Search Results (1,769)

This paper introduces a novel fractional-order fuzzy logic controller (FOFLC) designed for stator voltage control in standalone doubly fed induction generator (DFIG) systems used in wind energy applications. Unlike traditional fuzzy logic controllers (FLCs), which are limited by integer-order dynamics, the FOFLC leverages the advanced principles of fractional-order (FO) calculus. By integrating fuzzy logic with fractional-order operators, the FOFLC enhances system precision, adaptability, and interpretability while addressing the inherent limitations of conventional proportional-integral (PI) controllers and integer-order FLCs. A key innovation of the FOFLC is its dual-mode architecture, enabling it to operate seamlessly as either a traditional FLC or a fractional-order FOFLC controller. This versatility allows for independent tuning of fractional parameters, optimizing the system’s response to transients, steady-state errors, and disturbances. The controller’s flexibility makes it particularly well-suited for nonlinear and dynamically complex stand-alone renewable energy systems. The FOFLC is experimentally validated on a 3-kW DFIG test bench using the dSPACE-1104 platform under various operating conditions. Compared to a conventional PI controller, the FOFLC demonstrated superior performance, achieving 80% reduction in response time, eliminating voltage overshoot and undershoot, reducing stator power and torque ripples by over 46%, and decreasing total harmonic distortion (THD) of both stator voltage and current by more than 50%. These results confirm the FOFLC’s potential as a robust and adaptive control solution for stand-alone renewable energy systems, ensuring high-quality power output and reliable operation. Full article

This study examines rural walking tourism as a sustainable strategy for revitalizing regional economies and preserving natural environments, focusing on the DMZ Punch Bowl in South Korea. Although rural walking tourism has been widely promoted for sustainability, little is known about its operation in geopolitically sensitive and militarized ecological zones, such as the Korean DMZ. Adopting the qualitative case study method, we explored three essential conditions for sustainable rural walking tourism: environmental friendliness, experiential immersion and sense of place, and local economic revitalization through stakeholder cooperation. We employed a hybrid thematic analysis using inductive and deductive coding to analyze the triangulated data collected from interviews, field observations, and policy documents. In-depth interviews with ten walking tourism experts revealed that storytelling that emphasizes local history, ecological conservation, and unique cultural identity enhances tourists’ emotional attachment and sense of place immersion. The DMZ Punch Bowl case was selected due to its effective integration of these elements, achieved through a collaborative governance structure involving government agencies, military units, and local communities. The findings highlight that coordinated management and stakeholder cooperation are crucial for balancing land use policies, ecological preservation, and tourism safety. Additionally, walking tourism significantly contributes to local economic growth through direct spending, job creation, increased resident incomes, the sale of local specialties, and participation in experiential activities. This study provides valuable insights and a replicable model for sustainably developing walking tourism in similarly sensitive or ecologically significant rural areas. Full article

In contrast to traditional hydrogels, which are susceptible to water evaporation and structural degradation, non-hydrogel materials are engineered for superior stability and consistent performance. Here, we report an innovative piezoelectric polyvinyl chloride/multi-walled carbon nanotube polymer gel (PVC/MWCNT polymer gel, PMPG) with exceptional linearity (as low as 1.31%), high sensitivity (50–310.17 mV), rapid response (172–189 ms), and thermal stability. Under strain induction, ordered rearrangement of dipoles in PMPG and the enhancement of MWCNTs generate a potential difference. Increasing MWCNT content enhances output voltage, sensitivity, conductivity, maximum stress, Young’s modulus, and toughness, while reducing nonlinear error. Higher dibutyl adipate (DBA) content increases output voltage and slightly improves sensitivity but decreases mechanical strength. The optimal PMPG (PVC:DBA = 1:5, 1 wt% MWCNTs) exhibited outstanding performance. It exhibits a nonlinear error as low as 1.31%, a conductivity of 25.4 μS/cm, an 80% compressive strain tolerance (273 kPa stress), and dimensional stability for 90 days in air. By integrating PMPG with machine learning algorithms, soft robotic grippers gain advanced contact perception capabilities, enabling applications in medicine, rescue, exploration, and other fields requiring fine manipulation and adaptability. This work highlights PMPG’s potential as a stable, high-performance material for soft robotics and beyond. Full article

Background: Ensuring the safety of patients in the operating room, through the monitoring and prevention of adverse events is a central priority of healthcare delivery. In the professionalization of operating room nurses, the processes of identifying, assessing, developing, monitoring, and certifying transversal competencies are crucial. While national and international frameworks have attempted to define such competencies, they often vary in scope and remain inconsistently integrated into education and clinical practice. There is, therefore, a need for a comprehensive and structured identification of transversal competencies relevant to both perioperative and perianesthesiological nursing roles. Objectives: To formulate a validated and structured repertoire of transversal competencies demonstrated by operating room nurses in both perioperative and perianesthesiological contexts. Methods: A qualitative descriptive design was adopted, combining shadowed observation with Hierarchical Task Analysis (HTA). A convenience sample of 46 participants was recruited from a university and a public hospital in Italy. Data were collected between September 2021 and June 2023 and analyzed using content analysis and data triangulation. Results: Through a qualitative, inductive and iterative approach the study identified 15 transversal competencies, 50 sub-competencies, and 153 specific tasks and activities. Specifically, operating room nurses working in perioperative and perianesthesiological roles presented the following transversal competencies: communication and interpersonal relationships, situation awareness, teamwork, problem solving and decision-making, self-awareness, coping with stressors, resilience and fatigue management, leadership, coping with emotions, task and time management, ethical and sustainable thinking, adaptation to the context, critical thinking, learning through experiences, and data, information and digital content management. Each competency was associated with specific tasks observed. Conclusions: This framework complements the existing repertoire of technical-specialist competencies by integrating essential transversal competencies. It serves as a valuable tool for the assessment, validation, and certification of competencies related to patient and professional safety, emotional well-being, relational dynamics, and social competencies. The findings underscore the need for academic institutions to revise traditional training models and embed transversal competencies in both undergraduate and postgraduate nursing education. Full article

Sex workers and formerly incarcerated people with a cervix face significant structural, interpersonal, and emotional barriers to cervical cancer screening, despite being at elevated risk for HPV infection. HPV self-sampling (HPV-SS) is a validated, user-directed method that has the potential to address these barriers, yet it remains excluded from Ontario’s organized screening program. This qualitative study explored the lived experiences of structurally marginalized individuals with a cervix who were offered HPV-SS as part of a mixed-methods pilot in the Greater Toronto Area. Five virtual focus groups were conducted with 34 participants, including both those who used the HPV-SS kit and those who declined it. Using inductive thematic analysis, we identified barriers to traditional screening including fear, stigma, mistrust of healthcare providers, logistical constraints, and a lack of accessible information. HPV-SS was widely described as more acceptable, empowering, and emotionally manageable, offering participants autonomy, privacy, and control over their care. Concerns included swab design, uncertainty about correct use, and unclear follow-up after positive results. Participants offered concrete, community-informed recommendations to improve HPV-SS implementation, including opt-in distribution models, gender-affirming language, and trauma-informed educational materials. The findings highlight the urgent need to integrate HPV-SS into organized screening programs to advance equitable access to cervical cancer prevention for marginalized populations. Full article

Globally, many countries have promulgated extensive, contextually relevant disability legislative policies for children with hearing impairment/d/Deafness (HI/d/D). The alignment of policies with their implementation, with robust monitoring, is essential for effective early intervention (EI) and early education (EE) outcomes. The study’s purpose was to review current South African EI and EE regulations, acts, and policies in relation to children with HI/d/D from birth to age six. An adapted Arksey and O’Malley framework with inductive thematic analysis was applied to synthesise and evaluate relevant information. Documentation was sourced between 1993 and 2023 from the official South African government portal and Google online searches using keywords. While 7976 documents were initially identified with the broad search and 1249 with a refined category search, only 17 met the specific inclusion criteria for policies referencing hearing impairment in early intervention and education. Seventeen documents were selected for study inclusion, with sixteen mentioning HI/d/D and multi-disciplinary, multi-sectoral, family-centred, culturally sensitive considerations superficially. One document from the Department of Health (DoH) specifically addressed early hearing detection and intervention (EHDI). Three main themes emerged, including Partnerships, Participation and Integration, Screening, Identification and/or Intervention, and Education/Special Education. Greater engagement with South African EI and education policies is essential to strengthen implementation, especially across sectors and at the community level. Mandating EHDI guidelines is critical to improving service delivery and ensuring smoother transitions between health, education, and social services for children with hearing impairment. Full article

Asphalt pavements face escalating challenges from traffic loading, climate change, and material degradation, necessitating innovative maintenance solutions. Thermally induced self-healing technologies, leveraging the viscoelastic properties of asphalt binders, can autonomously repair microcracks through targeted thermal activation. This review explored thermally induced self-healing in asphalt mixtures, with a focus on leveraging steel slag as a functional aggregate to enhance sustainability and durability. Two thermal-activation methods, electromagnetic induction and microwave heating, were critically analyzed, highlighting their distinct advantages in heating efficiency, depth, and uniformity. Steel slag offers dual benefits: improving mechanical interlock and skid resistance in mixtures while facilitating efficient heat generation via electromagnetic induction or microwave heating. However, challenges such as hydration-induced expansion, heterogeneous slag composition, and energy-intensive heating processes impede widespread adoption. Pretreatment methods, including natural aging, carbonation, and surface modifications, are essential to mitigate volumetric instability and optimize slag performance. Key factors influencing healing efficacy, including binder properties, operational parameters (e.g., microwave power, frequency), and environmental trade-offs, were systematically evaluated. Future research directions emphasized standardized pretreatment protocols, hybrid heating technologies for uniform temperature distribution, and smart-infrastructure integration for predictive maintenance. Full article

The expected outstanding performance of GaN-based transistors in power applications, characterized by high switching frequency, efficiency, and compactness, requires that the design rules of converter layout optimization, filtering, and shielding need to be reexamined. Addressing the above topics, this paper reviews commercial GaN power transistors and specifies their integration techniques, including printed circuit board (PCB) embedded solutions. Then, referring to the optimization results of a half-bridge inverter leg, design techniques are presented that reduce the harmful effect of inductive and capacitive internal converter couplings, thus mitigating the electromagnetic interference (EMI) conducted emissions. Full article

Neutrophil extracellular trap (NET) formation is a process known as NETosis and is a critical innate immune response mechanism that can become pathologically dysregulated in various inflammatory, autoimmune, infectious, and neoplastic diseases. Reactive oxygen species (ROS) play a central role in NETosis induction, making antioxidants a promising therapeutic approach. This review outlines the molecular mechanisms underlying NET formation and highlights three principal antioxidant-based inhibitory strategies: NADPH oxidase (NOX) inhibition, ROS scavenging, and myeloperoxidase (MPO) inhibition. Evidence supports the use of agents such as diphenylene iodonium (NOX inhibitor), N-acetylcysteine and glutathione (ROS scavengers), and thiocyanate (MPO inhibitor), which significantly reduce NETosis in vitro and in vivo. Moreover, natural compounds like resveratrol show pleiotropic effects by modulating neutrophil activation, ROS production, and protease activity. Combination therapies that enhance total antioxidant capacity are particularly effective, though their translation to clinical practice faces challenges such as stimulus specificity, bioavailability, and maintaining immune competence. Antioxidant-based therapies thus represent a promising avenue for targeted NETosis modulation. Future research should focus on improving delivery systems, identifying NET-specific biomarkers, and integrating antioxidants into broader immunomodulatory strategies. Full article

Background/Objectives: AML is a heterogeneous hematological malignancy distinguished by the clonal expansion of immature myeloid progenitor cells. Despite advances in therapy, relapse rates remain high, and outcomes are poor. The WT1 gene has emerged as a potential contributor to leukemogenesis, but its clinical relevance at the transcriptional level is not fully understood. This study employed RNA sequencing as a discovery tool to identify WT1 gene expression in AML and further investigated its role in diagnosis, prognosis, and treatment response. Methods: Between 2020 and 2024, 345 diagnostic, 259 post-induction, and 70 relapse-stage BM or PB samples were prospectively collected from de novo AML patients at AIIMS, New Delhi. RNA sequencing was initially performed on five paired diagnosis-relapse samples to profile transcriptomic changes and assess WT1 expression dynamics. WT1 expression was further validated by qPCR. The relationship between WT1 expression and various clinical parameters was evaluated using Cox regression analysis to determine its impact on prognosis. Results: RNA sequencing and qPCR confirmed WT1 overexpression at diagnosis, which significantly declined following induction therapy. High WT1 expression at diagnosis was linked with adverse clinical characteristics, including elevated WBC counts and higher blast percentages and predicted poor survival outcomes. WT1 expression was identified as a significant prognostic marker, correlating with OS and EFS. Conclusions: By integrating RNA sequencing with targeted validation, this study highlights WT1 expression as a critical biomarker for AML diagnosis, prognosis, and treatment response. The findings suggest that WT1 expression may serve as a valuable tool for monitoring disease status, risk stratification, and guiding treatment decisions in AML, with potential applications for WT1-targeted precision therapies. Full article

In this paper, a winding inter-turn fault (ITF) diagnosis algorithm for electrical machines in integrated motor and drive (IMD) systems is proposed based on impedance analysis using space voltage vectors. An ITF alters the stator resistance, causing an imbalance in the motor’s impedance depending on the phase connection. This impedance asymmetry can be effectively utilized for fault diagnosis. However, in IMD systems, direct impedance measurement through mechanical terminal access is difficult due to the integrated structure. To address this, the impedance of the induction motor is analyzed electrically, without the need for physical disconnection, allowing practical implementation within integrated systems. The specific phase angle of the space voltage vector in the three-phase inverter is analyzed to replicate the electrical conditions of mechanical terminal configurations. Based on this approach, a fault diagnosis algorithm was developed by analyzing the variation in stator current and impedance with respect to space voltage vector angles. The effectiveness of the proposed method was verified through experimental validation using a 12kW three-phase induction motor and terminal box. Full article

The conventional linear economic model has intensified global resource depletion and environmental degradation, underscoring the pressing necessity for a transformation toward the Circular Economy (CE). Currently, research generally segregates materials, products and services within the CE, overlooking their hierarchy and interactions in circular performance. Employing a mixed methodology of induction and deduction, this study constructs a triple-level proposal for the CE from a design perspective. The proposal integrates material recycling, product reuse and service circulation into a multi-hierarchical progression, clarifying the priorities of the CE and sustainable design. It not only enriches the theoretical basis of the CE and sustainable design, but also offers a transformative perspective for optimizing circular performance. Case studies in the deductive stage provide measurable criteria to assess the performance of each level, while a design workshop featuring the CE canvas and heuristics is adopted to test the effectiveness of our proposal in guiding practice. The results demonstrate the theoretical and practical feasibility of the proposal. This study emphasizes the progression from materials to products and services, exploring the potential of the triple-level proposal in guiding design and improving circular performance. By proposing policy recommendations based on the proposal, this study provides stakeholders with an actionable roadmap for CE implementation. Full article

The variable-speed operation mode of pumped storage units improves the regulation performance and endows the units with characteristics such as isolation from the power grid, thereby affecting the system stability. This study establishes a detailed mathematical model for the connection of doubly fed induction generator-based variable-speed pumped storage (DFIG-VSPS) to a single-machine infinite bus system under power generation conditions in the synchronous rotation direct-quadrature-zero coordinate system. The introduction of the eigenvalue method to analyze the small-disturbance stability of doubly fed variable-speed pumped storage units and the use of participation factors to calculate the degree of influence of each state variable on the small-disturbance stability of the units are innovations of this study. The participation factor enhances flexibility, continuity, and efficiency in doubly fed variable-speed pumped storage by optimizing dynamic power paths and enabling multi-objective control coordination. While eigenvalue analysis is not new, this study is the first to apply it with participation factors to DFIG-VSPS, addressing gaps in prior simplified models. Furthermore, based on the changes in the characteristic root trajectories, the influence of changes in the speed control system parameters and converter controller parameters on the system stability was determined. Finally, the conclusions obtained were verified through simulation. The results indicate that increasing the time constant of water flow inertia poses a risk of system instability, and the increase in proportional parameters and decrease in integral parameters of the power outer loop controller significantly affect the system stability. Full article

The increasing demand for induction hobs necessitates efficient cooling systems to ensure the safe operation of electronic cut-outs. This study investigates the thermal representation of three different ignition designs integrated into an induction hob cooling system. A simplified model consisting of a radial fan, a daughterboard, and the electronics installed in the systems is used for the maintenance of the system. Remote measurements of air velocities at the cooler outlets are compared with the results obtained through programmable system dynamics (CFD) operations using FloEFD v2021.1 software. The findings of the study using the k-ε turbulence model show that Type 1 temperature is resistant to the lowest surface temperature for both the closest (IGBT 1) and the farthest (IGBT 2) temperature to the fan. Conversely, Type 3 temperatures exhibited high temperatures. Air velocity comparisons showed a maximum error rate of 30%, which is acceptable considering the variability in Type 1. Measurement system evaluation and DOE study were continued to increase the experimental range. This study demonstrates the utility offered by heatsink design in optimizing the cooling system of induction hobs and provides valuable insights for integrating thermal management systems. Full article

Natural compounds have garnered increasing interest as potential antitumor agents due to their multifaceted biological activities and relatively low toxicity profiles. This review focuses on three well-studied natural molecules: rhein, curcumin, and resveratrol, analyzing and comparing their antitumor potential across a variety of cancer models. For each compound, we present an integrated perspective encompassing natural sources, physicochemical properties, pharmacological and pharmacokinetic characteristics, and the latest in vitro and in vivo evidence of anticancer activity. Special attention is given to the molecular mechanisms underlying their antitumor effects, including the modulation of cell cycle regulators, induction of apoptosis, inhibition of metastasis and angiogenesis, and regulation of key signaling pathways such as NF-κB, PI3K/Akt/mTOR, STAT3, and MAPKs. Although numerous studies highlighted their therapeutic promise, significant barriers remain—particularly related to poor solubility and limited bioavailability—which have hindered clinical translation, especially in the case of rhein. Advances in nanotechnology-based drug delivery systems offer promising solutions to these limitations, enabling improved targeting and enhanced efficacy. This review underscores the need for continued preclinical and clinical investigations to fully elucidate the therapeutic value of these compounds and support their integration into modern oncological treatment strategies. Full article