Search Results (857)

Lithium-ion batteries (LIBs) have garnered extensive application across various domains. However, frequent safety incidents associated with these LIBs have emerged as a significant impediment to their further advancement. Consequently, there is an urgent necessity to develop a novel fire extinguishing agent that possesses both rapid fire suppression and efficient cooling capabilities, thereby effectively mitigating the occurrence and propagation of fires in LIBs. This study pioneers the development of an adaptive thermosensitive microcapsule (TM) fire extinguishing agent synthesized via in situ polymerization. The TM encapsulates a ternary composite core—perfluorohexanone (C₆F₁₂O), heptafluorocyclopentane (C₅H₃F₇), and 2-bromo-3,3,3-trifluoropropene (2-BTP)—within a melamine–urea–formaldehyde (MUF) resin shell. The TM was prepared via in situ polymerization, combined with FE-SEM, FTIR, TG–DSC, and laser particle size analysis to verify that the TM had a uniform particle size and complete coating structure. The results demonstrate that the TM can effectively suppress the thermal runaway (TR) of LIBs through the synergistic effects of physical cooling, chemical suppression, and gas isolation. Specifically, the peak TR temperature of a single-cell LIB is reduced by 14.0 °C, and the heating rate is decreased by 0.17 °C/s. Additionally, TM successfully blocked the propagation of TR thereby preventing its spread in the dual-LIB module test. Limitations of single-component agents are overcome by this innovative system by leveraging the ternary core’s complementary functionalities, enabling autonomous TR suppression without external systems. Furthermore, the TM design integrates precise thermal responsiveness, environmental friendliness, and cost-effectiveness, offering a transformative safety solution for next-generation LIBs. Full article

Technical aspects of desert locust (Schistocerca gregaria) management have markedly improved since the late 1980s. Examples include modernized electronic communication systems linking stakeholders, global positioning system precision for reporting and treatment of locust aggregations, ultra-low-volume insecticide formulations and application techniques that reduce both environmental impact and chemical use, and computerized integration of multidisciplinary data for monitoring and forecasting outbreaks, upsurges, and plagues. Despite the remote and rugged terrain where the species thrives, tools and vehicles for surveillance and control generally exist—although they are not always available when needed. As technical aspects of desert locust control continue to be surmounted, human-based factors remain substantial, underlying, multifaceted obstacles. Funding shortfalls are frequently cited but rarely analyzed in depth. This article focuses on these underlying human constraints, including rigid conceptual dogmas, diverse forms of insecurity, political interference, weak communication among stakeholders, decreasing donor interest, confusion between emergency response and development objectives, loss of institutional memory, inadequate staff training, and limited attention to dynamic, real-time developments. These human-based impediments are critical because they underlie systemic unpreparedness and hinder the transition toward more integrated, proactive, and sustainable locust management approaches. As such, they contribute to the onset, intensity, and prolonged duration of desert locust episodes. Full article

Background/Objectives: Artificial Intelligence (AI) is improving dentistry through increased accuracy in diagnostics, planning, and workflow automation. AI tools, including machine learning (ML) and deep learning (DL), are being adopted in oral medicine to improve patient care, efficiency, and lessen clinicians’ workloads. AI in dentistry, despite its use, faces an issue of acceptance, with its obstacles including ethical, legal, and technological ones. In this article, a review of current AI use in oral medicine, new technology development, and integration barriers is discussed. Methods: A narrative review of peer-reviewed articles in databases such as PubMed, Scopus, Web of Science, and Google Scholar was conducted. Peer-reviewed articles over the last decade, such as AI application in diagnostic imaging, predictive analysis, real-time documentation, and workflows automation, were examined. Besides, improvements in AI models and critical impediments such as ethical concerns and integration barriers were addressed in the review. Results: AI has exhibited strong performance in radiographic diagnostics, with high accuracy in reading cone-beam computed tomography (CBCT) scan, intraoral photographs, and radiographs. AI-facilitated predictive analysis has enhanced personalized care planning and disease avoidance, and AI-facilitated automation of workflows has maximized administrative workflows and patient record management. U-Net-based segmentation models exhibit sensitivities and specificities of approximately 93.0% and 88.0%, respectively, in identifying periapical lesions on 2D CBCT slices. TensorFlow-based workflow modules, integrated into vendor platforms such as Planmeca Romexis, can reduce the processing time of patient records by a minimum of 30 percent in standard practice. The privacy-preserving federated learning architecture has attained cross-site model consistency exceeding 90% accuracy, enabling collaborative training among diverse dentistry clinics. Explainable AI (XAI) and federated learning have enhanced AI transparency and security with technological advancement, but barriers include concerns regarding data privacy, AI bias, gaps in AI regulating, and training clinicians. Conclusions: AI is revolutionizing dentistry with enhanced diagnostic accuracy, predictive planning, and efficient administration automation. With technology developing AI software even smarter, ethics and legislation have to follow in order to allow responsible AI integration. To make AI in dental care work at its best, future research will have to prioritize AI interpretability, developing uniform protocols, and collaboration between specialties in order to allow AI’s full potential in dentistry. Full article

This publication marks yet another interdisciplinary contribution by the authors: a canon lawyer and a biblical theologian. They undertake a joint canonical and exegetical analysis of Ezra 9:1–2, reflecting on whether this passage might be counted among the biblical foundations that have informed the Catholic Church’s doctrine on mixed marriages and the diriment impediment arising from disparity of religion. Already, the title poses the research problem framed as a question, “Does the Biblical Injunction against Marriage with ‘Outsiders’ (Ezra 9:1–2) still Bind Catholics Today?” As a first step, the authors undertake an examination of the biblical pericope with a particular focus on the problem of intermarriage, contextualized within its historical setting and the reform initiated by Ezra. Special attention is given to Deuteronomy 7:3–4, which is considered a fundamental underpinning of Ezra’s position. Subsequently, the authors trace the historical evolution of the concepts of impedimentum disparitatis cultus and impedimentum mixtae religionis. The authors move on to discuss the contemporary teaching of the Catholic Church concerning mixed marriages and the granting of dispensations from the diriment impediment of disparity of cult. Particular attention is given to the prerequisites for obtaining the permission of the local ordinary and the aforesaid dispensation, nuanced from the perspective of the Catholic party and non-Catholic one. In the final section, the authors articulate the conclusions of their inquiry. Given the interdisciplinary nature of the study, their research methodology integrated scholarly sources from both biblical sciences and the canonical legal tradition. Full article

Background: Scientific evidence plays a critical role in informing public health decision-making processes. However, the extent, nature, and effectiveness of its use remain uneven across contexts. Despite the increasing volume of literature on the subject, previous syntheses have often suffered from narrow thematic, temporal, or geographic scopes. Objectives: This study undertook a comprehensive systematic literature review spanning 50 years to (i) synthesise current knowledge on the use of scientific evidence in public health decisions, (ii) identify key determinants, barriers, and enablers, (iii) evaluate implementation patterns, and (iv) propose future directions for research and practice. Methods: We adopted the PRISMA model (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). Moreover, we researched three large databases (Web of Science, Embase, and PubMed), and this study focused on articles published in the English and French languages between January 1974 and December 2024. Studies were analysed thematically and descriptively to identify trends, patterns, and knowledge gaps. Results: This review reveals a growing corpus of scholarship with a predominance of qualitative studies mainly published in public health journals. Evidence use is most frequently analysed at the national policy level. Analyses of the evolution of scientific production over time revealed significant shifts beginning as early as 2005. Critical impediments included limited access to reliable and timely data, a lack of institutional capacity, and insufficient training among policy-makers. In contrast, enablers encompass cross-sector collaboration, data transparency, and alignment between researchers and decision-makers. Conclusions: Addressing persistent gaps necessitates a more nuanced appreciation of interdisciplinary and contextual factors. Our findings call for proactive policies aimed at promoting the use of scientific evidence by improving the accessibility of health data (addressing the absence or lack of data, as well as its reliability, timeliness, and accessibility), and by training decision-makers in the use of scientific evidence for decision making. Furthermore, our findings advocate for better alignment between the agendas of healthcare professionals (e.g., data collection), researchers (e.g., the selection of research topics), and decision-makers (e.g., expectations and needs) in order to develop and implement public health policies that are grounded in and informed by scientific evidence. Full article

Leaf area index (LAI) is a crucial parameter reflecting the crown structure of the grassland. Accurately obtaining LAI is of great significance for estimating carbon sinks in grassland ecosystems. However, spectral noise interference and pronounced spatial heterogeneity within vegetation canopies constitute significant impediments to achieving high-precision LAI retrieval. This study used hyperspectral sensor mounted on an unmanned aerial vehicle (UAV) to estimate LAI in a typical grassland, Hulun Lake Basin. Multiple machine learning (ML) models were constructed to reveal a relationship between hyperspectral data and grassland LAI using two input datasets, namely spectral transformations and vegetation indices (VIs), while SHAP (SHapley Additive ExPlanation) interpretability analysis was further employed to identify high-contribution features in the ML models. The analysis revealed that grassland LAI has good correlations with the original spectrum at 550 nm and 750 nm–1000 nm, first and second derivatives at 506 nm–574 nm, 649 nm–784 nm, and vegetation indices including the triangular vegetation index (TVI), enhanced vegetation index 2 (EVI2), and soil-adjusted vegetation index (SAVI). In the models using spectral transformations and VIs, the random forest (RF) models outperformed other models (testing R² = 0.89/0.88, RMSE = 0.20/0.21, and RRMSE = 27.34%/28.98%). The prediction error of the random forest model exhibited a positive correlation with measured LAI magnitude but demonstrated an inverse relationship with quadrat-level species richness, quantified by Margalef’s richness index (MRI). We also found that at the quadrat level, the spectral response curve pattern is influenced by attributes within the quadrat, like dominant species and vegetation cover, and that LAI has positive relationship with quadrat vegetation cover. The LAI inversion results in this study were also compared to main LAI products, showing a good correlation (r = 0.71). This study successfully established a high-fidelity inversion framework for hyperspectral-derived LAI estimation in mid-to-high latitude grasslands of the Hulun Lake Basin, supporting the spatial refinement of continental-scale carbon sink models at a regional scale. Full article

Background/Objectives: The aim of this study was to evaluate baseline health measurements among transitional housing residents (n = 29) participating in an 8-week pilot wellness intervention. Methods: Researchers measured anthropometrics, body composition, muscular strength, cardiovascular indicators, physical activity, diet quality, and health-related perceptions. Researchers analyzed data using descriptive statistics and conventional content analysis. Results: Most participants were male, White, and food insecure. Mean BMI (31.8 ± 8.6 kg/m²), waist-to-hip ratio (1.0 ± 0.1 males, 0.9 ± 0.1 females), body fat percentage (25.8 ± 6.1% males, 40.5 ± 9.4% females), blood pressure (131.8 ± 17.9/85.2 ± 13.3 mmHg), and daily step counts exceeded recommended levels. Absolute grip strength (77.1 ± 19.4 kg males, 53.0 ± 15.7 kg females) and perceived general health were below reference standards. The Healthy Eating Index-2020 score (39.7/100) indicated low diet quality. Common barriers to healthy eating were financial constraints (29.6%) and limited cooking/storage facilities (29.6%), as well as to exercise, physical impediments (14.8%). Conclusions: Residents living in transitional housing have less favorable body composition, diet, and grip strength measures, putting them at risk for negative health outcomes. Wellness interventions aimed at promoting improved health-related outcomes while addressing common barriers to proper diet and exercise among transitional housing residents are warranted. Full article

The present study examines the barriers that prevent cooling system flexibility from being optimized. In the context of an increasing reliance on renewable energy sources, the necessity for flexible energy utilization is becoming increasingly apparent. A survey and discussion groups were conducted with various stakeholders within the cooling value chain to obtain their experiences and insights regarding barriers to flexibilization. The findings point out that economic, technological, and regulatory barriers are the primary factors impeding the implementation of flexible solutions. In particular, high investment costs, complex technical implementation, a lack of information, and a complicated legal framework were identified as significant impediments. To enhance the flexibility of cooling systems, coordinated efforts are necessary to address these barriers. Practical examples, training, and the standardization and digitalization of processes could facilitate the widespread implementation of flexible cooling systems. Full article

Whilst there has been an increasing trend of women holding academic positions in European Higher Tertiary Institutions (HTIs), leadership positions are held predominantly by men. The study draws on radical feminism theory with which its methodology is aligned by investigating the perceptions of both genders. To that end, the study categorizes the impediments holding women back from breaking the glass ceiling into endogenous and exogenous factors. By doing so, the authors are in a better position to recommend the implementation of policies and procedures to address this inequality and navigate towards achieving sustainable gender equality. The research was conducted using an online survey questionnaire administered among all academic and administrative staff of universities in the Republic of Cyprus, the country with the highest glass ceiling in the EU. The authors found that the binary genders differ in their perceptions of what keeps women from breaking the glass ceiling and that this is attributable to exogenous factors, namely, (a) the walls created by male leaders, reinforcing a feeling of marginalization and mansplaining; and (b) family obligations enhancing women’s experiencing a lack of time and burnout. Furthermore, the exogenous factors and the extremely gendered higher echelons of HTIs underpin the endogenous factor of self-sabotage, making women feel they would rather avoid the toxic leadership environment with its lack of professional credit, a view supported by radical feminism theory. The authors suggest practical policy implications to rectify the gender imbalance in leadership in HTIs and suggest directions for future research. Full article

Magnetocardiography (MCG) provides a non-invasive, contactless technique for evaluating the magnetic fields generated by cardiac electrical activity, offering unique spatial insights into cardiac electrophysiology. However, conventional MCG systems depend on superconducting quantum interference devices that require cryogenic cooling and magnetic shielded environments, posing considerable impediments to widespread clinical adoption. In this study, we present a novel MCG system utilizing a high-sensitivity, wide-dynamic-range magnetoresistive sensor array operating at room temperature. To mitigate environmental interference, identical sensors were deployed as reference channels, enabling adaptive noise cancellation (ANC) without the need for traditional magnetic shielding. MCG recordings were obtained from 40 healthy participants, with signals processed using ANC, R-peak-synchronized averaging, and Bayesian spatial signal separation. This approach enabled the reliable detection of key cardiac components, including P, QRS, and T waves, from the unshielded MCG recordings. Our findings underscore the feasibility of a cost-effective, portable MCG system suitable for clinical settings, presenting new opportunities for noninvasive cardiac diagnostics and monitoring. Full article

Loess deposits in China, covering extensive regions, exhibit distinctive physical and mechanical characteristics, including collapsibility and reduced mechanical strength. These properties contribute to heightened susceptibility to slope-related geological hazards, such as landslides and collapses, in these areas. The widespread distribution and challenging prevention of these geological disasters have emerged as significant impediments to both public safety and economic development in China. Moreover, geological disaster data originates from diverse sources and exists in substantial fragmented, decentralized, and unstructured formats, including textual records and graphical representations. These datasets exhibit complex structures and heterogeneous formats yet suffer from inadequate organization and storage due to the absence of unified descriptive standards. The lack of systematic categorization and standardized representation significantly hinders effective data integration and knowledge extraction across different sources. To address these challenges, this study proposes a novel loess slope stability assessment method employing a dendrogram neural network (GNN-TreeNet) integrated with knowledge graph technology. The methodology progresses through three phases: (1) construction of a multi-domain knowledge graph integrating a large number of loess slopes with historical disaster records, instability factor relationships, and empirical parameter correlations; (2) generation of expressive node embeddings capturing inherent connections via graph neural networks; (3) development and training of the GNN-TreeNet architecture that leverages the graph’s enhanced representation capacity for stability evaluation. This structured framework enables cross-disciplinary data synthesis and interpretable slope stability analysis through a systematic integration of geological, geographical, and empirical knowledge components. Full article

Clarifying the coordination and impediments of social, economic, and spatial connection in rural areas is essential for advancing rural revitalization, urban-rural integration, and regional coordinated development. Utilizing the 24 counties and districts in western Hunan as case studies, we developed an evaluation index system for sustainable rural development across three dimensions: social, economic, and spatial. We employed the coupling model, coordination model, and obstacle factor model to investigate the comprehensive development level, coupling and coordination status, and obstacle factors of the villages in the study area at three temporal points: 2002, 2012, and 2022. The findings indicate the following: (1) The degree of rural development in western Hunan has escalated swiftly throughout the study period, transitioning from relative homogeneity to a heterogeneous developmental landscape, accompanied by issues such as inadequate development and regional polarization. (2) The overall rural social, economic, and spatial indices are low, and the degree of coupling has increased variably across different study periods; the average coordination degree has gradually improved over time, yet the level of coordination remains low, and spatial development is unbalanced. (3) The criterion-level impediments hindering the sustainable development of rural society, economy, and space are, in descending order, social factors, spatial factors, and economic factors. The urbanization rate, total fixed investment rate, and arable land change rate are the primary impediments in most counties and cities. The study’s findings will inform the planning of rural development in ethnic regions, promote sustainable social and spatial advancement in the countryside, and serve as a reference for rural revitalization efforts. Full article

Incremental energy demand, environmental constraints, restrictions in the availability of energy resources, economic conditions, and political impact prompt the power sector toward deregulation. In addition to these impediments, electric power competition for power quality, reliability, availability, and cost forces utilities to maximize utilization of the existing infrastructure by flowing power on transmission lines near to their thermal limits. All these factors introduce problems related to power network stability, reliability, quality, congestion management, and security in restructured power systems. To overcome these problems, power-electronics-based FACTS devices are one of the beneficial solutions at present. In this review paper, the significant role of FACTS devices in restructured power networks and their technical benefits against various power system problems such as load frequency control, voltage stability, and congestion management will be presented. In addition, an extensive discussion about the comparison between different FACTS devices (series, shunt, and their combination) and comparison between various optimization techniques (classical, analytical, hybrid, and meta-heuristics) that support FACTS devices to achieve their respective benefits is presented in this paper. Generally, it is concluded that third-generation FACTS controllers are more popular to mitigate various power system problems (i.e., load frequency control, voltage stability, and congestion management). Moreover, a combination of multiple FACTS devices, with or without energy storage devices, is more beneficial compared to their individual usage. However, this is not commonly adopted in small power systems due to high installation or maintenance costs. Therefore, there is a trade-off between the selection and cost of FACTS devices to minimize the power system problems. Likewise, meta-heuristics and hybrid optimization techniques are commonly adopted to optimize FACTS devices due to their fast convergence, robustness, higher accuracy, and flexibility. Full article

In November 2024, the fourth annual Symposium focusing on early-age onset cancer (EAOC) was hosted by the Colorectal Cancer Resource & Action Network (CCRAN), assembling clinicians, researchers, and patients virtually to discuss challenges in early detection and diagnosis of individuals afflicted with EAOC across tumour types. The meeting addressed the rising rates of EAOC and identified strategies to overcome barriers to timely detection and diagnosis by closing gaps in public and healthcare provider knowledge on symptoms of cancer in younger adults and reducing inequities in standard screening for younger age groups. Discussions also encompassed the various factors that serve as impediments to accessing diagnostic testing and obtaining results, as well as the critical need for access to diagnostics such as comprehensive genomic profiling (CGP), the results of which could be imperative in helping to guide clinical decisions regarding effective and well-tolerated targeted therapies. The Symposium generated key calls to action regarding increasing EAOC education and awareness among primary care providers and the public, re-evaluation of cancer screening programs’ eligibility criteria to include younger populations, and mechanisms to reduce waiting times for diagnostic testing by addressing technologist shortages and improving access to CGP through national collaborative strategies and increased funding. Full article

Diabetic cardiomyopathy (DCM) in type 2 diabetes (T2D) may lead to heart failure and patient death. Fibroblast growth factor 21 (FGF21) is a therapeutic candidate for treating this disease. However, one impediment to its clinical use is its weak ability to activate downstream signaling pathways. In this study, based on our in-depth understanding of the binding properties of fibroblast growth factor receptor 1c (FGFR1c) with paracrine FGF1 and endocrine FGF21, we engineered a novel FGF21 analog named FGF21^D2D3. This was achieved by substituting the R96–V106 region of FGF21 (the binding site with the D2–D3 domain of FGFR1c) with the corresponding region from FGF1. Structural characterization and binding affinity tests showed that the analog’s capacity to bind FGFR1c was significantly enhanced compared to wild-type FGF21 (FGF21^WT). In a T2D mouse model, we found that FGF21^D2D3 had greater potency than FGF21^WT in improving hyperlipidemia and DCM. Furthermore, mechanistic studies revealed that FGF21^D2D3 more effectively bound FGFR1, activated AMPK, inhibited oxidative stress, and ameliorated DCM. Therefore, our data indicate that FGF21^D2D3 is a better substitute for FGF21^WT in treating DCM by improving dyslipidemia and directly suppressing oxidative stress via FGFR1–AMPK activation in T2D. Full article