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Search Results (372)

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13 pages, 2158 KB  
Article
Fast History Matching and Flow Channel Identification for Polymer Flooding Reservoir with a Physics-Based Data-Driven Model
by Zhijie Wei, Yongzheng Cui, Yanchun Su and Wensheng Zhou
Processes 2025, 13(8), 2610; https://doi.org/10.3390/pr13082610 - 18 Aug 2025
Viewed by 252
Abstract
The offshore reservoir development involves large injection and production rates and high injection pressures. High-permeability flow channels usually occur in offshore unconsolidated heavy-oil reservoirs during long-term water flux, substantially impacting the production performance. As one important method for identifying channeling, the numerical simulation [...] Read more.
The offshore reservoir development involves large injection and production rates and high injection pressures. High-permeability flow channels usually occur in offshore unconsolidated heavy-oil reservoirs during long-term water flux, substantially impacting the production performance. As one important method for identifying channeling, the numerical simulation method with a full-fidelity model is hampered by the low computational efficiency of the history matching process. The GPSNet model is extended for polymer flooding simulations, incorporating complex mechanisms including adsorption and shear-thinning effects, with solutions obtained through a fully implicit numerical scheme. Four flow channel characteristic parameters are proposed, and an evaluation factor M for flow channel identification is established with the comprehensive evaluation method. Finally, the field application of the GPSNet model is made and validated by the tracer interpretation result. The history matching speed based on the GPSNet model is 58 times faster than the full-fidelity ECLIPSE model. In addition, the application demonstrates a high degree of consistency with tracer monitoring results, confirming the accuracy and field feasibility. The new method enables rapid and accurate identification and prediction of large and dominant channels, offering effective guidance for targeted treatment of channels and sustainable development of polymer flooding. Full article
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17 pages, 362 KB  
Article
An Efficient Distributed Identity Selective Disclosure Algorithm
by Guanzheng Wang and Guoyan Zhang
Appl. Sci. 2025, 15(16), 8834; https://doi.org/10.3390/app15168834 - 11 Aug 2025
Viewed by 269
Abstract
Distributed digital identity is an emerging identity management technology aimed at achieving comprehensive interconnectivity between digital objects. However, there is still the problem of privacy leakage in distributed identities, and selective disclosure technology partially solves the privacy issue in distributed identities. Most of [...] Read more.
Distributed digital identity is an emerging identity management technology aimed at achieving comprehensive interconnectivity between digital objects. However, there is still the problem of privacy leakage in distributed identities, and selective disclosure technology partially solves the privacy issue in distributed identities. Most of the existing selective disclosure algorithms use anonymous credentials or hash functions. Anonymous credential schemes offer high security and meet the requirements of unforgeability and unlinkability, but their exponential operations result in low efficiency. The scheme based on hash functions, although more efficient, is susceptible to man-in-the-middle attacks. This article proposes an efficient selective disclosure scheme based on hash functions and implicit certificates. The attribute values are treated as leaf nodes of the Merkle tree, and the root node is placed in a verifiable credential. According to the implicit certificate algorithm process, a key pair that can use the credential is generated. During the attribute disclosure process, the user autonomously selects the attribute value to be presented and generates a verification path from the attribute to the root node. The verifier checks the Merkle tree verification path. All operations are completed within 10 ms while meeting the unforgeability requirements and resisting man-in-the-middle attacks. This article also utilizes the ZK-SNARK algorithm to hide the validation path of the Merkle tree, enhancing the security of the path during the disclosure process. The experimental results show that the selective disclosure algorithm performs well in both performance and privacy protection, with an efficiency 80% faster than that of existing schemes. This enhances the proposed scheme’s potential and value in the field of identity management; it also holds broad application prospects in fields such as the Internet of Things, finance, and others. Full article
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24 pages, 5391 KB  
Article
Advanced Linearization Methods for Efficient and Accurate Compositional Reservoir Simulations
by Ali Asif, Abdul Salam Abd and Ahmad Abushaikha
Computation 2025, 13(8), 191; https://doi.org/10.3390/computation13080191 - 8 Aug 2025
Viewed by 1054
Abstract
Efficient simulation of multiphase, multicomponent fluid flow in heterogeneous reservoirs is critical for optimizing hydrocarbon recovery. In this study, we investigate advanced linearization techniques for fully implicit compositional reservoir simulations, a problem characterized by highly nonlinear governing equations that challenge both accuracy and [...] Read more.
Efficient simulation of multiphase, multicomponent fluid flow in heterogeneous reservoirs is critical for optimizing hydrocarbon recovery. In this study, we investigate advanced linearization techniques for fully implicit compositional reservoir simulations, a problem characterized by highly nonlinear governing equations that challenge both accuracy and computational efficiency. We implement four methods—finite backward difference (FDB), finite central difference (FDC), operator-based linearization (OBL), and residual accelerated Jacobian (RAJ)—within an MPI-based parallel framework and benchmark their performance against a legacy simulator across three test cases: (i) a five-component hydrocarbon gas field with CO2 injection, (ii) a ten-component gas field with CO2 injection, and (iii) a ten-component gas field case without injection. Key quantitative findings include: in the five-component case, OBL achieved convergence with only 770 nonlinear iterations (compared to 841–843 for other methods) and reduced operator computation time to 9.6 of total simulation time, highlighting its speed for simpler systems; in contrast, for the more complex ten-component injection, FDB proved most robust with 706 nonlinear iterations versus 723 for RAJ, while OBL failed to converge; in noninjection scenarios, RAJ effectively captured nonlinear dynamics with comparable iteration counts but lower overall computational expense. These results demonstrate that the optimal linearization strategy is context-dependent—OBL is advantageous for simpler problems requiring rapid solutions, whereas FDB and RAJ are preferable for complex systems demanding higher accuracy. The novelty of this work lies in integrating these advanced linearization schemes into a scalable, parallel simulation framework and providing a comprehensive, quantitative comparison that extends beyond previous efforts in reservoir simulation literature. Full article
(This article belongs to the Special Issue Advances in Computational Methods for Fluid Flow)
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12 pages, 3315 KB  
Article
NeRF-RE: An Improved Neural Radiance Field Model Based on Object Removal and Efficient Reconstruction
by Ziyang Li, Yongjian Huai, Qingkuo Meng and Shiquan Dong
Information 2025, 16(8), 654; https://doi.org/10.3390/info16080654 - 31 Jul 2025
Viewed by 422
Abstract
High-quality green gardens can markedly enhance the quality of life and mental well-being of their users. However, health and lifestyle constraints make it difficult for people to enjoy urban gardens, and traditional methods struggle to offer the high-fidelity experiences they need. This study [...] Read more.
High-quality green gardens can markedly enhance the quality of life and mental well-being of their users. However, health and lifestyle constraints make it difficult for people to enjoy urban gardens, and traditional methods struggle to offer the high-fidelity experiences they need. This study introduces a 3D scene reconstruction and rendering strategy based on implicit neural representation through the efficient and removable neural radiation fields model (NeRF-RE). Leveraging neural radiance fields (NeRF), the model incorporates a multi-resolution hash grid and proposal network to improve training efficiency and modeling accuracy, while integrating a segment-anything model to safeguard public privacy. Take the crabapple tree, extensively utilized in urban garden design across temperate regions of the Northern Hemisphere. A dataset comprising 660 images of crabapple trees exhibiting three distinct geometric forms is collected to assess the NeRF-RE model’s performance. The results demonstrated that the ‘harvest gold’ crabapple scene had the highest reconstruction accuracy, with PSNR, LPIPS and SSIM of 24.80 dB, 0.34 and 0.74, respectively. Compared to the Mip-NeRF 360 model, the NeRF-RE model not only showed an up to 21-fold increase in training efficiency for three types of crabapple trees, but also exhibited a less pronounced impact of dataset size on reconstruction accuracy. This study reconstructs real scenes with high fidelity using virtual reality technology. It not only facilitates people’s personal enjoyment of the beauty of natural gardens at home, but also makes certain contributions to the publicity and promotion of urban landscapes. Full article
(This article belongs to the Special Issue Extended Reality and Its Applications)
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31 pages, 11269 KB  
Review
Advancements in Semantic Segmentation of 3D Point Clouds for Scene Understanding Using Deep Learning
by Hafsa Benallal, Nadine Abdallah Saab, Hamid Tairi, Ayman Alfalou and Jamal Riffi
Technologies 2025, 13(8), 322; https://doi.org/10.3390/technologies13080322 - 30 Jul 2025
Viewed by 1237
Abstract
Three-dimensional semantic segmentation is a fundamental problem in computer vision with a wide range of applications in autonomous driving, robotics, and urban scene understanding. The task involves assigning semantic labels to each point in a 3D point cloud, a data representation that is [...] Read more.
Three-dimensional semantic segmentation is a fundamental problem in computer vision with a wide range of applications in autonomous driving, robotics, and urban scene understanding. The task involves assigning semantic labels to each point in a 3D point cloud, a data representation that is inherently unstructured, irregular, and spatially sparse. In recent years, deep learning has become the dominant framework for addressing this task, leading to a broad variety of models and techniques designed to tackle the unique challenges posed by 3D data. This survey presents a comprehensive overview of deep learning methods for 3D semantic segmentation. We organize the literature into a taxonomy that distinguishes between supervised and unsupervised approaches. Supervised methods are further classified into point-based, projection-based, voxel-based, and hybrid architectures, while unsupervised methods include self-supervised learning strategies, generative models, and implicit representation techniques. In addition to presenting and categorizing these approaches, we provide a comparative analysis of their performance on widely used benchmark datasets, discuss key challenges such as generalization, model transferability, and computational efficiency, and examine the limitations of current datasets. The survey concludes by identifying potential directions for future research in this rapidly evolving field. Full article
(This article belongs to the Section Information and Communication Technologies)
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23 pages, 614 KB  
Article
Air Pollution, Credit Ratings, and Corporate Credit Costs: Evidence from China
by Haoran Wang and Jincheng Wang
Sustainability 2025, 17(15), 6829; https://doi.org/10.3390/su17156829 - 27 Jul 2025
Viewed by 437
Abstract
From the perspective of credit ratings, this paper studies the impact of air pollution on corporate credit costs and the impact mechanism. Based on 2007–2022 data on A-share listed companies in the Chinese capital market, this paper uses a two-way fixed effects model [...] Read more.
From the perspective of credit ratings, this paper studies the impact of air pollution on corporate credit costs and the impact mechanism. Based on 2007–2022 data on A-share listed companies in the Chinese capital market, this paper uses a two-way fixed effects model to examine the impact of air pollution on corporate credit costs and the impact mechanism. The results show that air pollution increases the credit costs for enterprises because air pollution affects the sentiment of rating analysts, leading them to give more pessimistic credit ratings to enterprises located in areas with severe air pollution. The moderating effect analysis reveals that the effect of air pollution on the increase in corporate credit costs is more pronounced for high-polluting industries, manufacturing industries, and regions with weaker bank competition. Further analysis reveals that in the face of rising credit costs caused by air pollution, enterprises tend to adopt a combination strategy of increasing commercial credit financing and reducing the commercial credit supply to cope. Although this response behavior alleviates corporations’ own financial pressure, it may have a negative effect on supply chain stability. This paper provides new evidence that reveals that air pollution is an implicit cost in the capital market, enriching research in the fields of environmental governance and capital markets. Full article
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14 pages, 2370 KB  
Article
DP-AMF: Depth-Prior–Guided Adaptive Multi-Modal and Global–Local Fusion for Single-View 3D Reconstruction
by Luoxi Zhang, Chun Xie and Itaru Kitahara
J. Imaging 2025, 11(7), 246; https://doi.org/10.3390/jimaging11070246 - 21 Jul 2025
Viewed by 494
Abstract
Single-view 3D reconstruction remains fundamentally ill-posed, as a single RGB image lacks scale and depth cues, often yielding ambiguous results under occlusion or in texture-poor regions. We propose DP-AMF, a novel Depth-Prior–Guided Adaptive Multi-Modal and Global–Local Fusion framework that integrates high-fidelity depth priors—generated [...] Read more.
Single-view 3D reconstruction remains fundamentally ill-posed, as a single RGB image lacks scale and depth cues, often yielding ambiguous results under occlusion or in texture-poor regions. We propose DP-AMF, a novel Depth-Prior–Guided Adaptive Multi-Modal and Global–Local Fusion framework that integrates high-fidelity depth priors—generated offline by the MARIGOLD diffusion-based estimator and cached to avoid extra training cost—with hierarchical local features from ResNet-32/ResNet-18 and semantic global features from DINO-ViT. A learnable fusion module dynamically adjusts per-channel weights to balance these modalities according to local texture and occlusion, and an implicit signed-distance field decoder reconstructs the final mesh. Extensive experiments on 3D-FRONT and Pix3D demonstrate that DP-AMF reduces Chamfer Distance by 7.64%, increases F-Score by 2.81%, and boosts Normal Consistency by 5.88% compared to strong baselines, while qualitative results show sharper edges and more complete geometry in challenging scenes. DP-AMF achieves these gains without substantially increasing model size or inference time, offering a robust and effective solution for complex single-view reconstruction tasks. Full article
(This article belongs to the Section AI in Imaging)
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20 pages, 4820 KB  
Article
Sem-SLAM: Semantic-Integrated SLAM Approach for 3D Reconstruction
by Shuqi Liu, Yufeng Zhuang, Chenxu Zhang, Qifei Li and Jiayu Hou
Appl. Sci. 2025, 15(14), 7881; https://doi.org/10.3390/app15147881 - 15 Jul 2025
Viewed by 531
Abstract
Under the upsurge of research on the integration of Simultaneous Localization and Mapping (SLAM) and neural implicit representation, existing methods exhibit obvious limitations in terms of environmental semantic parsing and scene understanding capabilities. In response to this, this paper proposes a SLAM system [...] Read more.
Under the upsurge of research on the integration of Simultaneous Localization and Mapping (SLAM) and neural implicit representation, existing methods exhibit obvious limitations in terms of environmental semantic parsing and scene understanding capabilities. In response to this, this paper proposes a SLAM system that integrates a full attention mechanism and a multi-scale information extractor. This system constructs a more accurate 3D environmental model by fusing semantic, shape, and geometric orientation features. Meanwhile, to deeply excavate the semantic information in images, a pre-trained frozen 2D segmentation algorithm is employed to extract semantic features, providing a powerful support for 3D environmental reconstruction. Furthermore, a multi-layer perceptron and interpolation techniques are utilized to extract multi-scale features, distinguishing information at different scales. This enables the effective decoding of semantic, RGB, and Truncated Signed Distance Field (TSDF) values from the fused features, achieving high-quality information rendering. Experimental results demonstrate that this method significantly outperforms the baseline-based methods in terms of mapping and tracking accuracy on the Replica and ScanNet datasets. It also shows superior performance in semantic segmentation and real-time semantic mapping tasks, offering a new direction for the development of SLAM technology. Full article
(This article belongs to the Special Issue Applications of Data Science and Artificial Intelligence)
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20 pages, 3148 KB  
Article
Performance Analysis of Stellar Refraction Autonomous Navigation for Cross-Domain Vehicles
by Yuchang Xu, Yang Zhang, Xiaokang Wang, Guanbing Zhang, Guang Yang and Hong Yuan
Remote Sens. 2025, 17(14), 2367; https://doi.org/10.3390/rs17142367 - 9 Jul 2025
Viewed by 342
Abstract
Stellar refraction autonomous navigation provides a promising alternative for cross-domain vehicles, particularly in near-space environments where traditional inertial and satellite navigation methods face limitations. This study develops a stellar refraction navigation system that utilizes stellar refraction angle observations and the Implicit Unscented Kalman [...] Read more.
Stellar refraction autonomous navigation provides a promising alternative for cross-domain vehicles, particularly in near-space environments where traditional inertial and satellite navigation methods face limitations. This study develops a stellar refraction navigation system that utilizes stellar refraction angle observations and the Implicit Unscented Kalman Filter (IUKF) for state estimation. A representative orbit with altitudes ranging from 60 km to 200 km is designed to simulate cross-domain flight conditions. The navigation performance is analyzed under varying conditions, including orbital altitude, as well as star sensor design parameters, such as limiting magnitude, field of view (FOV) value, and measurement error, along with different sampling intervals. The simulation results show that increasing the limiting magnitude from 5 to 8 reduced the position error from 705.19 m to below 1 m, with optimal accuracy reaching 0.89 m when using a 20° × 20° field of view and a 3 s sampling interval. In addition, shorter sampling intervals improved accuracy and filter stability, while longer intervals introduced greater integration drift. When the sampling interval reached 100 s, position error grew to the kilometer level. These findings validate the feasibility of using stellar refraction for autonomous navigation in cross-domain scenarios and provide design guidance for optimizing star sensor configurations and sampling strategies in future near-space navigation systems. Full article
(This article belongs to the Special Issue Autonomous Space Navigation (Second Edition))
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15 pages, 4430 KB  
Article
A Comprehensive Approach to Instruction Tuning for Qwen2.5: Data Selection, Domain Interaction, and Training Protocols
by Xungang Gu, Mengqi Wang, Yangjie Tian, Ning Li, Jiaze Sun, Jingfang Xu, He Zhang, Ruohua Xu and Ming Liu
Computers 2025, 14(7), 264; https://doi.org/10.3390/computers14070264 - 5 Jul 2025
Viewed by 642
Abstract
Instruction tuning plays a pivotal role in aligning large language models with diverse tasks, yet its effectiveness hinges on the interplay of data quality, domain composition, and training strategies. This study moves beyond qualitative assessment to systematically quantify these factors through extensive experiments [...] Read more.
Instruction tuning plays a pivotal role in aligning large language models with diverse tasks, yet its effectiveness hinges on the interplay of data quality, domain composition, and training strategies. This study moves beyond qualitative assessment to systematically quantify these factors through extensive experiments on data selection, data mixture, and training protocols. By quantifying performance trade-offs, we demonstrate that the implicit method SuperFiltering achieves an optimal balance, whereas explicit filters can induce capability conflicts. A fine-grained analysis of cross-domain interactions quantifies a near-linear competition between code and math, while showing that tool use data exhibits minimal interference. To mitigate these measured conflicts, we compare multi-task, sequential, and multi-stage training strategies, revealing that multi-stage training significantly reduces Conflict Rates while preserving domain expertise. Our findings culminate in a unified framework for optimizing instruction tuning, offering actionable, data-driven guidelines for balancing multi-domain performance and enhancing model generalization, thus advancing the field by providing a methodology to move from intuition to systematic optimization. Full article
(This article belongs to the Special Issue Natural Language Processing (NLP) and Large Language Modelling)
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21 pages, 550 KB  
Article
Latine Students’ STEM Identity Development: Reflecting on Implicit Biases, Imposter Syndrome, Self-Efficacy, and Support Systems
by Alyssa Guadalupe Cavazos, Valerie Leija and Javier Cavazos Vela
Educ. Sci. 2025, 15(7), 865; https://doi.org/10.3390/educsci15070865 - 5 Jul 2025
Viewed by 832
Abstract
This study used an equity ethic framework and a STEM identity model to contextualize and understand Latine students’ perceptions of STEM identity development. The purpose of this study was to investigate how Latine undergraduate students who engaged in STEM coursework perceived their learning [...] Read more.
This study used an equity ethic framework and a STEM identity model to contextualize and understand Latine students’ perceptions of STEM identity development. The purpose of this study was to investigate how Latine undergraduate students who engaged in STEM coursework perceived their learning experiences and stories of resilience through an equity ethic framework. Data were collected through interviews with 19 Latine college students attending a Hispanic-Serving Institution. Findings revealed the following themes related to Latine students’ STEM identity development and lived experiences in STEM coursework: implicit biases, imposter syndrome, self-efficacy, and support system and resources. Findings highlight the need for institutions of higher education to promote Latine students’ self-efficacy to positively influence STEM identity development while addressing systemic issues, such as implicit biases and imposter syndrome to create safe, growth-enhancing educational climates for students with minoritized identities. We provided implications to cultivate Latine students’ STEM identity development through inclusive teaching and learning practices that foster equitable learning environments as well as institutional resources that support students’ mental health and resilience. Implications of this study can be modeled at HSIs to positively influence STEM identity development and increase Latine students’ persistence in STEM fields. Full article
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19 pages, 920 KB  
Article
Ethicametrics: A New Interdisciplinary Science
by Fabio Zagonari
Stats 2025, 8(3), 50; https://doi.org/10.3390/stats8030050 - 22 Jun 2025
Cited by 1 | Viewed by 463
Abstract
This paper characterises Ethicametrics (EM) as a new interdisciplinary scientific research area focusing on metrics of ethics (MOE) and ethics of metrics (EOM), by providing a comprehensive methodological framework. EM is scientific: it is based on behavioural mathematical modelling to be statistically validated [...] Read more.
This paper characterises Ethicametrics (EM) as a new interdisciplinary scientific research area focusing on metrics of ethics (MOE) and ethics of metrics (EOM), by providing a comprehensive methodological framework. EM is scientific: it is based on behavioural mathematical modelling to be statistically validated and tested, with additional sensitivity analyses to favour immediate interpretations. EM is interdisciplinary: it spans from less to more traditional fields, with essential mutual improvements. EM is new: valid and invalid examples of EM (articles referring to an explicit and an implicit behavioural model, respectively) are scarce, recent, time-stable and discipline-focused, with 1 and 37 scientists, respectively. Thus, the core of EM (multi-level statistical analyses applied to behavioural mathematical models) is crucial to avoid biased MOE and EOM. Conversely, articles inside EM should study quantitatively any metrics or ethics, in any alternative context, at any analytical level, by using panel/longitudinal data. Behavioural models should be ethically explicit, possibly by evaluating ethics in terms of the consequences of actions. Ethical measures should be scientifically grounded by evaluating metrics in terms of ethical criteria coming from the relevant theological/philosophical literature. Note that behavioural models applied to science metrics can be used to deduce social consequences to be ethically evaluated. Full article
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24 pages, 472 KB  
Article
Uncovering the Hidden Curriculum in Health Professions Education
by Laura L. Wolford, Mirza J. Lugo-Neris, Callie Watkins Liu, Lexi E. Nieves, Christopher L. Rodriguez, Siya S. Patel, Sol Yi Lee and Keshrie Naidoo
Educ. Sci. 2025, 15(7), 791; https://doi.org/10.3390/educsci15070791 - 20 Jun 2025
Viewed by 1078
Abstract
In health professions education, the hidden curriculum is a set of implicit rules and expectations about how clinicians act and what they value. In fields that are very homogenous, such as rehabilitation professions, these expectations may have outsized impacts on students from minoritized [...] Read more.
In health professions education, the hidden curriculum is a set of implicit rules and expectations about how clinicians act and what they value. In fields that are very homogenous, such as rehabilitation professions, these expectations may have outsized impacts on students from minoritized backgrounds. This qualitative study examined the hidden curriculum in rehabilitation graduate programs—speech-language pathology, occupational therapy, and physical therapy—through the perspectives and experiences of 21 students from minoritized backgrounds. Semi-structured interviews explored their experiences with their programs’ hidden curricula. These revealed expectations about ways of being, interacting, and relating. Three overarching themes emerged, each reflecting tensions between conflicting values: (i) blend in but stand out; (ii) success lies in individualism, while de-prioritizing the individual; and (iii) fix the field, using your identities as a tool. When the expectations aligned with students’ expectations for themselves, meeting them was a source of pride. However, when the social expectations clashed with their own culture, dis/ability, gender, or neurotype, these tensions became an additional cognitive burden, and they rarely received mentorship for navigating it. Health professions programs might benefit from fostering students’ critical reflection on their hidden curricula and their fields’ cultural norms to foster greater belonging, agency, and identity retention. Full article
(This article belongs to the Special Issue Cross-Cultural Education: Building Bridges and Breaking Barriers)
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17 pages, 3664 KB  
Article
Neuroprotective Effect of Methylene Blue in a Rat Model of Traumatic Optic Neuropathy
by Nicolás S. Ciranna, Ronan Nakamura, Rafael Peláez, Álvaro Pérez-Sala, Patricia Sarrión, Juan C. Fernández, Alejandra Paganelli, Agustín P. Aranalde, Ulises P. Ruiz, Juan J. López-Costa, César F. Loidl, Alfredo Martínez and Manuel Rey-Funes
Pharmaceuticals 2025, 18(6), 920; https://doi.org/10.3390/ph18060920 - 19 Jun 2025
Viewed by 969
Abstract
Background: Traumatic optic neuropathy (TON) represents a major cause of vision loss worldwide, and treatment options are limited. Here, we study whether methylene blue (MB), a free radical scavenger, is able to prevent morphological and electrophysiological hallmarks of neuropathy in an animal [...] Read more.
Background: Traumatic optic neuropathy (TON) represents a major cause of vision loss worldwide, and treatment options are limited. Here, we study whether methylene blue (MB), a free radical scavenger, is able to prevent morphological and electrophysiological hallmarks of neuropathy in an animal model of TON. Methods: The left eyes of Wistar rats were subjected to intraorbital nerve crush (IONC) while the right ones were sham operated. The group of rats treated with MB (n = 16) received five intraperitoneal injections with 2.0 mg/kg MB in the 24 h following IONC while the control group (n = 16) received just vehicle (PBS) as a control. Twenty-one days after surgery, scotopic full field (scERG), scotopic oscillatory potentials (OP), photopic full field (phERG) and pattern (PERG) electroretinography were performed for retinal function assessment. Furthermore, the number of cell nuclei in the ganglion cell layer (GCL) was recorded in post mortem histological sections. Results: IONC induced very significant reductions in electrophysiological parameters including scotopic a- and b-wave, OPs, photopic b-wave, PhNR amplitude and N2 amplitude. In addition, it also generated a significant prolongation of the N2 implicit time, indicating a profound impact on retinal function. This was further corroborated by a very significant reduction in the number of neuronal nuclei in the GCL, suggesting an intense loss and functional impairment of retinal ganglion cells. MB treatment was able to prevent, partially or completely, all those parameters, indicating the efficiency of such approach. Conclusions: Since MB is already approved for clinical use and presents a high safety profile, it could be repurposed as a neuroprotective drug for ophthalmological applications once proper phase 2 clinical trials are accomplished. Full article
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19 pages, 3182 KB  
Article
A Sintering–Resting Strategy of Microwave Heating for Lithium Hydride Ceramic Based on Numerical Analysis of Thermal Effects
by Wenyan Zhang, Huayan Chen, Maobing Shuai, Xiangguo Zeng and Bin Huang
Materials 2025, 18(12), 2832; https://doi.org/10.3390/ma18122832 - 16 Jun 2025
Viewed by 411
Abstract
Lithium hydride (LiH) is one promising material for nuclear reactor shielding due to its high hydrogen content, but its poor mechanical strength and thermal conductivity pose challenges for fabricating large, crack-free ceramic components via conventional sintering. This study explores microwave sintering as a [...] Read more.
Lithium hydride (LiH) is one promising material for nuclear reactor shielding due to its high hydrogen content, but its poor mechanical strength and thermal conductivity pose challenges for fabricating large, crack-free ceramic components via conventional sintering. This study explores microwave sintering as a potential solution to enhance heating uniformity and reduce thermal stress during densification of bulk LiH ceramics. Using implicit function and level set methods, we numerically simulated the microwave field distribution and thermal response in both stationary and rotating samples. The results show that rotational heating improves temperature uniformity by up to 12.9% for specific samples, although uniform temperature control remains difficult through rotation alone. To mitigate stress accumulation from thermal gradients, we propose a cyclic sintering–resting strategy, which leverages LiH’s tensile strength–temperature envelope to guide safe and efficient processing. This strategy successfully reduced total sintering time from several days to 1.63 h without inducing cracks. Our findings offer practical insights into optimizing microwave sintering parameters for large-scale LiH ceramic production and contribute to enabling its application in advanced nuclear shielding systems. Full article
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