Search Results (3,880)

When women choose a contraceptive method, the decision depends not only on what they prefer but also on the quality of the information they encounter online and on how confident they feel about using a method. We examined how exposure to inaccurate online contraceptive information (“digital misinformation”) and uncertainty about contraceptive decisions (“decisional conflict”) related to mental health and quality of life in women with and without a history of abortion. This was a cross-sectional study of 134 women aged 18–42 years attending obstetrics–gynecology or family-planning services at one Romanian tertiary center. Women were grouped as having no prior abortion (n = 41), one prior abortion (n = 53), or repeat abortion (n = 40). We measured a study-specific digital misinformation index, an access barrier index, contraceptive self-efficacy, reproductive autonomy, depression (PHQ-9), anxiety (GAD-7), well-being (WHO-5), quality of life (WHOQOL-BREF), and current use of highly effective contraception. We compared groups and used regression, mediation, and exploratory profiling. Women with repeat abortion reported the most online misinformation (10.0 ± 2.0), the most decisional conflict (43.9 ± 9.3), the lowest quality of life (61.3 ± 5.6), and the lowest use of highly effective contraception (45.0%). More misinformation and more access barriers were each associated with greater decisional conflict, while higher self-efficacy was associated with less. In this cross-sectional sample, online misinformation and decisional uncertainty were associated with reproductive vulnerability more closely than abortion count alone. Findings are associational and require prospective confirmation. Full article

Introduction: Obstructed HemiVagina and Ipsilateral Renal Anomaly (OHVIRA) syndrome, also known as Herlyn–Werner–Wunderlich syndrome, is a rare congenital Müllerian duct anomaly, characterized by uterus didelphys, obstructed hemivagina, and ipsilateral renal agenesis. Symptoms typically appear shortly after menarche and include dysmenorrhea and pelvic pain. The psychological burden associated with fertility and reproductive outcomes in women with OHVIRA syndrome remains poorly investigated. Materials and methods: A 30-year-old primigravida with left renal agenesis and a history of vaginal abscess, dysmenorrhea, and chronic pelvic pain received a delayed OHVIRA syndrome diagnosis. The patient had previously been informed that spontaneous conception and an uncomplicated pregnancy were highly unlikely because of her congenital gynecological condition, resulting in significant fertility-related anxiety and psychological distress. Under careful supervision and counseling, she conceived successfully, and the pregnancy progressed without complications; an elective cesarean section was performed at term. A literature search using the PubMed and Embase databases was conducted between November 2025 to April 2026 to identify studies reporting reproductive outcomes and psychological aspects in patients diagnosed with OHVIRA syndrome and other Müllerian anomalies. Results: Evidence-based counseling contributed to improvement of quality of life and reduction of pregnancy-related anxiety of the reported patient with OHVIRA syndrome. A limited number of studies discuss the mental burden and fertility-related anxiety of patients with OHVIRA syndrome and other Müllerian anomalies. Conclusions: Spontaneous conception and uncomplicated pregnancy are possible for women with OHVIRA syndrome. The psychological burden associated with congenital gynecological conditions remains under-recognized and requires further investigation. Comprehensive counseling and interdisciplinary care are essential to improve reproductive education, mental health support, and pregnancy outcomes in patients with congenital gynecological anomalies. Full article

Introduction: Skates (Rajidae) are cornerstone elasmobranchs, yet their intrinsic biological constraints, like slow growth, late maturation, and low fecundity, render them exceptionally susceptible to anthropogenic pressure. Despite their ecological and economic importance, tracking their population trajectories is historically hindered by “taxonomic blurring” and aggregated reporting in commercial fisheries. Objective: This study evaluates long-term conservation trends and exploitation dynamics of Rajidae species in the Northeast Atlantic and the Mediterranean Sea. Methodology: We analyzed 31 Rajidae species across the Northeast Atlantic and the Mediterranean Sea (FAO Areas 27 and 37) by integrating IUCN Red List assessments, species-specific life-history traits (maximum body size and depth distribution), and FAO fisheries landing data from 1992 to 2023. Descriptive analyses and Spearman correlations were used to assess temporal trends in conservation status and exploitation patterns. Results: Our synthesis reveals that some species show improvements in IUCN Red List category assessments, likely driven by recent management interventions such as species-specific reporting, catch quotas, and targeted retention bans. However, we also identify a critical mismatch between policy and biology: current Total Allowable Catches (TACs) and minimum landing sizes often do not explicitly incorporate species-specific life-history traits, inadvertently favoring smaller, less-marketable taxa while leaving larger, vulnerable species at risk. While FAO landings offer a valuable broad-scale overview of exploitation, the results highlight the limitations of aggregated fisheries statistics for species-level conservation assessments. Conclusions: These findings underline the need to adopt more precise and species-specific fisheries management approaches for Rajidae, including expanded regional monitoring programs, the use of data collected by on-board observers or electronic monitoring tools, and improved control of data reporting procedures, to prevent continued aggregation of species-level data. Full article

Understanding the early life history of the endangered largemouth bronze gudgeon (C. guichenoti) is crucial for optimizing artificial rearing and conservation strategies. To provide a unified scientific basis for these efforts, this study characterized the ontogeny of C. guichenoti larvae from hatching to 30 days post-hatch (dph) by integrating analyses of allometric growth, digestive histology, and enzyme activities. Morphometric analysis revealed that total length increased exponentially with age. Positive allometric growth was observed in swimming organs (pectoral, dorsal, and caudal fins) and eye diameter, indicating a priority in developing locomotion and sensory capabilities for survival in lotic environments. Histological examination showed that the digestive tract became patent by 4 dph, and functional structures were established by 5 dph, coinciding with yolk sac absorption and the initiation of exogenous feeding. The digestive system reached near-adult maturity by 20 dph. Enzyme activity profiles showed that trypsin activity increased continuously, peaking at 30 dph, while amylase and alkaline phosphatase peaked at 20 dph. Lipase activity remained low until a slight increase at 30 dph. These results indicate that C. guichenoti larvae adopt a “locomotion-first” strategy, with the digestive system becoming functional at 5 dph and maturing by 20 dph. These findings collectively define the critical windows for artificial propagation, specifically guiding the timing of initial feeding and feed formulation. Full article

The vertebrate mitochondrial genome (mitogenome) is a small, circular DNA molecule typically ~16–17 kb in length, encoding 37 genes that are essential for the electron transport chain, the mechanism that drives mostly all the ATP synthesis in cells. Owing to its central role in energy metabolism, its structure is highly conserved across vertebrate lineages in both the number and relative position of each gene in the genome. Nevertheless, different variations have been found in several teleost lineages, including antarctic fishes (Nototheniidae), gadiforms, hatchetfishes (Sternoptychidae), and Batrachoidiformes. The explanation for these phenomena remains unknown yet may reflect shifts in functional constraints and can provide insights into lineage-specific and/or coevolutionary processes. This raises the possibility that mitogenome structure is related to habitat selection, potentially reflecting environmental influences on energetic regulation. To further test this hypothesis, we studied more than 400 teleost species across all major teleost lineages. The mitogenome sequences were downloaded from NCBI and annotated using two independent algorithms (MITOZ and MITOS) and then compared with a reference (Danio rerio) to find any deviation from the standard structure. Similarly, ecological data was downloaded from FishBase using the R Package “rfishbase” 5.0.3. Two independent ancestral reconstruction analyses were carried out for both traits, “Mitogenome” and “Habitat”, using a reference evolutionary tree for teleosts to unravel both evolutionary histories. The possible association between mitogenome and habitat was then assessed using a suite of phylogenetic comparative methods, including Pagel’s correlation test (corHMM) to evaluate whether both traits evolved in a correlated fashion, branch-level co-transition analysis to identify lineages where structural changes and habitat shifts co-occurred, and node-by-node comparisons of ancestral state probabilities across the phylogeny. Preliminary results suggest a correlation between some deep-sea environments and a modified mitogenome structure, with structural deviations tending to cluster in lineages inhabiting greater depths. These exploratory findings raise the possibility that changes in mitogenome architecture may be linked to adaptations in energetic metabolism required for life in extreme low-energy environments. Further analyses are underway to clarify the functional significance of these genomic changes and their relationship to ecological and metabolic pressures in teleost evolution. Full article

Vocational integration (VI) services aim to support sustainable employment for persons with disabilities. However, in individuals with spinal cord injury, evidence on effective intervention targets and the evaluation of sustainable integration remains limited. The Work–Life Study aims to build an evidence base for supporting sustainable employment in Switzerland by (1) identifying typical work–life trajectories; (2) examining key work–life transitions and their predictors; (3) establishing a multi-state model for intervention targets; (4) exploring individual work–life narratives; and (5) developing guidelines for personalized VI practice. The study combines a mixed methods design with a collaborative Integrated Knowledge Translation approach, actively involving VI professionals and individuals with spinal cord injury. Participants are recruited from the Swiss Spinal Cord Injury Cohort Study (SwiSCI). Work–life history data are collected through a Biographical Survey and Biographical Interviews and analyzed alongside SwiSCI data. Guideline development includes a stakeholder meeting with representatives from the Swiss Paraplegic Group, spinal cord injury clinics, individuals with spinal cord injury, employers, and disability insurers. Of 2041 eligible SwiSCI participants, 478 (23.4%) completed the Biographical Survey (median age 57.5 years; median time since injury 19.1 years), with responders and non-responders showing comparable characteristics. Work–life data closely matched existing SwiSCI data (rho > 0.8), indicating good recall. The resulting guidelines will help VI providers coordinate rehabilitation services to optimally promote sustainable employment for individuals with spinal cord injury. Full article

Across human history, water has sustained communities while also shaping religious imagination as a symbol of life, danger, purification, and renewal. This review examines how water acquires religious meaning through symbolic associations, ritual uses, theological interpretations, sacred landscapes, and material water infrastructures across more than five millennia, drawing on examples from ancient civilizations, long-standing Asian traditions, Indigenous religions of the Americas and the Caribbean, and the three major Abrahamic religions. The study explores how rivers, springs, rain, floods, wells, sacred basins, and ritual waters have been understood as signs of creation, purification, fertility, healing, divine presence, destruction, and renewal, while also remaining part of everyday practices of settlement, agriculture, health, and communal life. The comparative analysis highlights recurring patterns and cultural differences. In some traditions, water appears as a primordial substance from which life emerges; in others, it functions as a medium of moral cleansing, ritual preparation, communal prayer, or sacred geography. The study argues that the religious meaning of water is best understood through the interaction of four closely related dimensions: symbolic interpretation, ritual practice, sacred or culturally charged landscapes, and material water infrastructures. By bringing these dimensions together, the article uses the concept of hydraulic heritage to connect religious water symbolism with sacred basins, wells, springs, hammams, monastic water systems, irrigation rituals, and other inherited water-related landscapes and practices. These connections offer a culturally grounded perspective for contemporary discussions on environmental ethics, water protection, and societies’ responsibility toward natural resources. Full article

The Liezi constitutes an important link between the Lao-Zhuang tradition and later Daoism, yet it has long remained marginal in scholarship due to controversies surrounding its provenance. Moving beyond debates over textual authenticity, this article examines Liezi’s reflections on life and death through a comparative dialogue with Plato’s account of the soul’s journey with you 游 as a bridging notion. In the Liezi, life is construed as a temporary wandering and death an inevitable return. This understanding weakens fixed subjectivity and normative structures, articulating a mode of cultivation that emphasizes accommodation, detachment, and the coexistence with the myriad things in a quasi-religious cosmos. In Plato, by contrast, the soul persists as a moral subject journeying between the sensible and intelligible worlds. It is integrated into a religious cosmic order that unites epistemic with ethical dimensions and is ultimately oriented toward its purification and return to the intelligible world. The comparison reveals a structural divergence between the two thinkers in the ultimate placement of human existence, while also demonstrating how cross-cultural comparison can generate mutually illuminating insights and reopen reflection on the Liezi’s place in intellectual history. Full article

Introduction: The Lebranche mullet (Mugil liza) is a commercially important fish species in southeastern and southern Brazil, which serves as the primary spawning ground for the Southern stock that supports the Brazilian industrial seine fleet. However, this stock’s distribution extends into Argentine waters (northern Patagonian shelf), and the connectivity between mullets caught in Brazil and their breeding areas across South America remains poorly understood. The authors hypothesized that adult mullets landed by the Brazilian fleet consist of two distinct groups: A local group originating in Brazilian waters (BR1) and a migratory group (BR2) that uses nursery areas in Argentina (AR). BR2 presumably returns to its original nursery grounds after spawning, to recover reproductive tissues, following a different migratory pattern than BR1. Objectives: To test this, the study analyzed the micro-chemical life history of 134 otoliths from mullets aged 0+ to 11 years using LA-ICP-MS. Methodology: Two elemental ratios (Ba/Ca and Sr/Ca) were measured from the otolith core to the edge and modelled using a generalized additive model for scale and shape (GAMLSS). Life history transitions were evaluated by pairwise comparisons of fitted values among ages. Results: GAMLSS showed that Ba/Ca ratios differed significantly among groups (AR ≠ BR1 ≠ BR2). In contrast, Sr/Ca ratios were similar between AR and BR2 during the first four years of life, significantly differing from those of BR1. Using empirically established thresholds for estuarine vs. marine habitats, the study determined that BR2 individuals leave nursery areas between ages 5 and 6, migrate back around age 8, and live there one last time after age 10 (the species’ maximum age). BR1 leaves nurseries after age 4 and returns between ages 5 and 6, exhibiting a shorter reproductive cycle. Importantly, the analysis of reproductive tissue mass showed that the weight after age 7 approximately matched the weight at age 3. After recovery, reproductive tissues doubled in weight before the second migration to spawn at sea. Conclusions: These findings provide crucial insights into M. liza’s life cycle, highlighting the need for shared stock management not only with neighboring nations (Argentina and Brazil) but also on a regional scale. Full article

Introduction: Otoliths have been widely used in recent years as tracers of fish life history, ranging from visual aging to chemical analyses that reconstruct environmental conditions, migration patterns, and metabolic changes. Yet, Iberian endemic or endangered species are understudied. This study focuses on Andalusian barbel (Luciobarbus sclateri), endemic to the southern half of the Iberian Peninsula. Objective: The aim was to evaluate whether otolith chemical profiles can simultaneously support age estimation and reveal the impact of environmental variations, particularly hypoxia. Methodology: Fish were caught in two sites with different environmental properties, including strong hypoxia: the Guadalquivir estuary and the dock of Seville (which is isolated from the main river channel by a ship lock and could, therefore, be used as a control). Otolith chemical composition was analyzed from core-to-edge transects with a laser-inductively coupled plasma mass spectrometer (LA ICP-MS). Results: Patterns of variation in Mg and Mn in relation to hypoxia and environmental conditions are discussed. We visually counted growth rings in the sections, and we found a strong correlation (R² = 0.904) in Mg:Ca peaks with growth rings. Body condition, assessed using Fulton’s condition factor (K), differed between sites, with fish from the estuary exhibiting a lower condition than those from the dock. Conclusions: The strong correlation between counter growth rings and Mg:Ca peaks suggests that chemical analysis could be used as a valid method for supporting aging. The pattern of lower condition in fish from the estuary is consistent with persistent hypoxic events documented in the estuary but not within the dock environment. This whole approach provides a powerful framework to assess habitat quality and support conservation of L. sclateri in the Guadalquivir estuary. Full article

Sleep and dietary behavior are deeply conserved biological processes that co-evolved under ecological pressures shaping human anatomy, metabolism, immunity, cognition, and life history strategies. Major transitions in human dietary ecology, including plant-dominant hominin foraging, increased meat consumption, control of fire and cooking, agricultural domestication, industrialization, and postindustrial globalization, restructured nutrient intake, pathogen exposure, microbial ecology, metabolic demands, and temporal organization of behavior. Emerging evidence from evolutionary genomics, chronobiology, neuroendocrinology, and microbiome science indicates that sleep–feeding interactions represent a conserved adaptive regulatory module optimized for fluctuating energy availability and strong photoperiodic entrainment. Modern environments characterized by widespread availability of highly palatable, energy-dense foods rich in refined carbohydrates, added sugars, and multiple industrial additives, together with artificial light at night, continuous caloric access, sedentary behavior, and psychosocial stress produce a profound evolutionary mismatch destabilizing circadian–metabolic homeostasis. This mismatch is characterized by circadian disruption, temporal misalignment of feeding and sleep behaviors, and, in many populations, insufficient sleep duration. Within this conceptual landscape, the emerging framework of “evolutionary chrononutrition” proposes that metabolic health and sleep integrity depend not only on what humans eat, but critically on when food is consumed in relation to endogenous circadian architecture shaped across deep evolutionary time. This review synthesizes anthropological, physiological, and molecular evidence to develop an integrative evolutionary framework linking sleep and diet to contemporary cardiometabolic, neurodegenerative, inflammatory, and psychiatric disorders, with particular emphasis on how each major dietary transition plausibly altered sleep duration, architecture, circadian timing, neuroendocrine regulation, and the temporal alignment between feeding behavior and biological rhythms. Full article

Background/Objectives: Acute chest syndrome (ACS) is a frequent and potentially life-threatening complication of sickle cell disease (SCD) that often develops during hospitalization for vaso-occlusive crisis (VOC). The early identification of pediatric patients at risk remains challenging, particularly in high-prevalence settings. This study aimed to identify predictors of acute chest syndrome following vaso-occlusive crisis in children with SCD. Methods: We conducted a retrospective cohort study of children and adolescents (≤18 years) with confirmed SCD admitted for VOC to Cayenne Hospital Center, French Guiana, between January 2014 and September 2024. ACS that occurred during hospitalization or within 7 days of admission was recorded. Multivariable logistic regression was used to identify independent predictors, and model performance was assessed using receiver operating characteristic (ROC) analysis. Results: Among the 825 VOC episodes in 190 patients, 239 (29%) were complicated by ACS. Independent ACS predictors were thoracic or abdominal pain at presentation (adjusted odds ratio [aOR] 14, 95% CI 6–32, p < 0.001), prior history of ACS (aOR 7.4, 95% CI 4.5–12.1), and Hb SS or Sβ⁰ genotype (aOR 1.8, 95% CI 1.2–2.4), age > 10 years (aOR 1.6, 95% CI 1.1–2.4), male sex (aOR 1.6, 95% CI 1.1–2.4), Hydroxyurea treatment was associated with a higher risk of acute chest syndrome (aOR 8.7, 95% CI 5.2–14.5), likely reflecting greater baseline disease severity among treated patients. The probability threshold maximizing the Youden index was 0.67, corresponding to a Youden index of 0.56. At this threshold, the model had a sensitivity of 61%, a specificity of 95%, a positive predictive value of 85%, and a negative predictive value of 86%. The apparent area under the receiver operating characteristic curve was 0.87 (95% CI, 0.83–0.89). The receiver operating characteristic analysis yielded an area under the curve of 0.87, indicating good apparent discrimination. Conclusions: These findings support targeted monitoring and early preventive strategies during pediatric VOC admissions. Full article

Introduction: Elasmobranchs are key components of marine ecosystems but are particularly vulnerable to fishing pressure due to their life-history traits, including slow growth, late maturity, and low fecundity. The Gulf of Cádiz supports a diverse assemblage of coastal and deep-water elasmobranch species, many of which are subject to incidental capture in demersal fisheries. Reliable fishery-independent information on their distribution, relative abundance, and biomass is essential to assess population status and to inform ecosystem-based fisheries management in the northeastern Atlantic. This study aims to provide an updated overview of the composition, relative abundance, biomass, and occurrence of elasmobranch species in the Gulf of Cádiz, contributing baseline information for monitoring and conservation purposes. Methodology: Data were obtained from the ARSA bottom trawl survey carried out in March 2026 using a stratified random sampling design by depth. A total of 45 valid hauls were performed. Results: A total of 29 elasmobranch species belonging to Rajiformes, Carcharhiniformes, Squaliformes, Myliobatiformes, Hexanchiformes, and Torpediniformes were identified. Small demersal sharks and skates dominated the assemblage. Scyliorhinus canicula was the most frequent and abundant species, occurring in 37 hauls and showing the highest mean abundance and biomass. Other recurrent taxa included Torpedo marmorata, Etmopterus spinax, Leucoraja naevus, and Raja clavata. Several species of conservation concern, such as Rostroraja alba, Centrophorus uyato, and Galeorhinus galeus, were recorded at low frequencies and abundances, highlighting their rarity in survey catches. The assemblage reflected a clear dominance of shelf and upper-slope species with occasional captures of deep-water taxa. Conclusions: The ARSA survey provides a valuable snapshot of the current elasmobranch community in the Gulf of Cádiz, confirming the prevalence of small-bodied, benthic species and the low occurrence of large or vulnerable taxa. These results underscore the importance of continued standardized surveys to detect temporal trends and support management strategies aimed at the conservation of elasmobranch diversity in the gulf. Full article

This study investigates the population dynamics and seasonal reproductive patterns of Gambusia holbrooki, an invasive fish threatening biodiversity within arid springs of the Edgbaston Spring complex in Queensland, Australia. Using daily aging techniques, we uncover critical life history traits that inform targeted species management. Our findings reveal marked sex-specific mortality rates, with males exhibiting higher mortality than females, a pattern consistent with findings from Tasmania. Reproductive activity peaks were observed between September and November, but persisted throughout the year, excluding January and April of 2020, likely due to elevated water temperatures during these months. Growth modeling identified the power function as the best fit for describing G. holbrooki growth trajectories. These insights highlight the importance of seasonally informed control strategies to mitigate the ecological impact of this pest species. The study provides essential data to support conservation efforts and guide effective management of invasive fish in fragile arid spring ecosystems. Full article

The long-term psychological consequences of COVID-19 remain insufficiently understood in student populations. This study examined the association between post-COVID-19 consequences and psychological functioning in university students, focusing on the mediating role of trait anxiety. A total of 7482 students aged 17 to 23 years completed an online survey assessing COVID-19 history, post-COVID-19 consequences, psychological well-being (WHO-5), subjective happiness (SHS), life satisfaction (SWLS), and trait anxiety (STAI). Participants were classified into three groups: no history of COVID-19, COVID-19 without post-COVID-19 consequences, and COVID-19 with post-COVID-19 consequences. Group differences were analyzed using ANOVA with Tukey post hoc tests, followed by regression and mediation analyses controlling for age and sex. Students reporting post-COVID-19 consequences showed higher trait anxiety and lower psychological well-being, subjective happiness, and life satisfaction than both comparison groups. Regression analyses indicated that poorer psychological functioning was associated specifically with post-COVID-19 consequences rather than COVID-19 history per se. Mediation analyses among previously infected students showed that trait anxiety statistically mediated these associations, accounting for 61% of the effect on psychological well-being, 84% on subjective happiness, and 68% on life satisfaction. These findings highlight trait anxiety as an important psychological factor statistically accounting for the association between post-COVID-19 consequences and reduced well-being. Full article