Search Results (2,653)

Human papillomavirus (HPV) represents the most common sexually transmitted infection worldwide and a major public health challenge. Nearly all sexually active individuals will acquire HPV during their lifetime, with the highest prevalence observed in adolescents and young adults shortly after sexual debut. More than 200 genotypes have been described, ranging from low-risk types, mainly responsible for benign lesions, to high-risk types, which are associated with cervical, anogenital, and head and neck cancers. While most infections are transient and spontaneously cleared by the immune system, persistent high-risk HPV can lead to precancerous lesions and malignant transformation, often in synergy with other sexually transmitted pathogens or in the context of microbiome imbalance. The introduction of vaccines and advanced screening technologies has substantially modified prevention strategies. Vaccination coverage remains heterogeneous, with persistent gaps particularly among males due to cultural, social, and educational barriers. Schools are increasingly recognized as strategic environments to promote awareness, sex education, and gender-neutral vaccination. Innovative approaches such as microbiome modulation, therapeutic vaccines, and liquid biopsy biomarkers are emerging as promising perspectives. This review aims to provide an updated overview of HPV epidemiology, clinical impact, prevention strategies, and future frontiers, with special attention to adolescents as a priority target group. Full article

Background: High-dose cisplatin (≥200 mg/m² cumulative) remains the standard of care in concurrent chemoradiotherapy (CRT) for locally advanced head and neck squamous cell carcinoma (LA-HNSCC). However, its use is frequently limited by nephrotoxicity, including acute kidney disease (AKD). This recently described clinical renal syndrome encompasses functional alterations of the kidney lasting fewer than 3 months post-exposure. Although hydration protocols and antiemetic strategies are routinely applied to avoid reduction in oral liquid intake and to prevent dehydration that could worsen renal function, AKD continues to pose a threat to reach the therapeutic dose, to treatment completion, and long-term outcomes. Recent evidence supports the nephroprotective role of intravenous (IV) magnesium in mitigating cisplatin-induced tubular injury, yet prospective data on its impact in real-world LA-HNSCC settings remain limited. We aimed to prospectively investigate the incidence and characteristics of renal impairment, particularly AKD, in a real-world cohort of LA-HNSCC patients treated with high-dose cisplatin and standardized supportive therapy, including intravenous magnesium. Methods: We conducted a prospective observational study including 207 patients with LA- HNSCC undergoing high-dose cisplatin-based CRT (≥200 mg/m² cumulative dose), within a standardized supportive care protocol incorporating IV magnesium. Renal function was assessed over three cycles via serum creatinine and estimated glomerular filtration rate (eGFR). AKD was defined and staged according to KDIGO criteria. Clinical and biochemical predictors of AKD were explored. Results: AKD occurred in 5.3% of patients (11/207; 95% CI 2.7–9.3), with eight events between C1→C2, 3 between C2→C3, and 0 thereafter; recovery at the next cycle was 9.1% (1/11). Among them, 57.1% were classified as stage 1. A baseline eGFR < 90 mL/min/1.73 m² was associated with a higher AKD incidence (13.3% vs. 5.4%). Body mass index (BMI) was significantly associated with AKD in univariate analysis (p = 0.02), whereas no independent predictor emerged in multivariate analysis. Use of renin–angiotensin–aldosterone system (RAAS) inhibitors was more frequent among patients who developed AKD (p = 0.04). Renal function declined more steeply in AKD patients, with a median eGFR slope of −0.3917 mL/min/1.73 m²/day vs. −0.0483 mL/min/1.73 m²/day in those without AKD (p = 0.0005), irrespective of CKD stage. Conclusions: In a real-world cohort receiving high-dose cisplatin with structured nephroprotection including IV magnesium, AKD developed in approximately 10% of patients. Lower baseline eGFR, elevated BMI, and RAAS inhibitor use emerged as potential risk factors. These findings reinforce the importance of proactive renal monitoring and suggest a role for magnesium supplementation as an accessible strategy to enhance renal safety in curative-intent CRT. Full article

In the global agricultural production system, maintaining and improving soil quality are core elements for ensuring food security and sustainable agricultural development. As a key indicator of soil quality, the content and dynamic change in soil organic carbon have a profound impact on the physical, chemical and biological properties of soil, and play a decisive role in soil fertility, structural stability, water and fertilizer conservation capacity and microbial activity. However, its decomposition is slow, and a large number of straws returning to the field will impact crop growth; its combination with irrigation is a more reasonable solution, as it can significantly improve the soil environment, increase soil moisture and promote straw decomposition. Therefore, in order to further study the effects of different irrigation methods and straw-returning combinations on soil active-carbon content, an experiment was carried out in long-term arid and semi-arid areas under in-field corn cultivation during 2019–2020. Three irrigation modes were designed—flood irrigation (BI), shallow drip irrigation (SD) and drip irrigation under film (DP)—and straw returning (CS) and no straw returning (CK) were set up, with irrigation applied at critical corn growth stages (internode elongation, heading, bell mouth stage) to support plant growth. The results are as follows: (1) The content of soil organic carbon in different treatments had a gradual upward trend with the advance of growth period; the content of soil organic carbon in DP treatment was significantly higher than that in SD and BI treatment under the same straw returning mode, indicating that drip irrigation under film and straw-returning mode can synergistically improve soil fertility and organic carbon content. (2) Different irrigation methods and straw-returning methods have significant effects on the content of soil active organic carbon components. Different drip irrigation modes can significantly improve the content of soil POC and MBC compared with flood irrigation. The Kos of SD treatment is significantly higher than that of other irrigation treatments, and the CPMI is lower than that of the other two irrigation methods, indicating that the soil organic carbon of SD treatment is more stable. Therefore, under straw-returning conditions, drip irrigation can significantly improve the carbon content of soil components and the management index of soil carbon pool, thus significantly increasing the accumulation of soil organic matter. This study discussed the effects of straw returning on soil organic carbon composition and soil carbon pool index under different irrigation methods to provide theoretical and practical bases for the selection and promotion of straw-returning methods and rational irrigation methods in semi-arid areas. Full article

Steroid-induced osteonecrosis of the femoral head (SONFH) is a common and refractory orthopedic disorder, often resulting from prolonged or high-dose glucocorticoid use that impairs bone repair and vascularization. The critical impact of exosomes derived from bone mesenchymal stem cells (BMSCs) in bone regeneration has drawn increasing attention. In this study, we developed a novel type of exosomes derived from Magnesium-preconditioned BMSCs (Mg-Exos) and evaluated their therapeutic potential. In vitro experiments demonstrated that Mg-Exos effectively counteracted Dex-induced impairment in the angiogenic function of human umbilical vein endothelial cells (HUVECs) and the osteogenic differentiation of BMSCs. These findings highlight the promise of Mg-Exos as a potential cell-free therapeutic strategy for SONFH, acting through the concurrent enhancement of vascularization and bone formation. Consequently, this work lays a solid foundation for the future application of Mg-Exos in treating SONFH. Full article

With the increasing integration of variable renewable energy into power systems, the frequency regulation capability of hydroelectric units has become crucial for ensuring grid stability. In response to grid disturbances, where Primary Frequency Regulation (PFR) and Automatic Generation Control (AGC) are activated sequentially in actual operation, this paper employs parameter characteristic analysis to systematically investigate the influence of several factors—including turbine operating head, PWM parameters, and governor parameters—on the active power regulation process of hydroelectric units. The study first compares the response characteristics under different heads and PWM/pulse parameters within the AGC framework. It then examines the effects of pulse duration limits and integral adjustments on guide vane movement and correction efficiency. Finally, under the PFR framework, the impacts of head, steady-state slip coefficient, and integral gain on the amplitude and speed of frequency response are analyzed. Simulation results demonstrate that as the set value of Tkmax increases, the operating range of the guide vane opening within the pulse cycle expands, and the time required for power correction is significantly reduced. Specifically, when Tkmax is increased from 0.2 to 0.55, the regulation time is shortened by 44%. These findings offer theoretical guidance and practical insights for parameter optimization and operational scheduling of hydropower units. Full article

Background: Radiotherapy is a key treatment for head and neck cancers but often compromises oral health, partly through its impact on restorative materials. A specific concern is whether ionizing radiation alters the water absorption and solubility of fluoride-releasing restoratives, potentially affecting their durability. This study aimed to evaluate these properties following clinically relevant radiation exposure. Methods: Seven contemporary fluoride-releasing restorative materials (Fuji IX, Equia Forte HT, Fuji Triage, Activa Presto, Cention, Luminos, and Beautifil II) were tested (n = 10 per group). Specimens were either irradiated with 70 Gy in 35 fractions using a clinical linear accelerator or maintained as non-irradiated controls. Water absorption and solubility were measured over 35 days according to ISO 4049 protocols, and data were analyzed with repeated-measures ANOVA. Results: Across all materials, irradiated specimens exhibited slightly higher water absorption and solubility values compared to controls; however, differences were not statistically significant (p > 0.05). Material-specific trends were observed, with Fuji IX, Fuji Triage, Beautifil II, and Equia Forte showing relatively higher absolute values. Conclusions: Clinically relevant ionizing radiation did not significantly affect the water absorption or solubility of the tested fluoride-releasing restorative materials, suggesting preserved physicochemical stability under therapeutic conditions. Full article

Extensive practice has demonstrated that the continuous pursuit of high yields in the black soil region of Northeast China resulted in imbalances in soil nutrients and declines in both soil quality and water use efficiency. Alternate wetting and drying (AWD) irrigation offers a promising solution for increasing rice yield and maintaining soil fertility. However, the success of this irrigation method largely depends on its scheduling. This study examined the threshold effects of AWD on rice growth, yield, and soil nutrient availability in the Sanjiang Plain, a representative black soil region in Northeast China. A two-year trial was conducted from 2023 to 2024 at the Qixing National Agricultural Science and Technology Park. “Longjing 31”, a local cultivar, was selected as the experimental material. The lower limit of soil water content under AWD was set as the experimental factor, with three levels: −10 kPa (LA), −20 kPa (MA), and −30 kPa (SA). The local traditional irrigation practice, continuous flooding, served as the control treatment (CK). Indicators of rice growth and soil nutrient content were measured and analyzed at five growth stages: tillering, jointing, heading, milk ripening, and yellow ripening. The results showed that, compared to CK, AWD had minimal impact on rice plant height and tiller number, with no significant differences (p > 0.05). However, AWD affected leaf area index (LAI), shoot dry matter (SDM), yield, and soil nutrient availability. In 2023, control had little effect on rice plant height and tiller number among the different irrigation treatments. The LAI of LA was 11.1% and 22.5% higher than that of MA and SA, respectively, while SDM in LA was 10.5% and 17.2% higher than in MA and SA. Significant differences were found between LA and MA, as well as between LA and SA, whereas no significant differences were observed between MA and SA. The light treatment is beneficial to the growth and development of rice, while the harsh growth environment caused by the moderate and severe treatments is unfavorable to rice growth. The average contents of nitrate nitrogen (NO₃⁻-N), available phosphorus (AP), and available potassium (AK) in LA were 11.4%, 8.4%, and 9.3% higher than in MA, and 16.7%, 11.5%, and 15.0% higher than in SA, respectively. Significant differences were observed between LA and SA. This is because the light treatment facilitates the release of available nutrients in the soil, while the moderate and severe treatments hinder this process. Although panicle number per unit area and grain number per panicle in LA were 7.5% and 2.3% higher than in MA, and 10.8% and 2.2% higher than in SA, these differences were not statistically significant. Seed setting rate and thousand-grain weight showed little variation across irrigation treatments. The yield of LA was 10,233.3 kg hm⁻², 9.1% and 14.1% higher than that of MA and SA, respectively, with significant differences observed. Compared with the moderate and severe treatments, the light treatment increases indicators such as the number of panicles per unit area, grains per panicle, thousand-grain weight, and seed setting rate, resulting in significant differences among the treatments. Water use efficiency (WUE) decreased as the control level increased. The WUE of all AWD irrigation treatments was significantly higher than that of the control treatment (CK). Compared with CK, AWD reduces evaporation, percolation, and other water losses, leading to a significant decrease in water consumption. Meanwhile, the yield remains basically unchanged or even slightly increases, thus resulting in a higher WUE than CK. The trends in rice growth, soil nutrient indicators, and WUE in 2024 were generally consistent with those observed in 2023. In 2024, the yield of LA was 9832.7 kg hm⁻², 14.9% and 17.3% higher than that of MA and SA, respectively, with significant differences observed. Based on the results, the following conclusions are drawn: (1) AWD irrigation can affect the growth of rice, alter the status of available nutrients in the soil, and thereby cause changes in yield and WUE; (2) LA is the optimal treatment for increasing rice yield, improving the availability of soil available nutrients, and improving WUE; (3) Both MA and SA enhanced WUE; however, these practices negatively impacted rice growth and the concentration of soil available nutrients, leading to a concurrent decline in yield. To increase rice yield and maintain soil fertility, LA, with an irrigation upper limit of 30 mm and a soil water potential threshold of −10 kPa, is recommended for the Sanjiang Plain region. Full article

The South African Value-Added Tax (VAT) Act exhibits an illogical structure for digital imports. The complexity of digital import taxation creates uncertainty and has an impact on compliance, resulting in tax avoidance and diminished tax revenues. This study analysed the organisational structure of digital imports in the VAT Act as a legally complex element. This study established that the organisation of the VAT on digital imports complicates legislation and introduces ambiguity, leading to increased tax evasion and compliance, as well as administrative expenses. This study employed existing guidelines to simplify the VAT Act and improve the organisational structure regarding the VAT implications of digital imports. The methods used included a qualitative research technique utilising a doctrinal approach, as well as applied research. This study is the first to apply Hassan, Bornman and Sawyer’s VAT simplification framework to South African digital imports. The guidelines developed by these authors encompass section grouping, headings and subheadings, and explicit signposting, which were implemented in this article to effectively demonstrate and simplify the VAT consequences for digital imports. A logically structured VAT framework will improve clarity in digital import compliance, thereby reducing tax evasion. Therefore, this study contributes to tax compliance theory by proposing that a reduction in complexity and improvement in transparency mitigate tax evasion. Full article

Objectives: SailGP is an international professional mixed-sex sailing competition, which uses F50 foiling catamarans capable of reaching speeds up to ~100 km/h. This seminal study assesses injuries and illnesses observed by male and female sailors during trainings and competitions in SailGP’s third season. This study aims to assess injury and illness incidence, comparing results with other professional sailing events and high-performance sports. In addition, injury and illness risk factors (sex and position) will be explored with the goal to reduce morbidity for future seasons. Materials and Methods: This retrospective cohort design analysed medical records of male and female sailors during SailGP’s third season (April 2022 to May 2023). Risk factors assessed included sailor sex, sailor position (helm, strategist, grinder, flight controller and wing trimmer), sailing venue, wind speed and mechanism of injury/nature of illness. International Olympic Committee reporting guidelines on injuries and illnesses were followed, including the STROBE-SIIS checklist. Confidence intervals were set at 95%, statistical tests were two-sided and p-values < 0.05 were considered statistically significant. Results: A total of 40 on-water injuries were reported in 32 athletes. Injury incidence was greater during competitions than trainings, with strategists and then grinders being the most frequently injured positions. Competition injury incidence was 32.6 per 1000 h and 6.42 injuries per 365 days. Training injury incidence was 2.62 injuries per 1000 h and 3.82 injuries per 365 days. Knee, ankle, hand and head injuries were most prevalent, with three concussions observed during trainings and competitions (two female and one male). Direct impacts and falls during manoeuvres caused most injuries. Overall injury incidence (IRR = 2.69 [95% CI 1.41–5.16]), risk of training injuries (RR = 3.75 [95% CI 1.59–8.83], p = 0.001), risk of competition injuries (RR = 1.79 [95% CI 0.65–4.90], p = 0.25) and overall concussion risk (RR = 10.04 [95% CI 0.91–110.46], p = 0.02) were greater in females. Ten sailors accounted for 17 illnesses. Females had a 3.33 increase in training and competition illnesses (IRR = 3.33 [95% CI 0.94–11.81]). Conclusions: Competition injury incidence was higher than previous reported sailing studies. Knee injuries were most prevalent and direct impacts caused most injuries. Female sailors reported a higher injury and illness incidence. These results may guide injury prevention efforts and the development of an IOC-equivalent consensus statement. Future studies should examine time loss. Full article

This study investigates occupant–seat interaction dynamics in high-speed train frontal collisions. A finite element model of a second-class double seat was developed and simulated using LS-DYNA R12.1 software with a Hybrid III dummy, applying trapezoidal and triangular acceleration pulses per European and American standards. The research analyzes the impact of front-row seatback recline angles (0°, 10°, 20°) and seatback-to-base connection stiffness (1000 N/mm to 0 N/mm) on head, neck, chest, and leg injury severity. Results show that a 10° recline provides optimal protection under fixed stiffness. When optimizing both parameters, a 0° recline with approximately 300 N/mm stiffness minimizes composite injury metrics (HIC₁₅, N_ij, CTI). However, reducing stiffness at non-zero recline angles increases neck injury risk due to tray table displacement toward the cervical region. These findings emphasize the critical importance of integrated seat design optimization for rail passenger passive safety and highlight the need to mitigate tray table hazards. Full article

Partial Discharge (PD) measurement is one of the effective methods for assessing the internal insulation condition of power transformers in factories and substations. The pulse current signals generated by PD within transformer windings are significantly influenced by the winding structure during their propagation from the discharge source to the external measurement system. This influence may lead to misinterpretation of the insulation status, particularly in the analysis of PD measurement results. Such effects are closely related to the signal transmission path and distance and exhibit a strong correlation with the winding transfer function, manifesting as attenuation, distortion, or delay of the measured signals compared to the original PD waveforms. Therefore, it is essential to investigate the impact of the discharge path on the propagation characteristics of transformer windings and its effect on PD waveforms. This paper establishes a simplified distributed parameter model of a 180-turn single-winding multi-conductor transmission line using the finite element method and mathematical modeling, deriving the transfer functions between the winding head or winding end and various internal discharge positions. By injecting different types of PD waveforms collected in the laboratory at various discharge locations within the winding, the alterations of PD signals propagated to the winding head and winding end are simulated, and clustering analysis is performed on the propagated PD signals of different types. Full article

Introduction: Concussions are a growing concern in professional football due to their potential short- and long-term neurological consequences. Despite increasing global awareness, data on the epidemiology and clinical management of concussions in Portuguese football remain scarce. This preliminary exploratory study aimed to characterize the incidence, mechanisms, symptomatology, and medical response to concussions in Portugal’s Professional Football Leagues during the 2023/2024 season, based on reported cases. Methods: A retrospective observational analysis was conducted on head injuries reported by club medical teams during official matches in Liga Portugal First and Second Leagues. Collected variables included player position, time of injury, mechanism, symptoms, medical interventions and hospital referral. Results: Only six concussions were reported during official matches, with an overall incidence of 0.60 per 1000 player-hours. Most occurred in defenders, primarily due to head-to-head collisions, followed by ball impact, falls, and maxillofacial trauma. Injuries were more frequent during the final third of matches. Common symptoms included loss of consciousness, headache, and amnesia. Half of the players were referred to hospital care and underwent cranial CT scans. Among all variables analyzed, a statistically significant association was found between mechanism of injury and occurrence of amnesia (p = 0.014), with non-head-to-head impacts more frequently associated with amnesia. However, given the extremely limited sample size, this finding should be interpreted with extreme caution and requires replication in larger cohorts. Conclusions: This preliminary study suggests that defenders face a higher risk of head injuries, particularly from head-to-head impacts occurring late in matches. The prevalence of severe symptoms and the potential association between non-head-to-head impacts and amnesia highlight the need for more robust injury surveillance systems and underscore the importance of improved sideline assessment and return-to-play protocols. The findings emphasize the urgent need for comprehensive, standardized reporting mechanisms for concussions. Further research should explore long-term neurological effects and the effectiveness of preventive measures such as rule modifications, protective measures, and enhanced concussion management protocols, supported by more extensive and systematically collected data. Full article

Background/Objectives: The glymphatic system is a recently characterized glial-dependent waste clearance pathway in the brain, which makes use of perivascular spaces for cerebrospinal fluid exchange. Diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) offers a non-invasive method for estimating perivascular flow, but its biological specificity and susceptibility to methodological variation, particularly head position during MRI acquisition, remain as threats to the validity of this technique. This study aimed to assess the prevalence of current DTI-ALPS practices, evaluate the impact of head orientation on ALPS index calculation, and propose a novel computational approach to improve measurement validity. Methods: We briefly reviewed DTI-ALPS literature to determine the use of head-orientation correction strategies. We then analyzed diffusion MRI data from 172 participants in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) to quantify the influence of head orientation on ALPS indices computed using the conventional Unrotated-ALPS, a vecrec-corrected ALPS, and the new LD-ALPS method proposed within. Results: A majority of studies employed Unrotated-ALPS, which does not correct for head orientation. In our sample, Unrotated-ALPS values were significantly associated with absolute head pitch (r₁₆₉ = −0.513, p < 0.001), indicating systematic bias. This relationship was eliminated using either vecreg or LD-ALPS. Additionally, LD-ALPS showed more sensitivity to cognitive status as measured by Mini-Mental State Examination scores. Conclusions: Correcting for head orientation is essential in DTI-ALPS studies. The LD-ALPS method, while computationally more demanding, improves the reliability and sensitivity of perivascular fluid estimates, supporting its use in future research on aging and neurodegeneration. Full article

Background: Glenoid radiolucenct lines (gRLL) and glenoid component subsidence (gSC) after anatomic total shoulder arthroplasty (aTSA) have traditionally been linked to implant loosening and functional decline. However, their impact on long-term clinical outcomes remains unclear. This study aimed to evaluate whether gRLL and gSC are associated with inferior clinical or functional results in patients without revision surgery. Methods: In this retrospective study, 52 aTSA cases (2008–2015) were analyzed with a minimum of five years of clinical and radiographic follow-up. Based on final imaging, patients were categorized according to the presence and extent of gRLL and gSC. Clinical outcomes included the Constant-Murley Score, DASH, VAS for pain, and range of motion (ROM). Radiographic parameters included the critical shoulder angle (CSA), acromiohumeral distance (AHD), lateral offset (LO), humeral head-stem index (HSI), and cranial humeral head decentration (DC). Group comparisons were conducted between: (1) ≤2 vs. 3 gRLL zones, (2) 0 vs. 1 zone, (3) 0 vs. 3 zones, (4) gSC vs. no gSC, and (5) DC vs. no DC. Results: Demographics and baseline characteristics were comparable across groups. Functional scores (Constant, DASH), pain (VAS), and ROM were largely similar. Patients with extensive gRLL showed reduced external rotation (p = 0.01), but the difference remained below the MCID. Similarly, gSC was associated with lower forward elevation (p = 0.04) and external rotation (p = 0.03), both below MCID thresholds. No significant differences were observed for DC. Conclusions: Neither extensive gRLL nor gSC significantly impaired long-term clinical or functional outcomes. As these radiographic changes can occur in the absence of symptoms, regular radiographic monitoring is essential, and revision decisions should be made individually in cases of progressive bone loss. Full article

This paper presents a qualitative exploratory study based on the analysis of a representative sample of 35 projects carried out during the period 2020–2022 by six Spanish newspapers: elDiario.es, ABC, IDEAL, El Correo, ElConfidencial.com and El País. This study aims to detect and analyze the main elements of multimedia, crossmedia and transmedia content in the selected projects using an original analysis sheet designed for this research. In relation to the categories proposed in the categorization model, in this work we will focus on analyzing two in particular: authorship and information architecture. The projects were selected based on criteria of appropriateness, quality and innovation, as well as the results of semi-structured interviews with the heads and innovation managers (laboratories) of the media included in the framework of the projects ‘NEWSNET: News, Networks, and Users in the Hybrid Media System: Transformation of the Media Industry and the News in the Post-Industrial Era’ and ‘IAMEDIA: Impact of Artificial Intelligence and Algorithms on Online Media, Journalist and Audiences’. The aim of the qualitative analysis is to propose a list of aspects, characteristics, and fundamentals in the ideation, elaboration, and distribution of these types of products. We conclude that the results of applying the designed analysis sheet help us to understand these processes and also to propose alternatives and improvements in its design and implementation Full article