Search Results (3,032)

Regulatory sandboxes have evolved from specialised FinTech tools into broader mechanisms of regulatory experimentation. As artificial intelligence (AI) applications become embedded in credit decisioning, payment-fraud detection, identity verification, crypto-asset compliance, customer-facing advice and supervisory analytics, sandbox design increasingly affects how legal and institutional responsibility is allocated among regulators, participating firms, technology vendors and users. This article provides a comparative doctrinal and institutional analysis of accountability and liability in AI-related financial regulatory sandboxes. It clarifies the relevant AI modalities, distinguishes accountability (answerability and enforceability during sandbox participation) from liability (contractual, tort/product and regulatory/public law responsibility after harm), and maps framework-level safeguards across the European Union, the United Kingdom, Singapore, Norway and Hungary. The analysis does not seek to measure sandbox effectiveness empirically. Instead, it examines how publicly available legal and regulatory materials structure the allocation of duties before, during and after sandbox testing. The article shows that sandboxes generally do not operate as liability shields. Their legal significance lies in reallocating ex ante accountability duties—documentation, disclosure, monitoring, human oversight and exit planning—while preserving baseline liability rules. An Accountability and Liability Protocol is proposed to clarify roles, protect baseline consumer rights, support evidentiary traceability and connect sandbox learning to enforceable post-sandbox obligations. Full article

Background/Objectives: The aim of this study is to describe clavicular morphometric parameters and key bony landmarks relevant to plate-and-screw fixation and ligamentous reconstruction procedures. Methods: Morphometric measurements were performed on 179 adult human clavicles: 84 right and 95 left. Linear measurements were obtained using a Mitutoyo digital caliper (0.01 mm precision). Angular measurements were conducted using ImageJ software (LOCI, University of Wisconsin, Madison, USA). Results: The mean distance between the sternal articular surface and the midpoint of the sternoclavicular curvature was 49.23 ± 8.86 mm. The mean distance between the midpoints of the sternoclavicular and acromioclavicular curvatures was 65.16 ± 12.17 mm. The mean distance between the midpoint of the acromioclavicular curvature and the acromial articular surface was 41.58 ± 4.85 mm. The mean sternoclavicular angle was 153.31 ± 9.53° and the mean acromioclavicular angle was 119.95 ± 10.92°. The average thickness of the narrowest middle part of the clavicle was 11.61 ± 1.77 mm. The mean projection distance from the middle part of the clavicle to the most prominent point of the conoid tubercle was 43.81 ± 6.33 mm. The distances from the middle part of the clavicle to the medial trapezoid line and to the lateral impression of the costoclavicular ligament were 50.10 ± 6.31 mm and 42.29 ± 5.88 mm, respectively. The mean projected clavicular length was 142.76 ± 12.29 mm. Conclusions: In conclusion, these findings offer an anatomical reference that may assist radiological evaluation of clavicular shortening and support orthopaedic surgeons in implant selection and planning of ligament reconstruction procedures. Full article

The most important input for modelling the water flow in an inundation area is the Digital Terrain Model (DTM). The significance of DTM accuracy increases with activities related to the re-opening of floodplains to rivers, according to the Biodiversity Strategy 2030 issued by the European Committee in 2022. In this study, three Digital Terrain Models were compared: two DTMs (fourth and fifth versions) generated as Czech standards by the State Administration of Land Surveying and Cadastre, and a purpose-built DTM created by the CzechGlobe institute, CAS. A series of hydraulic calculations were carried out combining the three DTMs with the set of discharges corresponding to return periods of 1, 5, 20, and 100 years. The “typical” inundation area on the right bank of the Morava River was chosen to compare the modelling results. DTM inaccuracy affected the hydraulic modelling results primarily when smaller discharges passed the inundation area, mostly due to DTM inaccuracies in local open channels and water-collecting ditches, which are poorly and erroneously depicted when using the less-accurate fourth- and fifth-version DTMs. This study also shows that there was no direct correlation between the locations of DTM inaccuracies and differences in water levels obtained via hydraulic modelling, which dropped with increasing flood discharge. The error in the calculated water level exceeded approximately 0.75 m for Q₁ and approximately 0.33 m for Q₁₀₀. The error depends on the morphology and segmentation of the floodplain, the configuration of the hydraulic model, local changes and human interventions in the area, and the type of DTM, the technology used, and its accuracy and resolution. This study contributes to assessment of the accuracy of hydraulic modelling in flood inundation areas and indicates how DTM accuracy affects hydraulic modelling outcomes. Full article

This article analyses the Italian Legislative Delegation Bill of 4 September 2025 (DDL 2025), which proposes the recontextualization of healthcare liability through the introduction of Article 590-septies into the Italian Criminal Code (c.p.) and the amendment of Article 590-sexies c.p. and of Articles 5 and 7 of the Gelli-Bianco Act (Law No. 24/2017). The study examines the extent to which the reform, if enacted, would produce a shift of criminal negligence liability from the individual frontline clinician towards the apex management figures of healthcare organizations—at both the corporate and hospital levels—and under what conditions such a shift would be compatible with the constitutional principle of personal criminal responsibility (Art. 27 Const.) and with the evidentiary criteria for criminally relevant omission. Adopting a doctrinal and jurisprudential analysis approach, the study formulates a falsifiable hypothesis, accompanied by four ex post verifiability indicators observable over a five-year time horizon following the possible entry into force of the provision. The analysis demonstrates how the DDL 2025 would recontextualize the notion of culpa—encompassing imperizia (lack of skill), negligenza (negligence), and imprudenza (imprudence), functionally comparable to forms of criminal negligence in common law systems—by linking fault assessment to contextual factors such as organizational deficiencies and resource scarcity. This approach would adopt a deflationary framework, establishing a distinction between avoidable human error and errors caused by systemic dysfunctions and foreshadowing a potential shift of liability towards apex management, who are required to ensure organizational models adequate to patient safety. This orientation, far from constituting a doctrinal novelty, would formalize ex lege a trajectory already established in civil and criminal case law of the Court of Cassation (Cass. No. 6386/2023, “Travaglino”), further intersecting with the administrative liability regime for organizations under Legislative Decree 231/2001. Significant interpretive challenges remain, related to the application of criminal liability criteria to the omissive conduct of healthcare managers, as well as to the contrasting international evidence on the behavioural effectiveness of medical liability reforms. The redefinition of top-management liability would therefore be configured not merely as a tool for the protection of the individual professional but as a derived constitutional guarantee of the right to health and the safety of care, pursued through formalized risk governance, the integration of incident reporting and organizational audit systems, the transition towards Enterprise Risk Management models, and the traceability of apex decision-making processes. Examples drawn from other European jurisdictions illustrate the heterogeneity of legal approaches to medical fault and frame the Italian proposal as a context-specific solution that nonetheless could contribute to the international debate on institutional and organizational accountability for patient safety. Full article

The persistently high prevalence of gender-based violence and harassment (GBVH) in higher education institutions is a well established phenomenon, as is the inadequacy of institutional responses and the silencing of those who aim or attempt to report it. Drawing on Ahmed’s concept of ‘non-performativity’, ‘institutional speech acts that do not bring into effect what they name’, this paper argues that the non-performativity of anti-bullying and harassment policy is an exercise of power, consistent with Agócs concept of institutionalised resistance. Reporting misconduct is intentionally transformational, but seen as a threat to powerful organisational actors, who exercise institutional power to enact procedures in such a way that victim-survivors are unvoiced and tricked into ‘reluctant acquiescence’ with adverse consequences on their personal and occupational health. We employ documentary analysis to critique policies and procedures for GBVH in Irish universities, and specifically how institutional power is exercised through policy documents. The analysis is based on ten pseudonymised universities, rendering a sample size of 23 documents, pertaining to GBVH for staff. We find that the tone and language employed in policies, and the way in which the informal and formal approaches in anti-bullying and harassment policies frame the problem, serve the interests of the institution. Confidentiality clauses, the framing of the problem as an individualistic, incident-based problem, to be resolved case-by-case, and quasi-legal processes facilitate non-performativity, preserving institutional power and the status quo. From a public health perspective such inertia undermines efforts to prevent harm and promote workplace wellbeing. Meaningful reform will require that HEIs employ alternative tools capable of unsettling these entrenched institutional arrangements and to adopt alternative, proactive tools that prioritise accountability, transparency, prevention and health gain. We suggest new tools in the form of victim-centred, trauma-informed, remediation- and restorative-based approaches. Full article

This study offers a critical re-examination of contemporary euthanasia debates through an Islamic legal lens, with particular focus on requests for euthanasia arising from psychological suffering within the context of mental disorders. Within bioethical discourse, advocates of euthanasia predominantly justify their position on the grounds of individual autonomy and the alleviation of unbearable suffering, framing it as consistent with modern medicine’s aspiration to optimize quality of life. Yet, by elevating autonomy and self-determination as supreme moral values, it risks reducing the human condition to its cognitive and volitional dimensions, thereby overlooking the existential, spiritual, and affective aspects of suffering. In contrast, Islamic law regards life as a divine trust bestowed by God. Human beings are understood as stewards—rather than absolute proprietors—of their lives and are thus accountable before God for their preservation. From this perspective, psychological pain—akin to physical pain—may serve as a means of moral refinement, spiritual purification, and divine testing. Methodologically, the study conducts a textual and analytical examination of Islamic legal sources, complemented by practical examples that illustrate how psychological suffering transforms into requests for euthanasia, thereby examining how these sources ought to be understood through concrete cases. Furthermore, the study aims to examine whether appeals to a “right to die,” grounded in experiences of psychological suffering, can find any juridical legitimacy within the framework of Islamic law. Full article

The present study investigated the effect of a 3D-printed nanocomposite scaffold on bone healing in vivo. The scaffolds used were made from the bioresorbable thermoplastic polycaprolactone polymer, blended with Multi-Walled Carbon Nanotubes functionalized with chitosan, and manufactured with a rectilinear infill pattern and interconnected pores of 500 μm in size. The study included three groups of 10 Wistar rats, in which a 2 mm bone defect was created in the middle of the right femur. In the scaffold/peptide group, the gap was filled with the scaffold loaded with a peptide corresponding to human pleiotrophin amino acids 48-56 (PTN_48-56), and the fracture was stabilized with a 12 mm K-wire as an intramedullary nail. In the scaffold group, the scaffold did not contain the peptide, and in the control group, the bone defect was stabilized without the use of a scaffold. Radiological examination revealed that bone healing was achieved on average in 6.6 weeks in the scaffold/peptide group, 7.2 weeks in the scaffold group, and 8.1 weeks in the control group. Histopathological examination performed 2 weeks postoperatively showed that angiogenesis in the scaffold/peptide group was 1.5 times higher than in the scaffold group and 2.5 times higher than in the control group. In conclusion, our osteo-inductive 3D-printed scaffold covered with PTN_48-56 is a promising option for accelerating bone defect healing. Full article

Existing thermal sensation prediction models typically examine the relationship between skin temperature and thermal sensation during cooling or heating seasons. However, due to significant fluctuations in indoor thermal environments during shoulder seasons and considerable individual variation in clothing preferences, traditional thermal sensation prediction models demonstrate poor predictive performance during shoulder seasons. This study aims to investigate the relationship between facial skin temperature and clothing insulation versus thermal sensation under shoulder seasonal conditions and to establish a predictive model for human thermal sensation influenced by clothing insulation. First, facial temperature data under different clothing conditions are collected online using infrared thermal imaging equipment. Subjective thermal sensations are obtained through questionnaires, enabling analysis of the influence of relationships among clothing insulation, facial temperature, and thermal sensation. Subsequently, correlation analysis is used to identify the facial temperature zones closely related to human thermal sensation. Finally, a random forest algorithm is employed to establish a thermal sensation prediction model. Research findings indicate that during shoulder seasons, the left and right cheeks and lips exhibit a higher correlation with thermal sensation. Due to variations in clothing insulation, thermal sensation models based solely on facial temperature characteristics demonstrate lower predictive accuracy and struggle to overcome interference caused by individual clothing differences. After incorporating clothing insulation as a key input feature parameter, the model’s Root Mean Square Error decreased from 0.869 to 0.533, representing a 38.7% improvement in prediction accuracy. This demonstrates that the clothing insulation parameter plays a crucial role in enhancing the precision of human thermal sensation prediction models during shoulder seasons. Full article

Background: Minimally invasive aesthetic procedures using atmospheric plasma devices are increasingly applied to improve skin laxity and age-related loss of firmness. These systems generate a localized plasma arc at the tissue surface, enabling controlled and spatially confined tissue interaction; however, quantitative histological data on the extent of plasma-induced tissue effects remain limited. Materials and Methods: This ex vivo study evaluated freshly collected porcine kidney, liver, and skeletal muscle tissues (n = 3 per tissue type). Tissue sublimation defects were produced using the Plasma IQ device under conditions representative of standard clinical use, applying two predefined settings (“LOW” and “HIGH”). Immediately after treatment, specimens were fixed in 10% neutral buffered formalin and processed into formalin-fixed paraffin-embedded (FFPE) blocks. Sections were stained with hematoxylin and eosin (H&E), and the diameter and depth of the sublimation zones were measured by light microscopy. Results: Plasma IQ exposure consistently produced well-demarcated superficial sublimation defects in all tissues. The HIGH setting increased the diameter of the sublimation zones compared with the LOW setting across all tissue types, whereas the depth differences were smaller and tissue-dependent. Lesions exhibited a characteristic flattened, cone-shaped morphology, with diameter exceeding depth. No histologically detectable collateral damage was observed beyond the immediate sublimation zone. Conclusions: Atmospheric plasma treatment induces controlled and spatially confined tissue sublimation with clearly defined histological boundaries and limited penetration depth. These findings provide quantitative histological support for the localized tissue effects of plasma-based devices and their rationale in aesthetic procedures. Full article

Introduction: During an excavation in 2022 of a mass grave within a cemetery in Castilla-La Mancha containing the remains of executed victims of the Spanish Civil War and Francoist dictatorship, the scientific team discovered a medallion with a name and a date inscribed on it. The medallion was associated with an individual recovered from a grave containing 12 other individuals in 5 separate stratigraphic layers. This paper aims to outline the identification process of the deceased from the skeletal remains and associated medallion. Methods: This process included archival research, gathering witness testimonies, archaeological evidence, osteological examination and DNA analysis. Results: After restoration, the medallion revealed the words “VIVA LA FIJL. VIVA LA FAI.” on one face and “MUERO POR LA LIBERTAD.” on the other. The human skeletal remains associated with the medallion showed male morphological characteristics and were estimated to be between 21 and 30 years old at the time of death, with a height between 1.64 and 1.67 m. There was skeletal evidence of ballistic trauma on the right mandible and the right scapula. Genetic analysis confirmed an mtDNA match with his maternal niece. Discussion/Conclusions: This study demonstrates the importance of a multidisciplinary approach to the identification of human remains from the Spanish Civil War and the Dictatorship which followed, and how the objects found within a mass grave can be useful in aiding a positive identification. Full article

Artificial intelligence (AI) is transforming how organizations develop human potential, offering scalable and data-driven support for coaching and capability building. This study proposes and validates a conceptual framework for integrating AI into organizational coaching processes to enhance competence development and strategic alignment. AI-supported coaching in this research is treated as an emerging organizational technology whose potential organizational value depends less on model capability and more on governance design, decision rights, and auditable evaluation outputs. Following a mixed-methods, multi-phase design, the research combined a Systematic Literature Review (SLR) with the construction of a layered design architecture in which OSCAR serves as the primary coaching-process scaffold, complemented by KSA for competency specification, Situational Leadership for adaptive guidance, and KPIs for monitoring and governance. The framework structures AI-supported coaching across 10 interrelated phases, from contextual anchoring to review and measurement, while preserving iterative re-entry to earlier phases whenever review evidence, contextual change, or insufficient progress makes adjustment necessary. Prototyping demonstrated feasibility and coherence across models, while the focus group provided qualitative expert feedback on the framework’s clarity, governance needs, and perceived usefulness for competence development. At this stage, however, the KPI structures generated by the framework and the descriptive comparison across AI tools should be interpreted as prototype-level outputs rather than as empirically validated performance measures or evidence of added value over baseline approaches. Because the evaluation relied on two fictional prototyping scenarios and a small expert-oriented focus group (n = 6), the findings should be interpreted as evidence of prototype demonstration and qualitative refinement rather than of real-world effectiveness or organizational impact. The study also does not include a control group or comparison with traditional human coaching, so the added value of the AI-supported framework over alternative coaching arrangements remains a question for future empirical testing. Findings suggest that AI can usefully support organizational coaching by personalizing dialogue, structuring reflection, and generating auditable development artefacts, provided ethical safeguards and human oversight remain integral. The research contributes a preliminarily validated, ethics-informed, and governance-aware framework for AI adoption in organizational coaching and offers practical insights for embedding AI-enabled development in learning organizations. Full article

Traditional talent development models were designed before the AI revolution and do not consider artificial agents as possible sources of development. artificial intelligence is quickly infiltrating education spaces—but our thinking about learning has not caught up with how we can productively pair learners with both human and artificial intelligence. Addressing this gap, we introduce Human–AI Symbiotic Theory (HAIST), a novel theoretical framework designed for AI-facilitated environments, which posits how learners can productively leverage both humans and AI as “development partners” across the entire talent development process. We begin with a comprehensive integration of ideas and theory from the literature on talent development, AI for learning, and human–AI collaboration and use these insights to build HAIST for the specific context of talent development. HAIST comprises three mechanisms—Complementary Intelligence Activation (CIA), Dynamic Adaptive Co-Regulation (DACR), and Agency-Preserving Scaffolding (APS)—that are grounded in prior theory and research on topics like sociocultural theory, self-regulated learning, and distributed cognition. We then demonstrate how HAIST can be applied throughout all phases of talent development while highlighting implications for traditionally underserved learners like adult learners, student veterans, multilingual learners, and first-generation learners. We provide an applied example of how the three mechanisms work in tandem to support talent development and discuss points of tension that must be navigated when applying HAIST (e.g., between adaptation and optimization vs. agency). Lastly, we highlight how considerations of ethics and learner rights (algorithmic bias, learner voice, etc.) should be considered when operationalizing HAIST. Overall, HAIST can serve as a foundational theory to not only understand how talent development should occur between learners and both humans and AI, but also to consider the process of instruction design in AI-mediated learning environments. Full article

Objective: Dog ear infections can have a variety of multifactorial causes, some of which are regarded as zoonotic. Thus, the present study was aimed at understanding the microbial causes, clinical evaluation, molecular analysis and associated risk factors of ear infections in dogs for their management. Methods: A total of 167 dogs were screened for ear infections based on history and clinical signs. An auricular swab was collected and processed with standard methods. Head tilting to the afflicted side, ear pain when palpated, pawing at the ear and purulent discharges from the ear canal were typical clinical symptoms. Results: A total of 13.77% of dogs were positive for ear infection, and among these, 13.17% showed unilateral right-sided ear infections. Dogs with pendulous ears (56.52%), Labrador breeds (34.78%), males (56.52%), dogs older than 4 years (52.17%), and during the monsoon season (65.21%) had higher rates of ear infections among the total dogs screened (n = 167) for aural infections. Anaemia, leukocytosis, neutrophilia, and elevated levels of total protein, cholesterol, BUN, and AST were observed in dogs with ear infections. Cytological analyses showed the presence of yeast cells and bacteria, along with hyperkeratosis and degenerated neutrophils. Mammaliicoccus sciuri, Bacillus cereus, Klebsiella aerogenes, Pseudomonas aeruginosa, and Malassezia spp. were the organisms isolated. Bacterial isolates showed high sensitivity to gentamicin for the otitis treatment. Clinical Significance: This study highlights the need for preventive measures to curb the spread of potentially zoonotic pathogens such as Bacillus cereus and Klebsiella aerogenes, which can pose significant threats to both human and animal health. Full article

Rising planetary temperatures and extreme heat events have led to an increased incidence of heat-related illnesses, such as heat stroke, globally. Widespread adoption of measures to prevent and treat heat-related illnesses is an increasingly urgent issue given the rising global temperatures; promotion of such evidence-based strategies is needed to reduce heat-related morbidity and mortality globally. Such heat-related environmental illnesses are differentially experienced by those without access to ambient cooling and those engaged in outdoor work and recreation. Moreover, the adverse impacts of heat-related illness experienced by residents of the Global South necessitates the inclusion of high-quality recommendations around prevention and treatment into clinical and public health practice in order to address health equity and human rights considerations. The current guidance on prevention strategies and therapeutic interventions for heat-related illness has been iterated and published by the Wilderness Medical Society (WMS). In this critical appraisal, we have summarized the evidence-based guidelines and highlighted the updated recommendations that reflect evolving issues in heat illness research. Application of the Appraisal of Guidelines for Research and Evaluation (AGREE) II framework has enabled a quality assessment of the guidelines to be performed, which we present herein. The adoption of evidence-based practices around heat-related illness has the potential to reduce morbidity and mortality and improve global population-level health in light of the warming climate. Full article

Purpose: Access to assistive technology (AT) is a fundamental human right and a critical component of Universal Health Coverage (UHC). In the Middle East and North Africa (MENA) region, the scarcity of trained professionals remains a significant barrier to AT service provision. This study evaluates the effectiveness and perceived usefulness of the Assistive Technology Training Program (ATTP), a specialized continuing education initiative designed to build workforce capacity among rehabilitation and healthcare professionals. Methods: A convergent mixed methods design was used to analyze quantitative pre/post-test scores and qualitative focus group open-ended responses. Quantitative data were gathered from 386 participants across 11 MENA countries using a pre- and post-test assessment of AT knowledge. Qualitative utility and participant satisfaction were assessed through a 5-point Likert scale survey evaluating content relevance, trainer expertise, and facilities. Association tests (ANOVA and t-tests) were conducted to identify factors influencing knowledge gain. Results: Participants demonstrated a statistically significant improvement in AT knowledge, with the overall mean score increasing from 3.67 ± 1.13 to 7.50 ± 1.25 (p < 0.001). High levels of satisfaction were reported, with 92% of participants rating the training as “Very Good” or “Excellent” regarding its relevance to clinical needs. Association tests revealed that professional background (p < 0.001), employment status (p = 0.0017), level of education (p = 0.011), and prior training experience (p = 0.026) were significant factors in the magnitude of improvement, although all subgroups achieved significant learning gains. Qualitative thematic analysis per the focus group discussions using the WHO-GATE 5 P framework identified three major themes: (1) Structural Challenges: Issues with Products and Provision point toward a need for better infrastructure and localized supply chains. (2) Human Capital: Personnel barriers emphasize that training shouldn’t just be for professionals, but should extend to caregivers as well. (3) Systemic and Social Change: Policy and People focus on the “soft” side of AT moving toward user-involved guidelines and fighting social stigma to ensure rights are upheld. Conclusions: The ATTP is an impactful educational intervention that significantly enhances the foundational competencies of healthcare professionals in the MENA region. By addressing knowledge gaps and fostering practical skills, the program serves as a preliminary model that demonstrates potential for building regional capacity and supporting the United Nations’ Sustainable Development Goal (SDG) #3 related to health and wellbeing and SDG #4 related to quality education and lifelong learning opportunities for all. Further research is required to evaluate its long-term scalability and clinical impact. Full article