Search Results (2,653)

Background: Critical illness leads to profound metabolic, neuroendocrine and immune disorders that affect the prognosis of patients treated in intensive care units (ICUs). The ketogenic diet, a high-fat and low-carbohydrate eating model, is gaining increasing importance as a potential metabolic intervention in the ICU. Preliminary data suggest that the ketogenic diet (KD) may support the control of seizures in a super-refractive epileptic state (SRSE), stabilize glycemia, reduce insulin demand, and modulate the immune response in sepsis. The aim of this review was to present a synthetic presentation of the current state of knowledge regarding use of the KD in intensive care patients. Methods: The review was carried out in accordance with the guidelines of the Joanna Briggs Institute and PRISMA-ScR. PubMed, Scopus, EBSCO, Web of Science, Google Scholar and Cochrane Library databases were searched (10–19 April 2026) using the Population–Concept–Context model. Full-text observational studies, randomized trials and reviews of the use of KDs in ICU patients were included. Data extraction was performed independently by two reviewers. Results: Of the 42 publications identified, seven studies were included in the analysis. The KD was feasible and safe in both critically ill adults and children. In SRSE, most patients achieved stable ketosis within a few days, which often allowed for reduction or discontinuation of anesthetics. In sepsis, the KD led to glycemic stabilization, reduced insulin demand and reduced immune deregulation; in one study, “after day 4, none of the patients in the KD group required insulin treatment.” The KD also showed beneficial effects on cellular bioenergetics and mitochondrial function. The safety profile was acceptable and adverse reactions were manageable with appropriate monitoring. Conclusions: The KD represents a promising, non-pharmacological metabolic intervention in intensive care, particularly in the treatment of SRSE and in the stabilization of glucose metabolism in sepsis and other critical conditions. Despite the growing number of positive clinical observations, the available evidence remains limited due to small samples, heterogeneous protocols, and a lack of randomized trials. Further, well-designed prospective studies are needed to determine optimal KD implementation protocols and identify the patient populations that benefit most. Full article

The objective of this study was to examine the physicochemical properties of maltodextrins derived from starch isolated from red- and purple-fleshed potatoes, in comparison to those obtained from light-fleshed potatoes. The investigation focused on several parameters, including dextrose equivalent (DE), non-carbohydrate components, maltooligosaccharide profile, particle size, surface morphology, water-binding capacity, solubility, rheological properties, structural composition as determined by Fourier transform infrared spectroscopy (FT-IR), and molecular weights. Maltodextrins sourced from the starch of colored potato varieties exhibit superior functional properties, notably nearly 100% solubility and enhanced water absorption capacity. This is attributed to their fine microstructure, which promotes hydration and facilitates the diffusion of water into the interior of the particles, in contrast to maltodextrins derived from the starch of yellow potato varieties. This phenomenon is also influenced by the maltooligosaccharide profile, characterized by a high proportion of low-molecular-weight sugars, lower molecular weights, and polydispersity (Pd), as well as the low SPAN of these maltodextrins. Additionally, maltodextrins derived from the starch of yellow potato varieties (Tajfun and Lord) formed soft gels, whereas those from colored potatoes resulted in hard gels. Full article

Owing to clonal integration and morphological plasticity, clonal plants generally exhibit higher fitness in nutrient-heterogeneous environments. Indocalamus latifolius (Keng) McClure is a clonal plant with considerable economic value in China. However, the mechanisms of clonal integration and morphological plasticity in I. latifolius under phosphorus (P) heterogeneous conditions remain unclear. To clarify the mechanisms, a pot experiment was performed with I. latifolius clonal fragments consisting of mother ramet, rhizome, and daughter ramet. The experiment used a two-factor design with the following six treatments: P addition regime (uniform P addition, localized P addition to mother ramets, and localized P addition to daughter ramets) and rhizome status (connection vs. severance). Biomass allocation, root morphological plasticity, and the allocation pattern of P and non-structural carbohydrates were determined. The results showed that localized P addition increased the biomass of ramets growing in high-P patches and the total biomass of the clonal system compared with uniform P addition. Under three P supply regimes, rhizome connection significantly improved the biomass and P accumulation of daughter ramets relative to rhizome severance. In heterogeneous P environments, rhizome connection facilitated the proliferation of finer root and raised the soluble sugar concentrations in belowground tissues of ramets located in low-P patches compared with rhizome severance. In conclusion, resource allocation within the I. latifolius clonal system is prioritized toward daughter ramets and ramets in high-P patches. Clonal integration can promote compensatory root growth and morphological modification in ramets located in low-P patches. Localized P addition to mother ramets combined with the maintenance of rhizome connectivity between mother and daughter ramets is more conducive to the overall growth of the clonal system. Full article

Diabetic neuropathy (DN) is a multifactorial complication of diabetes mellitus driven by chronic hyperglycemia, insulin resistance, and disturbed metabolic homeostasis, leading to progressive injury of both the peripheral and central nervous systems. This study investigated whether L-serine supplementation could attenuate DN through dose-dependent metabolic and neuroprotective mechanisms in a high-fat diet (HFD) plus streptozotocin (STZ)-induced diabetic rat model. Male Wistar rats (n = 8 per group) were allocated to five groups: normal control (NC), diabetic control (DC), pioglitazone (PIO; 1.5 mg/kg/day), low-dose L-serine (S1; 200 mg/kg/day), and high-dose L-serine (S2; 400 mg/kg/day). After 60 days of oral gavage, behavioural testing, glucose and insulin profiling, HOMA-IR calculation, brain histopathology, nerve growth factor (NGF) immunohistochemistry, and LC–MS/MS-based proteomic analysis of cerebral tissue were performed. Diabetic rats exhibited marked hyperglycaemia (355.33 ± 4.72 mg/dL), hyperinsulinaemia, severe insulin resistance (HOMA-IR 16.8 ± 3.2; a 14-fold increase), impaired thermal nociception, motor dysfunction, and pronounced neuronal degeneration. L-serine supplementation significantly improved metabolic status: S1 reduced HOMA-IR by 77.4% and S2 by 87.5% relative to diabetic controls (p < 0.001). High-dose L-serine produced greater improvements in thermal sensitivity, motor coordination (rotarod latency 26.67 ± 1.52 s vs. 16.1 ± 0.85 s in DC; p < 0.05), and NGF expression (8.6-fold increase vs. DC). Histopathology confirmed attenuation of neuronal injury and gliosis in both treatment groups. Exploratory, group-level proteomic profiling identified dose-specific molecular signatures: S1 was predominantly associated with carbohydrate, lipid, and biosynthetic pathways, whereas S2 was associated with synaptic, neurotransmission-related, and proteostasis pathways. Within the constraints of an exploratory design—group-level pooled proteomics, analysis of cerebral rather than peripheral-nerve tissue, and only two doses—these findings indicate that L-serine attenuates the metabolic and behavioural features of experimental diabetic neuropathy and generates the testable hypothesis of dose-dependent neuro-metabolic remodelling. The proteomic signatures are hypothesis-generating and require orthogonal validation before any mechanistic or translational inference can be drawn. Full article

The high-rate biological contactor (HRBC) is an enhanced-primary, biosorption-based, carbon-diversion wastewater treatment process with short hydraulic retention time (HRT), short solids retention time (SRT), low dissolved oxygen (DO), and high food-to-microorganism ratio (F/M). This paper presents modifications to a commercial full-plant wastewater biodegradation model using extracellular polymeric substances (EPS) in waste activated sludge (WAS) to simulate pilot test biosorption data. Bench-scale HRBC tests found that each mg of EPS as COD (COD_EPS) biosorbed 1.02 mg sCOD contained in raw wastewater. The fraction of AS organics identified as EPS in terms of COD was 37% in a conventional AS (CAS), 33% in a trickling filter-solids contact (TF/SC), and 18% in a membrane bioreactor (MBR). The modeling process used stoichiometry equations to convert EPS from its constituent concentrations (carbohydrates, proteins, humic acids, uronic acids) into COD. The conversion did not alter the finding that the normalized total EPS showed a positive relationship with soluble chemical oxygen demand sCOD biosorption with a 0.91 coefficient of determination. The modified commercial biodegradation model gave a maximum error of −12.6% when simulating pilot-scale results, and 80% of all data points were less than ±10% error. The modified model predicted 16% sCOD biosorption by EPS using the design data for a full-scale HRBC facility currently under construction. Full article

This study investigated the effects of moisture content (80% vs. 70%) and Lactiplantibacillus plantarum inoculation on the fermentation quality, microbial community structure, and metabolite profiles of amaranth (Amaranthus hypochondriacus) silage using integrated microbiomics (full-length 16S rRNA sequencing) and untargeted metabolomics (UPLC-MS/MS). The results showed that high-moisture silage without inoculation (AhGCK) exhibited poor fermentation quality, characterized by high pH (5.09) and low lactic acid content (1.42% FM). Inoculation with L. plantarum significantly reduced pH (to 4.16) and increased lactic acid accumulation (to 3.65% FM) under high-moisture conditions. Wilting to 70% moisture combined with L. plantarum inoculation (AhSLP) achieved the best fermentation quality, with the lowest pH (4.20) and highest lactic acid (4.46% FM). Microbial community analysis revealed that Enterobacter cloacae dominated in AhGCK, whereas L. plantarum, Lentilactobacillus buchneri, and Levilactobacillus brevis became dominant after inoculation and wilting. Metabolomics identified 497 compounds across all treatments, with differential metabolites primarily enriched in pathways related to amino acid metabolism, carbohydrate metabolism, and biosynthesis of secondary metabolites such as diterpenoids and isoquinoline alkaloids. Highly significant correlations (p < 0.01) were observed between Enterobacter and cyclohexylammonium, between dTDP-3-O-methyl-β-L-rhamnose and 2-hydroxy-2H-benzo[h]chromene-2-carboxylate, between Lentilactobacillus and 3-ketosucrose (positive), and between Limosilactobacillus and 8-methylthiooctyl glucosinolate (positive), whereas Lactiplantibacillus and Escherichia Shigella showed no correlations with differential metabolites. These findings indicate that inoculating Lactobacillus plantarum at specific moisture levels (80% and 70%) promotes directed microbial community succession (as exemplified by positive correlations of Lentilactobacillus and Limosilactobacillus with beneficial metabolites) and optimized metabolite accumulation, which significantly lowers dry matter loss during fermentation and enhances the output of usable silage. This mechanism offers a practical theoretical foundation for improving amaranth silage production and boosting feed yield. Full article

Background: Acute intermittent porphyria (AIP) is the most common and severe form of acute hepatic porphyria, caused by heterozygous mutations in the HMBS gene. Due to its non-specific clinical manifestations and low clinical awareness among clinicians, AIP is frequently misdiagnosed, leading to significant diagnostic delays and potentially fatal complications. Case presentation: We report a 20-year-old female patient who presented with a 9-month history of recurrent abdominal pain, paralytic ileus, unexplained liver injury, and hyponatremia, followed by progressive limb weakness. She was initially misdiagnosed with Guillain–Barré syndrome (GBS) and received intravenous immunoglobulin and systemic glucocorticoids. However, her condition deteriorated, and she developed life-threatening respiratory muscle paralysis requiring invasive mechanical ventilation. The diagnosis of AIP was confirmed by positive urinary porphobilinogen (PBG) testing and identification of the heterozygous HMBS c.517C>T pathogenic variant. The patient was treated with high-dose carbohydrate loading therapy and comprehensive supportive care, resulting in gradual clinical improvement. Discussion and Conclusions: This case exemplifies the substantial diagnostic challenges associated with AIP, especially when it manifests with peripheral neuropathy that closely mimics GBS. The triad of absent albuminocytologic dissociation in cerebrospinal fluid, preceding visceral symptoms, and inadequate response to standard first-line GBS therapy should immediately raise clinical suspicion for AIP. Enhanced clinical awareness of this rare disorder and timely implementation of urinary PBG screening are of paramount importance to prevent irreversible neurological complications and optimize long-term patient outcomes. Full article

Background/Objectives: Short-term low-fermentable oligo-, di-, and monosaccharide and polyol (FODMAP) diets can reduce exercise-associated gastrointestinal symptoms (Ex-GIS); however, their effects on the gut microbiome, short-chain fatty acids (SCFAs), and gastrointestinal biomarkers remain unclear. This study explored the effects of 48 h dietary FODMAP manipulation within a high-carbohydrate diet on faecal bacterial and SCFA profiles, and their relationships with exercise-induced gastrointestinal syndrome (EIGS) biomarkers, Ex-GIS, and performance. Methods: Twelve endurance athletes experiencing Ex-GIS were randomly allocated to a 48 h high-carbohydrate (mean ± SD: 12.1 ± 1.8 g∙d⁻¹)–high-FODMAP (HC-HFOD) (54.8 ± 10.5 g∙d⁻¹) and a 48 h high-carbohydrate–low-FODMAP (HC-LFOD) (3.0 ± 0.2 g∙d⁻¹) diet before 2 h of running at 60% $\dot{V}$O_2max, followed by a 1 h distance test (22.9 ± 1.2 °C, 46 ± 8% RH). Baseline faecal samples were collected before exercise trials to determine faecal bacterial and SCFA profiles. Blood samples were collected pre- and post-exercise to determine plasma I-FABP, sCD14, and CRP concentrations. Ex-GIS were recorded every 15 min throughout exercise. Results: Faecal bacterial α-diversity and relative abundance (RA%) at the phylum level were unchanged following both diets, while several family- and genus-level taxa RA% values were changed (p < 0.05), with greater shifts after HC-HFOD. HC-HFOD significantly increased faecal total-SCFA (p = 0.004), acetic (p = 0.002), and butyric (p = 0.028) acid concentrations. Strong positive and negative correlations between bacterial RA% and EIGS biomarkers and Ex-GIS were observed. Strong negative correlations with bacterial RA% and performance were observed. Conclusions: The 48 h HC-HFOD resulted in greater increases in bacterial RA% and SCFA concentrations compared with baseline. Bacterial RA% correlated bidirectionally with EIGS biomarkers and Ex-GIS, alongside strong negative associations with performance. Full article

Background/Objectives: Cancer pathophysiology involves metabolic disturbances, and exercise improves muscle metabolism, but little is known about the effect of concurrent high-intensity interval plus resistance training (CT_HIIT+RT) on the resting and exercise metabolism of breast cancer survivors with risk factors related to metabolic syndrome (MetS). The purpose of this study was to determine the effects of 8 weeks of CT_HIIT+RT on the fat and carbohydrate (CHO) metabolism during rest and progressive exercise post-exercise intervention in breast cancer survivors with histories of high- and low-volume chemotherapy. Methods: An experimental study was conducted in which (n = 21) women breast cancer survivors (age: 58.7 ± 8.7 years) were divided by history of high- (HV_chemo, ≥8 to 16 sessions, n = 10) or low-volume (LV_chemo, ≤7 chemo sessions, n = 11) chemotherapy. The fat (RFAT_ox) and CHO oxidation during 10 min of resting was measured (i.e., including the area under curve [AUC] points within this time), as well as the fat (ExFAT_ox) and CHO (ExCHO_ox) oxidation during progressive exercise, before and after 8 weeks of CT_HIIT+RT by indirect calorimetry. Additionally, risk factors related to MetS were described from pre- to post-intervention. Results: At rest, the HV_chemo group showed significant increases in the AUC of RFAT_ox (∆ + 23.7, p < 0.0001), similar to the LV_chemo group (∆ + 14.0, p < 0.0001). The HV_chemo group showed significant increases in the AUC of RCHO_ox (∆ + 109.7, p < 0.0001), similar to the LV_chemo group (∆ + 107.5, p < 0.0001). During progressive exercise, the ExFAT_ox was increased in the HV_chemo group (∆ + 0.12 g/min, p = 0.006), similar to the ExCHO_ox (∆ + 0.52 g/min, p = 0.013) of this group. The proportion of subjects categorized with MetS were significantly reduced in blood pressure, Glu and triglyceride components. Conclusions: Eight weeks of CT_HIIT+RT may promote favorable metabolic and cardiometabolic adaptations in breast cancer survivors regardless of the chemotherapy exposure volume. However, these findings should be interpreted cautiously due to the small sample size and lack of a true non-exercise control group. Full article

Food waste is a readily digestible and fermentable feedstock for waste to energy bioprocesses. Approximately one third of food is wasted, thus making improvements in food waste valorization is essential for a circular economy. Laboratory results must be reproducible and as representative of scaled performance as possible to facilitate knowledge sharing between research groups. Food waste used in laboratory studies is often collected in situ or overly simplistic synthetic mixtures are used. Food waste collected in situ from any one local source at a single time point (e.g., grab samples from a cafeteria or restaurant) are not reproducible or nationally representative; additionally, overly simple synthetic mixtures are reproducible, but lack the complexity of real food waste and are not nationally representative. Thus, an adequately complex, reproducible, and nationally representative food waste recipe is needed to standardize the feedstocks used in laboratory scale food waste digestion and fermentation studies. In this work, we developed a food waste recipe made from widely and commercially available ingredients which is based on national-scale food wastage data in the United States. The nationally representative food waste mixture was 45.4% carbohydrates, 32.5% lipids, and 13.4% proteins. The biomethane potential was 495 ± 44 mL CH₄/g VS and the food waste mixture was suitable for use in low-pH bench-scale arrested anaerobic digesters. This design approach can be adapted for other regions and countries where food loss data are available. Full article

Background/Objectives: This meta-analysis aimed to quantify the combined ergogenic effects of caffeine (CAF) and carbohydrate (CHO) on high-intensity interval exercise (HIIE) performance and to identify potential moderating factors. Methods: Four databases were systematically searched to identify randomized crossover trials assessing CAF combined with CHO (CAF + CHO) on HIIE performance (i.e., exercise time, distance, or total work). A three-level random-effects meta-analysis was performed to calculate pooled Hedge’s g (g) values. Moderator effects were explored through subgroup analyses, including control group (placebo-, CHO-, and CAF-controlled), CHO administration (mouth rinse and ingestion), and training status (recreationally active and trained). Results: Eleven studies met the inclusion criteria (n = 105; 8 female). CAF + CHO significantly enhanced HIIE performance (g = 0.44, 95% CI: 0.23–0.66). Subgroup analyses indicated that CAF + CHO mouth rinsing (g = 0.91, CI: 0.49–1.33) yielded superior effects compared to CAF + CHO ingestion (g = 0.33, CI: 0.14–0.52) (p for subgroup < 0.05). Performance improvements with CAF + CHO were observed for CHO- and placebo-controlled trials, but not in CAF-controlled trials, without significant subgroup effects (p for subgroup > 0.05). Importantly, evidence of publication bias was identified, and the overall certainty of evidence was graded as low according to the GRADE framework. Conclusions: CAF + CHO appears to be effective for enhancing HIIE performance, with greater benefits observed when CHO is administered via mouth rinsing rather than ingestion. Preliminary evidence suggests that CAF may play a key role in CAF + CHO strategies. However, given the limited number of female participants, the generalizability of these findings to both sexes is limited. Additional high-quality trials are needed to establish more definitive recommendations. Full article

Several studies on diet and microbiome have predominantly focused on the gut microbiome. However, much of the salivary microbiome remains unexplored. This study examined the influence of Thai desserts with varying glycemic indices on the salivary microbiome. A total of 30 healthy adults aged 18–45 years were enrolled in a randomized trial and allocated to one of three intervention groups, with each receiving a culturally specific Thai dessert standardardized to provide 50 g of available carbohydrates: Phetchaburi’s Custard Cake (PCC; low-GI, 192 g), Saraburi’s Curry Puff (SCP; medium-GI, 98 g), or Lampang’s Crispy Rice Cracker (LCRC; high-GI, 68 g). Salivary and dessert microbiome compositions were characterized at baseline and 24 h post-intervention using 16S rRNA sequencing to evaluate bacterial diversity and relative abundance across multiple taxonomic levels. Firmicutes were highly abundant (over 76%) in all Thai desserts tested. Proteobacteria were found in both SCP (15.1 ± 6.6%) and LCRC (6.5 ± 3.4%). Actinobacteriota was slightly higher in the high-GI group (6.3 ± 3.1%) compared to the medium-GI group (3.0 ± 2.2%). Bacillus was dominant in PCC, while Streptococcus, Carnobacterium, and Clostridium sensu stricto 1 were prevalent in SCP. Anoxybacillus, Clostridium sensu stricto 12, Terrilactibacillus, Geobacillus, and Weissella were found in LCRC. Desserts with different types of glycemic index showed modest short-term changes in the relative abundance of some salivary bacteria. Notably, Porphyromonas showed a relative increase in the high-GI group compared to the low-GI group (1.8 [0.3, 4.0] vs. −1.9 [−3.2, 0.8], p < 0.05), while Streptococcus, saccharolytic bacteria, slightly increased in both the high-GI and medium-GI groups. Prevotella showed a slight relative decrease in the low-GI group. Although these microorganisms have been previously associated with dysbiosis and periodontitis in longer-term studies, the clinical relevance of these short-term compositional changes remains unclear and should be interpreted with caution. These preliminary findings suggest that local Thai desserts with varying GIs may be associated with transient shifts in salivary microbiota composition; however, whether such changes contribute to dysbiosis or adverse oral health outcomes requires further investigation through longitudinal studies with larger sample sizes. Full article

Background: Adequate nutrition during young adulthood is essential for health promotion, optimal physiological function, and the prevention of non-communicable diseases. However, evidence describing both nutrient adequacy and compliance with dietary recommendations in well-characterized samples of young adults remains limited. Therefore, the aim of the present study was to describe macronutrient and micronutrient adequacy and to quantify compliance with current dietary recommendations in young adults using an individualized energy-adjusted nutrient adequacy approach (NARm), and to explore sex differences to identify priority targets to inform tailored health promotion and public health nutrition strategies. Methods: This cross-sectional study included 74 young adults aged 18–45 years participating in the NutAF project. Dietary intake was assessed using a 5-day dietary record, including three weekdays and two weekend days. Modified nutrient adequacy ratios (NARm), adjusted according to individualized total daily energy expenditure, were calculated for macronutrients and micronutrients. The prevalence of compliance with current dietary recommendations was also determined. Differences between men and women were analyzed using independent samples t-tests. Results: Protein and total lipid intake levels exceeded recommended values in most participants, whereas carbohydrate adequacy was below recommendations. Regarding micronutrients, adequate intake was observed for several nutrients; however, low adequacy and low compliance rates were identified for calcium, folate, vitamin D, and omega-3 and omega-6 polyunsaturated fatty acids. No participants met the recommendations for vitamin D. No significant sex differences were observed for most nutrients. Conclusions: Despite intake levels above recommendations for some macronutrients, young adults included in this study exhibited inadequate intake and low compliance with current dietary recommendations for several key nutrients. No relevant sex differences were observed for most nutrients. These findings, obtained using an individualized energy-adjusted nutrient adequacy approach (NARm), underscore the need for targeted nutritional strategies, including nutrition education and micronutrient-focused interventions, aimed at improving dietary adequacy and supporting health promotion in this population. Full article

Extreme flooding has emerged as a major climate risk for low-lying Australian macadamia (Macadamia spp.) orchards, yet the physiological mechanisms underlying tree decline remain poorly understood. We investigated whole-plant responses to complete submergence in young, grafted macadamia trees by subjecting plants to one- and two-week floods, as well as repeated flooding. Following emergence from the flood water, photosynthetic rate (A) and stomatal conductance (g_s) declined progressively with increased flood duration and repeated exposure. Grafted plants of G on H2 maintained a more resilient photosynthetic apparatus post-flood than G grafted on Beaumont, as reflected by a smaller decline in maximum assimilation rates as well as biochemical capacities for ribulose 1,5 bisphosphate (RuBP) carboxylation (V_cmax), and RuBP regeneration (J_max). Despite these differences in leaf-level function, prolonged and repeated flooding triggered a cascade of post-flood stress symptoms in both rootstocks, including progressive canopy dieback, sharp reductions in root biomass, depletion of total non-structural carbohydrates, and ultimately scion mortality. Collectively, these findings indicate that plants only partially tolerated one week of complete submergence, whereas longer or repeated flooding severely compromised carbon balance and plant survival in both rootstocks. Full article

This study characterized eleven grape pomace varieties from São Paulo and Rio Grande do Sul (Brazil) in terms of proximate composition, total phenolic content, and the total and bioaccessible fractions of inorganic elements and phenolic compounds. On a dry basis, ash, protein, lipid, and carbohydrate contents ranged from 1.4–2.9%, 6.4–13.5%, 8.6–14.7%, and 72.1–83.6%, respectively. Total phenolic content ranged from 567 to 1843 mg GAE/100 g. The contents of essential elements (Ca, Fe, Zn, Cu, Mg, Mn, P, Na, and K) and trace elements (Al, Co, As, Se, Mo, Cd, Sb, Ba, Hg, and Pb) showed wide variation among the varieties studied. Regarding bioaccessibility, low values were observed for Fe, Zn, and Ca, while significant percentages were detected for Mg (27–30%), Mn (1–14%), P (16–26%), Cu (5.5–13%), Co (29–72%), Al (2–13%), and Ba (ND-9%), as well as levels of bioaccessible phenolic compounds (7–19%). The grape pomaces evaluated in this study presented variable levels of total phenolic compounds and minerals, although the bioaccessible fractions varied among the analyzed elements and compounds. These findings contribute to the characterization of Brazilian grape pomaces and indicate their potential applicability as value-added agro-industrial by-products in food formulations, while highlighting the importance of considering bioaccessibility when assessing their nutritional relevance. Full article