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Search Results (961)

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26 pages, 5518 KB  
Article
Mechanism of Time-Dependent Deformation and Support Collaborative Failure in Water-Rich Red-Bed Soft Rock Tunnels
by Jin Wu, Feng Peng, Zhiyi Jin, Zhize Han, Geng Cheng and Jiaxin Jia
Appl. Sci. 2025, 15(17), 9810; https://doi.org/10.3390/app15179810 (registering DOI) - 7 Sep 2025
Abstract
Substantial time-dependent deformation and support failure in deep tunnels through water-rich red-bed soft rock present critical engineering challenges, yet the underlying mechanisms under hydro-mechanical coupling remain inadequately quantified. This study integrates wireless remote monitoring, laboratory testing, and theoretical analysis to investigate the stress-deformation [...] Read more.
Substantial time-dependent deformation and support failure in deep tunnels through water-rich red-bed soft rock present critical engineering challenges, yet the underlying mechanisms under hydro-mechanical coupling remain inadequately quantified. This study integrates wireless remote monitoring, laboratory testing, and theoretical analysis to investigate the stress-deformation behavior of surrounding rock and support structures. Results reveal that deformation evolves through four distinct stages as follows: sharp, slow, stable, and creep, with the creep stage—governed by pore-water pressure—accounting for over 40% of total displacement. Groundwater-induced clay mineral hydration and stress redistribution significantly weaken rock self-support capacity. Support elements exhibit degraded performance; rock bolts suffer interfacial bond failure, steel arches yield asymmetrically, and the secondary lining resists transmitted deformation pressure. A novel deformation rate-based failure criterion is proposed, revealing a progressive “local breakthrough-chain transmission–global instability” failure pathway. These findings provide a theoretical basis for stability control in deep buried tunnels under hydro-mechanical coupling. Full article
(This article belongs to the Special Issue Advances in Smart Underground Construction and Tunneling Design)
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20 pages, 12005 KB  
Article
Reactivation Mechanism of Ancient Accumulation Landslides Synergistically Triggered by Excavation Disturbance and Critical Rainfall Infiltration
by Jiayong Zhang, Jinhong Chen, Yigen Qin, Xiaotong Xu, Wenlong Gou and Kunpeng Lu
Water 2025, 17(17), 2640; https://doi.org/10.3390/w17172640 (registering DOI) - 6 Sep 2025
Abstract
The reactivation of the Longdongpo ancient colluvial landslide in Sinan County, Guizhou Province represents a typical multi-factor coupled failure. Based on detailed geological investigations and FLAC3D fluid–solid coupling numerical simulations, this study reveals its complex reactivation mechanisms. The analysis demonstrates that long-term [...] Read more.
The reactivation of the Longdongpo ancient colluvial landslide in Sinan County, Guizhou Province represents a typical multi-factor coupled failure. Based on detailed geological investigations and FLAC3D fluid–solid coupling numerical simulations, this study reveals its complex reactivation mechanisms. The analysis demonstrates that long-term groundwater action has significantly weakened the slip zone at the soil–bedrock interface, causing strength degradation and inducing prolonged quasi-stable creep deformation of the slope. The artificial cut slopes formed in the middle-to-lower sections disrupted the original stress field and induced localized plastic deformation. Crucially, the numerical simulation identified a 5 m rainfall infiltration depth as the threshold triggering abrupt instability; when exceeding this critical value (simulated as 10 m and 16 m infiltration depths), pore water pressure surged (>2.7 MPa) and displacement dramatically increased (>2.2 m), reducing shear strength along the potential failure surface to critical levels. This process culminated in the full connection of the shear surface and the landslide’s catastrophic reactivation. This work quantitatively elucidates the chain-reaction mechanism of “long-term groundwater weakening → engineering disturbance initiation → critical-depth rainfall infiltration triggering”, providing vital quantitative evidence for regional ancient landslide risk prevention. Full article
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20 pages, 911 KB  
Article
The Instability in the Dimensions of Polynomial Splines of Mixed Smoothness over T-Meshes
by Pengxiao Wang
Mathematics 2025, 13(17), 2886; https://doi.org/10.3390/math13172886 (registering DOI) - 6 Sep 2025
Abstract
Mixed-smoothness splines facilitate localized control over smoothness; however, the issue of dimensional instability in mixed-smoothness spline spaces remains unstudied in the existing literature. This paper studies such instabilities over T-meshes, where different orders of smoothness are required across interior mesh segments. Using the [...] Read more.
Mixed-smoothness splines facilitate localized control over smoothness; however, the issue of dimensional instability in mixed-smoothness spline spaces remains unstudied in the existing literature. This paper studies such instabilities over T-meshes, where different orders of smoothness are required across interior mesh segments. Using the smoothing cofactor-conformality method, we introduce a constraint on T-meshes to derive a stable dimension formula for mixed-smoothness spline spaces. Furthermore, we show dimensional instability in cases involving T-cycles and nested T-cycles. By defining a singularity factor for each T-cycle, we demonstrate that both dimensional instabilities and structural degenerations are associated with these singularity factors. The work contributes to a deeper understanding of spline spaces defined over non-tensor-product structures. Full article
15 pages, 6813 KB  
Article
Mass Transfer Mechanism and Process Parameters in Glycerol Using Resonant Acoustic Mixing Technology
by Ning Ma, Guangbin Zhang, Xiaofeng Zhang, Yuqi Gao and Shifu Zhu
Processes 2025, 13(9), 2845; https://doi.org/10.3390/pr13092845 - 5 Sep 2025
Viewed by 23
Abstract
Resonant acoustic technology utilizes low-frequency vertical harmonic vibrations to induce full-field mixing effects in processed materials, and it is regarded as a “disruptive technology in the field of energetic materials”. Although numerous scholars have investigated the mechanisms of resonant acoustic mixing, there remains [...] Read more.
Resonant acoustic technology utilizes low-frequency vertical harmonic vibrations to induce full-field mixing effects in processed materials, and it is regarded as a “disruptive technology in the field of energetic materials”. Although numerous scholars have investigated the mechanisms of resonant acoustic mixing, there remains a lack of parameter selection methods for improving product quality and production efficiency in engineering practice. To address this issue, this study employs phase-field modeling and fluid–structure coupling methods to numerically simulate the transport process of glycerol during resonant acoustic mixing. The research reveals the mass transfer mechanism within the flow field, establishes a liquid-phase distribution index for quantitatively characterizing mixing effectiveness, and clarifies the enhancement effect of fluid transport on solid particle mixing through particle tracking methods. Furthermore, parameter studies on vibration frequency and amplitude were conducted, yielding a critical curve for guiding parameter selection in engineering applications. The results demonstrate that Faraday instability first occurs at the fluid surface, generating Faraday waves that drive large-scale vortices for global mass transfer, followed by localized mixing through small-scale vortices. The transport process of glycerol during resonant acoustic mixing comprises three distinct stages: stable Faraday wave oscillation, rapid mass transfer during flow field destabilization, and localized mixing upon stabilization. Additionally, increasing either vibration frequency or amplitude effectively enhances both the rate and effectiveness of mass transfer. These findings offer theoretical guidance for optimizing process parameters in resonant acoustic mixing applications. Full article
(This article belongs to the Section Materials Processes)
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22 pages, 3169 KB  
Article
Preliminary Results on Hydrogen Concentration Time Series in Spring Gases from the Pamir–Western Himalayan Syntaxis: Variability and Tectonic Instability
by Jiao Tian, Jingchao Li, Yuwen Wang, Miao He, Shihan Cui, Bingyu Yao, Zhaojun Zeng, Jinyuan Dong, Changhui Ju, Chang Lu and Xiaocheng Zhou
Appl. Sci. 2025, 15(17), 9736; https://doi.org/10.3390/app15179736 - 4 Sep 2025
Viewed by 185
Abstract
Identifying reliable geochemical signals that reflect crustal stress evolution remains a major challenge in earthquake monitoring. Spring fluids, due to their deep circulation and rapid response, provide an important window into fault-zone processes. This study presents three years (May 2022–March 2025) of hourly [...] Read more.
Identifying reliable geochemical signals that reflect crustal stress evolution remains a major challenge in earthquake monitoring. Spring fluids, due to their deep circulation and rapid response, provide an important window into fault-zone processes. This study presents three years (May 2022–March 2025) of hourly hydrogen gas (H2) concentration monitoring in spring gases from the Muji Basin on the northern Pamir Plateau, integrated with meteorological and seismic data. H2 concentrations exhibited a stable diurnal pattern, positively correlated with water and air temperatures and negatively correlated with atmospheric pressure. Short-term anomalies during seismically quiet periods may reflect a combination of temperature-dependent solubility effects and transient degassing caused by localized gas accumulation and sudden release under heterogeneous fault and aquifer conditions. During seismically active phases, sustained increases in H2 concentrations were also recorded; however, such anomalies did not consistently precede earthquakes, instead reflecting broader phases of tectonic instability and episodic fault-zone degassing. These findings highlight the potential of long-term H2 monitoring to improve our understanding of the coupling between crustal stress, fluid transport, and degassing processes in tectonically active regions. Full article
(This article belongs to the Section Earth Sciences)
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23 pages, 5091 KB  
Article
Erosion, Mechanical and Microstructural Evolution of Cement Stabilized Coarse Soil for Embankments
by Adel Belmana, Victor Cavaleiro, Mekki Mellas, Luis Andrade Pais, Hugo A. S. Pinto, Vanessa Gonçalves, Maria Vitoria Morais, André Studart and Leonardo Marchiori
Geotechnics 2025, 5(3), 62; https://doi.org/10.3390/geotechnics5030062 - 4 Sep 2025
Viewed by 101
Abstract
Internal erosion is a significant issue caused by water flow within soils, resulting in structural collapse of hydraulic structures, particularly in coarse soils located near rivers. These soils typically exhibit granulometric instability due to low clay content, resulting in poor hydraulic and mechanical [...] Read more.
Internal erosion is a significant issue caused by water flow within soils, resulting in structural collapse of hydraulic structures, particularly in coarse soils located near rivers. These soils typically exhibit granulometric instability due to low clay content, resulting in poor hydraulic and mechanical properties. To mitigate this problem, cement treatment is applied as an alternative to soil removal, reducing transportation and storage costs. The hole erosion test (HET) and Crumbs tests, shearing behaviour through consolidated undrained (CU) triaxial, and microstructure analyses regarding scanning electron microscopy (SEM), mercury intrusion porosimeter (MIP) and thermogravimetric analysis (TGA) were conducted for untreated and treated coarse soil specimens with varying cement contents (1%, 2%, and 3%) and curing durations (1, 7, and 28 days). The findings indicate a reduction in the loss of eroded particles and overall stability of treated soils, along with an improvement in mechanical properties. SEM observations reveal the development of hydration gel after treatment, which enhances cohesion within the soil matrix, corroborated by TGA analyses. MIP reveals the formation of a new class of pores, accompanied by a reduction in dry density. This study demonstrates that low cement addition can transform locally unsuitable soils into durable construction materials, reducing environmental impact and supporting sustainable development. Full article
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16 pages, 4975 KB  
Article
Optimization of Energy Harvesting Performance and Local Resonance Instability Phenomenon Suppression in Piezoelectric Cantilever Beams with Arrayed Grooves
by Yan Zhang, Qi Li, Haodong Sun, Kaiming Sun, Yuanjing Mou and Jie Wan
Vibration 2025, 8(3), 50; https://doi.org/10.3390/vibration8030050 - 3 Sep 2025
Viewed by 221
Abstract
This study addresses the performance optimization of piezoelectric cantilever beam energy harvesters by proposing a design method based on surface arrayed groove modulation. Through systematic investigation of the effects of single grooves (upper surface, lower surface, and double-sided grooves) and arrayed grooves on [...] Read more.
This study addresses the performance optimization of piezoelectric cantilever beam energy harvesters by proposing a design method based on surface arrayed groove modulation. Through systematic investigation of the effects of single grooves (upper surface, lower surface, and double-sided grooves) and arrayed grooves on the power generation performance of piezoelectric cantilever beams, the coupling mechanism of stiffness modulation, Local resonance instability phenomenon, and energy conversion in groove design is revealed. The results show that while single grooves can improve the output voltage by altering the neutral axis position, groove widths exceeding 20 mm induce Local resonance instability phenomenon, leading to energy dissipation. In contrast, arrayed grooves effectively suppress Local resonance instability phenomenon by uniformly distributing the grooves, significantly enhancing energy conversion efficiency. The optimized arrayed groove configuration (groove width: 4 mm, depth: 1 mm, number: 7) achieves a peak voltage of 549.525 mV, representing a 17.3% improvement over the ungrooved structure, without inducing narrow-bandwidth effects. Additionally, this design exhibits excellent process compatibility and can be fabricated using conventional machining methods, reducing costs by 30–45% compared to additive manufacturing. This study provides important optimization directions and technical references for the design of piezoelectric cantilever beam energy harvesters. Full article
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22 pages, 10287 KB  
Article
Spatial and Seasonal Characteristics of the Submesoscale Energetics in the Northwest Pacific Subtropical Ocean
by Yunlong Fei, Shaoqing Zhang, Kaidi Wang, Yangyang Yu, Yang Gao and Tong Cui
J. Mar. Sci. Eng. 2025, 13(9), 1691; https://doi.org/10.3390/jmse13091691 - 2 Sep 2025
Viewed by 156
Abstract
The spatial and seasonal characteristics of submesoscales in the Northwest Pacific Subtropical Ocean are thoroughly investigated here using a submesoscale-permitting model within a localized multiscale energetics framework, in which three scale windows termed background, mesoscale, and submesoscale are decomposed. It is found that [...] Read more.
The spatial and seasonal characteristics of submesoscales in the Northwest Pacific Subtropical Ocean are thoroughly investigated here using a submesoscale-permitting model within a localized multiscale energetics framework, in which three scale windows termed background, mesoscale, and submesoscale are decomposed. It is found that submesoscale energetics are highly geographically inhomogeneous. In the Luzon Strait, baroclinic and barotropic instabilities are the primary mechanisms for generating submesoscale available potential energy (APE) and kinetic energy (KE), and they exhibit no significant seasonal variations. Although buoyancy conversion experiences pronounced seasonal cycles and serves as the main sink of submesoscale APE in winter and spring, its contribution to submesoscale KE is negligible. The major sinks of submesoscale KE are advection, horizontal pressure work, and dissipation. In the Western Boundary Current transition and Subtropical Countercurrent (STCC) interior open ocean zone, submesoscales undergo significant seasonality, with large magnitudes in winter and spring. In spring and winter, baroclinic instability dominates the generation of submesoscale APE via forward cascades, while KE is mainly energized by buoyancy conversion and dissipated by the residual term. Meanwhile, in summer and autumn, submesoscales are considerably weak. Additionally, submesoscale energetics in the Western Boundary Current transition zone are slightly greater than those in the STCC interior open ocean zone, which is attributed to the strengthened straining of the Western Boundary Current and mesoscale eddies. Full article
(This article belongs to the Section Physical Oceanography)
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23 pages, 5034 KB  
Article
Study on Early Warning of Stiffness Degradation and Collapse of Steel Frame Under Fire
by Ming Xie, Fangbo Xu, Xiangdong Wu, Zhangdong Wang, Li’e Yin, Mengqi Xu and Xiang Li
Buildings 2025, 15(17), 3146; https://doi.org/10.3390/buildings15173146 - 2 Sep 2025
Viewed by 255
Abstract
Frequent building fires seriously threaten the safety of steel structures. According to the data, fire accidents account for about 35% of the total number of production safety accidents. The collapse of steel structures accounted for 42% of the total collapse. The early warning [...] Read more.
Frequent building fires seriously threaten the safety of steel structures. According to the data, fire accidents account for about 35% of the total number of production safety accidents. The collapse of steel structures accounted for 42% of the total collapse. The early warning problem of steel structure fire collapse is imminent. This study aims to address this challenge by establishing a novel early warning framework, which is used to quantify the critical early warning threshold of steel frames based on elastic modulus degradation and its correlation with ultrasonic wave velocity under different collapse modes. The sequential thermal–mechanical coupling numerical method is used in the study. Firstly, Pyrosim is used to simulate the high-fidelity fire to obtain the real temperature field distribution, and then it is mapped to the Abaqus finite element model as the temperature load for nonlinear static analysis. The critical point of structural instability is identified by monitoring the mutation characteristics of the displacement and the change rate of the key nodes in real time. The results show that when the steel frame collapses inward as a whole, the three-level early warning elastic modulus thresholds of the beam are 153.6 GPa, 78.6 GPa, and 57.5 GPa, respectively. The column is 168.7 GPa, 122.4 GPa, and 72.6 GPa. Then the three-level warning threshold of transverse and longitudinal wave velocity is obtained. The three-stage shear wave velocity warning thresholds of the fire column are 2828~2843 m/s, 2409~2434 m/s, and 1855~1874 m/s, and the three-stage longitudinal wave velocity warning thresholds are 5742~5799 m/s, 4892~4941 m/s, and 3804~3767 m/s. The core innovation of this study is to quantitatively determine a three-level early warning threshold system, which corresponds to the three stages of significant degradation initiation, local failure, and critical collapse. Based on the theoretical relationship, these elastic modulus thresholds are converted into corresponding ultrasonic wave velocity thresholds. The research results provide a direct and reliable scientific basis for the development of new early warning technology based on acoustic emission real-time monitoring and fill the gap between the mechanism research and engineering application of steel structure fire resistance design. Full article
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23 pages, 34310 KB  
Article
One-to-Many Retrieval Between UAV Images and Satellite Images for UAV Self-Localization in Real-World Scenarios
by Jiaqi Li, Yuli Sun, Yaobing Xiang and Lin Lei
Remote Sens. 2025, 17(17), 3045; https://doi.org/10.3390/rs17173045 - 1 Sep 2025
Viewed by 403
Abstract
Matching drone images to satellite reference images is a critical step for achieving UAV self-localization. Existing drone visual localization datasets mainly focus on target localization, where each drone image is paired with a corresponding satellite image slice, typically with identical coverage. However, this [...] Read more.
Matching drone images to satellite reference images is a critical step for achieving UAV self-localization. Existing drone visual localization datasets mainly focus on target localization, where each drone image is paired with a corresponding satellite image slice, typically with identical coverage. However, this one-to-one approach does not reflect real-world UAV self-localization needs as it cannot guarantee exact matches between drone images and satellite tiles nor reliably identify the correct satellite slice. To bridge this gap, we propose a one-to-many matching method between drone images and satellite reference tiles. First, we enhance the UAV-VisLoc dataset, making it the first in the field tailored for one-to-many imperfect matching in UAV self-localization. Second, we introduce a novel loss function, Incomp-NPair Loss, which better reflects real-world imperfect matching scenarios than traditional methods. Finally, to address challenges such as limited dataset size, training instability, and large-scale differences between drone images and satellite tiles, we adopt a Vision Transformer (ViT) baseline and integrate CNN-extracted features into its patch embedding layer. Full article
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21 pages, 2002 KB  
Article
Grey Wolf Optimizer Based on Variable Population and Strategy for Moving Target Search Using UAVs
by Ziyang Li, Zhenzu Bai and Bowen Hou
Drones 2025, 9(9), 613; https://doi.org/10.3390/drones9090613 - 31 Aug 2025
Viewed by 205
Abstract
Unmanned aerial vehicles (UAVs) are increasingly favored for emergency search and rescue operations due to their high adaptability to harsh environments and low operational costs. However, the dynamic nature of search path endpoints, influenced by target movement, limits the applicability of shortest path [...] Read more.
Unmanned aerial vehicles (UAVs) are increasingly favored for emergency search and rescue operations due to their high adaptability to harsh environments and low operational costs. However, the dynamic nature of search path endpoints, influenced by target movement, limits the applicability of shortest path models between fixed points in moving target search problems. Consequently, the moving target search problem using UAVs in complex environments presents considerable challenges, constituting an NP-hard problem. The Grey Wolf Optimizer (GWO) is known for addressing such problems. However, it suffers from limitations, including premature convergence and instability. To resolve these constraints, a Grey Wolf Optimizer with variable population and strategy (GWO-VPS) is developed in this work. GWO-VPS implements a variable encoding scheme for UAV movement patterns, combining motion-based encoding with path-based encoding. The algorithm iteratively alternates between global optimization and local smoothing phases. The global optimization phase incorporates: (1) a Q-learning-based strategy selection; (2) position updates with obstacle avoidance and energy consumption reduction; and (3) adaptive exploration factor. The local smoothing phase employs four path smoothing operators and Q-learning-based strategy selection. Experimental results demonstrate that GWO-VPS outperforms both enhanced GWO variants and standard algorithms, confirming the algorithm’s effectiveness in UAV-based moving target search simulations. Full article
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24 pages, 3844 KB  
Article
Structural Failure and Mechanical Response of Buried Pipelines Under Offshore Fault Dislocation
by Chengzhu Qiu, Shuai Tian and Yujie Wang
Appl. Sci. 2025, 15(17), 9450; https://doi.org/10.3390/app15179450 - 28 Aug 2025
Viewed by 260
Abstract
Fault activity represents a significant geological hazard to buried pipeline infrastructure. The associated stratigraphic dislocation may lead to severe deformation, instability, or even rupture of the pipeline, thereby posing a serious threat to the safe operation of oil and gas transportation systems. This [...] Read more.
Fault activity represents a significant geological hazard to buried pipeline infrastructure. The associated stratigraphic dislocation may lead to severe deformation, instability, or even rupture of the pipeline, thereby posing a serious threat to the safe operation of oil and gas transportation systems. This study employs the 3D nonlinear finite element method to systematically investigate the mechanical behavior of buried steel pipes subjected to fault-induced dislocation, with particular emphasis on critical parameters including fault offset, internal pressure, and the diameter-to-thickness ratio. The study reveals that buried pipelines subjected to fault dislocation typically undergo a progressive failure process, transitioning from the elastic stage to yielding, followed by plastic deformation and eventual fracture. The diameter-to-thickness ratio is found to significantly affect the structural stiffness and deformation resistance of the pipeline. A lower diameter-to-thickness ratio improves deformation compatibility and enhances the overall structural stability of the pipeline. Internal pressure exhibits a dual effect: within a moderate range, it enhances pipeline stability and delays the onset of structural buckling; however, excessive internal pressure induces circumferential tensile stress concentration, thereby increasing the risk of local buckling and structural instability. The findings of this study provide a theoretical basis and practical guidance for the design of buried pipelines in fault-prone areas to withstand and accommodate ground misalignment. Full article
(This article belongs to the Topic Exploitation and Underground Storage of Oil and Gas)
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12 pages, 1173 KB  
Article
A Comprehensive Molecular and Clinical Study of Patients with Young-Onset Colorectal Cancer
by Elham Nasrollahi, Shuaichao Wang, Rami Yanes, Cyndi Gonzalez Gomez, Tara Magge, Abigail Overacre, Ronan Hsieh, Ashley Mcfarquhar, Curtis Tatsuoka, Aatur Singhi, Anwaar Saeed and Ibrahim Halil Sahin
Cancers 2025, 17(17), 2763; https://doi.org/10.3390/cancers17172763 - 25 Aug 2025
Viewed by 451
Abstract
Background: Young-onset colorectal cancer (YO-CRC) has emerged as a distinct clinical entity, often presenting at advanced stages. Despite the increasing incidence, the molecular and clinical underpinnings of YO-CRC remain underexplored. This study aims to characterize the clinical and molecular features of YO-CRC [...] Read more.
Background: Young-onset colorectal cancer (YO-CRC) has emerged as a distinct clinical entity, often presenting at advanced stages. Despite the increasing incidence, the molecular and clinical underpinnings of YO-CRC remain underexplored. This study aims to characterize the clinical and molecular features of YO-CRC and to evaluate their impact on OS. Methods: We reviewed 110 patients diagnosed with YO-CRC at our institution who underwent next-generation sequencing. Demographic, clinical, and molecular data, including age, gender, race, tumor location, cancer stage, and mutation status (KRAS, NRAS, BRAF, POLE, ERBB-2/HER2, microsatellite status), were collected by reviewing electronic medical records. For OS analysis, we focused on patients diagnosed with de novo stage IV. Cox proportional hazards regression and Kaplan–Meier survival analysis were utilized to assess the association of these factors with OS, with statistical significance determined by a p-value threshold of <0.05. Results: Among 110 patients, n = 44 (40%) presented with local disease (stage 1–3), while n = 66 (60%) presented with de novo metastatic disease at the time of diagnosis. The median age at diagnosis was 44.5 years. The cohort consisted of 64% males and 36% females, with 84% of patients identified as White. Most tumors were left-sided (77%), including the distal colon/sigmoid (44%) and rectum (33%). KRAS and BRAF mutations were present in 36% and 5.5%, respectively. ERBB-2/HER2 amplification and microsatellite instability were observed in 4.5% and 6.4%, respectively. Tumor mutation burden (TMB) was <10 in 57% of patients, with 14% having TMB > 20. CNV analysis revealed that 14% of patients had copy gains, 12% had concurrent gains/losses, and 31% had copy losses. Among 66 patients with de novo metastatic disease, 44% had died by the time of analysis, with a median overall survival (OS) of 43.6 months (95% CI, 28.7—not reached). KRAS mutations were found to be significantly associated with worse survival outcomes. Cox regression analysis reveals the prognostic significance of KRAS status, with a hazard ratio (HR) of 3.52 (95% CI: 1.59–7.76, p = 0.002), indicating a significantly higher risk of death for KRAS-mutant YO-CRC patients. Conclusions: Patients with YO-CRC are more likely to present with de novo metastatic disease and left-sided tumors with distinct molecular characteristics. KRAS mutations are a key prognostic factor in YO-CRC, highlighting the need for therapeutic interventions to improve outcomes in this high-risk group. Full article
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17 pages, 5462 KB  
Article
Degradation and Sustainability: Analysis of Structural Issues in the Eduardo Caldeira Bridge, Machico
by Raul Alves, Sérgio Lousada, José Manuel Naranjo Gómez and José Cabezas
Infrastructures 2025, 10(9), 224; https://doi.org/10.3390/infrastructures10090224 - 22 Aug 2025
Viewed by 272
Abstract
This paper presents a detailed analysis of the severe structural anomalies that led to the urgent rehabilitation of the Eduardo Caldeira Bridge in Machico, Madeira. Situated in a challenging coastal environment with complex volcanic geology, the bridge exhibited a critical failure of its [...] Read more.
This paper presents a detailed analysis of the severe structural anomalies that led to the urgent rehabilitation of the Eduardo Caldeira Bridge in Machico, Madeira. Situated in a challenging coastal environment with complex volcanic geology, the bridge exhibited a critical failure of its bearing devices, which were assigned the highest defect severity rating (Grade 5). A multidisciplinary diagnostic methodology, combining visual inspection data, non-destructive testing, and geotechnical analysis, was employed to identify the root causes of this degradation. The investigation concluded that the bearing failure was not due to widespread material deterioration but was directly linked to significant lateral structural displacements, exacerbated by localized geotechnical instabilities. This paper details the data-driven rehabilitation strategy that was subsequently implemented, including the complete replacement of the bearings and substructure stabilization measures. The study provides a valuable case study of a complex, mechanics-driven failure mode and demonstrates that for such critical infrastructure, a proactive management model integrating advanced technologies like Structural Health Monitoring (SHM) and Building Information Modelling (BIM) is essential for ensuring long-term safety and resilience. Full article
(This article belongs to the Special Issue Sustainable Bridge Engineering)
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27 pages, 3350 KB  
Article
Anaerobic Co-Digestion of Food Waste in Ghana: Biological Methane Potential and Process Stabilisation Challenges in a Rural Setting
by Raquel Arnal-Sierra, Simone Colantoni, Albert Awopone, Isaac Boateng, Kingsley Agyapong, Frederick Kwaku Sarfo, Daniele Molognoni and Eduard Borràs
Sustainability 2025, 17(17), 7590; https://doi.org/10.3390/su17177590 - 22 Aug 2025
Viewed by 458
Abstract
In rural Ghana, limited access to affordable, clean cooking fuels drives the need for decentralised waste-to-energy solutions. Anaerobic co-digestion (AcoD) offers a viable route for transforming organic residues into renewable energy, with the added benefit of improved process stability resulting from substrate synergy. [...] Read more.
In rural Ghana, limited access to affordable, clean cooking fuels drives the need for decentralised waste-to-energy solutions. Anaerobic co-digestion (AcoD) offers a viable route for transforming organic residues into renewable energy, with the added benefit of improved process stability resulting from substrate synergy. This study aims to evaluate the technical feasibility and stabilisation challenges of AcoD, using locally available fruit waste and beet molasses at a secondary school in Bedabour (Ghana). Biological methane potential (BMP) assays of different co-digestion mixtures were conducted at two inoculum-to-substrate (I/S) ratios (2 and 4), identifying the highest yield (441.54 ± 45.98 NmL CH4/g VS) for a mixture of 75% fruit waste and 25% molasses at an I/S ratio of 4. Later, this mixture was tested in a 6 L semi-continuous AcoD reactor. Due to the high biodegradability of the substrates, volatile fatty acid (VFA) accumulation led to acidification and process instability. Three low-cost mitigation strategies were evaluated: (i) carbonate addition using eggshell-derived sources, (ii) biochar supplementation to enhance buffering capacity, and (iii) the integration of a bioelectrochemical system (BES) into the AcoD recirculation loop. The BES was intended to support VFA removal and enhance methane recovery. Although they temporarily improved the biogas production, none of the strategies ensured long-term pH stability of the AcoD process. The results underscore the synergistic potential of AcoD to enhance methane yields but also reveal critical stability limitations under high-organic-loading conditions in low-buffering rural contexts. Future implementation studies should integrate substrates with higher alkalinity or adjusted organic loading rates to ensure sustained performance. These findings provide field-adapted insights for scaling-up AcoD as a viable renewable energy solution in resource-constrained settings. Full article
(This article belongs to the Section Environmental Sustainability and Applications)
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