Search Results (197)

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental condition marked by persistent inattention, hyperactivity, and impulsivity. Despite its considerable global prevalence, key gaps remain in our understanding of the structural and molecular changes underlying ADHD which complicate adult diagnosis, as symptoms present differently from those observed during childhood ADHD. On the other hand, while psychostimulants effectively mitigate some symptoms, significant controversy surrounds their long-term effects on cognition, learning, and memory, and day-to-day living. Moreover, our understanding of how various medications given to alleviate ADHD symptoms during pregnancy impact the developing fetal brain also remains largely unexplored. Here, we discuss the subtle differences between ADHD in children and adults and how these symptoms alter brain development and maturation. We further examine changes in monoamine signaling in ADHD and how psychostimulant and non-pharmacological treatments modulate these neural networks. We evaluate and discuss findings as they pertain to the long-term use of ADHD medications, including in utero exposure, on cognitive outcomes, and contextualize these findings with mechanistic insights from animal models. Full article

Background/Objectives: Attention Deficit Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder frequently associated with other neuropsychiatric conditions, characterized by high clinical heterogeneity and a complex genetic background. Recent studies suggest that copy number variations (CNVs) may contribute to ADHD susceptibility, particularly when involving genes related to brain development, attention regulation, and impulse control. This study investigated the association between CNVs and ADHD phenotype by identifying patients with and without potential pathogenic CNVs. Methods: We evaluated 152 well-characterized ADHD pediatric patients through comprehensive clinical assessments, including dysmorphic features, brain MRI, EEG patterns, and cognitive testing. CNVs were identified using array Comparative Genomic Hybridization (array-CGH). Participants were classified as carrying potentially causative CNVs (PC-CNVs), non-causative CNVs (NC-CNVs), or without CNVs (W-CNVs) and statistically compared across clinical and neurodevelopmental measures. Results: CNVs were identified in 81 participants (53%), comprising 13 with PC-CNVs (8.5%) and 68 with NC-CNVs (44.7%). ADHD symptoms were pronounced across all groups, but PC-CNVs showed a higher burden of comorbidities, suggesting a stronger genetic contribution to ADHD complexity. Significant differences were observed in oppositional behavior, inattentive symptoms, brain MRI findings, and developmental language anomalies. Several CNVs involved genes previously implicated in neurodevelopmental disorders, supporting a potential genetic contribution to the clinical complexity of ADHD. Conclusions: This exploratory study supports the role of CNVs in ADHD susceptibility and highlights the value of genetic screening for understanding clinical variability. Larger studies are needed to clarify genotype–phenotype correlations in ADHD and to guide personalized clinical management. Full article

Inattention and hyperactivity/impulsivity that feature Attention-Deficit/Hyperactivity Disorder (ADHD) may be challenging in the classroom setting. However, little is known about language teachers’ self-efficacy and the approaches they would employ to deal with context-specific ADHD-like behaviours. Therefore, this mixed-method study used the vignette methodology to investigate the self-reported efficacy and teaching approaches of 62 pre-service English language teachers from Japan, Poland, Turkey, and Ukraine in managing ADHD-like behaviours in six hypothetical classroom scenarios. By comparing diverse educational and cultural contexts, the study aimed to identify convergences and divergences in coping with these behaviours to promote evidence-based approaches in inclusive language teaching. Data were gathered using an online questionnaire with both open- and closed-ended questions on a Likert-type scale. The findings indicate that participants feel moderately confident in managing ADHD-like behaviours; however, some statistically significant country-related differences were observed. A number of similar teaching approaches were identified across the sample, but prominent country-specific differences in approaching specific ADHD-like behaviours were present. The approaches used by participants align with evidence-based recommendations for teaching students with ADHD to some extent. The discussed implications of the study inform pre-service teachers’ education and call for approaches that are more universal in design and language-skill-development-oriented. Full article

Attention Deficit Hyperactivity Disorder (ADHD) is one of the most prevalent neurodevelopmental disorders in childhood and adolescence, characterized by symptoms of inattention, hyperactivity, and impulsivity. These symptoms often interfere with academic, social, and family functioning. In recent years, the use of digital tools and video games has garnered attention as an innovative and engaging approach for neurocognitive rehabilitation. The primary objective of this randomized controlled study was to investigate the comparative effects of two cognitive intervention approaches—one based on new technologies and one using traditional methods—on attention, inhibitory control, and processing speed in children and adolescents diagnosed with ADHD. Thirty-three participants aged 6–17 years were randomly assigned to either an experimental group (n = 17), which received Nintendo Switch-based therapy, or a control group (n = 16), which received traditional board game therapy. Both interventions lasted 8 weeks and included 16 sessions. Outcomes were assessed using the WISC-V, STROOP, and CARAS-R tests. Results showed significant within-group improvements in both groups. The control group exhibited gains in sustained attention and inhibitory control (CARAS-R and STROOP tests, p < 0.05), while the experimental group improved significantly in processing speed, as measured by the WISC-V (p = 0.001). However, no significant differences were found between groups. These findings suggest that both interventions may be effective for enhancing different cognitive processes in children with ADHD. Importantly, the use of familiar digital technologies like the Nintendo Switch may promote greater motivation and adherence to treatment. Further research with larger samples and long-term follow-up is warranted to validate and extend these preliminary findings, as the current sample size was not powered to detect medium or small effects. Full article

Attention Deficit Hyperactivity Disorder (ADHD) is a lifelong condition; however, traditional treatment focuses on hyperactivity and inattention, which is largely a manifestation of pediatric ADHD. Studies are limited regarding cognitive difficulties, as seen in adult ADHD, as well as treatment strategies for this population. This review of the literature examines multiple recent studies that discuss various novel treatment strategies for cognitive impairment in adults with ADHD. A targeted literature review was conducted using PubMed to identify recent studies on cognitive dysfunction in adults with ADHD, with an emphasis on emerging treatment strategies. Data collected included sample size, intervention strategies, cognitive function, and side effects. Studies on non-invasive brain stimulation revealed significant effects on executive function in adult ADHD patients. Other studies revealed statistically significant improvements in cognitive flexibility and response inhibition in modafinil users. Another study demonstrated significant improvement in working memory with off label use of viloxazine for adults. This review of the literature describes the effectiveness of novel treatment strategies of adult ADHD including non-stimulant medications, behavioral therapies and neurofeedback. This highlights the need for treatment modalities that enhance cognitive outcomes and further research into long-term efficacy and safety of these novel interventions and implementing psychological treatment into medical management of adult ADHD. Full article

Attention deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterised by inattention, hyperactivity, and impulsivity, frequently observed in juvenile offenders. This systematic review explores the interplay between ADHD and juvenile delinquency, focusing on behavioural, psychological, and social dimensions. Following the PRISMA guidelines, a systematic literature review was conducted using EBSCO Discovery Service, Science Direct, PubMed, and snowballing techniques. Studies meeting specific inclusion criteria, including juvenile offenders diagnosed with ADHD and comparisons to non-offender or non-ADHD control groups, were analysed. The methodological quality of studies was assessed using the Joanna Briggs Institute appraisal tools. A total of 21 studies were included, highlighting significant associations between ADHD and juvenile delinquency. ADHD symptoms, especially impulsivity and emotional dysregulation, were linked to an earlier onset of offending and higher rates of property crimes. Comorbidities such as conduct disorder, substance use disorder, and depression exacerbated these behaviours. Sociodemographic factors like low education levels and adverse family environments were also critical modifiers. Early intervention and tailored treatment approaches were emphasised to address these challenges. The findings underscore the need for early diagnosis, individualised treatment, and integrative rehabilitation programmes within the juvenile justice system to mitigate long-term risks and promote social inclusion. Full article

Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder with chronic inattention, hyperactivity, and impulsivity and is linked with significant functional impairment. Despite being highly prevalent, diagnosis of ADHD continues to rely on subjective assessment reports of behavior and is often delayed or inaccurate. This review summarizes current advances in biomarkers and neuropsychological tests for the improvement of ADHD diagnosis and treatment. Key biomarkers are neuroimaging methods (e.g., structural and functional MRI), electrophysiological measures (e.g., EEG, ERP), and biochemical measures (e.g., cortisol, vitamin D). Additionally, novel experimental measures, e.g., eye-tracking, pupillometry, and microbiome analysis, hold the promise to be objective and dynamic measures of ADHD symptoms. The review also comments on the impact of the burden of ADHD on quality of life, e.g., emotional well-being, academic achievement, and social functioning. Additionally, differences between individuals, such as age, sex, comorbidities, and the impact of social and family support, are also addressed in relation to ADHD outcomes. In summary, we highlight the potential of these emerging biomarkers and tools to revolutionize ADHD diagnosis and guide personalized treatment strategies. These insights have significant implications for improving patient outcomes. Full article

Background and objectives. Symptoms of Attention Deficit Hyperactivity Disorder (ADHD) are frequently present in university students, even without a clinical diagnosis, and may be aggravated by various factors. This study analyzes the relationship between these symptoms and the use of alcohol, tobacco, cannabis, and other drugs by young university students. Materials and methods. A cross-sectional study was conducted with 397 university students using an anonymous online questionnaire. ADHD symptoms were assessed with the Adult ADHD Self-Report Scale (ASRS), alcohol use with the Alcohol Use Disorders Identification Test (AUDIT-C), nicotine dependence with the Fagerström test, cannabis use with the Cannabis Abuse Screening Test (CAST), and the use of other substances with an adaptation of the latter. Results. The mean age was 21.4 years, and most participants (76.6%) were women. Of the participants, 46.1% presented symptoms compatible with ADHD according to the ASRS. The most frequent items were difficulty maintaining attention during boring tasks (77.3%), avoiding tasks that require mental effort (76.8%), and being easily distracted by noise or external activity (73.8%). Significant differences were found between ASRS scores and gender, with scores being higher and more consistent among those students who identified themselves as non-binary gender (male or female) (p < 0.01). A significant association was also found between smoking and a higher ASRS score (p < 0.01). Although no significant associations with body mass index were detected, a trend toward greater symptomatology was observed in obese individuals. In multivariate analysis, still gender and smoking significantly (p = 0.12 and p = 0.031, respectively) predicted ADHD symptoms (ASRS score). The model R = 0.228 (R squared = 0.052, F = 1.62, p = 0.077). No statistically significant differences were found between ADHD symptoms and the use of alcohol, cannabis, or other substances in either bivariate or multivariate analyses. Conclusions. This study underscores the importance of early detection of ADHD symptoms in the university setting, considering factors such as gender and smoking habit. Future research should focus on aggravating factors such as academic stress and problematic technology use. Full article

Objectives: Attention deficit hyperactivity disorder (ADHD) is among the most common neurodevelopmental disorders affecting women of reproductive age. Previous data on this condition did not study its different symptom clusters separately. Our aim was to compare perinatal outcomes between women with hyperactivity cluster (ADHD) and those with the inattentive cluster (attention deficit disorder (ADD)). Methods: A retrospective population-based study utilizing data from the Healthcare Cost and Utilization Project–Nationwide Inpatient Sample (HCUP-NIS). All deliveries or maternal deaths from 2004 to 2014 were available for analysis, and perinatal outcomes were compared between participants with an ADD diagnosis and those with an ADHD diagnosis. A multivariate logistic regression was used to control for confounders. Results: During the study period, there were 9,096,788 deliveries. Of them, 7103 had an ADHD diagnosis, and 2928 had an ADD diagnosis. Women with ADHD, compared to those with ADD, were more likely to be younger than 25 years of age; to be Black; to be from a lower income quartile; to smoke tobacco during pregnancy; and to use illicit drugs (p < 0.001 for all). Using multivariate logistic regression, women with ADHD, compared to those with ADD, had a higher rate of hypertensive disorders of pregnancy (HDPs) (aOR 1.19, 95% CI 1.03–1.37, p = 0.02), preterm delivery (aOR 1.19, 95% CI 1.01–1.39, p = 0.038), maternal infection (aOR 1.39, 95% CI 1.04–1.85, p = 0.024), and small-for-gestational-age (SGA) neonates (aOR 1.33, 95% CI 1.04–1.69, p = 0.022). Conclusions: Women with an ADHD diagnosis, compared to those with ADD, had a higher incidence of various maternal and neonatal complications, including HDPs, preterm delivery, and SGA neonates. Full article

Background/Objectives: Attention-Deficit Hyperactivity Disorder (ADHD) is an immensely heterogeneous developmental disorder, uniquely impacting each individual. Physical movement is a promising adjunct behavioral treatment that can promote executive functioning in children with ADHD. The current study used neuroimaging and behavioral techniques to investigate the impact of movement during executive functioning on dorsolateral prefrontal cortical (DLPFC) activity and inhibitory control in children with ADHD, with particular focus on key individual difference factors in ADHD, such as subtype, severity, and gender. Methods: Twenty-eight children with ADHD completed a Stroop task while remaining stationary (stationary condition) and while desk cycling (movement condition). Simultaneous functional near-infrared spectroscopy (fNIRS) recorded oxygenated and deoxygenated changes in hemoglobin within the left DLPFC. Participants were categorized into ADHD subtype (hyperactive/impulsive, inattention, combined), ADHD severity (low, moderate, high), and gender (male, female). Results: Those with the hyperactive and combined ADHD subtypes, those with high ADHD severity, and males with ADHD showed greater DLPFC activation when engaging in movement during executive functioning compared to remaining stationary. In contrast, those with the inattentive ADHD subtype, those with low-to-moderate ADHD severity, and females with ADHD showed greater DLPFC activation when remaining stationary during executive functioning compared to engaging in movement. Inhibitory control improved in the stationary condition for females who were predominantly inattentive. Conclusions: This work underscores the importance of considering individual difference factors in ADHD when designing physical activity interventions, as treatment efficacy may vary. Full article

Objective: This observational cross-sectional study aimed to comprehensively evaluate sensory–cognitive performance in children diagnosed with Attention-Deficit/Hyperactivity Disorder (ADHD), with a focus on auditory processing, visual–perceptual abilities, visual–motor integration, and oculomotor function. The study further examined how hyperactivity, age, and gender may influence these domains. Methods: A total of 70 non-medicated children with clinically diagnosed ADHD (mean age = $9.1\pm 2.4$ years; 67.1% male), all with normal visual acuity, were assessed using four standardized instruments: the Test of Auditory Processing Skills, Third Edition (TAPS-3), the Test of Visual Perceptual Skills, Fourth Edition (TVPS-4), the Beery–Buktenica Developmental Test of Visual–Motor Integration, Sixth Edition (VMI-6), and the Developmental Eye Movement (DEM) Test. Statistical analyses included one sample and independent samples t-tests, one-way ANOVA, and Pearson correlation coefficients. Results: Participants demonstrated significantly above-average performance in auditory processing (TAPS-3: $\mu =108.4$, $std=7.8$), average visual–perceptual abilities (TVPS-4: $\mu =100.9$, $std=7.2$), slightly below-average visual–motor integration (VMI-6: $\mu =97.1$, $std=9.0$), and marked deficits in oculomotor efficiency (DEM ratio: $\mu =87.3$, $std=18.1$). Statistically significant differences were observed across these domains (t-values ranging from 2.9 to 7.2, $p<0.01$). Children with hyperactive-impulsive presentations exhibited lower horizontal DEM scores ($\mu =73.4$, $std=12.3$) compared to inattentive counterparts ($\mu =82.9$, $std=16.2$; $p=0.009$). Age and sex influenced specific subtest scores, with boys and children aged 8–9 years achieving higher outcomes in word memory ($p=0.042$) and visual discrimination ($p=0.034$), respectively. Moderate correlations were identified between auditory and visual–perceptual skills ($r=0.32$, $p=0.007$), and between visual–perceptual and oculomotor performance ($r=0.25$, $p=0.035$). Conclusions: The findings from this sample reveal a distinct sensory–cognitive profile in children with ADHD, characterized by relatively preserved auditory processing and pronounced oculomotor deficits. These results underscore the value of a multimodal assessment protocol that includes oculomotor and visual efficiency evaluations. The conclusions pertain specifically to the cohort studied and should not be generalized to all populations with ADHD without further validation. Full article

Background: Based on the multitude of findings, nutrition is becoming increasingly important in the treatment of attention deficit/hyperactivity disorder (ADHD) in children. One promising approach is the so-called oligoantigenic diet (OD). This intervention involves avoiding certain foods that often trigger intolerances and allergies. Previous studies have shown that around 60% of patients experienced a significant reduction in ADHD symptoms after completing such a diet. The aim of the present study was to further confirm the efficacy of the OD within an analysis focusing on the symptom of impulsivity. Materials and Methods: In the present study, the Parent Rating of the Diagnostic System of Mental Disorders in Children and Adolescents (DISYPS-II FBB-ADHD) questionnaire was used to measure the severity of ADHD symptoms. Of 34 children and adolescents (between 7 and 18 years of age) screened and included in this study, 31 participants completed the 4-week OD diet. Results: The corresponding post-diet analysis showed significant short-term improvements for the DISYPS-II FBB-ADHD total score, compared to the start of the diet. This pattern of results also applied to the respective subscales of the DISYPS-II FBB-ADHD questionnaire. A follow-up evaluation conducted 3.5 years after the intervention with 21 participants suggested that the improvements in ADHD symptoms were maintained over time. Specifically, 66.7% of the participants continued to meet the responder criterion, with particularly notable and lasting reductions in impulsivity. Discussion: These results suggest that the beneficial effects of the oligoantigenic diet followed by identifying and avoiding individual intolerant foods may persist long term, and participants’ dietary habits may have also evolved over the years. Conclusion: The oligoantigenic diet may have long-term therapeutic potential for reducing ADHD symptoms, especially impulsivity, in children and adolescents. Full article

Background/Objectives: Variations of the latrophilin-3 (Lphn3) gene have been associated with attention-deficit hyperactivity disorder (ADHD). To explore the functional influence of this gene, Lphn3 knockout (KO) rats were generated and have thus far demonstrated deficits in ADHD-relevant phenotypes, including working memory, impulsivity, and hyperactivity. However, inattention remains unexplored. Methods: We assessed automatic attention in Lphn3 KO (n = 19) and their control line (wildtype/WT, n = 20) through use of the following auditory event-related potentials (ERPs): P1, N1, P2, and N2. We also extended this exploratory study by comparing these same ERPs in spontaneously hypertensive rats (SHRs, n = 16), the most commonly studied animal model of ADHD, to their control line (Wistar–Kyoto/WKY, n = 20). Electroencephalograms (EEG) were recorded using subdermal needle electrodes at frontocentral sites while freely moving rats were presented with five-tone trains (50 ms tones, 400 ms tone onset asynchronies) with varying short (1 s) and long (5 s) inter-train intervals. Peak amplitudes and latencies were analyzed using GLM-mixed ANOVAs to assess differences across genotypes (KO vs. WTs) and strains (SHRs vs. WKYs). Results: The KOs did not demonstrate any significant differences in peak amplitudes relative to the WT controls, suggesting that the null expression of Lphn3 does not result in the development of inefficiencies in automatic attention. However, the SHRs exhibited significantly reduced peak P1 (and peak-to-peak P1–N1) values relative to the WKYs. These attenuations likely reflect inefficiencies in bottom-up arousal networks that are necessary for efficient automatic processing. Conclusions: Distinct findings between these animal models likely reflect differing alterations in dopamine and noradrenaline neurotransmission that may underlie ADHD-relevant phenotypes. Full article

Introduction: Obsessive-compulsive disorder (OCD) and attention-deficit/hyperactivity disorder (ADHD) are neuropsychiatric diagnoses that commonly co-occur, as approximately 25% of youth with OCD also have a diagnosis of ADHD and 11% of youth with ADHD have OCD. Individuals with ADHD and OCD are also commonly treated for symptoms of depression, anxiety, and traumatic experiences. Conversely, Black and Latiné youth in the United States have limited access to culturally responsive providers to address these conditions due to systemic racism; the lower rates of appropriate diagnosis, treatment, and inclusion in research create worsening symptoms of OCD. Thus, we sought to understand how ADHD symptoms affect OCD symptoms and how these comorbid diagnoses, in addition to anxiety disorders, affect reported anxiety, depression, and trauma for Black and/or Latiné teens. Procedures: Participants (N = 48) are Black and/or Latina/é/o youth with ADHD in the United States. Self and parent-report measures were completed for ADHD, anxiety, and depression, and a semi-structured interview was conducted to assess current mental health diagnoses (OCD, ADHD, trauma). Results: A path analysis showed higher levels of ADHD inattentive (ADHDI) symptoms (β = 0.34) were positively associated with obsessions. In contrast, higher ADHD hyperactive/impulsivity symptoms (ADHDHI) (β = −0.11) were negatively associated with obsessions. Neither ADHDI nor ADHDHI symptoms were associated with compulsions. Interestingly, ADHDI (β = 0.33) & obsessions (β = 0.28) were both associated with depression; however, ADHDHI was negatively associated with depression (β = −0.29). Importantly, ADHDI was associated with trauma (β = 0.13) and obsessions were strongly associated with anxiety (β = 0.38). Conclusions: These findings may allow for better screenings and treatments for co-occurring OCD and ADHD symptoms and a greater understanding of the impact depression, anxiety, and trauma have on neurodivergent Black and/or Latiné youth. Full article

Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by inappropriate levels of inattention, hyperactivity, or impulsivity. Recent concerns suggest a potential link between increased screen time and the manifestation of ADHD symptoms. This study examined the relationship between screen time and ADHD-related symptoms in neurotypical children aged 3–18 years in the Eastern Province of Saudi Arabia. Data were collected through an online questionnaire completed by caregivers, focusing on screen time habits, ADHD-related symptoms (measured using the SNAP-IV scale), and potential confounders. A total of 324 children participated, with a slight male predominance (52.2%) and a median age of 9.07 years. Most of the children were Saudi nationals (97.5%) and resided in urban areas (70.7%). Using screens for more than 5 h was associated with higher total SNAP-IV scores. Multivariate analysis revealed that unrestricted screen time, related disorders, and lower maternal education were strongly associated with higher SNAP-IV scores. This study revealed a notable association between screen time characteristics, sociodemographic factors, and ADHD-related symptom severity in children in the Eastern Province of Saudi Arabia. Full article