Search Results (739)

The sexual generation of Schlechtendalia chinensis (Bell) is pivotal for gallnut yield yet cannot feed due to mouthpart degeneration. Could respiratory metabolic rate (RMR) modulation compensate for nutritional deficits? We quantified the RMR across key developmental stages of sexual morphs (including parental sexuparae and progeny fundatrices) using an LI-6400XT portable photosynthesis system equipped with a customized insect respiration chamber (6400-89). All morphotypes exhibited significantly lower nocturnal RMRs compared to their diurnal rates (p < 0.05), while RMRs did not differ significantly between morning (9:00–12:00) and afternoon (14:00–17:00) (p > 0.05). Significant RMR variation occurred among morphotypes: females and sexuparae displayed the lowest rates, fundatrices were intermediate, and males exhibited remarkably elevated rates (2–3 times higher than those of females or sexuparae). Both sexes showed a characteristic RMR trajectory: elevated at birth and declining during early postnatal development, followed by a gradual resurgence that culminated in peak values on postnatal day 8, coinciding with mating. This physiological zenith was immediately succeeded by marked respiratory metabolic downregulation following copulation, with RMRs decreasing substantially during the post-copulatory phase. Our findings demonstrate significant intergenerational and intersexual RMR differentiation. This research addresses critical knowledge gaps in the respiratory metabolism of S. chinensis, is the first to elucidate a nutrient adaptation strategy through respiratory metabolic regulation under non-trophic conditions, and provides actionable insights for optimizing gallnut production in controlled cultivation systems. Full article

Compared to studies in school settings, little attention has been paid to bullying in the child protection system (PS), even though these children, adolescents, and youth are one of the most vulnerable groups, with the highest prevalence of bullying. This study aims to analyze, according to gender and nationality, the perception of adolescents and youth in the Spanish PS of the bullying and gender-based bullying situations that take place in their protection facility, as well as their response to these situations and the relationship with the training they received in gender equality, sexual diversity and bullying. Two hundred forty-nine adolescents and youth from 58 centers/facilities of the PS in Spain, with an average age of 16.38 years, participated. Of these, 37.3% had Spanish nationality. A correlational study was conducted using a cross-sectional random sample survey. It was found that 30.9% of the participants identify bullying situations, which reached 34.9% for LGBTIQ-phobic bullying and 37.7% for sexist bullying. Girls identify situations of both bullying and sexist bullying more, and girls and both male and female Spanish adolescents and youth attribute greater severity to these problems and respond more positively in favor of the victims. Those who have received more training in gender equality, sexual diversity, and bullying support bully victims more significantly. According to our current knowledge, this study addresses for the first time the phenomenon of bullying and gender-based bullying in the context of the PS from a perspective of gender, nationality, and the formative dimension. It also highlights the need for mandatory training in gender-equality and sexual diversity for adolescents/youth and educational professionals of the PS, as well as the creation of specific anti-bullying protocols with an inclusive approach. Full article

Background: Chemsex, the intentional use of psychoactive substances to enhance sexual experiences, is an emerging public health issue in Brazil, associated with increased risks of sexually transmitted infections and complex psychosocial vulnerabilities. Despite the universal coverage provided by the Unified Health System (SUS), individuals who practice chemsex often encounter barriers to healthcare, including stigma, discrimination, and a lack of specialized services. To date, no comprehensive reviews appear to synthesize evidence on how this population accesses healthcare in the Brazilian context; existing knowledge remains fragmented across individual studies. Objectives: The aim is to map and synthesize the available evidence regarding access to health services among people who engage in chemsex in Brazil, identifying health needs, professional demands, barriers, and facilitators. Methods: The protocol follows the Joanna Briggs Institute methodology for scoping reviews and PRISMA-ScR guidelines. A systematic search will be conducted in MEDLINE (PubMed), Embase, Scopus, SciELO, and LILACS for studies published between 2014 and 2024 in Portuguese, English, or Spanish. Data will be summarized using descriptive and narrative synthesis, presented in tables and thematic categories. Studies will be included if they address chemsex or sexualized drug use in Brazil and report on healthcare access, regardless of gender identity, sexual orientation, or drug type. Studies that do not address chemsex, focus on drug use outside a sexual context, or are unrelated to Brazil will be excluded. Expected results: The review is expected to identify key barriers and facilitators to healthcare access, highlight knowledge gaps for underrepresented groups, and support recommendations for research, policy, and practice to improve care for people engaging in chemsex in Brazil. By focusing on an underexplored intersection of drug use, sexuality, and healthcare access in Latin America, this study aims to provide an innovative contribution to public health literature. Full article

Background/Objectives: Low HPV vaccine uptake persists in Saudi Arabia despite improving awareness. This study aimed to assess the level of awareness, knowledge, and uptake of the human papillomavirus (HPV) vaccine among female medical students in Saudi Arabia, and to identify key demographic, academic, and informational factors that predict vaccination behavior. It also sought to explore perceived barriers influencing vaccine acceptance within this population. Methods: A multi-center cross-sectional survey recruited 246 female medical students from five Saudi universities using convenience sampling. An anonymous, structured, and validated questionnaire assessed HPV/vaccine knowledge, attitudes, uptake, and perceived barriers. Data were analyzed using descriptive statistics, t-tests, ANOVA, correlation, and logistic regression. Results: Overall, 82.9% of participants had heard of HPV and 78.9% knew of the vaccine, but only 10.3% demonstrated high vaccine-specific knowledge. While 69.5% expressed willingness to be vaccinated, only 22.8% had received at least one dose. The most reported barriers were perceived lack of necessity (45.3%), abstinence from sexual activity (41.3%), and safety concerns (34.7%). Logistic regression indicated that higher academic year and higher vaccine-specific knowledge significantly predicted vaccine uptake (p < 0.001). Conclusions: Despite high general awareness, low vaccine-specific knowledge and cultural framing constrain HPV vaccine uptake among future prescribers. Universities should integrate cancer-prevention framing into curricula, strengthen female-to-female counseling, and provide on-campus vaccination opportunities. Addressing knowledge gaps and sociocultural barriers is critical to improving HPV vaccine coverage in Saudi Arabia. Full article

Background: Women who experience intimate partner violence (IPV) have a higher likelihood of experiencing detrimental physical, psychological and sexual and reproductive health (SRH) outcomes. However, a gap remains in published literature on SRH interventions available to women experiencing IPV. Methods: A scoping review was undertaken to examine: What is the nature of sexual and reproductive healthcare interventions provided to women experiencing IPV? Five databases (APA PsycInfo, CINAHL Complete, Informit, PubMed and Scopus) were searched on 9 October 2023 for peer-reviewed systematic reviews or primary research published from 1 January 2004–present. The search was repeated on 11 June 2025 to ensure recency of studies. Two researchers independently screened studies at title and abstract, and full-text levels. The two searches yielded a total of 10,844 studies, of which nine were included in the review. Results: Due to the heterogenous nature of the studies, thematic analysis was undertaken with four themes being identified: Outcomes of interventions; Positive impact of personalised and patient-centred care; Professionals’ knowledge, education and training as a facilitator; and Barriers to effective IPV intervention implementation in healthcare. SRH interventions available to women who experienced IPV can empower survivors, improve access to care, and enhance service quality. Conclusions: Evidence-based models of care that are intersectional, trauma-informed and integrated into SRH and IPV services are critical to ensure future work supports women of differing backgrounds who have experienced IPV. Future research should include evaluating effectiveness of interventions, identifying and addressing systemic barriers, and supporting underrepresented groups. Full article

This paper examines the sexual and reproductive health (SRH) knowledge, experiences, service access, and unmet needs of Rohingya adolescent refugee girls living in the camps of Cox’s Bazar, Bangladesh. The refugee population in these camps is approximately 1.3 million, with more than half under the age of 18 and girls representing over one quarter of the total. Given the growing proportion of adolescent girls, SRH knowledge and service provision are critical both for the refugee community and for Bangladesh’s broader sustainable development goals. Drawing on direct accounts from adolescent girls and insights from community-based key informants, this research explores levels of SRH awareness, willingness to seek care, encounters with sexual violence, understanding of sexually transmitted diseases, and reproductive health priorities. It also identifies barriers to service delivery faced by healthcare and humanitarian providers. The findings highlight how cultural norms, social constraints, and religious beliefs intersect with structural barriers—including lack of education, financial dependence, gender-based violence, and the need for parental or spousal consent—to restrict access to SRH services. Despite these challenges, some participants reported successfully receiving reproductive health care. This paper calls for coordinated action from the government, humanitarian agencies, and social service organisations to improve both the availability and accessibility of SRH services for adolescent refugee girls. Strategies should include enhanced outreach, culturally responsive engagement, and sustained follow-up care to promote safety, dignity, and well-being within the camps. Full article

Skeletons serve as the body’s fundamental structure and perform multiple vital functions, and thus even subtle modifications can lead to functional changes. However, studies on sexual shape dimorphism in the appendicular skeletons of anurans remain scarce, especially for fossorial species. Herein, we investigated the sexual differences in the external morphology and internal skeletal shape of girdles and limbs of fossorial Kaloula rugifera during the breeding season. The results reveal the following: (1) Males exhibit significantly longer forelimbs and hindlimbs, suggesting advantages in male—male competition and amplexus. (2) Males possess more curved and dilated coracoids and broader pubis-ischium regions, which may enhance forelimb contraction efficiency and hindlimb locomotor performance. (3) Males feature a more developed crista ventralis, likely enhancing forelimb flexion for tightly grasping females during mating. In contrast, females display a torsioned femur and robust hindlimb morphology, suggesting adaptations for digging and load-bearing. These findings provide insights into how anurans optimize reproductive fitness and ecological adaptations through morphological specialization. To our knowledge, this study presents the first examination of sexual shape dimorphism in anuran appendicular skeletons utilizing three-dimensional geometric morphometrics. Full article

Background: Ischemia–reperfusion injury (IRI) is a major contributor to acute kidney injury (AKI). While the precise mechanisms of AKI are still incompletely defined, extensive evidence highlights tubular cell injury and death as key factors in its development. Necroptosis has recently emerged as a critical pathway in the pathogenesis of ischemia–reperfusion-induced AKI (IR-AKI). Although sex differences in susceptibility to IR-AKI have been reported, it remains unclear whether there are sex differences in necroptosis dynamics and whether these differences underlie the observed sexual dimorphism in kidney IRI. This study aimed to address these questions. Methods: male and female C57BL/6 J mice were subjected to AKI via ischemia induced by bilateral renal pedicle clamping for 18 min at 37 °C. Plasma, urine, and kidney samples were collected at 0 h, 3 h, 6 h, 12 h, 24 h, 48 h, and 72 h post-reperfusion. Kidney injury and function were assessed by measuring plasma creatinine (PCr), blood urea nitrogen (BUN) levels, and histological damage (PAS and cleaved caspase3 staining). Necroptosis activation was assessed by quantifying phosphorylated forms of key markers: p-RIPK1 and p-MLKL. To explore the role of sex hormones in regulating necroptosis dynamics, ovariectomized female mice were subjected to the same IR-AKI protocol, and their kidney injury and functional outcomes were compared with those of intact counterparts. Results: The PCr was 0.35 ± 0.04 and 0.32 ± 0.06 mg/dL for males and females, respectively, at 3 h of IR. The levels exponentially increased to 2.05 ± 0.18 at 48 h post-reperfusion in the males but only gradually to 0.94 ± 0.13 mg/dL in females. Necroptosis activation began as early as 3 h post-IR in males but was delayed until ~6 h in females. Males exhibited stronger and more sustained necroptosis activation than females, showing elevated phosphorylation levels of pRIPK1 and pMLKL in Western blot. Female sex hormone deficiency exacerbated the female response to IR-induced injury, which reduced the sex difference in the dynamic of the necroptotic activation and subsequent kidney injury. To our knowledge, this is the first study to characterize sex differences in the initiation and progression of necroptosis and subsequent injury in a mouse model of IR-AKI. Conclusions: Our findings reveal distinct temporal patterns of programmed cell death between sexes. Necroptosis-targeted therapies require early intervention in males, which can be delayed in females after IR-AKI, highlighting the need for sex-specific therapeutic windows. Full article

(1) Background: Violence against healthcare professionals is becoming a growing concern for healthcare systems and a public health issue, and in Portugal it remains undocumented at a national level, leaving a critical knowledge gap. This scenario compromises the development of effective public policies and evidence-based institutional strategies, which are essential for guiding policymakers in the implementation of preventive measures and appropriate safety protocols to assess the nature, frequency, and key factors contributing to violence against healthcare professionals (doctors and nurses) in clinical settings. (2) Methods: This is a quantitative, descriptive, and cross-sectional study. The sample size was 440 professionals (n = 440). Between January and May 2024, healthcare professionals (physicians and nurses) working in four local health units located in the south of Portugal were invited to participate in this study via institutional e-mail. Data was collected using a structured questionnaire on the healthcare professional’s sociodemographic and work-related characteristics and aspects related to violence towards healthcare professionals in the workplace. Unconditional logistic regression models were fitted to compute crude odds ratios (ORs) and 95% confidence intervals (95%CIs) for the association between sociodemographic and work-related characteristics and violence at work. (3) Results: Nearly 40% of the healthcare professionals sampled reported having been victims of violence in the workplace, and, among these, the majority reported experiencing psychological violence (94.2%), followed by physical violence (46.2%), another type of violence (39.1%), and sexual violence (4.1%). Incidents were mostly occasional (65.5%), occurring during the daytime (51.5%) and on weekdays (84.8%). Healthcare professionals aged between 34 and 55 years old were approximately twice as likely to experience violence compared to those who were 56 years old or older (OR = 2.28; 95%CI 1.33–3.90). Also, those who had been with the organization for more than 4 years (5–7 years: OR = 2.37; 95%CI 1.05–5.37. ≥8 years: OR = 1.87; 95%CI 1.00–3.50), as well as those who worked shifts (OR = 1.84; 95%CI 1.25–2.72), reported incidents of violence more frequently. (4) Conclusions: The low response rate (12.5%) and cross-sectional design limit the generalizability of the results, which should be interpreted considering these methodological limitations. Workplace violence in Portugal is a reality, and it requires solutions. Information related to violent incidents must be comprehensively gathered to understand the full extent of the problem and develop prevention strategies based on potentially changeable risk factors to minimize the negative effects of workplace violence. Full article

We analysed the socioeconomic, behavioural, and protection factors (PFs) influences on the HIV combined prevention (CP) strategy among Brazilian Amazonian men who have sex with men (MSMs). PFs are resources that reduce the effect of adversity and help people maintain their well-being. Methods: Cross-sectional study employing a convenient sample of MSMs living in the metropolitan region of Belém. A questionnaire containing socioeconomic, behavioural, PFs, and behaviour/knowledge concerning CP questions was used. “Behaviour/knowledge concerning CP” was defined as a dependent variable and received a maximum score of 16 points. The Mann–Whitney and Kruskal–Wallis tests and multiple linear regression were employed. Results: Our sample comprised 384 MSMs scoring an average of 7.83 points (±1.9). Contributing to lower scores were “not talking about sex life with confidants”, “not talking with work colleagues about personal life and sexually transmissible infections”, and “not participating in non-governmental organisations.” On the other hand, “not being happy in the neighbourhood of residency” contributed to higher scores. Conclusion: Peer support and social inclusion are essential for increasing MSMs’ access to CP. Full article

Sexual health constitutes a fundamental aspect of overall well-being, with direct implications for individual development and the broader social and economic progress of communities. Promoting environments that ensure sexual experiences free from coercion, discrimination, and violence is a key public health priority. Sexuality, in this regard, should be understood as an inherent dimension of human experience, shaped by biological, cultural, cognitive, and ideological factors. Accordingly, sexual health education requires a holistic and multidimensional approach that integrates sociocultural, biographical, and professional perspectives. This study aims to examine the level of knowledge and training in sexual health among nursing students and healthcare professionals, as well as to assess the extent to which sexual health content is incorporated into nursing curricula at Spanish universities. A scoping review was conducted using the Dialectical Structural Model of Care (DSMC) as the theoretical framework. The findings indicate a significant lack of knowledge regarding sexual health among both nursing students and healthcare professionals, largely due to educational and structural limitations. Furthermore, sexual health education remains underrepresented in nursing curricula and is frequently addressed from a narrow, fragmented biomedical perspective. These results highlight the urgent need for the comprehensive integration of sexual health content into nursing education. Strengthening curricular inclusion is essential to ensure the preparation of competent professionals capable of delivering holistic, inclusive, and empowering care in this critical area of health. Full article

This study examines how Ontario’s Health and Physical Education curriculum addresses the needs of young adults with disabilities. A total of 54 individuals aged 18–35 years old with developmental, learning, or physical disabilities who had completed secondary school in Ontario participated in a cross-sectional mixed-methods survey. Participants were recruited through disability-focused community networks and a university psychology participant pool. They completed the Sex Education subscale of the Sexual Knowledge, Experience, Feelings and Needs Scale, a 35-item sexual knowledge questionnaire, and open-ended questions. Quantitative data were analyzed using descriptive statistics and independent samples t-tests; qualitative responses were examined using thematic analysis. Participants reported limited factual knowledge, minimal classroom representation, and heavy reliance on independent learning. Barriers included inaccessible materials, teacher discomfort, and the absence of disability narratives in sexuality units. Findings point to three priorities: revising curriculum content, expanding educator training, and creating disability-affirming resources. These measures will help ensure comprehensive and rights-based sexuality education that supports the autonomy and well-being of students with disabilities. Full article

Intersectionality is a concept used to explain the power dynamics and inequalities that some groups experience owing to the interconnection of social differences such as in gender, sexual identity, poverty status, race, geographic location, disability, and education. The relation between software engineering, feminism, and intersectionality has been addressed by some studies thus far, but it has never been codified before. In this paper, we employ the commonly used ABC Framework for empirical software engineering to show the contributions of intersectional software engineering (ISE) as a field of software engineering. In addition, we highlight the power dynamic, unique to ISE studies, and define gender-forward intersectionality as a way to use gender as a starting point to identify and examine inequalities and discrimination. We show that ISE is a field of study in software engineering that uses gender-forward intersectionality to produce knowledge about power dynamics in software engineering in its specific domains and environments. Employing empirical software engineering research strategies, we explain the importance of recognizing and evaluating ISE through four dimensions of dynamics, which are people, processes, products, and policies. Beginning with a set of 10 seminal papers that enable us to define the initial concepts and the query for the systematic mapping study, we conduct a systematic mapping study leads to a dataset of 140 primary papers, of which 15 are chosen as example papers. We apply the principles of ISE to these example papers to show how the field functions. Finally, we conclude the paper by advocating the recognition of ISE as a specialized field of study in software engineering. Full article

Sexual consent is one of the most important tools used in the prevention of sexual violence, for which adolescents are especially vulnerable. However, it is unclear how sexual consent processes are defined and used by this population. To bridge this gap in knowledge, this scoping review sought to identify and synthesize the existing empirical research findings on sexual consent conceptualizations and processes among adolescents, as well as determine critical gaps in knowledge. Forty-three articles were reviewed following a systematic search of six academic databases. Articles were included if they were original empirical work published in English between January 1990 and March 2020, included adolescents aged 10 to 17 in their sample, and specifically studied sexual consent conceptualization, communication, and/or behavior. Seventeen articles, diverse in study design and geography, met these criteria and were analyzed. The findings suggest a propensity for adolescents to abstractly define sexual consent as verbal and direct in nature while simultaneously espousing indirect and non-verbal behavioral processes when presented with “real life” scenarios (e.g., vignettes, reflections on personal experience). In addition, the results reveal the significance of concepts like gender norms, normative refusals, and silence as key aspects of adolescent sexual consent. This review demonstrates that research on sexual consent among adolescents is highly limited overall, and the findings that are available indicate some concerning perceptions. Full article

Background and objectives: Duloxetine is widely used for the treatment of major depressive disorder (MDD), generalized anxiety disorder (GAD), and various types of neuropathic pain. While its efficacy is well documented in clinical trials, less is known about how it is perceived and utilized in routine psychiatric practice. To address this knowledge gap, we conducted a cross-sectional observational study involving 80 psychiatrists from Spain to assess real-world clinical attitudes toward duloxetine. Methods: Participants completed a 20-item multiple-choice questionnaire that examined familiarity, perceived efficacy in multiple conditions (MDD, GAD, neuropathic pain, somatization, and quality of life), and perspectives on tolerability, safety, adherence, and overall satisfaction. Results: Survey results indicated that a large majority of psychiatrists frequently prescribe duloxetine, particularly for patients with MDD and comorbid chronic pain. Notably, 94% rated it as either “more effective” or “much more effective” for diabetic peripheral neuropathic pain. Psychiatrists reported a high perceived efficacy of duloxetine: 94% rated it as “more effective” or “much more effective” for diabetic peripheral neuropathy, and 93% gave similarly positive ratings for general neuropathic pain. For somatization, 70% found it “effective” or “very effective”, and 83% observed improvements in quality of life for many of their patients. Psychiatrists generally reported favorable perceptions of duloxetine’s tolerability profile: 97.5% rated it as the antidepressant associated with the least weight gain, and 82.5% perceived fewer sexual side effects compared to other options. Sedation and gastrointestinal side effects were generally considered mild or less severe. In terms of treatment adherence, 69% rated it as “better” or “much better” than other antidepressants, and 80% found its combination with other antidepressants to be “favorable” or “very favorable”. Overall satisfaction was high, with 99% of psychiatrists reporting being either “satisfied” or “very satisfied” with its use. The side effect profile was generally viewed as manageable, with low perceived rates of weight gain, sedation, and sexual dysfunction. Furthermore, 96% of respondents expressed a willingness to recommend duloxetine to their colleagues. Conclusions: Psychiatrists reported highly favorable attitudes toward duloxetine, viewing it as a flexible treatment option in routine care. However, these findings reflect clinicians’ subjective perceptions rather than objective clinical outcomes and should be interpreted accordingly. Full article