provides case examples and discusses the potential development of phage therapy, examining its ethical and legal considerations in the context of current clinical practices. Additionally, it explores the advantages of utilizing phage products in patients for whom existing therapeutic options are limited or unavailable. Further clinical studies are necessary to broaden the understanding of phages, their dosage, and a standardised delivery system. These efforts are essential to ensure that phage-based therapy is not viewed as experimentation but as a routine medical treatment. Bacterial viruses are unlikely to become a miracle cure or a panacea for infections, but they may find an important role in medicine. Full legalisation of this treatment could help solve the problem of multidrug-resistant infectious diseases on a global scale. Full article

Background and Objectives: Partial nephrectomy is the standard treatment for small renal tumors, balancing cancer control with renal function preservation. Robot-assisted partial nephrectomy (RAPN) has improved surgical precision and reduced morbidity. Near-infrared fluorescence (NIRF) imaging with indocyanine green (ICG) improves intraoperative visualization of renal vasculature and tissue perfusion, potentially enabling selective arterial clamping to reduce ischemic injury. This study updates contemporary evidence on NIRF/ICG-guided RAPN, focusing on intraoperative, perioperative, and renal function outcomes. Materials and Methods: We systematically queried PubMed, Scopus, and Web of Science databases up to June 2025 for controlled prospective and retrospective studies comparing NIRF/ICG-guided RAPN (selective clamping or zero-ischemia) versus conventional RAPN with main artery clamping in adults with renal masses. Data were synthesized narratively, and random-effects meta-analyses were performed on warm ischemia time (WIT), operative time, estimated blood loss, transfusion rate, length of hospital stay, complication rate, positive surgical margins, and variation in renal function. Results: Eleven studies (10 full-text and one abstract), including two randomized controlled trials, encompassing a patient population of 893 patients (403 NIRF/ICG-guided RAPN and 490 conventional RAPN), were included. Ischemia strategies varied between no clamping, selective or super-selective clamping for NIRF/ICG, and main artery clamping for controls. ICG doses ranging from 3 to 7.5 mg or 0.5–7 mL. Most evidence was classified as level 2b or 3b, indicating a moderate to serious risk of bias. Meta-analysis showed that compared to conventional RAPN, NIRF/ICG-guided RAPN was associated with a shorter WIT (MD: −1.30 min, 95% CI: −2.51 to −0.09; p = 0.039), with no differences in other outcomes. Renal function favored NIRF/ICG at discharge and short-term follow-up, although the difference was not statistically significant. Conclusions: NIRF/ICG reduces WIT during RAPN without increasing perioperative risks. The technique shows promise for better preserving functional outcomes. However, further well-designed, large-scale trials with longer follow-up are needed to confirm these benefits and define clinical indications. Full article

Shale gas wastewater from hydraulic fracturing poses significant environmental risks due to its high salinity and complex inorganic composition. This study investigates the behavior of major and trace inorganic constituents across a full-scale treatment train in the Sichuan Basin, China. Despite multi-stage processes including equalization, flocculation, flotation, biological reactors, membrane filtration, and clarification, key inorganic species such as Cl, Na, Br, Sr, Li, and B remained largely persistent in the final effluent with values of 13,760, 8811, 70, 95.9, 26.6, and 60.2 mg/L, respectively. Geochemical tracers including Br/Cl (average: 0.0022 mM/mM), Na/Br (average: 125 mg/mg), and Sr/Ca (average: 0.15 mM/mM) ratios, combined with halide endmember mixing models, revealed that salinity primarily originated from highly evaporated formation brines, with limited evidence for halite dissolution or external contamination. Elevated Sr (average: 89.3 mg/L) and Ca (average: 274 mg/L) levels relative to Mg (average: 32 mg/L) suggest significant water–rock interaction. Environmental risk assessments showed that concentrations of several elements in treated effluent greatly exceeded national and international discharge or reuse standards. These findings underscore the limitations of conventional treatment technologies and highlight the urgent need for advanced processes and regulatory frameworks that address the unique challenges of high-TDS (total dissolved solids) unconventional wastewater. Full article

Municipal solid waste (MSW) management is identified as a significant sustainability concern. Source segregation (SS) is the most effective method of managing MSW, and anaerobic digestion (AD) is the most efficient treatment method. The aim of this study was to analyze the impact of waste collection rules on the efficiency and performance of AD. The potential biomethane yields for SS-kitchen waste and SS-biowaste were calculated, determined in laboratory tests, and verified full-scale. The content of the organic fraction in SS-biowaste reached about 81 to 86%; however, regarding SS-kitchen waste, it reached almost 92%. The primary contaminants were plastics. The obtained biogas yield was slightly higher for SS-kitchen waste (136.2 m³/ton), compared to SS-biowaste (116.6 m³/ton). The pH values, acidity, and alkalinity indicated no risk of exploitation using both feedstocks. However, in the case of SS-kitchen waste, the acetic acid content was about 2.5 times higher than that of SS-biowaste. Furthermore, the acetic acid was noted in the outlet section (about 140–160 mg/kg), indicating no complete organic matter decomposition. Regarding SS-kitchen waste, the calculated methane yield reached 137.1 m³_CH4/ton and laboratory tests showed a methanogenic potential of 129.7 m³_CH4/ton, while at full-scale, it reached about 82.2 m³_CH4/ton. The research confirmed that the SS of biowaste positively impacts MSW management by improving waste composition and increasing recycling possibilities. AD is an effective biowaste treatment process, allowing energy recovery from waste. Full article

Seasonal temperature variations significantly impact biological wastewater treatment performance, particularly affecting extracellular polymeric substance (EPS) composition and sludge settling characteristics in activated sludge systems. This study investigated the temperature-induced EPS response mechanisms and their effects on nitrogen removal efficiency in a full-scale modified Bardenpho wastewater treatment plant, combined with laboratory-scale evaluation of EPS-optimizing microbial agents for performance enhancement. Nine-month seasonal monitoring revealed that when the wastewater temperature dropped below 15 °C, the total nitrogen (TN) removal efficiency decreased from 86.5% to 80.6%, with a trend of significantly increasing polysaccharides (PS) in dissolved organic matter (DOM) and loosely-bound EPS (LB-EPS) and markedly decreasing tightly-bound EPS (TB-EPS). During the low-temperature periods, when the sludge volume index (SVI) exceeded 150 mL/g, deteriorated settling performance could primarily be attributed to the reduced TB-EPS content and increased LB-EPS accumulation. Microbial community analysis showed that EPS secretion-promoting genera of Trichococcus, Terrimonas, and Defluviimonas increased during the temperature recovery phase rather than initial temperature decline phase. Laboratory-scale experiments demonstrated that EPS-optimizing microbial agents dominated by Mesorhizobium (54.2%) effectively reduced protein (PN) and PS contents in LB-EPS by 70.2% and 54.5%, respectively, while maintaining stable nutrient removal efficiency. These findings provide mechanistic insights into temperature–EPS interactions and offer practical technology for improving winter operation of biological wastewater treatment systems. Full article

Listeria monocytogenes is a major public health concern in milk and ready-to-eat dairy products. To meet consumer demand for fresher, minimally processed foods with high nutritional and sensory quality, several non-thermal technologies are being explored as alternatives to conventional heat treatments. This systematic review (2020–2025), following PRISMA guidelines, examines recent applications of selected non-thermal technologies to control Listeria in milk and dairy matrices. Peer-reviewed studies available in full-text, in English or Spanish, focusing on applications at laboratory or pilot plant scales, with milk or dairy produced onsite or purchased, containing Listeria sp., were included. Studies with applications to plant-based or non-dairy products or those not inoculated with Listeria, were excluded. Conference abstracts, corrections, editorials, letters, news, and scientific opinions were excluded as well. The databases searched were Web of Science, Scopus, and ProQuest, which were last consulted in April 2025. Given the naturality of the review, the risk of bias was assessed through independent screening by two of the researchers, focusing on clear objectives, analytical validity, statistical analysis, and methodology. The results are presented in tabulated format. Of the 157 records identified, 22 were included in this review. Seven of the records reported hurdle technologies, while fifteen reported single technology applications, with high-pressure processing being the most frequent. Limitations observed are primarily the use of unreported strains, a lack of information regarding the initial load of inoculum, and expected log reductions. The equipment used is mostly at the laboratory scale, except for HPP. Non-thermal technologies present a promising option for the control of Listeria in dairy products. The basic principles of GMP, HACCP, and cold-chain control in dairy processing are of special importance in safety assurance. This research was funded by Vicerrectoría de Investigación, Universidad de Costa Rica, grant number 735-C3-460. Full article

Sandwich panels, widely used in factory and warehouse construction, are highly susceptible to fire due to their fragile surfaces and polyurethane-insulated cores. Such structures facilitate rapid fire spread, significantly increasing the risk of extensive thermal damage. Although conventional measures, such as surface pre-wetting, are commonly utilized, their effectiveness is limited due to rapid evaporation. To address this issue, the current study evaluates the effectiveness of compressed air foam (CAF) applied as a pre-application treatment for delaying fire spread. Full-scale fire experiments were conducted to measure temperature variations across sandwich panel surfaces treated under three different conditions: untreated, water-treated, and CAF-treated. Experimental results indicated that CAF effectively formed a stable insulating barrier, maintaining temperatures well below critical thresholds, compared to untreated and water-treated panels. CAF application demonstrated superior thermal protection, reducing internal temperatures by up to 78% compared to untreated conditions and by 67.5% compared to water-treated conditions. These findings underscore the practical importance of adopting CAF pre-application as a proactive fire mitigation strategy, significantly enhancing fire safety standards in industrial and storage facilities constructed with sandwich panels. Full article

Relevance of the problem and aim of the work: Ankylosis of the temporomandibular joint (TMJ) affects physical, psychological, and social well-being and quality of life. One of the most frequently used surgical interventions for the treatment of temporomandibular joint ankylosis is interpositional arthroplasty, particularly in cases where joint preservation is feasible, with different autologous fats: dermis fat, buccal fat pad, and full thickness skin-subcutaneous fat. The aim of the work was to evaluate the efficiency of using different autologous fats in temporomandibular joint ankylosis treatment with interposition arthroplasty method. Materials and Methods: This systematic literature review was conducted according to PRISMA guidelines and registered in the PROSPERO database (CRD420251038325). A comprehensive search was performed in PubMed, the Cochrane Library, and ScienceDirect databases using combinations of keywords: (temporomandibular joint disorders OR temporomandibular joint) AND (adipose tissue or autologous) AND (ankylosis OR arthroplasty). Inclusion criteria were clinical studies conducted on human subjects, written in English, that evaluated the use of autologous fat in interpositional arthroplasty for TMJ ankylosis. The main outcome measures included postoperative maximum mouth opening (MMO), pain intensity, and relative fat volume contraction. Risk of bias was assessed using the Cochrane RoB 2 tool for randomized controlled trials and the Newcastle–Ottawa Scale for cohort studies. Most included studies were of moderate to high quality. Results: A total of 20 publications were selected, including a total of 369 patients. In a qualitative analysis, the best results for maximal opening of mouth (MOM) at 3, 6, 12, and more than 12 months were obtained with dermal fat. After 3 months, the MOM was 40.0 ± 2.7 mm, after 6 months—40.80 ± 4.26 mm, after 12 months—41.9 ± 4.0 mm, after more than 12 months—43.5 mm. The lowest pain intensity was observed using dermal fat taken from the iliac crest region. The rate of volumetric fat shrinkage was greater using buccal fat pad than dermis fat. Conclusions: The most commonly used types of autologous fat in interposition arthroplasty in ankylosis are the following: dermal fat from the abdominal region (iliac crest, subumbilical area, groin), buccal fat pad and full-thickness subcutaneous fat. The best results after the surgical treatment of TMJ ankylosis with interposition arthroplasty are obtained using dermis fat. Full article

Several types of self-balancing vehicles have been successfully developed and commercialized in the past two decades, both as manned vehicles and as autonomous mobile robots. At the same time, due to their characteristic instability and underactuation, a large body of research has been devoted to their control. However, despite this practical and theoretical interest, the current publicly available literature does not cover their systematic design and development. In particular, overall processes that lead to a finished vehicle starting from a set of requirements and specifications have not been examined in the literature. Within this context, this paper contributes a comprehensive mechatronic, dynamics-based procedure for the design of this class of vehicles; to promote clarity of exposition, the procedure is systematically presented using Model-Based Systems Engineering tools and principles. In particular, the proposed design method is developed and formalized starting from an original description of the vehicle, which is treated as a complex system composed of several interconnected multi-domain components that exchange power and logical flows through suitable interfaces. A key focus of this work is the analysis of these exchanges, with the goal of defining a minimal set of quantities that should be necessarily considered to properly design the vehicle. As a salient result, the design process is organized in a logical sequence of steps, each having well-defined inputs and outputs. The procedure is also graphically outlined using standardized formalisms. The design method is shown to cover all the mechanical, electrical, actuation, measurement and control components of the system, and to allow the unified treatment of a large variety of different vehicle variants. The procedure is then applied to a specific case study, with the goal of developing the detailed design of a full-scale vehicle. The main strengths of the proposed approach are then widely highlighted and discussed. Full article

The unsuitable performance of or deficit in basic sanitation infrastructure, especially in sparsely populated rural communities, remains critical, particularly in many developing regions, and demands sustainable, cost-effective, and easily operated solutions. Thus, the objective of this Review is to analyze design parameters for evapotranspiration tanks (EvapTs), adopted as nature-based solutions for zero-discharge domestic sewage treatment. The literature search was conducted using the Scopus and Web of Science databases, complemented by backward citation tracking. From 4434 records, 29 studies were selected based on specific criteria, such as the availability of design data and their application in urban or rural contexts. The main findings indicated required areas per inhabitant ranging from 0.5 to 7.7 m², primarily influenced by climate conditions and the type of plant used. Statistical analysis showed a negative correlation between the area of the evaporation tanks and the mean annual temperature, with a Pearson correlation coefficient (r of −0.74). For mean annual temperatures between 19 and 27 degrees Celsius, linear regression showed a variation between 4.7 and 0.6 m²/inhabitant with a reduction coefficient of −0.51 per degree Celsius, suggesting that warmer climates require smaller system areas per capita. Most studies were conducted at full scale, with Brazil accounting for the highest number of publications. EvapT is identified as a promising ecological technology that is particularly suitable for rural settings. However, it still requires technical standardization, cost–benefit analysis, and research on social acceptance. The adoption of clear design criteria may enhance system replicability, support public policy development, and contribute to SDG 6—Clean Water and Sanitation for All. Full article

Tavapadon, a novel oral dopamine-D1R/D5R partial agonist, has been studied in recent years for the treatment of late-stage development Parkinson’s disease (PD). Levodopa, a dopamine precursor that currently remains the gold-standard first-line therapy for PD motor symptoms, serves as a benchmark against emerging dopaminergic agents. By selectively activating D1-family receptors on direct-pathway medium neurons, Tavapadon differs in that it delivers levodopa-level motor benefit while avoiding its many D2R/D3R-mediated adverse effects. In placebo-controlled trials, Tavapadon produced clear, clinically meaningful gains in motor function and day-to-day activities, as captured by the Unified Parkinson’s Disease Rating Scale (UPDRS). Recent late-stage results have revealed that Tavapadon maintains superior UPDRS outcomes in de novo patients and, when added to levodopa, extended “ON” time periods of reliable motor control free of troublesome dyskinesia, without introducing new safety concerns. In studies, nausea, headache, and somnolence were the most frequent adverse events. Hallucinations, orthostatic hypotension, and impulse-control disorders remained comparable to placebo, reflecting minimal D2R/D3R-mediated effects. Preclinical primate studies have demonstrated levodopa-like motor rescue with markedly less dyskinesia, a pattern mirrored in clinical add-on trials. Collectively, evidence indicates that Tavapadon can match levodopa-mediated symptomatic efficacy, lower dyskinesia liability compared with levodopa or earlier full D1 receptor (D1R) agonists, and offer the convenience of once-daily dosing characteristics, which may bridge the therapeutic gap between levodopa and the current D2R/D3R agonists in PD management. In the present investigation, the emerging clinical role for Tavapadon is described, along with the mechanism of action, clinical efficacy, safety, and future directions. Full article

Digital dentistry is undergoing rapid evolution, with three-dimensional imaging technologies increasingly integrated into routine clinical workflows. Originally developed for accurate dental arch reconstruction, modern intraoral scanners have demonstrated expanding versatility in capturing intraoral mucosal as well as perioral cutaneous structures. Concurrently, photogrammetry has emerged as a powerful method for full-face digital reconstruction, particularly valuable in orthodontic and prosthodontic treatment planning. These advances offer promising applications in forensic sciences, where high-resolution, three-dimensional documentation of anatomical details such as palatal rugae, lip prints, and bite marks can provide objective and enduring records for legal and investigative purposes. This study explores the forensic potential of two digital acquisition techniques by presenting two cadaveric cases of animal bite injuries. In the first case, an intraoral scanner (Dexis 3600) was used in an unconventional extraoral application to directly scan skin lesions. In the second case, photogrammetry was employed using a digital single-lens reflex (DSLR) camera and Agisoft Metashape, with standardized lighting and metric scale references to generate accurate 3D models. Both methods produced analyzable digital reconstructions suitable for forensic archiving. The intraoral scanner yielded dimensionally accurate models, with strong agreement with manual measurements, though limited by difficulties in capturing complex surface morphology. Photogrammetry, meanwhile, allowed for broader contextual reconstruction with high texture fidelity, albeit requiring more extensive processing and scale calibration. A notable advantage common to both techniques is the avoidance of physical contact and impression materials, which can compress and distort soft tissues, an especially relevant concern when documenting transient evidence like bite marks. These results suggest that both technologies, despite their different origins and operational workflows, can contribute meaningfully to forensic documentation of bite-related injuries. While constrained by the exploratory nature and small sample size of this study, the findings support the viability of digitized, non-destructive evidence preservation. Future perspectives may include the integration of artificial intelligence to assist with morphological matching and the establishment of digital forensic databases for pattern comparison and expert review. Full article

The purpose of this study was to design a Pt/TiO₂–ZrO₂ catalytic-based treatment system to remove ethanol and oxygen (O₂) from a gaseous feed stream. The ultimate target application was the conversion of ethanol and O₂ to carbon dioxide (CO₂) and water (H₂O) from a feed stream of CO₂ in a commercial beer brewing operation. Bench-scale reactions were performed at 250 °C and 300 °C, representing two temperatures under practical consideration for a full-scale catalytic reactor. The target gaseous feed stream would be expected to have a relatively low (near-stoichiometric) concentration of O₂, so the effect of O₂ concentration was also studied. On the bench scale, ethanol was completely converted to CO₂ under low flow rate conditions, and the reactions proceeded through volatile and non-volatile reaction intermediates. Results from the bench-scale tests were used to make predictions for designing a pilot-scale catalytic reactor under conditions of high and low O₂ concentration. A pilot-scale reactor was constructed and installed in a commercial brewing facility, and results from testing the pilot-scale reactor are also presented. The pilot-scale system reduced the feed stream ethanol concentrations by 99.9% while concomitantly reducing the O₂ concentrations over the course of a six-day demonstration period without generating unacceptable levels of byproducts. Full article