Search Results (2,209)

The rational design and regulation of interfacial microenvironments represents an effective strategy for enhancing reaction performance. Previous studies have demonstrated that constructing air–liquid–solid triphase interfaces can substantially enhance catalytic reactions involving gaseous reactants. However, research on regulating the triphasic interfacial microenvironment remains limited and challenging. Herein, we fabricated a triphase photocatalytic system by depositing hydrophobic materials onto ordered TiO₂ porous (OTP), achieving significantly enhanced performance in visible-light-driven dye-sensitized photooxidation. Further, we regulated the triphasic microenvironment by systematically adjusting the chain length of hydrophobic molecules. It was found that the chain length greatly affects the interfacial properties, including O₂ concentration, the organic molecule adsorption and the interfacial electron transfer efficiency, thereby influencing photocatalytic reaction kinetics and pathways. We demonstrated a high-performance triphase photocatalytic system using 1H,1H,2H,2H-perfluorooctyl triethoxysilane as the hydrophobic material, which optimized multiple interfacial properties through synergistic effects, leading to optimal photocatalytic performance. Full article

Mitochondrial dysfunction drives persistent inflammation in severe asthma, yet its upstream metabolic regulation remains unclear. Induced sputum from patients with severe asthma was analyzed and integrated with transcriptomic datasets from independent cohorts. Two mouse models (C57BL/6J) were used for in vivo validation with multi-omics profiling, and mechanistic studies were performed in air–liquid interface-cultured primary human airway epithelial cells. Glutathione reduced form (GSHr) was markedly depleted in sputum and associated with poor disease control and mixed granulocytic inflammation in patients with severe asthma. Multi-omics analyses revealed coordinated disruption of glutathione (GSH) metabolism, including oxidized GSH accumulation, reduced synthesis and glutathione-S-transferase activity, and impaired mitochondrial GSH transport. GSH supplementation alleviated airway inflammation, oxidative stress, and mitochondrial dysfunction, whereas pharmacological inhibition of GST exacerbated these effects. Mitochondrial analyses identified suppressed SLC25A39 expression as a key mediator of defective GSH transport and redox imbalance. Transcriptomic profiling of airway biopsies showed upregulation of Neuropilin-1 (Nrp1), closely associated with altered glutathione pathways. Targeting the Nrp1 b1 domain restored mitochondrial GSH metabolism and attenuated airway inflammation. These findings identify an Nrp-centered metabolic pathway that disrupts mitochondrial homeostasis and drives inflammatory amplification, highlighting mitochondria-targeted therapeutic strategies for severe asthma. Full article

Nickel-based superalloy GH3625 is widely used in extreme environments due to its exceptional high-temperature strength and corrosion resistance; however, optimizing its comprehensive performance through precise microstructural control remains a critical challenge. In this study, the effect of withdrawal rate (10–200 μm/s) on the microstructural evolution, mechanical properties, and corrosion resistance of GH3625 alloy was investigated using a liquid-metal-cooled directional solidification system. The microstructural characteristics, elemental segregation, and phase distributions were systematically analyzed via OM, SEM, and EDS, followed by uniaxial tensile and electrochemical polarization tests. The results show that with increasing withdrawal rate, the solid–liquid interface morphology evolves from cellular to cellular-dendritic and finally to fully dendritic. Correspondingly, the primary dendrite arm spacing decreases from 270.4 μm to 100.2 μm, and the secondary dendrite arm spacing decreases from 66.5 μm to 12.3 μm. The area fraction of the detrimental Laves phase first decreases and then increases, reaching a minimum at 100 μm/s. Correspondingly, the yield strength increases from 282 MPa to 409 MPa, and the corrosion resistance is optimized at 100 μm/s. The microstructure–property relationships are discussed based on second-phase strengthening theory and microstructural refinement. This study provides a theoretical basis and practical process windows for optimizing directional solidification parameters to achieve enhanced mechanical and corrosion performance in GH3625 alloy. Full article

Cold-mercury gilding uses mercury as an adhesive to bond gold foil onto the surface of copper and silver artifacts. This technique and mercury gilding (fire gilding) both belong to the Au-Hg system and are closely related in technology. Clarifying the technical differences between them is of great significance for revealing the developmental sequence of ancient gilding technologies. On the basis of reconstructing traditional fire gilding, simulated cold-mercury-gilded samples were successfully prepared using experimental archeological methods, and multi-scale characterization was performed using SEM-EDS, XRD, and XPS. The results show that the surface of cold-mercury-gilded samples displays a micromorphology of folded and overlapped gold foil accompanied by locally dense particle aggregation. The cross-section of the gold layer exhibits a multilayer stacked structure, in which mercury is enriched at the gold layer/substrate interface and forms an AuHgCu/Ag diffusion layer. Room-temperature-stable Au-Hg and Ag-Hg phases such as Au₂Hg and AgHg are present in the gold layer, reflecting complex phase transformation behavior of the Au-Hg/Ag-Hg system at room temperature. During cold-mercury gilding, liquid mercury first adheres to the gold foil, and then interdiffusion and phase reactions occur between mercury, gold, and copper/silver atoms at room temperature. Intermetallic compounds and diffusion layers formed at the interface achieve firm bonding between the gold layer and the substrate. Both cold-mercury gilding and mercury gilding achieve metallurgical bonding through atomic interdiffusion. However, affected by differences in the initial state of mercury and operating temperature, the phase transformation and atomic diffusion behaviors of the system differ significantly, which are ultimately reflected in the cross-sectional structure of the gold layer, the composition of the interfacial diffusion layer, and the types of phases. Therefore, mercury-gilded artifacts show superior gold layer durability and bonding strength with the substrate compared with cold-mercury-gilded artifacts. Both techniques pioneered the application of mercury in metallic gilding and represent important innovations in ancient surface decoration technology. Full article

Raman spectroscopy is capable of determining the composition of mixtures quantitatively and qualitatively. However, this technology reaches its limits when used to examine liquid dispersed mixtures of substances. In these emulsions, light scattering occurs at the interfaces of the particles and/or droplets, leading to signal losses that make the results impossible to evaluate. Our previous publications have shown, however, that it is possible to quantify the signal losses using a scattered light probe. In an investigation of the water–toluene–acetone emulsion, the acetone concentration could be determined with a root mean squared error of prediction (RMSEP) of up to 1.5 wt%. Based on this method, further analyses are now being carried out to demonstrate that the correction also makes it possible to determine the acetone concentration in each individual liquid phase. First, a ternary diagram is analytically created by establishing stable conditions and separating the phases for individual measurement. In a second step, the samples are measured as a dispersed mixture with the droplets as interfering factors, demonstrating that the same concentration differences can be measured between both phases. Full article

A thin-film surface plasmon resonance (SPR) sensor is presented using a prism-coupled Kretschmann configuration and an optimized multilayer architecture incorporating black phosphorus (BP) as an ultrathin overlayer. The response is modeled at 633 nm under TM polarization using the transfer-matrix method. Low-concentration sensing conditions in the 1–5 ng/mL range are represented through small effective-refractive-index perturbations of the aqueous sensing medium, providing a preliminary optical framework for evaluating refractive-index response in biosensing-related scenarios. The coupling prism, Au film thickness, and Si₃N₄ spacer thickness are optimized to control resonance depth, linewidth, and angular shift. The optimized CaF₂/Au/Si₃N₄/BP configuration exhibits systematic condition-dependent displacement of the SPR minimum and an evanescent-field distribution that remains strongly localized at the sensing interface while extending into the sensing medium, enabling refractive-index interrogation. High angular sensitivity is obtained at low levels, reaching 517.62°/RIU at 2 ng/mL and 482.82°/RIU at 1 ng/mL, with quality factors above 120 RIU⁻¹ in the same regime. Composite indicators (figure of merit and contrast signal factor) peak at intermediate levels, whereas resonance broadening at higher levels reduces the quality factor and increases the inferred limit of detection, evidencing a sensitivity–resolution trade-off. Benchmarking against reported SPR platforms indicates that BP-assisted interface engineering provides a competitive low-level operating window within a preliminary refractive-index-sensing framework that is relevant to future biosensor design. These results motivate further experimental validation, including BP stabilization, surface biofunctionalization, and practical implementation under liquid-phase sensing conditions. Full article

The exceptional stability of C-F bonds renders PFAS highly persistent in aqueous environments, posing significant challenges for conventional treatment technologies. While plasma-based technologies show promise, their efficiency is often limited by poor gas–liquid mass transfer in bulk liquid. Here, an in-house constructed ultrasonic atomization–dielectric barrier discharge (UEN-DBD) system was developed to promote PFAS degradation under non-thermal plasma conditions. Ultrasonic atomization generated microdroplets, which promoted PFAS enrichment at the surface of microdroplets and facilitate interactions with plasma-generated reactive species. Using perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS) as model compounds, degradation behavior was evaluated over an initial concentration range of 0.01–1.0 ppm. At 0.01 ppm, degradation efficiencies of 96.06% for PFOA and 94.86% for PFOS were achieved within 5 min. Electron paramagnetic resonance (EPR) spectroscopy confirmed the formation of oxidative radicals (·OH) and suggested a mixed redox environment involving reactive species, potentially including superoxide (O₂·⁻) or hydrated electrons (e_aq⁻), in the discharge-treated system. High-resolution mass spectrometry results are consistent with a stepwise chain-shortening pathway dominated by successive –CF₂– scission, while fluoride-release measurements provided supporting evidence for partial defluorination. These findings advance the understanding of plasma-assisted PFAS degradation at the gas–liquid interface and provide a basis for the further development of plasma-assisted PFAS treatment strategies. Full article

To address the existing challenges in mold slag thickness measurement—such as the susceptibility of contact sensors to high-temperature degradation and the limitation of non-contact methods to detecting only the upper slag surface—this study proposes an integrated approach that fuses millimeter-wave radar and eddy current sensors for measuring mold slag thickness in a continuous casting mold. The method innovatively combines two sensing principles: the millimeter-wave radar employs an improved FFT-CZT² high-precision ranging algorithm to perform high-resolution scanning of the solid slag upper surface, reconstructing its topography (error: $\pm$1 mm), while Mel-frequency cepstral coefficients (MFCC) are applied to extract features from the radar intermediate-frequency signals, combined with an enhanced PSO-BP neural network algorithm to predict the thickness of the solid slag layer (error: $\pm$5 mm). Concurrently, an eddy current sensor monitors the liquid slag–molten steel interface position (error: $\pm$1 mm). Through dual-sensor data fusion, the upper surface topography data and solid slag thickness obtained from the radar are spatially registered in three dimensions with the molten steel level information derived from the eddy current sensor. This integration ultimately enables the non-contact synchronous measurement of three key parameters within the mold: solid slag layer thickness, liquid slag layer thickness inversion, and molten steel level. Furthermore, by reconstructing the upper slag surface morphology, the method successfully resolves practical issues such as uneven material distribution, local material deficiency, or excessive feeding. Preliminary experimental verification confirms that the proposed method maintains stable performance even under high-temperature and complex environmental conditions. It thus provides a real-time, accurate, and full-cross-section monitoring solution for mold slag in continuous casting, offering significant practical value for the development of smart steel plants. Full article

Amidst the high global reliance on petroleum, this study addresses energy inefficiency in beam-pumping units used for oil extraction. We developed a tubular solid–liquid triboelectric nanogenerator (TENG) based on fluorinated polydimethylsiloxane (PDMS) films. Self-assembled surface modification with fluorosilane molecular chains enhanced charge transfer, achieving a 2.7-fold increase with 13F-PDMS. The enclosed tubular design utilizes periodic liquid-electrode contact to generate a volumetric effect. Experiments investigated the influence of liquid composition and device configuration on performance. Using a 1.69 mol/L FeCl₃ solution with four series-connected units, the TENG reached 29 V and 263 nA, powering 150 LEDs. This demonstrates its potential for harvesting reciprocating mechanical energy from pumping units to reduce operational energy consumption. Full article

A library of twelve heteroditopic bis-urea and bis-thiourea receptors supported on Merrifield and Wang resins was prepared by solid-phase synthesis. The receptors incorporate dual hydrogen-bond-donor units for anion binding and a polyether spacer that simultaneously functions as a cation-binding site, enabling ion-pair recognition at the solid–liquid interface. Molecular recognition studies were performed using several inorganic and tetraalkylammonium salts, and fluorescence changes were monitored by microplate measurements in DMSO and DMSO/H₂O (95:5, v/v). Univariate and factorial statistical analyses revealed statistically significant fluorescence changes and identified the structural variables governing guest recognition in each medium. Under the conditions examined, several systems exhibited reproducible ion-pair-induced fluorescence responses, highlighting the influence of receptor type and spacer architecture. These findings provide a basis for the rational optimization of supported receptors for sensing and extraction applications. Full article

Microbiological contamination of drinking water remains a significant public health concern worldwide, necessitating the development of efficient and environmentally friendly disinfection technologies. This study investigated the effectiveness and physicochemical mechanisms of water treatment using high-frequency electrical discharge plasma. Experimental research was conducted employing a laboratory dielectric barrier discharge reactor operating at 10–30 kHz and 10–25 kV, with treatment durations ranging from 5 to 20 min. Plasma exposure resulted in pronounced physicochemical changes in the aqueous medium, including a decrease in pH from 7.1–7.3 to 5.4–6.0 and an increase in electrical conductivity from 280–340 µS/cm to 480–620 µS/cm. The formation of reactive oxygen species, including hydroxyl radicals, ozone, and hydrogen peroxide, was confirmed, with hydrogen peroxide concentrations varying between 0.35 and 1.20 mg/L. Microbiological analysis demonstrated a reduction in microbial concentration from approximately 10⁵–10⁶ CFU/mL to 10²–10³ CFU/mL, corresponding to 3–4 log inactivation. The results indicated that microbial reduction was strongly associated with the generation of reactive species and treatment duration. Energy density within the range of 0.3–1.2 kWh/m³ was found to support effective disinfection performance. The findings demonstrated that high-frequency plasma treatment established a strong oxidative environment leading to microbial membrane disruption and cellular damage. Overall, the study confirmed the potential of high-frequency electrical discharge plasma technology as a promising approach for drinking water disinfection and provided a basis for further optimization and scale-up investigations. Full article

Chronic exposure to benzo[a]pyrene (BaP), a Group 1 IARC carcinogen, is a major driver of lung carcinogenesis; however, how sustained subcytotoxic exposure reprograms bronchial epithelium toward preneoplastic states remains poorly defined. Here, we subjected BEAS-2B human bronchial epithelial cells to 12 weeks of continuous BaP at environmentally relevant concentrations (0.1 and 1.0 µM) and interrogated the resulting phenotypes using an integrated multi-scale framework encompassing functional toxicology, RT-qPCR, RNA-seq, phospho-kinase/NF-κB arrays, and organotypic air–liquid interface (ALI) cultures. Cells maintained metabolic competence throughout, evidenced by sustained CYP1A1 and CYP1B1 induction at both acute (4 h) and chronic (12-week) timepoints, while accumulating genotoxic stress as demonstrated by dose-dependent nuclear γ-H2AX foci formation and ATM phosphorylation (Ser1981). RNA-seq revealed a dose-dependent transcriptional shift: 0.1 µM BaP yielded 119 differentially expressed genes (DEGs; |log2FC| ≥ 1, FDR < 0.05), whereas 1.0 µM generated 255 DEGs. Downregulated transcripts were enriched for extracellular matrix and cell-adhesion programs (COL14A1, ADAMTS2, CSMD3, CADM3), while upregulated genes encompassed inflammatory, calcium-signaling, and vesicle-trafficking modules (NFATC4, CSF2RA, SYT1, PCLO). Phospho-kinase/NF-κB arrays confirmed a p53/NF-κB signaling nexus, with concurrent activation of MAPK/ERK (Thr202/Tyr204) and PI3K/Akt (Ser473) pathways. Despite persistent genotoxic stress, cells did not acquire anchorage-independent growth and remained non-tumorigenic in vivo. Critically, ALI organotypic cultures derived from BaP-exposed cells exhibited histological dysplasia, nuclear pleomorphism, and disrupted apical-basal polarity. These findings mechanistically link chronic BaP exposure to an initiation-like preneoplastic state and establish a validated 2D/3D multi-omics platform for PAH-driven lung carcinogenesis research. Full article

Hydrogen-mediated microbial electrosynthesis (MES) of chemicals from CO₂ relies on effective gas–liquid transfer at the cathode interface, yet the extent to which cathode surface area regulates acetate productivity remains insufficiently quantified. In this study, three identical MES reactors equipped with stainless-steel cathodes of different geometric areas (8 × 1, 8 × 4, and 8 × 16 cm²) were operated at a constant electric current of 0.3 A. The largest cathode significantly accelerated hydrogen mass transfer (k_La = 0.592 h⁻¹), reaching dissolution equilibrium within 3 min, which was nearly twice as fast as the smallest electrode. Upon inoculation with enriched acetate-producing microbial consortia, the 8 × 16 cm²_cathode reactor fed with CO₂ achieved the highest steady-state acetate concentration of 32 g·L⁻¹ produced at a rate of 2.12 g·L⁻¹·d⁻¹, with 94% hydrogen utilization, and 59% coulombic efficiency. In contrast, smaller electrodes exhibited rapid bubble detachment and reduced residence time, thereby limiting microbial gas uptake, and resulting in low acetate productivity. These findings demonstrate that cathode surface area is a key engineering lever controlling both hydrogen availability and electron recovery efficiency in H₂-driven MES. The results provide practical guidance for electrode design and scale-up of CO₂-to-acetate bioconversion via the MES process. Full article

Anode-less battery architectures, which eliminate the host anode material, have attracted considerable attention as a promising approach to increase energy density, simplify cell manufacturing, and improve safety in next-generation energy storage systems. This review provides a structured and integrative overview on the current research landscape of anode-less cells, spanning both liquid- and solid-electrolyte technologies. It first introduces the fundamental principles, key advantages, and inherent challenges of the anode-less concept. Advanced characterization techniques, including electrochemical, interfacial, morphological, and operando approaches, are then discussed as essential tools for probing metal plating/stripping behavior and degradation mechanisms. The core of the review examines how system design governs performance, addressing strategies for liquid electrolytes, including current collector design, electrolyte formulation, and deposition control, as well as solid electrolytes, with an emphasis on interfacial engineering, fundamental limitations, and extensions to Na- and K-based batteries. By integrating insights across these systems, the review identifies critical challenges, including unstable solid-electrolyte interphases, dendrite formation, and interfacial contact loss. Finally, a development pyramid is introduced as a conceptual framework linking fundamental research to practical implementation, outlining key priorities from interface control and full-cell compatibility to long-term reliability while also highlighting industrial pathways toward hybrid and fully solid-state anode-less batteries. Full article

Photocatalytic CO₂ reduction to high-value-added C₂+ products is a practical route from an economic viewpoint for advancing the industrialization of CO₂ conversion. Despite significant progress in catalyst modification in recent years (such as defect engineering, heterostructure construction, and single-atom modification), the generation of C₂+ products still faces challenges due to the slow kinetics of multi-electron reactions and the high thermodynamic barrier for C-C coupling. Moreover, the severely imbalanced molar ratio of CO₂ to H₂O in the traditional liquid-phase reaction systems exacerbated the challenge to the unfavorable situation. This article summarizes various strategies to improve the yield of C₂+ products through the regulation of reaction environments, including: (1) increasing the partial pressure of CO₂ to enhance its solubility; (2) using alternative solvents like ionic liquids to reduce water content; (3) transitioning the reaction system from liquid phase to gas phase; (4) designing a three-phase (gas–liquid–solid) interface or floating photocatalysts to optimize reactant transfer and local concentration; (5) utilizing photothermal synergistic effects to enhance the reaction temperature and efficiency under concentrated light. It also discusses the role of different reactor designs in improving the reaction environment. Finally, it emphasizes that future research should pay more attention to the optimization of the reaction environment engineering in addition to catalyst design, providing new perspectives for achieving efficient and highly selective C₂+ products in CO₂ photoreduction. Full article